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Entry version 163 (13 Feb 2019)
Sequence version 2 (13 Jun 2006)
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Protein

Versican core protein

Gene

Vcan

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Hyaluronic acid, Lectin

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Versican core protein
Alternative name(s):
Chondroitin sulfate proteoglycan core protein 2
Short name:
Chondroitin sulfate proteoglycan 2
Large fibroblast proteoglycan
PG-M
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Vcan
Synonyms:Cspg2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:102889 Vcan

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001752324 – 3357Versican core proteinAdd BLAST3334

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi44 ↔ 130By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi172 ↔ 243By similarity
Disulfide bondi196 ↔ 217By similarity
Disulfide bondi270 ↔ 333By similarity
Disulfide bondi294 ↔ 315By similarity
Glycosylationi330N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi351N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi441N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi807N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi914N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi951N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1305N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1371N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1678N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2053N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2243N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2361N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2585PhosphoserineCombined sources1
Modified residuei2586PhosphoserineCombined sources1
Glycosylationi2626N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3029N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3055 ↔ 3066By similarity
Disulfide bondi3060 ↔ 3075By similarity
Disulfide bondi3077 ↔ 3086By similarity
Disulfide bondi3093 ↔ 3104By similarity
Disulfide bondi3098 ↔ 3113By similarity
Disulfide bondi3115 ↔ 3124By similarity
Disulfide bondi3131 ↔ 3142By similarity
Disulfide bondi3159 ↔ 3251By similarity
Disulfide bondi3227 ↔ 3243By similarity
Disulfide bondi3258 ↔ 3301By similarity
Disulfide bondi3287 ↔ 3314By similarity
Glycosylationi3331N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3341N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q62059

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q62059

PeptideAtlas

More...
PeptideAtlasi
Q62059

PRoteomics IDEntifications database

More...
PRIDEi
Q62059

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q62059

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q62059

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform V2 is found only in brain.

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Disappears after the cartilage development.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FBLN1.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q62059, 2 interactors

Molecular INTeraction database

More...
MINTi
Q62059

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000105173

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q62059

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q62059

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 146Ig-like V-typeAdd BLAST123
Domaini150 – 245Link 1PROSITE-ProRule annotationAdd BLAST96
Domaini251 – 347Link 2PROSITE-ProRule annotationAdd BLAST97
Domaini3051 – 3087EGF-like 1PROSITE-ProRule annotationAdd BLAST37
Domaini3089 – 3125EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini3138 – 3252C-type lectinPROSITE-ProRule annotationAdd BLAST115
Domaini3256 – 3316SushiPROSITE-ProRule annotationAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni348 – 1308GAG-alpha (glucosaminoglycan attachment domain)Add BLAST961
Regioni1309 – 3051GAG-betaAdd BLAST1743

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

EGF-like domain, Immunoglobulin domain, Repeat, Signal, Sushi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFXS Eukaryota
ENOG410ZPDG LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000168523

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG051140

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q62059

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q62059

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00033 CCP, 1 hit
cd03588 CLECT_CSPGs, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
3.10.100.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR033987 CSPG_CTLD
IPR016187 CTDL_fold
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR000538 Link_dom
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00008 EGF, 2 hits
PF00059 Lectin_C, 1 hit
PF00084 Sushi, 1 hit
PF07686 V-set, 1 hit
PF00193 Xlink, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01265 LINKMODULE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00032 CCP, 1 hit
SM00034 CLECT, 1 hit
SM00181 EGF, 2 hits
SM00179 EGF_CA, 2 hits
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SM00445 LINK, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 1 hit
SSF56436 SSF56436, 3 hits
SSF57535 SSF57535, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 2 hits
PS01187 EGF_CA, 1 hit
PS50835 IG_LIKE, 1 hit
PS01241 LINK_1, 2 hits
PS50963 LINK_2, 2 hits
PS50923 SUSHI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 4 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform V0 (identifier: Q62059-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLINMKGILW MCSTLLLTHA LHQAKMETSP PVKGSLSGKV VLPCHFSTLP
60 70 80 90 100
TLPPNYNTSE FLRIKWSKME VDKNGKDIKE TTVLVAQNGN IKIGQDYKGR
110 120 130 140 150
VSVPTHPDDV GDASLTMVKL RASDAAVYRC DVMYGIEDTQ DTMSLAVDGV
160 170 180 190 200
VFHYRAATSR YTLNFAAAQQ ACLDIGAVIA SPEQLFAAYE DGFEQCDAGW
210 220 230 240 250
LSDQTVRYPI RAPREGCYGD MMGKEGVRTY GFRSPQETYD VYCYVDHLDG
260 270 280 290 300
DVFHITAPSK FTFEEAEAEC TSRDARLATV GELQAAWRNG FDQCDYGWLS
310 320 330 340 350
DASVRHPVTV ARAQCGGGLL GVRTLYRFEN QTCFPLPDSR FDAYCFKPKQ
360 370 380 390 400
NISEATTIEM NILAETSSPS LSKEPHMVPD RATPVIPLAT ELPIFTTHFP
410 420 430 440 450
PAGNIVNSEQ KSVVYSQAIT GRLATESPTT TRNTINSWDL NDSLASGSGP
460 470 480 490 500
LGMPDISEIK EEELRSTTVI SQHATGSQAV ITEDTQTHES VSQIEQIEVG
510 520 530 540 550
PLVTSMEITN HISLKELPEK NKTPYESTEV TLEHTTEMPT VSASPELATT
560 570 580 590 600
SHYGFTLRED DREDRTLTVR SDQSTRVFSQ IPEVITVSKT SEDTTYSQLG
610 620 630 640 650
DLESISTSTI TMLGTDRSLI DKEKEPKTNG KVTEDEFGQS QPTTTFPSQH
660 670 680 690 700
LTEVELLPYS GDTTSVEGIS TVIYPSLQTD VTQGRERTET PRPELKKDPY
710 720 730 740 750
TVDEIPEKVT KDPFIGKTEE VFSGMPLSTS SSESSVERTE SVSPALTIEK
760 770 780 790 800
LTGKPTEARD VEEMTTLTRL ETDVTKSDKD VTRVHLTHST LNVEVVTVSK
810 820 830 840 850
WPGDEDNSTS KPLPSTEHAG FTKLPPVPLS TIGINGKDKE IPSFTDGGGE
860 870 880 890 900
YTLFPDGTPK PLEKVSEEDL ASGELTVTFH TSTSIGSAEK SASGEPTTGD
910 920 930 940 950
RFLPTTSTED QVINATAEGS ALGEDTEASK PLFTGPPFVH TSDVEELAFV
960 970 980 990 1000
NYSSTQEPTT YVDISHTSPL SIIPKTEWSV LETSVPLEDE ILGKSDQDIL
1010 1020 1030 1040 1050
EQTHLEATMS PGALRTTGVS QGETQEEPQT PGSPFPTFSS TAVMAKETTA
1060 1070 1080 1090 1100
FEEGEGSTYT PSEGRLMTGS ERVPGLETTP VGTSYPPGAI TDQEVEMDTM
1110 1120 1130 1140 1150
VTLMSTIRPT VVSSTESEVI YEAEGSSPTE FASTLRPFQT HVTQLMEETT
1160 1170 1180 1190 1200
EEGKKASLDY TDLGSGLFEP RATELPKFPS TPSDISVFTA IDSLHRTPPL
1210 1220 1230 1240 1250
SPSSSFTEEQ RVFEEESSEK TTGDILPGES VTQHPVTTLI DIVAMKTESD
1260 1270 1280 1290 1300
IDHMTSKPPV TQPTRPSVVE RKTTSKTQEL STSTPAAGTK FHPDINVYII
1310 1320 1330 1340 1350
EVRENKTGRL SDMIVSGHPI DSESKEEEPC SEETDPLHDL FAEILPELPD
1360 1370 1380 1390 1400
SFEIDIYHSE EDEDGEEDCV NATDVTTTPS VQYINGKQLV TTVPKDPEAA
1410 1420 1430 1440 1450
EARRGQYESV APSQNFPDSS ATDTHQFILA ETESSTTMQF KKSKEGTELL
1460 1470 1480 1490 1500
EITWKPETYP ETPDHVSSGE PDVFPTLSSH DGKTTRWSES ITESSPNLEN
1510 1520 1530 1540 1550
PVHKQPKPVP LFPEESSGEG AIEQASQETI LSRATEVALG KETDQSPTLS
1560 1570 1580 1590 1600
TSSILSSSVS VNVLEEEPLT LTGISQTDES MSTIESWVEI TPSQTVKFSE
1610 1620 1630 1640 1650
SSSAPIIEGS GEVEENKNKI FNMVTDLPQR DPTDTLSPLD MSKIMITNHH
1660 1670 1680 1690 1700
IYIPATIAPL DSKLPSPDAR PTTVWNSNST SEWVSDKSFE GRKKKENEDE
1710 1720 1730 1740 1750
EGAVNAAHQG EVRAATERSD HLLLTPELES SNVDASSDLA TWEGFILETT
1760 1770 1780 1790 1800
PTESEKEMAN STPVFRETIG VANVEAQPFE HSSSSHPRVQ EELTTLSGNP
1810 1820 1830 1840 1850
PSLFTDLGSG DASTGMELIT ASLFTLDLES ETKVKKELPS TPSPSVEISS
1860 1870 1880 1890 1900
SFEPTGLTPS TVLDIEIAGV MSQTSQKTLI SEISGKPTSQ SGVRDLYTGF
1910 1920 1930 1940 1950
PMGEDFSGDF SEYPTVSYPT MKEETVGMGG SDDERVRDTQ TSSSIPTTSD
1960 1970 1980 1990 2000
NIYPVPDSKG PDSTVASTTA FPWEEVMSSA EGSGEQLASV RSSVGPVLPL
2010 2020 2030 2040 2050
AVDIFSGTES PYFDEEFEEV AAVTEANERP TVLPTAASGN TVDLTENGYI
2060 2070 2080 2090 2100
EVNSTMSLDF PQTMEPSKLW SKPEVNLDKQ EIGRETVTKE KAQGQKTFES
2110 2120 2130 2140 2150
LHSSFAPEQT ILETQSLIET EFQTSDYSML TTLKTYITNK EVEEEGMSIA
2160 2170 2180 2190 2200
HMSTPGPGIK DLESYTTHPE APGKSHSFSA TALVTESGAA RSVLMDSSTQ
2210 2220 2230 2240 2250
EEESIKLFQK GVKLTNKESN ADLSFSGLGS GGALPPLPTT SVNLTDMKQI
2260 2270 2280 2290 2300
ISTLYAETSH MESLGTSILG DKMEDHERME DVSSNEVRML ISKIGSISQD
2310 2320 2330 2340 2350
STEALDTTLS HTGTEEPTTS TLPFVKLMDL ERSPKQDPSG GKRKPKTHRP
2360 2370 2380 2390 2400
QTMSGLISNE NSSASEAEEG ATSPTAFLPQ TYSVEMTKHF APSESQPSDL
2410 2420 2430 2440 2450
FNVNSGEGSG EVDTLDLVYT SGTTQASSQG DSMLASHGFL EKHPEVSKTE
2460 2470 2480 2490 2500
AGATDVSPTA SAMFLHHSEY KSSLYPTSTL PSTEPYKSPS EGIEDGLQDN
2510 2520 2530 2540 2550
IQFEGSTLKP SRRKTTESII IDLDKEDSKD LGLTITESAI VKSLPELTSD
2560 2570 2580 2590 2600
KNIIIDIDHT KPVYEYIPGI QTDLDPEIKL ESHGSSEESL QVQEKYEGAV
2610 2620 2630 2640 2650
TLSPTEESFE GSGDALLAGY TQAIYNESVT PNDGKQAEDI SFSFATGIPV
2660 2670 2680 2690 2700
SSTETELHTF FPTASTLHIP SKLTTASPEI DKPNIEAISL DDIFESSTLS
2710 2720 2730 2740 2750
DGQAIADQSE VISTLGHLEK TQEEYEEKKY GGPSFQPEFF SGVGEVLTDP
2760 2770 2780 2790 2800
PAYVSIGSTY LIAQTLTELP NVVRPSDSTH YTEATPEVSS LAELSPQIPS
2810 2820 2830 2840 2850
SPFPVYVDNG VSKFPEVPHT SAQPVSTVTS SQKSIESPFK EVHANIEETI
2860 2870 2880 2890 2900
KPLGGNVHRT EPPSMSRDPA LDVSEDESKH KLLEELETSP TKPETSQDFP
2910 2920 2930 2940 2950
NKAKDHIPGE TVGMLAGIRT TESEPVITAD DMELGGATQQ PHSASAAFRV
2960 2970 2980 2990 3000
ETGMVPQPIQ QEPERPTFPS LEINHETHTS LFGESILATS EKQVSQKILD
3010 3020 3030 3040 3050
NSNQATVSST LDLHTAHALS PFSILDNSNE TAFLIGISEE SVEGTAVYLP
3060 3070 3080 3090 3100
GPDLCKTNPC LNGGTCYPTE TSYVCTCAPG YSGDQCELDF DECHSNPCRN
3110 3120 3130 3140 3150
GATCVDGFNT FRCLCLPSYV GALCEQDTET CDYGWHKFQG QCYKYFAHRR
3160 3170 3180 3190 3200
TWDAAERECR LQGAHLTSIL SHEEQMFVNR VGHDYQWIGL NDKMFEHDFR
3210 3220 3230 3240 3250
WTDGSALQYE NWRPNQPDSF FSAGEDCVVI IWHENGQWND VPCNYHLTYT
3260 3270 3280 3290 3300
CKKGTVACGQ PPVVENAKTF GKMKPRYEIN SLIRYHCKDG FIQRHLPTIR
3310 3320 3330 3340 3350
CLGNGRWAMP KITCMNPSAY QRTYSKKYLK NSSSAKDNSI NTSKHEHRWS

RRQETRR
Length:3,357
Mass (Da):366,787
Last modified:June 13, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAE82A0D942B8323A
GO
Isoform V1 (identifier: Q62059-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     348-348: P → R
     349-1308: Missing.

Show »
Length:2,397
Mass (Da):262,705
Checksum:i07CB2047C10A2226
GO
Isoform V2 (identifier: Q62059-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1309-3051: Missing.

Show »
Length:1,614
Mass (Da):178,258
Checksum:iD1B5E6E19671DC56
GO
Isoform V3 (identifier: Q62059-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     348-348: P → R
     349-3051: Missing.

Show »
Length:654
Mass (Da):74,177
Checksum:iA996C1142D8FCD16
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PYH0E9PYH0_MOUSE
Versican core protein
Vcan
3,354Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9QMK3E9QMK3_MOUSE
Versican core protein
Vcan
655Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9QMK2E9QMK2_MOUSE
Versican core protein
Vcan
1,615Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3XA35G3XA35_MOUSE
MCG116562, isoform CRA_a
Vcan mCG_116562
2,394Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8BS97Q8BS97_MOUSE
Versican core protein
Vcan Cspg2
368Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E0CZC0E0CZC0_MOUSE
Versican core protein
Vcan
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7B603F7B603_MOUSE
Versican core protein
Vcan
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7B6F7F7B6F7_MOUSE
Versican core protein
Vcan
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti126A → G (PubMed:16141072).Curated1
Sequence conflicti1657I → T (PubMed:16141072).Curated1
Sequence conflicti1673 – 1679TVWNSNS → QFGIQTA (PubMed:16141072).Curated7

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_003087348P → R in isoform V1 and isoform V3. 3 Publications1
Alternative sequenceiVSP_003090349 – 3051Missing in isoform V3. 1 PublicationAdd BLAST2703
Alternative sequenceiVSP_003088349 – 1308Missing in isoform V1. 2 PublicationsAdd BLAST960
Alternative sequenceiVSP_0030891309 – 3051Missing in isoform V2. 1 PublicationAdd BLAST1743

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D16263 mRNA Translation: BAA03796.1
D28599 mRNA No translation available.
D32040 mRNA Translation: BAA06802.1
AK014525 mRNA Translation: BAB29411.3

Protein sequence database of the Protein Information Resource

More...
PIRi
A55535

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.158700
Mm.410783

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Versican

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16263 mRNA Translation: BAA03796.1
D28599 mRNA No translation available.
D32040 mRNA Translation: BAA06802.1
AK014525 mRNA Translation: BAB29411.3
PIRiA55535
UniGeneiMm.158700
Mm.410783

3D structure databases

ProteinModelPortaliQ62059
SMRiQ62059
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ62059, 2 interactors
MINTiQ62059
STRINGi10090.ENSMUSP00000105173

PTM databases

iPTMnetiQ62059
PhosphoSitePlusiQ62059

Proteomic databases

jPOSTiQ62059
PaxDbiQ62059
PeptideAtlasiQ62059
PRIDEiQ62059

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:102889 Vcan

Phylogenomic databases

eggNOGiENOG410IFXS Eukaryota
ENOG410ZPDG LUCA
HOGENOMiHOG000168523
HOVERGENiHBG051140
InParanoidiQ62059
PhylomeDBiQ62059

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q62059

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

CDDicd00033 CCP, 1 hit
cd03588 CLECT_CSPGs, 1 hit
Gene3Di2.60.40.10, 1 hit
3.10.100.10, 3 hits
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR033987 CSPG_CTLD
IPR016187 CTDL_fold
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR000538 Link_dom
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00008 EGF, 2 hits
PF00059 Lectin_C, 1 hit
PF00084 Sushi, 1 hit
PF07686 V-set, 1 hit
PF00193 Xlink, 2 hits
PRINTSiPR01265 LINKMODULE
SMARTiView protein in SMART
SM00032 CCP, 1 hit
SM00034 CLECT, 1 hit
SM00181 EGF, 2 hits
SM00179 EGF_CA, 2 hits
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SM00445 LINK, 2 hits
SUPFAMiSSF48726 SSF48726, 1 hit
SSF56436 SSF56436, 3 hits
SSF57535 SSF57535, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 2 hits
PS01187 EGF_CA, 1 hit
PS50835 IG_LIKE, 1 hit
PS01241 LINK_1, 2 hits
PS50963 LINK_2, 2 hits
PS50923 SUSHI, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCSPG2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q62059
Secondary accession number(s): Q62058, Q9CUU0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 13, 2006
Last modified: February 13, 2019
This is version 163 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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