UniProtKB - Q62053 (PE2R2_MOUSE)
Protein
Prostaglandin E2 receptor EP2 subtype
Gene
Ptger2
Organism
Mus musculus (Mouse)
Status
Functioni
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.
GO - Molecular functioni
- prostaglandin E receptor activity Source: MGI
GO - Biological processi
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: BHF-UCL
- cellular response to prostaglandin E stimulus Source: BHF-UCL
- inflammatory response Source: GO_Central
- positive regulation of cytosolic calcium ion concentration Source: GO_Central
- positive regulation of gastric mucosal blood circulation Source: MGI
- regulation of cell population proliferation Source: MGI
- response to lipopolysaccharide Source: MGI
- response to progesterone Source: CACAO
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-MMU-391908 Prostanoid ligand receptors R-MMU-418555 G alpha (s) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: Prostaglandin E2 receptor EP2 subtypeShort name: PGE receptor EP2 subtype Short name: PGE2 receptor EP2 subtype Alternative name(s): Prostanoid EP2 receptor |
Gene namesi | Name:Ptger2 Synonyms:Ptgerep2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:97794 Ptger2 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- cell Source: GOC
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 24 | ExtracellularSequence analysisAdd BLAST | 24 | |
Transmembranei | 25 – 48 | Helical; Name=1Sequence analysisAdd BLAST | 24 | |
Topological domaini | 49 – 66 | CytoplasmicSequence analysisAdd BLAST | 18 | |
Transmembranei | 67 – 92 | Helical; Name=2Sequence analysisAdd BLAST | 26 | |
Topological domaini | 93 – 112 | ExtracellularSequence analysisAdd BLAST | 20 | |
Transmembranei | 113 – 133 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 134 – 152 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 153 – 177 | Helical; Name=4Sequence analysisAdd BLAST | 25 | |
Topological domaini | 178 – 199 | ExtracellularSequence analysisAdd BLAST | 22 | |
Transmembranei | 200 – 224 | Helical; Name=5Sequence analysisAdd BLAST | 25 | |
Topological domaini | 225 – 262 | CytoplasmicSequence analysisAdd BLAST | 38 | |
Transmembranei | 263 – 286 | Helical; Name=6Sequence analysisAdd BLAST | 24 | |
Topological domaini | 287 – 299 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 300 – 323 | Helical; Name=7Sequence analysisAdd BLAST | 24 | |
Topological domaini | 324 – 362 | CytoplasmicSequence analysisAdd BLAST | 39 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Chemistry databases
ChEMBLi | CHEMBL2488 |
DrugCentrali | Q62053 |
GuidetoPHARMACOLOGYi | 341 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000070055 | 1 – 362 | Prostaglandin E2 receptor EP2 subtypeAdd BLAST | 362 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 6 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 110 ↔ 188 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MaxQBi | Q62053 |
PaxDbi | Q62053 |
PRIDEi | Q62053 |
PTM databases
PhosphoSitePlusi | Q62053 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000037759 Expressed in 113 organ(s), highest expression level in left lung lobe |
ExpressionAtlasi | Q62053 baseline and differential |
Genevisiblei | Q62053 MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000038483 |
Chemistry databases
BindingDBi | Q62053 |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656 Eukaryota ENOG410XRW9 LUCA |
GeneTreei | ENSGT00970000193383 |
HOGENOMi | HOG000115475 |
InParanoidi | Q62053 |
KOi | K04259 |
OMAi | GYGQYVQ |
OrthoDBi | 972015at2759 |
PhylomeDBi | Q62053 |
TreeFami | TF324982 |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR008365 Prostanoid_rcpt IPR001923 Prostglndn_EP2_rcpt |
PANTHERi | PTHR11866 PTHR11866, 1 hit PTHR11866:SF8 PTHR11866:SF8, 1 hit |
Pfami | View protein in Pfam PF00001 7tm_1, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR01788 PROSTANOIDR PR00581 PRSTNOIDEP2R |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q62053-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDNFLNDSKL MEDCKSRQWL LSGESPAISS VMFSAGVLGN LIALALLARR
60 70 80 90 100
WRGDTGCSAG SRTSISLFHV LVTELVLTDL LGTCLISPVV LASYSRNQTL
110 120 130 140 150
VALAPESHAC TYFAFTMTFF SLATMLMLFA MALERYLSIG YPYFYRRHLS
160 170 180 190 200
RRGGLAVLPV IYGASLLFCS LPLLNYGEYV QYCPGTWCFI RHGRTAYLQL
210 220 230 240 250
YATMLLLLIV AVLACNISVI LNLIRMHRRS RRSRCGLSGS SLRGPGSRRR
260 270 280 290 300
GERTSMAEET DHLILLAIMT ITFAICSLPF TIFAYMDETS SLKEKWDLRA
310 320 330 340 350
LRFLSVNSII DPWVFAILRP PVLRLMRSVL CCRTSLRTQE AQQTSCSTQS
360
SASKQTDLCG QL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D50589 mRNA Translation: BAA09137.1 BC005440 mRNA Translation: AAH05440.1 |
CCDSi | CCDS26972.1 |
PIRi | S66674 |
RefSeqi | NP_032990.1, NM_008964.4 |
Genome annotation databases
Ensembli | ENSMUST00000046891; ENSMUSP00000038483; ENSMUSG00000037759 |
GeneIDi | 19217 |
KEGGi | mmu:19217 |
UCSCi | uc007tgd.2 mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D50589 mRNA Translation: BAA09137.1 BC005440 mRNA Translation: AAH05440.1 |
CCDSi | CCDS26972.1 |
PIRi | S66674 |
RefSeqi | NP_032990.1, NM_008964.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000038483 |
Chemistry databases
BindingDBi | Q62053 |
ChEMBLi | CHEMBL2488 |
DrugCentrali | Q62053 |
GuidetoPHARMACOLOGYi | 341 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
PhosphoSitePlusi | Q62053 |
Proteomic databases
MaxQBi | Q62053 |
PaxDbi | Q62053 |
PRIDEi | Q62053 |
Genome annotation databases
Ensembli | ENSMUST00000046891; ENSMUSP00000038483; ENSMUSG00000037759 |
GeneIDi | 19217 |
KEGGi | mmu:19217 |
UCSCi | uc007tgd.2 mouse |
Organism-specific databases
CTDi | 5732 |
MGIi | MGI:97794 Ptger2 |
Phylogenomic databases
eggNOGi | KOG3656 Eukaryota ENOG410XRW9 LUCA |
GeneTreei | ENSGT00970000193383 |
HOGENOMi | HOG000115475 |
InParanoidi | Q62053 |
KOi | K04259 |
OMAi | GYGQYVQ |
OrthoDBi | 972015at2759 |
PhylomeDBi | Q62053 |
TreeFami | TF324982 |
Enzyme and pathway databases
Reactomei | R-MMU-391908 Prostanoid ligand receptors R-MMU-418555 G alpha (s) signalling events |
Miscellaneous databases
ChiTaRSi | Ptger2 mouse |
PROi | PR:Q62053 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000037759 Expressed in 113 organ(s), highest expression level in left lung lobe |
ExpressionAtlasi | Q62053 baseline and differential |
Genevisiblei | Q62053 MM |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR008365 Prostanoid_rcpt IPR001923 Prostglndn_EP2_rcpt |
PANTHERi | PTHR11866 PTHR11866, 1 hit PTHR11866:SF8 PTHR11866:SF8, 1 hit |
Pfami | View protein in Pfam PF00001 7tm_1, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR01788 PROSTANOIDR PR00581 PRSTNOIDEP2R |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PE2R2_MOUSE | |
Accessioni | Q62053Primary (citable) accession number: Q62053 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1996 | |
Last modified: | November 13, 2019 | |
This is version 159 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot