Platelet-activating factor receptor

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• G protein-coupled purinergic nucleotide receptor activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• lipopolysaccharide binding Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Lipopolysaccharide-induced biphasic inositol 1,4,5-trisphosphate response and tyrosine phosphorylation of 140-kilodalton protein in mouse peritoneal macrophages."
    Shinji H., Akagawa K.S., Tsuji M., Maeda M., Yamada R., Matsuura K., Yamamoto S., Yoshida T.
    J. Immunol. 158:1370-1376(1997) [PubMed] [Europe PMC] [Abstract]
• lipopolysaccharide receptor activity Source: MGIInferred from mutant phenotypeⁱ
  • "Lipopolysaccharide-induced biphasic inositol 1,4,5-trisphosphate response and tyrosine phosphorylation of 140-kilodalton protein in mouse peritoneal macrophages."
    Shinji H., Akagawa K.S., Tsuji M., Maeda M., Yamada R., Matsuura K., Yamamoto S., Yoshida T.
    J. Immunol. 158:1370-1376(1997) [PubMed] [Europe PMC] [Abstract]
• mitogen-activated protein kinase binding Source: MGI
• phospholipid binding Source: MGI
• platelet activating factor receptor activity Source: MGI

GO - Biological processⁱ

• cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine Source: Ensembl
• cellular response to cAMP Source: Ensembl
• cellular response to fatty acid Source: Ensembl
• cellular response to gravity Source: Ensembl
• chemotaxis Source: UniProtKB-KW
• cytokine production Source: MGIInferred from mutant phenotypeⁱ
  • "Platelet-activating factor receptor deficiency delays elimination of adult worms but reduces fecundity in Strongyloides venezuelensis-infected mice."
    Negrao-Correa D., Souza D.G., Pinho V., Barsante M.M., Souza A.L., Teixeira M.M.
    Infect. Immun. 72:1135-1142(2004) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled receptor signaling pathway Source: MGI
• inflammatory response Source: MGIInferred from mutant phenotypeⁱ
  • "Platelet-activating factor receptor deficiency delays elimination of adult worms but reduces fecundity in Strongyloides venezuelensis-infected mice."
    Negrao-Correa D., Souza D.G., Pinho V., Barsante M.M., Souza A.L., Teixeira M.M.
    Infect. Immun. 72:1135-1142(2004) [PubMed] [Europe PMC] [Abstract]
• inositol trisphosphate biosynthetic process Source: MGIInferred from mutant phenotypeⁱ
  • "Lipopolysaccharide-induced biphasic inositol 1,4,5-trisphosphate response and tyrosine phosphorylation of 140-kilodalton protein in mouse peritoneal macrophages."
    Shinji H., Akagawa K.S., Tsuji M., Maeda M., Yamada R., Matsuura K., Yamamoto S., Yoshida T.
    J. Immunol. 158:1370-1376(1997) [PubMed] [Europe PMC] [Abstract]
• negative regulation of blood pressure Source: MGI
• parturition Source: MGI
• phosphatidylinositol-mediated signaling Source: MGI
• positive regulation of blood vessel diameter Source: MGI
• positive regulation of cellular extravasation Source: MGI
• positive regulation of gastro-intestinal system smooth muscle contraction Source: MGI
• positive regulation of inositol phosphate biosynthetic process Source: MGI
• positive regulation of interleukin-6 biosynthetic process Source: MGI
• positive regulation of leukocyte cell-cell adhesion Source: MGI
• positive regulation of leukocyte tethering or rolling Source: MGI
• positive regulation of maternal process involved in parturition Source: MGI
• positive regulation of neutrophil degranulation Source: MGI
• positive regulation of phospholipase C activity Source: MGI
• positive regulation of sensory perception of pain Source: MGI
• positive regulation of smooth muscle cell proliferation Source: MGI
• positive regulation of smooth muscle contraction Source: MGI
• positive regulation of transcytosis Source: MGI
• positive regulation of translation Source: MGI
• positive regulation of tumor necrosis factor production Source: MGI
• positive regulation of vasoconstriction Source: MGI
• positive regulation of voltage-gated chloride channel activity Source: MGI
• regulation of transcription by RNA polymerase II Source: MGI
• response to dexamethasone Source: Ensembl
• response to lipopolysaccharide Source: MGIInferred from mutant phenotypeⁱ
  • "Lipopolysaccharide-induced biphasic inositol 1,4,5-trisphosphate response and tyrosine phosphorylation of 140-kilodalton protein in mouse peritoneal macrophages."
    Shinji H., Akagawa K.S., Tsuji M., Maeda M., Yamada R., Matsuura K., Yamamoto S., Yoshida T.
    J. Immunol. 158:1370-1376(1997) [PubMed] [Europe PMC] [Abstract]
• response to symbiotic bacterium Source: Ensembl
• transcytosis Source: MGI

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• mitogen-activated protein kinase binding Source: MGI

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MEHNGSFRVD SEFRYTLFPI VYSVIFILGV VANGYVLWVF ANLYPSKKLN 
        60         70         80         90        100
EIKIFMVNLT MADLLFLITL PLWIVYYYNE GDWILPNFLC NVAGCLFFIN 
       110        120        130        140        150
TYCSVAFLGV ITYNRYQAVA YPIKTAQATT RKRGISLSLI IWVSIVATAS 
       160        170        180        190        200
YFLATDSTNL VPNKDGSGNI TRCFEHYEPY SVPILVVHVF IAFCFFLVFF 
       210        220        230        240        250
LIFYCNLVII HTLLTQPMRQ QRKAGVKRRA LWMVCTVLAV FIICFVPHHV 
       260        270        280        290        300
VQLPWTLAEL GYQTNFHQAI NDAHQITLCL LSTNCVLDPV IYCFLTKKFR 
       310        320        330        340 
KHLSEKFYSM RSSRKCSRAT SDTCTEVIVP ANQTPIVSLK N          

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. 7-transmembrane G-linked receptors
   List of 7-transmembrane G-linked receptor entries
3. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot