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Protein

Astrocytic phosphoprotein PEA-15

Gene

Pea15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm. Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface (By similarity).By similarity1 Publication

Miscellaneous

Increases PLD1 and PLD2 levels, possibly by stabilizing the protein.

GO - Molecular functioni

  • protein kinase C binding Source: MGI

GO - Biological processi

Keywordsi

Biological processApoptosis, Sugar transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-112409 RAF-independent MAPK1/3 activation
R-MMU-5673001 RAF/MAP kinase cascade

Names & Taxonomyi

Protein namesi
Recommended name:
Astrocytic phosphoprotein PEA-15
Alternative name(s):
15 kDa phosphoprotein enriched in astrocytes
Gene namesi
Name:Pea15
Synonyms:Pea15a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:104799 Pea15a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi104S → A: Abolishes inhibitory effect on FAS-mediated apoptosis. Does not change effect on TNFRSF1A-mediated apoptosis. 1 Publication1
Mutagenesisi116S → A: Abolishes inhibitory effect on FAS-mediated apoptosis. Does not change effect on TNFRSF1A-mediated apoptosis. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001912831 – 130Astrocytic phosphoprotein PEA-15Add BLAST130

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei61PhosphoserineBy similarity1
Modified residuei90PhosphoserineCombined sources1
Modified residuei104Phosphoserine; by PKCCombined sources1 Publication1
Modified residuei116Phosphoserine; by CaMK2Combined sources1 Publication1

Post-translational modificationi

Phosphorylated by protein kinase C and calcium-calmodulin-dependent protein kinase. These phosphorylation events are modulated by neurotransmitters or hormones.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ62048
PaxDbiQ62048
PeptideAtlasiQ62048
PRIDEiQ62048

PTM databases

iPTMnetiQ62048
PhosphoSitePlusiQ62048

Expressioni

Tissue specificityi

Predominantly expressed in the brain. Low levels in some peripheral organs.

Gene expression databases

BgeeiENSMUSG00000013698 Expressed in 296 organ(s), highest expression level in ear
CleanExiMM_PEA15A
ExpressionAtlasiQ62048 baseline and differential
GenevisibleiQ62048 MM

Interactioni

Subunit structurei

Binds RPS6KA3, MAPK3 and MAPK1. Interacts with CASP8 and FADD (By similarity). Transient interaction with PLD1 and PLD2.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Hk2O085282EBI-8314750,EBI-8344432

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202103, 2 interactors
DIPiDIP-60009N
IntActiQ62048, 2 interactors
MINTiQ62048
STRINGi10090.ENSMUSP00000013842

Structurei

Secondary structure

1130
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ62048
SMRiQ62048
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 81DEDPROSITE-ProRule annotationAdd BLAST79

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni98 – 107Microtubule-bindingSequence analysis10
Regioni122 – 129Microtubule-bindingSequence analysis8

Phylogenomic databases

eggNOGiKOG3573 Eukaryota
ENOG410ZQIE LUCA
GeneTreeiENSGT00390000000230
HOGENOMiHOG000049048
HOVERGENiHBG053557
InParanoidiQ62048
OMAiETHNKLD
OrthoDBiEOG091G0TNX
PhylomeDBiQ62048
TreeFamiTF332405

Family and domain databases

CDDicd08338 DED_PEA15, 1 hit
InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR001875 DED_dom
IPR029546 PEA15
PANTHERiPTHR15094 PTHR15094, 1 hit
PfamiView protein in Pfam
PF01335 DED, 1 hit
SMARTiView protein in SMART
SM00031 DED, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50168 DED, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q62048-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEYGTLLQD LTNNITLEDL EQLKSACKED IPSEKSEEIT TGSAWFSFLE
60 70 80 90 100
SHNKLDKDNL SYIEHIFEIS RRPDLLTMVV DYRTRVLKIS EEEELDTKLT
110 120 130
RIPSAKKYKD IIRQPSEEEI IKLAPPPKKA
Length:130
Mass (Da):15,054
Last modified:November 1, 1996 - v1
Checksum:i780F93A40B2834A8
GO
Isoform 2 (identifier: Q62048-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-57: Missing.
     58-58: D → N

Show »
Length:108
Mass (Da):12,544
Checksum:iBCF0527AE97E42AF
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z375D3Z375_MOUSE
Phosphoprotein-enriched in astrocyt...
Pea15a
92Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00773636 – 57Missing in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_00773758D → N in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86694 Genomic DNA Translation: CAA60387.1
AK089070 mRNA Translation: BAC40734.1
AK153141 mRNA Translation: BAE31752.1
AK153493 mRNA Translation: BAE32041.1
AK161635 mRNA Translation: BAE36504.1
AK161977 mRNA Translation: BAE36662.1
BC038282 mRNA Translation: AAH38282.1
CCDSiCCDS15510.1 [Q62048-1]
PIRiS55385
RefSeqiNP_001316798.1, NM_001329869.1 [Q62048-1]
NP_001316800.1, NM_001329871.1 [Q62048-2]
NP_035193.1, NM_011063.3 [Q62048-1]
XP_006496765.1, XM_006496702.1 [Q62048-1]
UniGeneiMm.544

Genome annotation databases

EnsembliENSMUST00000013842; ENSMUSP00000013842; ENSMUSG00000013698 [Q62048-1]
ENSMUST00000111247; ENSMUSP00000106878; ENSMUSG00000013698 [Q62048-2]
GeneIDi18611
KEGGimmu:18611
UCSCiuc007dpy.1 mouse [Q62048-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86694 Genomic DNA Translation: CAA60387.1
AK089070 mRNA Translation: BAC40734.1
AK153141 mRNA Translation: BAE31752.1
AK153493 mRNA Translation: BAE32041.1
AK161635 mRNA Translation: BAE36504.1
AK161977 mRNA Translation: BAE36662.1
BC038282 mRNA Translation: AAH38282.1
CCDSiCCDS15510.1 [Q62048-1]
PIRiS55385
RefSeqiNP_001316798.1, NM_001329869.1 [Q62048-1]
NP_001316800.1, NM_001329871.1 [Q62048-2]
NP_035193.1, NM_011063.3 [Q62048-1]
XP_006496765.1, XM_006496702.1 [Q62048-1]
UniGeneiMm.544

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LS7NMR-A1-92[»]
ProteinModelPortaliQ62048
SMRiQ62048
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202103, 2 interactors
DIPiDIP-60009N
IntActiQ62048, 2 interactors
MINTiQ62048
STRINGi10090.ENSMUSP00000013842

PTM databases

iPTMnetiQ62048
PhosphoSitePlusiQ62048

Proteomic databases

EPDiQ62048
PaxDbiQ62048
PeptideAtlasiQ62048
PRIDEiQ62048

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000013842; ENSMUSP00000013842; ENSMUSG00000013698 [Q62048-1]
ENSMUST00000111247; ENSMUSP00000106878; ENSMUSG00000013698 [Q62048-2]
GeneIDi18611
KEGGimmu:18611
UCSCiuc007dpy.1 mouse [Q62048-1]

Organism-specific databases

CTDi18611
MGIiMGI:104799 Pea15a

Phylogenomic databases

eggNOGiKOG3573 Eukaryota
ENOG410ZQIE LUCA
GeneTreeiENSGT00390000000230
HOGENOMiHOG000049048
HOVERGENiHBG053557
InParanoidiQ62048
OMAiETHNKLD
OrthoDBiEOG091G0TNX
PhylomeDBiQ62048
TreeFamiTF332405

Enzyme and pathway databases

ReactomeiR-MMU-112409 RAF-independent MAPK1/3 activation
R-MMU-5673001 RAF/MAP kinase cascade

Miscellaneous databases

ChiTaRSiPea15a mouse
PROiPR:Q62048
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000013698 Expressed in 296 organ(s), highest expression level in ear
CleanExiMM_PEA15A
ExpressionAtlasiQ62048 baseline and differential
GenevisibleiQ62048 MM

Family and domain databases

CDDicd08338 DED_PEA15, 1 hit
InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR001875 DED_dom
IPR029546 PEA15
PANTHERiPTHR15094 PTHR15094, 1 hit
PfamiView protein in Pfam
PF01335 DED, 1 hit
SMARTiView protein in SMART
SM00031 DED, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50168 DED, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPEA15_MOUSE
AccessioniPrimary (citable) accession number: Q62048
Secondary accession number(s): Q3U5N7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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