UniProtKB - Q62077 (PLCG1_MOUSE)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
Plcg1
Functioni
Catalytic activityi
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H+By similarityEC:3.1.4.11By similarityThis reaction proceeds in the forwardBy similarity direction.
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H+By similarityThis reaction proceeds in the forwardBy similarity direction.
Cofactori
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 335 | PROSITE-ProRule annotation | 1 | |
Active sitei | 380 | PROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 165 – 176 | PROSITE-ProRule annotationAdd BLAST | 12 |
GO - Molecular functioni
- calcium-dependent phospholipase C activity Source: UniProtKB
- calcium ion binding Source: InterPro
- glutamate receptor binding Source: MGI
- insulin receptor binding Source: MGI
- neurotrophin TRKA receptor binding Source: MGI
- phosphatidylinositol phospholipase C activity Source: Reactome
- phosphoprotein binding Source: MGI
- protein kinase binding Source: MGI
- receptor tyrosine kinase binding Source: UniProtKB
GO - Biological processi
- calcium ion transport Source: MGI
- calcium-mediated signaling Source: MGI
- cell migration Source: MGI
- cellular response to epidermal growth factor stimulus Source: UniProtKB
- epidermal growth factor receptor signaling pathway Source: UniProtKB
- inositol trisphosphate biosynthetic process Source: MGI
- in utero embryonic development Source: MGI
- modulation of chemical synaptic transmission Source: SynGO
- phosphatidylinositol metabolic process Source: UniProtKB
- phospholipid catabolic process Source: InterPro
- positive regulation of angiogenesis Source: MGI
- positive regulation of blood vessel endothelial cell migration Source: MGI
- positive regulation of endothelial cell apoptotic process Source: MGI
- positive regulation of epithelial cell migration Source: UniProtKB
- positive regulation of release of sequestered calcium ion into cytosol Source: MGI
- positive regulation of vascular endothelial cell proliferation Source: MGI
- protein secretion Source: MGI
- regulation of store-operated calcium channel activity Source: MGI
- T cell receptor signaling pathway Source: MGI
Keywordsi
Molecular function | Hydrolase, Transducer |
Biological process | Lipid degradation, Lipid metabolism |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
BRENDAi | 3.1.4.11, 3474 |
Reactomei | R-MMU-1169408, ISG15 antiviral mechanism R-MMU-1855204, Synthesis of IP3 and IP4 in the cytosol R-MMU-186763, Downstream signal transduction R-MMU-202433, Generation of second messenger molecules R-MMU-2029485, Role of phospholipids in phagocytosis R-MMU-210990, PECAM1 interactions R-MMU-212718, EGFR interacts with phospholipase C-gamma R-MMU-2424491, DAP12 signaling R-MMU-2871796, FCERI mediated MAPK activation R-MMU-2871809, FCERI mediated Ca+2 mobilization R-MMU-5218921, VEGFR2 mediated cell proliferation R-MMU-5654219, Phospholipase C-mediated cascade: FGFR1 R-MMU-5654221, Phospholipase C-mediated cascade, FGFR2 R-MMU-5654227, Phospholipase C-mediated cascade, FGFR3 R-MMU-5654228, Phospholipase C-mediated cascade, FGFR4 R-MMU-8853659, RET signaling R-MMU-9026527, Activated NTRK2 signals through PLCG1 R-MMU-9034793, Activated NTRK3 signals through PLCG1 |
Names & Taxonomyi
Protein namesi | Recommended name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1Curated (EC:3.1.4.11By similarity)Alternative name(s): Phosphoinositide phospholipase C-gamma-1 Phospholipase C-gamma-1 Short name: PLC-gamma-1 |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:97615, Plcg1 |
Subcellular locationi
Other locations
- lamellipodium By similarity
- ruffle By similarity
Note: Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment.By similarity
Cytosol
- cytosol Source: MGI
Nucleus
- COP9 signalosome Source: MGI
Plasma Membrane
- plasma membrane Source: MGI
Other locations
- cell projection Source: MGI
- cell-cell junction Source: MGI
- clathrin-coated vesicle Source: MGI
- cytoplasm Source: MGI
- glutamatergic synapse Source: SynGO
- lamellipodium Source: UniProtKB
- ruffle Source: UniProtKB
- Schaffer collateral - CA1 synapse Source: SynGO
Keywords - Cellular componenti
Cell projectionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000088499 | 2 – 1302 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1Add BLAST | 1301 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 506 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 771 | Phosphotyrosine; by SYKCombined sources | 1 | |
Modified residuei | 775 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 783 | Phosphotyrosine; by ITK, SYK and TXKBy similarity | 1 | |
Modified residuei | 977 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 1221 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1227 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1233 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1248 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1253 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 1263 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q62077 |
jPOSTi | Q62077 |
MaxQBi | Q62077 |
PaxDbi | Q62077 |
PRIDEi | Q62077 |
PTM databases
iPTMneti | Q62077 |
PhosphoSitePlusi | Q62077 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000016933, Expressed in floor plate of midbrain and 267 other tissues |
ExpressionAtlasi | Q62077, baseline and differential |
Interactioni
Subunit structurei
Interacts (via SH2 domain) with FGFR1, FGFR2, FGFR3 and FGFR4 (phosphorylated).
Interacts with RALGPS1.
Interacts (via SH2 domains) with VIL1 (phosphorylated at C-terminus tyrosine phosphorylation sites).
Interacts (via SH2 domain) with RET (By similarity).
Interacts with AGAP2 via its SH3 domain.
Interacts with LAT (phosphorylated) upon TCR activation.
Interacts (via SH3 domain) with the Pro-rich domain of TNK1. Associates with BLNK, VAV1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion.
Interacts with CBLB in activated T-cells; which inhibits phosphorylation.
Interacts with SHB.
Interacts (via SH3 domain) with the Arg/Gly-rich-flanked Pro-rich domains of KHDRBS1/SAM68. This interaction is selectively regulated by arginine methylation of KHDRBS1/SAM68.
Interacts with INPP5D/SHIP1, THEMIS and CLNK.
Interacts with FLT4 and KIT.
Interacts with AXL (By similarity).
Interacts with SYK; activates PLCG1 (By similarity).
Interacts with FLT1 (tyrosine-phosphorylated).
Interacts (via SH2 domain) with PDGFRA and PDGFRB (tyrosine phosphorylated).
Interacts with PIP5K1C.
Interacts with NTRK1 and NTRK2 (phosphorylated upon ligand-binding).
Interacts with TESPA1 (By similarity).
Interacts with GRB2, LAT and THEMIS upon TCR activation in thymocytes; the association is weaker in the absence of TESPA1.
By similarity14 PublicationsBinary interactionsi
Hide detailsQ62077
With | #Exp. | IntAct |
---|---|---|
Epor [P14753] | 4 | EBI-300133,EBI-617901 |
Grb2 [Q60631] | 2 | EBI-300133,EBI-1688 |
Lat [O54957] | 5 | EBI-300133,EBI-6390034 |
Lepr [P48356] | 2 | EBI-300133,EBI-2257257 |
GO - Molecular functioni
- glutamate receptor binding Source: MGI
- insulin receptor binding Source: MGI
- neurotrophin TRKA receptor binding Source: MGI
- phosphoprotein binding Source: MGI
- protein kinase binding Source: MGI
- receptor tyrosine kinase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 202238, 38 interactors |
CORUMi | Q62077 |
DIPi | DIP-29284N |
IntActi | Q62077, 23 interactors |
MINTi | Q62077 |
STRINGi | 10090.ENSMUSP00000099404 |
Miscellaneous databases
RNActi | Q62077, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 27 – 142 | PH 1PROSITE-ProRule annotationAdd BLAST | 116 | |
Domaini | 152 – 187 | EF-handPROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 320 – 464 | PI-PLC X-boxPROSITE-ProRule annotationAdd BLAST | 145 | |
Domaini | 489 – 523 | PH 2; first partPROSITE-ProRule annotationAdd BLAST | 35 | |
Domaini | 550 – 657 | SH2 1PROSITE-ProRule annotationAdd BLAST | 108 | |
Domaini | 668 – 756 | SH2 2PROSITE-ProRule annotationAdd BLAST | 89 | |
Domaini | 791 – 851 | SH3PROSITE-ProRule annotationAdd BLAST | 61 | |
Domaini | 895 – 931 | PH 2; second partPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 953 – 1070 | PI-PLC Y-boxPROSITE-ProRule annotationAdd BLAST | 118 | |
Domaini | 1071 – 1194 | C2PROSITE-ProRule annotationAdd BLAST | 124 |
Domaini
Keywords - Domaini
Repeat, SH2 domain, SH3 domainPhylogenomic databases
eggNOGi | KOG1264, Eukaryota |
GeneTreei | ENSGT00940000158901 |
InParanoidi | Q62077 |
OMAi | YGGKKQH |
OrthoDBi | 368239at2759 |
PhylomeDBi | Q62077 |
TreeFami | TF313216 |
Family and domain databases
CDDi | cd09932, SH2_C-SH2_PLC_gamma_like, 1 hit cd10341, SH2_N-SH2_PLC_gamma_like, 1 hit cd11970, SH3_PLCgamma1, 1 hit |
Gene3Di | 2.30.29.30, 1 hit 2.60.40.150, 1 hit 3.20.20.190, 2 hits 3.30.505.10, 2 hits |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR001192, PI-PLC_fam IPR016279, PLC-gamma IPR028380, PLC-gamma1 IPR035023, PLC-gamma_C-SH2 IPR035024, PLC-gamma_N-SH2 IPR017946, PLC-like_Pdiesterase_TIM-brl IPR035724, PLCgamma1_SH3 IPR000909, PLipase_C_PInositol-sp_X_dom IPR001711, PLipase_C_Pinositol-sp_Y IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
PANTHERi | PTHR10336, PTHR10336, 1 hit PTHR10336:SF173, PTHR10336:SF173, 1 hit |
Pfami | View protein in Pfam PF00168, C2, 1 hit PF00388, PI-PLC-X, 1 hit PF00387, PI-PLC-Y, 1 hit PF00017, SH2, 2 hits PF00018, SH3_1, 1 hit |
PIRSFi | PIRSF000952, PLC-gamma, 1 hit |
PRINTSi | PR00390, PHPHLIPASEC PR00401, SH2DOMAIN PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00239, C2, 1 hit SM00233, PH, 3 hits SM00148, PLCXc, 1 hit SM00149, PLCYc, 1 hit SM00252, SH2, 2 hits SM00326, SH3, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF50044, SSF50044, 1 hit SSF51695, SSF51695, 1 hit SSF55550, SSF55550, 2 hits |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 1 hit PS50003, PH_DOMAIN, 2 hits PS50007, PIPLC_X_DOMAIN, 1 hit PS50008, PIPLC_Y_DOMAIN, 1 hit PS50001, SH2, 2 hits PS50002, SH3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MAGVATPCAN GCGPGAPSEA EVLHLCRSLE VGTVMTLFYS KKSQRPERKT
60 70 80 90 100
FQVKLETRQI TWSRGADKIE GSIDIREIKE IRPGKTSRDF DRYQEDPAFR
110 120 130 140 150
PDQSHCFVIL YGMEFRLKTL SLQATSEDEV NMWIKGLTWL MEDTLQAATP
160 170 180 190 200
LQIERWLRKQ FYSVDRNRED RISAKDLKNM LSQVNYRVPN MRFLRERLTD
210 220 230 240 250
LEQRSGDITY GQFAQLYRSL MYSAQKTMDL PFLETNALRT GERPEHCQVS
260 270 280 290 300
LSEFQQFLLE YQGELWAVDR LQVQEFMLSF LRDPLREIEE PYFFLDELVT
310 320 330 340 350
FLFSKENSVW NSQLDAVCPD TMNNPLSHYW ISSSHNTYLT GDQFSSESSL
360 370 380 390 400
EAYARCLRMG CRCIELDCWD GPDGMPVIYH GHTLTTKIKF SDVLHTIKEH
410 420 430 440 450
AFVASEYPVI LSIEDHCSIA QQRNMAQHFR KVLGDTLLTK PVDIAADGLP
460 470 480 490 500
SPNQLRRKIL IKHKKLAEGS AYEEVPTSVM YSENDISNSI KNGILYLEDP
510 520 530 540 550
VNHEWYPHYF VLTSSKIYYS EETSSDQGNE DEEEPKEASS STELHSSEKW
560 570 580 590 600
FHGKLGAGRD GRHIAERLLT EYCIETGAPD GSFLVRESET FVGDYTLSFW
610 620 630 640 650
RNGKVQHCRI HSRQDAGTPK FFLTDNLVFD SLYDLITHYQ QVPLRCNEFE
660 670 680 690 700
MRLSEPVPQT NAHESKEWYH ASLTRAQAEH MLMRVPRDGA FLVRKRNEPN
710 720 730 740 750
SYAISFRAEG KIKHCRVQQE GQTVMLGNSE FDSLVDLISY YEKHPLYRKM
760 770 780 790 800
KLRYPINEEA LEKIGTAEPD YGALYEGRNP GFYVEANPMP TFKCAVKALF
810 820 830 840 850
DYKAQREDEL TFTKSAIIQN VEKQDGGWWR GDYGGKKQLW FPSNYVEEMI
860 870 880 890 900
NPAVLEPERE HLDENSPLGD LLRGVLDVPA CQIAIRPEGK NNRLFVFSIS
910 920 930 940 950
MPSVAQWSLD VAADSQEELQ DWVKKIREVA QTADARLTEG KMMERRKKIA
960 970 980 990 1000
LELSELVVYC RPVPFDEEKI GTERACYRDM SSFPETKAEK YVNKAKGKKF
1010 1020 1030 1040 1050
LQYNRLQLSR IYPKGQRLDS SNYDPLPMWI CGSQLVALNF QTPDKPMQMN
1060 1070 1080 1090 1100
QALFMAGGHC GYVLQPSTMR DEAFDPFDKS SLRGLEPCVI CIEVLGARHL
1110 1120 1130 1140 1150
PKNGRGIVCP FVEIEVAGAE YDSTKQKTEF VVDNGLNPVW PAKPFHFQIS
1160 1170 1180 1190 1200
NPEFAFLRFV VYEEDMFSDQ NFLAQATFPV KGLKTGYRAV PLKNNYSEDL
1210 1220 1230 1240 1250
ELASLLIKID IFPAKENGDL SPFSGISLRE RASDASSQLF HVRAREGSFE
1260 1270 1280 1290 1300
ARYQQPFEDF RISQEHLADH FDSRERSTSD GPSSATNLIE DPLHDKLWKC
SL
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA2A4A6 | A2A4A6_MOUSE | 1-phosphatidylinositol 4,5-bisphosp... | Plcg1 | 1,290 | Annotation score: | ||
G3UXP4 | G3UXP4_MOUSE | Phosphoinositide phospholipase C | Plcg1 | 513 | Annotation score: | ||
F6SLL0 | F6SLL0_MOUSE | 1-phosphatidylinositol 4,5-bisphosp... | Plcg1 | 132 | Annotation score: | ||
G3V016 | G3V016_MOUSE | 1-phosphatidylinositol 4,5-bisphosp... | Plcg1 | 110 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 966 | D → A in CAA64639 (PubMed:8687404).Curated | 1 | |
Sequence conflicti | 984 | P → R in CAA64639 (PubMed:8687404).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC065091 mRNA Translation: AAH65091.1 X95346 mRNA Translation: CAA64639.1 |
CCDSi | CCDS16996.1 |
RefSeqi | NP_067255.2, NM_021280.3 |
Genome annotation databases
Ensembli | ENSMUST00000103115; ENSMUSP00000099404; ENSMUSG00000016933 |
GeneIDi | 18803 |
KEGGi | mmu:18803 |
UCSCi | uc008nra.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC065091 mRNA Translation: AAH65091.1 X95346 mRNA Translation: CAA64639.1 |
CCDSi | CCDS16996.1 |
RefSeqi | NP_067255.2, NM_021280.3 |
3D structure databases
SMRi | Q62077 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 202238, 38 interactors |
CORUMi | Q62077 |
DIPi | DIP-29284N |
IntActi | Q62077, 23 interactors |
MINTi | Q62077 |
STRINGi | 10090.ENSMUSP00000099404 |
PTM databases
iPTMneti | Q62077 |
PhosphoSitePlusi | Q62077 |
Proteomic databases
EPDi | Q62077 |
jPOSTi | Q62077 |
MaxQBi | Q62077 |
PaxDbi | Q62077 |
PRIDEi | Q62077 |
Protocols and materials databases
ABCDi | Q62077, 1 sequenced antibody |
Antibodypediai | 3796, 1119 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000103115; ENSMUSP00000099404; ENSMUSG00000016933 |
GeneIDi | 18803 |
KEGGi | mmu:18803 |
UCSCi | uc008nra.1, mouse |
Organism-specific databases
CTDi | 5335 |
MGIi | MGI:97615, Plcg1 |
Phylogenomic databases
eggNOGi | KOG1264, Eukaryota |
GeneTreei | ENSGT00940000158901 |
InParanoidi | Q62077 |
OMAi | YGGKKQH |
OrthoDBi | 368239at2759 |
PhylomeDBi | Q62077 |
TreeFami | TF313216 |
Enzyme and pathway databases
BRENDAi | 3.1.4.11, 3474 |
Reactomei | R-MMU-1169408, ISG15 antiviral mechanism R-MMU-1855204, Synthesis of IP3 and IP4 in the cytosol R-MMU-186763, Downstream signal transduction R-MMU-202433, Generation of second messenger molecules R-MMU-2029485, Role of phospholipids in phagocytosis R-MMU-210990, PECAM1 interactions R-MMU-212718, EGFR interacts with phospholipase C-gamma R-MMU-2424491, DAP12 signaling R-MMU-2871796, FCERI mediated MAPK activation R-MMU-2871809, FCERI mediated Ca+2 mobilization R-MMU-5218921, VEGFR2 mediated cell proliferation R-MMU-5654219, Phospholipase C-mediated cascade: FGFR1 R-MMU-5654221, Phospholipase C-mediated cascade, FGFR2 R-MMU-5654227, Phospholipase C-mediated cascade, FGFR3 R-MMU-5654228, Phospholipase C-mediated cascade, FGFR4 R-MMU-8853659, RET signaling R-MMU-9026527, Activated NTRK2 signals through PLCG1 R-MMU-9034793, Activated NTRK3 signals through PLCG1 |
Miscellaneous databases
BioGRID-ORCSi | 18803, 0 hits in 12 CRISPR screens |
ChiTaRSi | Plcg1, mouse |
PROi | PR:Q62077 |
RNActi | Q62077, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000016933, Expressed in floor plate of midbrain and 267 other tissues |
ExpressionAtlasi | Q62077, baseline and differential |
Family and domain databases
CDDi | cd09932, SH2_C-SH2_PLC_gamma_like, 1 hit cd10341, SH2_N-SH2_PLC_gamma_like, 1 hit cd11970, SH3_PLCgamma1, 1 hit |
Gene3Di | 2.30.29.30, 1 hit 2.60.40.150, 1 hit 3.20.20.190, 2 hits 3.30.505.10, 2 hits |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR001192, PI-PLC_fam IPR016279, PLC-gamma IPR028380, PLC-gamma1 IPR035023, PLC-gamma_C-SH2 IPR035024, PLC-gamma_N-SH2 IPR017946, PLC-like_Pdiesterase_TIM-brl IPR035724, PLCgamma1_SH3 IPR000909, PLipase_C_PInositol-sp_X_dom IPR001711, PLipase_C_Pinositol-sp_Y IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
PANTHERi | PTHR10336, PTHR10336, 1 hit PTHR10336:SF173, PTHR10336:SF173, 1 hit |
Pfami | View protein in Pfam PF00168, C2, 1 hit PF00388, PI-PLC-X, 1 hit PF00387, PI-PLC-Y, 1 hit PF00017, SH2, 2 hits PF00018, SH3_1, 1 hit |
PIRSFi | PIRSF000952, PLC-gamma, 1 hit |
PRINTSi | PR00390, PHPHLIPASEC PR00401, SH2DOMAIN PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00239, C2, 1 hit SM00233, PH, 3 hits SM00148, PLCXc, 1 hit SM00149, PLCYc, 1 hit SM00252, SH2, 2 hits SM00326, SH3, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF50044, SSF50044, 1 hit SSF51695, SSF51695, 1 hit SSF55550, SSF55550, 2 hits |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 1 hit PS50003, PH_DOMAIN, 2 hits PS50007, PIPLC_X_DOMAIN, 1 hit PS50008, PIPLC_Y_DOMAIN, 1 hit PS50001, SH2, 2 hits PS50002, SH3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PLCG1_MOUSE | |
Accessioni | Q62077Primary (citable) accession number: Q62077 Secondary accession number(s): Q6P1G1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | January 24, 2006 | |
Last modified: | February 10, 2021 | |
This is version 197 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot