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Protein

Paired mesoderm homeobox protein 2A

Gene

Phox2a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi90 – 149HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Paired mesoderm homeobox protein 2A
Alternative name(s):
Aristaless homeobox protein homolog
PHOX2A homeodomain protein
Paired-like homeobox 2A
Gene namesi
Name:Phox2a
Synonyms:Arix, Phox2, Pmx2, Pmx2a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:106633 Phox2a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000492601 – 280Paired mesoderm homeobox protein 2AAdd BLAST280

Proteomic databases

MaxQBiQ62066
PaxDbiQ62066
PRIDEiQ62066

PTM databases

iPTMnetiQ62066
PhosphoSitePlusiQ62066

Expressioni

Gene expression databases

BgeeiENSMUSG00000007946 Expressed in 105 organ(s), highest expression level in superior cervical ganglion
CleanExiMM_PHOX2A
GenevisibleiQ62066 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000008090

Structurei

3D structure databases

ProteinModelPortaliQ62066
SMRiQ62066
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi193 – 198Poly-Pro6
Compositional biasi233 – 242Poly-Gly10

Sequence similaritiesi

Belongs to the paired homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0484 Eukaryota
ENOG4111QRU LUCA
GeneTreeiENSGT00900000140809
HOGENOMiHOG000013060
HOVERGENiHBG053590
InParanoidiQ62066
KOiK09330
OMAiVPYKFFS
OrthoDBiEOG091G0YX9
PhylomeDBiQ62066
TreeFamiTF351612

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q62066-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDYSYLNSYD SCVAAMEASA YGDFGACSQP GGFQYSPLRP AFPAAGPPCP
60 70 80 90 100
ALGSSNCALG ALRDHQPAPY SAVPYKFFPE PSGLHEKRKQ RRIRTTFTSA
110 120 130 140 150
QLKELERVFA ETHYPDIYTR EELALKIDLT EARVQVWFQN RRAKFRKQER
160 170 180 190 200
AASAKGAAGA TGAKKGEARC SSEDDDSKES TCSPTPDSTA SLPPPPAPSL
210 220 230 240 250
ASPRLSPSPL PAALGSGPGP QPLKGALWAG VAGGGGGGPG TGAAELLKAW
260 270 280
QPAEPGPGPF SGVLSSFHRK PGPALKTNLF
Length:280
Mass (Da):29,417
Last modified:November 1, 1996 - v1
Checksum:iF7CBFBCE66B57A5D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75014 mRNA Translation: CAA52923.1
CCDSiCCDS21514.1
PIRiI48713
RefSeqiNP_032913.1, NM_008887.2
UniGeneiMm.5028

Genome annotation databases

EnsembliENSMUST00000008090; ENSMUSP00000008090; ENSMUSG00000007946
GeneIDi11859
KEGGimmu:11859
UCSCiuc009ipe.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75014 mRNA Translation: CAA52923.1
CCDSiCCDS21514.1
PIRiI48713
RefSeqiNP_032913.1, NM_008887.2
UniGeneiMm.5028

3D structure databases

ProteinModelPortaliQ62066
SMRiQ62066
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000008090

PTM databases

iPTMnetiQ62066
PhosphoSitePlusiQ62066

Proteomic databases

MaxQBiQ62066
PaxDbiQ62066
PRIDEiQ62066

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000008090; ENSMUSP00000008090; ENSMUSG00000007946
GeneIDi11859
KEGGimmu:11859
UCSCiuc009ipe.2 mouse

Organism-specific databases

CTDi401
MGIiMGI:106633 Phox2a

Phylogenomic databases

eggNOGiKOG0484 Eukaryota
ENOG4111QRU LUCA
GeneTreeiENSGT00900000140809
HOGENOMiHOG000013060
HOVERGENiHBG053590
InParanoidiQ62066
KOiK09330
OMAiVPYKFFS
OrthoDBiEOG091G0YX9
PhylomeDBiQ62066
TreeFamiTF351612

Miscellaneous databases

PROiPR:Q62066
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000007946 Expressed in 105 organ(s), highest expression level in superior cervical ganglion
CleanExiMM_PHOX2A
GenevisibleiQ62066 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPHX2A_MOUSE
AccessioniPrimary (citable) accession number: Q62066
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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