UniProtKB - Q62053 (PE2R2_MOUSE)
Protein
Prostaglandin E2 receptor EP2 subtype
Gene
Ptger2
Organism
Mus musculus (Mouse)
Status
Functioni
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.
GO - Molecular functioni
- prostaglandin E receptor activity Source: MGI
GO - Biological processi
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: BHF-UCL
- cellular response to prostaglandin E stimulus Source: BHF-UCL
- inflammatory response Source: GO_Central
- positive regulation of cytosolic calcium ion concentration Source: GO_Central
- positive regulation of gastric mucosal blood circulation Source: MGI
- regulation of cell population proliferation Source: MGI
- response to lipopolysaccharide Source: MGI
- response to progesterone Source: CACAO
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-MMU-391908, Prostanoid ligand receptors R-MMU-418555, G alpha (s) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: Prostaglandin E2 receptor EP2 subtypeShort name: PGE receptor EP2 subtype Short name: PGE2 receptor EP2 subtype Alternative name(s): Prostanoid EP2 receptor |
Gene namesi | Name:Ptger2 Synonyms:Ptgerep2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:97794, Ptger2 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 24 | ExtracellularSequence analysisAdd BLAST | 24 | |
Transmembranei | 25 – 48 | Helical; Name=1Sequence analysisAdd BLAST | 24 | |
Topological domaini | 49 – 66 | CytoplasmicSequence analysisAdd BLAST | 18 | |
Transmembranei | 67 – 92 | Helical; Name=2Sequence analysisAdd BLAST | 26 | |
Topological domaini | 93 – 112 | ExtracellularSequence analysisAdd BLAST | 20 | |
Transmembranei | 113 – 133 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 134 – 152 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 153 – 177 | Helical; Name=4Sequence analysisAdd BLAST | 25 | |
Topological domaini | 178 – 199 | ExtracellularSequence analysisAdd BLAST | 22 | |
Transmembranei | 200 – 224 | Helical; Name=5Sequence analysisAdd BLAST | 25 | |
Topological domaini | 225 – 262 | CytoplasmicSequence analysisAdd BLAST | 38 | |
Transmembranei | 263 – 286 | Helical; Name=6Sequence analysisAdd BLAST | 24 | |
Topological domaini | 287 – 299 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 300 – 323 | Helical; Name=7Sequence analysisAdd BLAST | 24 | |
Topological domaini | 324 – 362 | CytoplasmicSequence analysisAdd BLAST | 39 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Chemistry databases
ChEMBLi | CHEMBL2488 |
DrugCentrali | Q62053 |
GuidetoPHARMACOLOGYi | 341 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000070055 | 1 – 362 | Prostaglandin E2 receptor EP2 subtypeAdd BLAST | 362 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 6 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 110 ↔ 188 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MaxQBi | Q62053 |
PaxDbi | Q62053 |
PRIDEi | Q62053 |
PTM databases
GlyGeni | Q62053, 1 site |
PhosphoSitePlusi | Q62053 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000037759, Expressed in granulocyte and 134 other tissues |
ExpressionAtlasi | Q62053, baseline and differential |
Genevisiblei | Q62053, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000038483 |
Chemistry databases
BindingDBi | Q62053 |
Miscellaneous databases
RNActi | Q62053, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01000000214569 |
HOGENOMi | CLU_045991_0_2_1 |
InParanoidi | Q62053 |
OMAi | IFAYMDE |
OrthoDBi | 972015at2759 |
PhylomeDBi | Q62053 |
TreeFami | TF324982 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR008365, Prostanoid_rcpt IPR001923, Prostglndn_EP2_rcpt |
PANTHERi | PTHR11866, PTHR11866, 1 hit PTHR11866:SF8, PTHR11866:SF8, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01788, PROSTANOIDR PR00581, PRSTNOIDEP2R |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q62053-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDNFLNDSKL MEDCKSRQWL LSGESPAISS VMFSAGVLGN LIALALLARR
60 70 80 90 100
WRGDTGCSAG SRTSISLFHV LVTELVLTDL LGTCLISPVV LASYSRNQTL
110 120 130 140 150
VALAPESHAC TYFAFTMTFF SLATMLMLFA MALERYLSIG YPYFYRRHLS
160 170 180 190 200
RRGGLAVLPV IYGASLLFCS LPLLNYGEYV QYCPGTWCFI RHGRTAYLQL
210 220 230 240 250
YATMLLLLIV AVLACNISVI LNLIRMHRRS RRSRCGLSGS SLRGPGSRRR
260 270 280 290 300
GERTSMAEET DHLILLAIMT ITFAICSLPF TIFAYMDETS SLKEKWDLRA
310 320 330 340 350
LRFLSVNSII DPWVFAILRP PVLRLMRSVL CCRTSLRTQE AQQTSCSTQS
360
SASKQTDLCG QL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D50589 mRNA Translation: BAA09137.1 BC005440 mRNA Translation: AAH05440.1 |
CCDSi | CCDS26972.1 |
PIRi | S66674 |
RefSeqi | NP_032990.1, NM_008964.4 |
Genome annotation databases
Ensembli | ENSMUST00000046891; ENSMUSP00000038483; ENSMUSG00000037759 |
GeneIDi | 19217 |
KEGGi | mmu:19217 |
UCSCi | uc007tgd.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D50589 mRNA Translation: BAA09137.1 BC005440 mRNA Translation: AAH05440.1 |
CCDSi | CCDS26972.1 |
PIRi | S66674 |
RefSeqi | NP_032990.1, NM_008964.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000038483 |
Chemistry databases
BindingDBi | Q62053 |
ChEMBLi | CHEMBL2488 |
DrugCentrali | Q62053 |
GuidetoPHARMACOLOGYi | 341 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q62053, 1 site |
PhosphoSitePlusi | Q62053 |
Proteomic databases
MaxQBi | Q62053 |
PaxDbi | Q62053 |
PRIDEi | Q62053 |
Protocols and materials databases
Antibodypediai | 10768, 571 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000046891; ENSMUSP00000038483; ENSMUSG00000037759 |
GeneIDi | 19217 |
KEGGi | mmu:19217 |
UCSCi | uc007tgd.2, mouse |
Organism-specific databases
CTDi | 5732 |
MGIi | MGI:97794, Ptger2 |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01000000214569 |
HOGENOMi | CLU_045991_0_2_1 |
InParanoidi | Q62053 |
OMAi | IFAYMDE |
OrthoDBi | 972015at2759 |
PhylomeDBi | Q62053 |
TreeFami | TF324982 |
Enzyme and pathway databases
Reactomei | R-MMU-391908, Prostanoid ligand receptors R-MMU-418555, G alpha (s) signalling events |
Miscellaneous databases
BioGRID-ORCSi | 19217, 0 hits in 19 CRISPR screens |
ChiTaRSi | Ptger2, mouse |
PROi | PR:Q62053 |
RNActi | Q62053, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000037759, Expressed in granulocyte and 134 other tissues |
ExpressionAtlasi | Q62053, baseline and differential |
Genevisiblei | Q62053, MM |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR008365, Prostanoid_rcpt IPR001923, Prostglndn_EP2_rcpt |
PANTHERi | PTHR11866, PTHR11866, 1 hit PTHR11866:SF8, PTHR11866:SF8, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01788, PROSTANOIDR PR00581, PRSTNOIDEP2R |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PE2R2_MOUSE | |
Accessioni | Q62053Primary (citable) accession number: Q62053 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 165 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families