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UniProtKB - Q62059 (CSPG2_MOUSE)

Entry version 176 (07 Apr 2021)
Sequence version 2 (13 Jun 2006)
Previous versions | rss
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Protein

Versican core protein

Gene

Vcan

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Hyaluronic acid, Lectin

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-1971475, A tetrasaccharide linker sequence is required for GAG synthesis
R-MMU-2022870, Chondroitin sulfate biosynthesis
R-MMU-2022923, Dermatan sulfate biosynthesis
R-MMU-2024101, CS/DS degradation
R-MMU-3000178, ECM proteoglycans
R-MMU-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275, Post-translational protein phosphorylation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Versican core protein
Alternative name(s):
Chondroitin sulfate proteoglycan core protein 2
Short name:
Chondroitin sulfate proteoglycan 2
Large fibroblast proteoglycan
PG-M
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Vcan
Synonyms:Cspg2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:102889, Vcan

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection, Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001752324 – 3357Versican core proteinAdd BLAST3334

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi44 ↔ 130By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi172 ↔ 243By similarity
Disulfide bondi196 ↔ 217By similarity
Disulfide bondi270 ↔ 333By similarity
Disulfide bondi294 ↔ 315By similarity
Glycosylationi330N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi351N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi441N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi807N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi914N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi951N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1305N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1371N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1678N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2053N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2243N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2361N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2585PhosphoserineCombined sources1
Modified residuei2586PhosphoserineCombined sources1
Glycosylationi2626N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3029N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3055 ↔ 3066By similarity
Disulfide bondi3060 ↔ 3075By similarity
Disulfide bondi3077 ↔ 3086By similarity
Disulfide bondi3093 ↔ 3104By similarity
Disulfide bondi3098 ↔ 3113By similarity
Disulfide bondi3115 ↔ 3124By similarity
Disulfide bondi3131 ↔ 3142By similarity
Disulfide bondi3159 ↔ 3251By similarity
Disulfide bondi3227 ↔ 3243By similarity
Disulfide bondi3258 ↔ 3301By similarity
Disulfide bondi3287 ↔ 3314By similarity
Glycosylationi3331N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3341N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.By similarity
Proteolytically cleaved by ADAMTS5 and ADAMTS15 in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei1401 – 1402Cleavage; by ADAMTS151 Publication2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q62059

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q62059

PeptideAtlas

More...PeptideAtlasi		Q62059

PRoteomics IDEntifications database

More...PRIDEi		Q62059

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		284036 [Q62059-1]
284037 [Q62059-2]
284038 [Q62059-3]
284039 [Q62059-4]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		2818, 2 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q62059, 17 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q62059

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q62059

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the retina (at protein level) (PubMed:29777959). Isoform V2: Only expressed in brain (PubMed:7822336).2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

In embryonic skeletal muscle, significantly up-regulated from 12.5 dpc to 15.5 dpc (PubMed:23233679). Decreased levels in postnatal skeletal muscle (PubMed:23233679). In myoblasts, dramatically up-regulated when myoblasts reach confluence and contact inhibition, remaining high throughout the differentiation process (PubMed:23233679). Disappears after the cartilage development.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FBLN1.

1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		Q62059, 2 interactors

Molecular INTeraction database

More...MINTi		Q62059

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000105173

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q62059, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q62059

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 146Ig-like V-typeAdd BLAST123
Domaini150 – 245Link 1PROSITE-ProRule annotationAdd BLAST96
Domaini251 – 347Link 2PROSITE-ProRule annotationAdd BLAST97
Domaini3051 – 3087EGF-like 1PROSITE-ProRule annotationAdd BLAST37
Domaini3089 – 3125EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini3138 – 3252C-type lectinPROSITE-ProRule annotationAdd BLAST115
Domaini3256 – 3316SushiPROSITE-ProRule annotationAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni348 – 1308GAG-alpha (glucosaminoglycan attachment domain)Add BLAST961
Regioni1309 – 3051GAG-betaAdd BLAST1743

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the aggrecan/versican proteoglycan family.Curated

Keywords - Domaini

EGF-like domain, Immunoglobulin domain, Repeat, Signal, Sushi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QRBE, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q62059

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q62059

Family and domain databases

Conserved Domains Database

More...CDDi		cd00033, CCP, 1 hit
cd03588, CLECT_CSPGs, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 1 hit
3.10.100.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR018378, C-type_lectin_CS
IPR033987, CSPG_CTLD
IPR016187, CTDL_fold
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR013106, Ig_V-set
IPR000538, Link_dom
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00008, EGF, 2 hits
PF00059, Lectin_C, 1 hit
PF00084, Sushi, 1 hit
PF07686, V-set, 1 hit
PF00193, Xlink, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01265, LINKMODULE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00032, CCP, 1 hit
SM00034, CLECT, 1 hit
SM00181, EGF, 2 hits
SM00179, EGF_CA, 2 hits
SM00409, IG, 1 hit
SM00406, IGv, 1 hit
SM00445, LINK, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726, SSF48726, 1 hit
SSF56436, SSF56436, 3 hits
SSF57535, SSF57535, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00010, ASX_HYDROXYL, 1 hit
PS00615, C_TYPE_LECTIN_1, 1 hit
PS50041, C_TYPE_LECTIN_2, 1 hit
PS00022, EGF_1, 2 hits
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 2 hits
PS01187, EGF_CA, 1 hit
PS50835, IG_LIKE, 1 hit
PS01241, LINK_1, 2 hits
PS50963, LINK_2, 2 hits
PS50923, SUSHI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 4 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform V0 (identifier: Q62059-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLINMKGILW MCSTLLLTHA LHQAKMETSP PVKGSLSGKV VLPCHFSTLP 
        60         70         80         90        100
TLPPNYNTSE FLRIKWSKME VDKNGKDIKE TTVLVAQNGN IKIGQDYKGR 
       110        120        130        140        150
VSVPTHPDDV GDASLTMVKL RASDAAVYRC DVMYGIEDTQ DTMSLAVDGV 
       160        170        180        190        200
VFHYRAATSR YTLNFAAAQQ ACLDIGAVIA SPEQLFAAYE DGFEQCDAGW 
       210        220        230        240        250
LSDQTVRYPI RAPREGCYGD MMGKEGVRTY GFRSPQETYD VYCYVDHLDG 
       260        270        280        290        300
DVFHITAPSK FTFEEAEAEC TSRDARLATV GELQAAWRNG FDQCDYGWLS 
       310        320        330        340        350
DASVRHPVTV ARAQCGGGLL GVRTLYRFEN QTCFPLPDSR FDAYCFKPKQ 
       360        370        380        390        400
NISEATTIEM NILAETSSPS LSKEPHMVPD RATPVIPLAT ELPIFTTHFP 
       410        420        430        440        450
PAGNIVNSEQ KSVVYSQAIT GRLATESPTT TRNTINSWDL NDSLASGSGP 
       460        470        480        490        500
LGMPDISEIK EEELRSTTVI SQHATGSQAV ITEDTQTHES VSQIEQIEVG 
       510        520        530        540        550
PLVTSMEITN HISLKELPEK NKTPYESTEV TLEHTTEMPT VSASPELATT 
       560        570        580        590        600
SHYGFTLRED DREDRTLTVR SDQSTRVFSQ IPEVITVSKT SEDTTYSQLG 
       610        620        630        640        650
DLESISTSTI TMLGTDRSLI DKEKEPKTNG KVTEDEFGQS QPTTTFPSQH 
       660        670        680        690        700
LTEVELLPYS GDTTSVEGIS TVIYPSLQTD VTQGRERTET PRPELKKDPY 
       710        720        730        740        750
TVDEIPEKVT KDPFIGKTEE VFSGMPLSTS SSESSVERTE SVSPALTIEK 
       760        770        780        790        800
LTGKPTEARD VEEMTTLTRL ETDVTKSDKD VTRVHLTHST LNVEVVTVSK 
       810        820        830        840        850
WPGDEDNSTS KPLPSTEHAG FTKLPPVPLS TIGINGKDKE IPSFTDGGGE 
       860        870        880        890        900
YTLFPDGTPK PLEKVSEEDL ASGELTVTFH TSTSIGSAEK SASGEPTTGD 
       910        920        930        940        950
RFLPTTSTED QVINATAEGS ALGEDTEASK PLFTGPPFVH TSDVEELAFV 
       960        970        980        990       1000
NYSSTQEPTT YVDISHTSPL SIIPKTEWSV LETSVPLEDE ILGKSDQDIL 
      1010       1020       1030       1040       1050
EQTHLEATMS PGALRTTGVS QGETQEEPQT PGSPFPTFSS TAVMAKETTA 
      1060       1070       1080       1090       1100
FEEGEGSTYT PSEGRLMTGS ERVPGLETTP VGTSYPPGAI TDQEVEMDTM 
      1110       1120       1130       1140       1150
VTLMSTIRPT VVSSTESEVI YEAEGSSPTE FASTLRPFQT HVTQLMEETT 
      1160       1170       1180       1190       1200
EEGKKASLDY TDLGSGLFEP RATELPKFPS TPSDISVFTA IDSLHRTPPL 
      1210       1220       1230       1240       1250
SPSSSFTEEQ RVFEEESSEK TTGDILPGES VTQHPVTTLI DIVAMKTESD 
      1260       1270       1280       1290       1300
IDHMTSKPPV TQPTRPSVVE RKTTSKTQEL STSTPAAGTK FHPDINVYII 
      1310       1320       1330       1340       1350
EVRENKTGRL SDMIVSGHPI DSESKEEEPC SEETDPLHDL FAEILPELPD 
      1360       1370       1380       1390       1400
SFEIDIYHSE EDEDGEEDCV NATDVTTTPS VQYINGKQLV TTVPKDPEAA 
      1410       1420       1430       1440       1450
EARRGQYESV APSQNFPDSS ATDTHQFILA ETESSTTMQF KKSKEGTELL 
      1460       1470       1480       1490       1500
EITWKPETYP ETPDHVSSGE PDVFPTLSSH DGKTTRWSES ITESSPNLEN 
      1510       1520       1530       1540       1550
PVHKQPKPVP LFPEESSGEG AIEQASQETI LSRATEVALG KETDQSPTLS 
      1560       1570       1580       1590       1600
TSSILSSSVS VNVLEEEPLT LTGISQTDES MSTIESWVEI TPSQTVKFSE 
      1610       1620       1630       1640       1650
SSSAPIIEGS GEVEENKNKI FNMVTDLPQR DPTDTLSPLD MSKIMITNHH 
      1660       1670       1680       1690       1700
IYIPATIAPL DSKLPSPDAR PTTVWNSNST SEWVSDKSFE GRKKKENEDE 
      1710       1720       1730       1740       1750
EGAVNAAHQG EVRAATERSD HLLLTPELES SNVDASSDLA TWEGFILETT 
      1760       1770       1780       1790       1800
PTESEKEMAN STPVFRETIG VANVEAQPFE HSSSSHPRVQ EELTTLSGNP 
      1810       1820       1830       1840       1850
PSLFTDLGSG DASTGMELIT ASLFTLDLES ETKVKKELPS TPSPSVEISS 
      1860       1870       1880       1890       1900
SFEPTGLTPS TVLDIEIAGV MSQTSQKTLI SEISGKPTSQ SGVRDLYTGF 
      1910       1920       1930       1940       1950
PMGEDFSGDF SEYPTVSYPT MKEETVGMGG SDDERVRDTQ TSSSIPTTSD 
      1960       1970       1980       1990       2000
NIYPVPDSKG PDSTVASTTA FPWEEVMSSA EGSGEQLASV RSSVGPVLPL 
      2010       2020       2030       2040       2050
AVDIFSGTES PYFDEEFEEV AAVTEANERP TVLPTAASGN TVDLTENGYI 
      2060       2070       2080       2090       2100
EVNSTMSLDF PQTMEPSKLW SKPEVNLDKQ EIGRETVTKE KAQGQKTFES 
      2110       2120       2130       2140       2150
LHSSFAPEQT ILETQSLIET EFQTSDYSML TTLKTYITNK EVEEEGMSIA 
      2160       2170       2180       2190       2200
HMSTPGPGIK DLESYTTHPE APGKSHSFSA TALVTESGAA RSVLMDSSTQ 
      2210       2220       2230       2240       2250
EEESIKLFQK GVKLTNKESN ADLSFSGLGS GGALPPLPTT SVNLTDMKQI 
      2260       2270       2280       2290       2300
ISTLYAETSH MESLGTSILG DKMEDHERME DVSSNEVRML ISKIGSISQD 
      2310       2320       2330       2340       2350
STEALDTTLS HTGTEEPTTS TLPFVKLMDL ERSPKQDPSG GKRKPKTHRP 
      2360       2370       2380       2390       2400
QTMSGLISNE NSSASEAEEG ATSPTAFLPQ TYSVEMTKHF APSESQPSDL 
      2410       2420       2430       2440       2450
FNVNSGEGSG EVDTLDLVYT SGTTQASSQG DSMLASHGFL EKHPEVSKTE 
      2460       2470       2480       2490       2500
AGATDVSPTA SAMFLHHSEY KSSLYPTSTL PSTEPYKSPS EGIEDGLQDN 
      2510       2520       2530       2540       2550
IQFEGSTLKP SRRKTTESII IDLDKEDSKD LGLTITESAI VKSLPELTSD 
      2560       2570       2580       2590       2600
KNIIIDIDHT KPVYEYIPGI QTDLDPEIKL ESHGSSEESL QVQEKYEGAV 
      2610       2620       2630       2640       2650
TLSPTEESFE GSGDALLAGY TQAIYNESVT PNDGKQAEDI SFSFATGIPV 
      2660       2670       2680       2690       2700
SSTETELHTF FPTASTLHIP SKLTTASPEI DKPNIEAISL DDIFESSTLS 
      2710       2720       2730       2740       2750
DGQAIADQSE VISTLGHLEK TQEEYEEKKY GGPSFQPEFF SGVGEVLTDP 
      2760       2770       2780       2790       2800
PAYVSIGSTY LIAQTLTELP NVVRPSDSTH YTEATPEVSS LAELSPQIPS 
      2810       2820       2830       2840       2850
SPFPVYVDNG VSKFPEVPHT SAQPVSTVTS SQKSIESPFK EVHANIEETI 
      2860       2870       2880       2890       2900
KPLGGNVHRT EPPSMSRDPA LDVSEDESKH KLLEELETSP TKPETSQDFP 
      2910       2920       2930       2940       2950
NKAKDHIPGE TVGMLAGIRT TESEPVITAD DMELGGATQQ PHSASAAFRV 
      2960       2970       2980       2990       3000
ETGMVPQPIQ QEPERPTFPS LEINHETHTS LFGESILATS EKQVSQKILD 
      3010       3020       3030       3040       3050
NSNQATVSST LDLHTAHALS PFSILDNSNE TAFLIGISEE SVEGTAVYLP 
      3060       3070       3080       3090       3100
GPDLCKTNPC LNGGTCYPTE TSYVCTCAPG YSGDQCELDF DECHSNPCRN 
      3110       3120       3130       3140       3150
GATCVDGFNT FRCLCLPSYV GALCEQDTET CDYGWHKFQG QCYKYFAHRR 
      3160       3170       3180       3190       3200
TWDAAERECR LQGAHLTSIL SHEEQMFVNR VGHDYQWIGL NDKMFEHDFR 
      3210       3220       3230       3240       3250
WTDGSALQYE NWRPNQPDSF FSAGEDCVVI IWHENGQWND VPCNYHLTYT 
      3260       3270       3280       3290       3300
CKKGTVACGQ PPVVENAKTF GKMKPRYEIN SLIRYHCKDG FIQRHLPTIR 
      3310       3320       3330       3340       3350
CLGNGRWAMP KITCMNPSAY QRTYSKKYLK NSSSAKDNSI NTSKHEHRWS 

RRQETRR
Length:3,357
Mass (Da):366,787
Last modified:June 13, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAE82A0D942B8323A
GO
Isoform V1 (identifier: Q62059-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     348-348: P → R
     349-1308: Missing.

Show »
Length:2,397
Mass (Da):262,705
Checksum:i07CB2047C10A2226
GO
Isoform V2 (identifier: Q62059-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1309-3051: Missing.

Show »
Length:1,614
Mass (Da):178,258
Checksum:iD1B5E6E19671DC56
GO
Isoform V3 (identifier: Q62059-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     348-348: P → R
     349-3051: Missing.

Show »
Length:654
Mass (Da):74,177
Checksum:iA996C1142D8FCD16
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PYH0E9PYH0_MOUSE
Versican core protein
Vcan
3,354Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9QMK2E9QMK2_MOUSE
Versican core protein
Vcan
1,615Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9QMK3E9QMK3_MOUSE
Versican core protein
Vcan
655Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3XA35G3XA35_MOUSE
Versican core protein
Vcan
2,394Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8BS97Q8BS97_MOUSE
Versican core protein
Vcan Cspg2
368Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7B603F7B603_MOUSE
Versican core protein
Vcan
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E0CZC0E0CZC0_MOUSE
Versican core protein
Vcan
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7B6F7F7B6F7_MOUSE
Versican core protein
Vcan
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti126A → G (PubMed:16141072).Curated1
Sequence conflicti1657I → T (PubMed:16141072).Curated1
Sequence conflicti1673 – 1679TVWNSNS → QFGIQTA (PubMed:16141072).Curated7

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_003087348P → R in isoform V1 and isoform V3. 3 Publications1
Alternative sequenceiVSP_003090349 – 3051Missing in isoform V3. 1 PublicationAdd BLAST2703
Alternative sequenceiVSP_003088349 – 1308Missing in isoform V1. 2 PublicationsAdd BLAST960
Alternative sequenceiVSP_0030891309 – 3051Missing in isoform V2. 1 PublicationAdd BLAST1743

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D16263 mRNA Translation: BAA03796.1
D28599 mRNA No translation available.
D32040 mRNA Translation: BAA06802.1
AK014525 mRNA Translation: BAB29411.3

Protein sequence database of the Protein Information Resource

More...PIRi		A55535

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Versican

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16263 mRNA Translation: BAA03796.1
D28599 mRNA No translation available.
D32040 mRNA Translation: BAA06802.1
AK014525 mRNA Translation: BAB29411.3
PIRiA55535

3D structure databases

SMRiQ62059
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ62059, 2 interactors
MINTiQ62059
STRINGi10090.ENSMUSP00000105173

PTM databases

GlyConnecti2818, 2 N-Linked glycans (1 site)
GlyGeniQ62059, 17 sites
iPTMnetiQ62059
PhosphoSitePlusiQ62059

Proteomic databases

jPOSTiQ62059
PaxDbiQ62059
PeptideAtlasiQ62059
PRIDEiQ62059
ProteomicsDBi284036 [Q62059-1]
284037 [Q62059-2]
284038 [Q62059-3]
284039 [Q62059-4]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q62059, 2 sequenced antibodies

Organism-specific databases

MGIiMGI:102889, Vcan

Phylogenomic databases

eggNOGiENOG502QRBE, Eukaryota
InParanoidiQ62059
PhylomeDBiQ62059

Enzyme and pathway databases

ReactomeiR-MMU-1971475, A tetrasaccharide linker sequence is required for GAG synthesis
R-MMU-2022870, Chondroitin sulfate biosynthesis
R-MMU-2022923, Dermatan sulfate biosynthesis
R-MMU-2024101, CS/DS degradation
R-MMU-3000178, ECM proteoglycans
R-MMU-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275, Post-translational protein phosphorylation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Vcan, mouse

Protein Ontology

More...PROi		PR:Q62059
RNActiQ62059, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Family and domain databases

CDDicd00033, CCP, 1 hit
cd03588, CLECT_CSPGs, 1 hit
Gene3Di2.60.40.10, 1 hit
3.10.100.10, 3 hits
InterProiView protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR018378, C-type_lectin_CS
IPR033987, CSPG_CTLD
IPR016187, CTDL_fold
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR013106, Ig_V-set
IPR000538, Link_dom
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00008, EGF, 2 hits
PF00059, Lectin_C, 1 hit
PF00084, Sushi, 1 hit
PF07686, V-set, 1 hit
PF00193, Xlink, 2 hits
PRINTSiPR01265, LINKMODULE
SMARTiView protein in SMART
SM00032, CCP, 1 hit
SM00034, CLECT, 1 hit
SM00181, EGF, 2 hits
SM00179, EGF_CA, 2 hits
SM00409, IG, 1 hit
SM00406, IGv, 1 hit
SM00445, LINK, 2 hits
SUPFAMiSSF48726, SSF48726, 1 hit
SSF56436, SSF56436, 3 hits
SSF57535, SSF57535, 1 hit
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 1 hit
PS00615, C_TYPE_LECTIN_1, 1 hit
PS50041, C_TYPE_LECTIN_2, 1 hit
PS00022, EGF_1, 2 hits
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 2 hits
PS01187, EGF_CA, 1 hit
PS50835, IG_LIKE, 1 hit
PS01241, LINK_1, 2 hits
PS50963, LINK_2, 2 hits
PS50923, SUSHI, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCSPG2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q62059
Secondary accession number(s): Q62058, Q9CUU0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 13, 2006
Last modified: April 7, 2021
This is version 176 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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