UniProtKB - Q62028 (PLA2R_MOUSE)
Secretory phospholipase A2 receptor
Pla2r1
Functioni
GO - Molecular functioni
- carbohydrate binding Source: UniProtKB-KW
- phospholipase binding Source: UniProtKB
- signaling receptor activity Source: UniProtKB
GO - Biological processi
- cytokine production Source: UniProtKB
- negative regulation of arachidonic acid secretion Source: UniProtKB
- negative regulation of phospholipase A2 activity Source: UniProtKB
- oxidative stress-induced premature senescence Source: UniProtKB
- positive regulation of arachidonic acid secretion Source: UniProtKB
- positive regulation of DNA damage response, signal transduction by p53 class mediator Source: UniProtKB
- positive regulation of glomerular visceral epithelial cell apoptotic process Source: MGI
- reactive oxygen species metabolic process Source: UniProtKB
- receptor-mediated endocytosis Source: UniProtKB
- replicative senescence Source: UniProtKB
Keywordsi
Molecular function | Receptor |
Biological process | Endocytosis |
Ligand | Lectin |
Enzyme and pathway databases
Reactomei | R-MMU-1482788, Acyl chain remodelling of PC R-MMU-1482801, Acyl chain remodelling of PS R-MMU-1482839, Acyl chain remodelling of PE R-MMU-1482922, Acyl chain remodelling of PI R-MMU-1482925, Acyl chain remodelling of PG R-MMU-1483166, Synthesis of PA |
Names & Taxonomyi
Protein namesi | Recommended name: Secretory phospholipase A2 receptorShort name: PLA2-R Short name: PLA2R Alternative name(s): 180 kDa secretory phospholipase A2 receptor M-type receptor Cleaved into the following chain: |
Gene namesi | Name:Pla2r1 Synonyms:Pla2g1br |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:102468, Pla2r1 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- cell surface Source: MGI
- integral component of membrane Source: UniProtKB-KW
- receptor complex Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 27 – 1396 | ExtracellularSequence analysisAdd BLAST | 1370 | |
Transmembranei | 1397 – 1417 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1418 – 1487 | CytoplasmicSequence analysisAdd BLAST | 70 |
Keywords - Cellular componenti
Cell membrane, Membrane, SecretedPathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | By similarityAdd BLAST | 26 | |
ChainiPRO_5000139804 | 27 – 1487 | Secretory phospholipase A2 receptorAdd BLAST | 1461 | |
ChainiPRO_0000311251 | 27 – ? | Soluble secretory phospholipase A2 receptorCurated |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 55 ↔ 68 | By similarity | ||
Disulfide bondi | 93 ↔ 110 | By similarity | ||
Glycosylationi | 97 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 181 ↔ 207 | By similarity | ||
Disulfide bondi | 195 ↔ 222 | By similarity | ||
Glycosylationi | 239 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 263 ↔ 356 | By similarity | ||
Disulfide bondi | 333 ↔ 348 | By similarity | ||
Disulfide bondi | 408 ↔ 503 | By similarity | ||
Disulfide bondi | 480 ↔ 495 | By similarity | ||
Disulfide bondi | 617 ↔ 634 | By similarity | ||
Disulfide bondi | 699 ↔ 796 | By similarity | ||
Disulfide bondi | 774 ↔ 788 | By similarity | ||
Disulfide bondi | 840 ↔ 937 | By similarity | ||
Disulfide bondi | 914 ↔ 929 | By similarity | ||
Glycosylationi | 928 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1066 ↔ 1086 | By similarity | ||
Glycosylationi | 1107 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1122 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1131 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1208 ↔ 1222 | By similarity | ||
Disulfide bondi | 1279 ↔ 1376 | By similarity | ||
Disulfide bondi | 1353 ↔ 1368 | By similarity |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q62028 |
PeptideAtlasi | Q62028 |
PRIDEi | Q62028 |
PTM databases
GlyGeni | Q62028, 6 sites |
PhosphoSitePlusi | Q62028 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSMUSG00000054580, Expressed in retina and 235 other tissues |
Genevisiblei | Q62028, MM |
Interactioni
Subunit structurei
Interacts with sPLA2-IB/PLA2G1B; this interaction mediates intracellular signaling as well as clearance of extracellular sPLA2-IB/PLA2G1B via endocytotic pathway (PubMed:10066760).
Interacts with sPLA2-X/PLA2G10; this interaction mediates sPLA2-X/PLA2G10 clearance and inactivation (PubMed:10922494, PubMed:11741598).
3 PublicationsGO - Molecular functioni
- phospholipase binding Source: UniProtKB
Protein-protein interaction databases
IntActi | Q62028, 1 interactor |
MINTi | Q62028 |
STRINGi | 10090.ENSMUSP00000108144 |
Miscellaneous databases
RNActi | Q62028, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 42 – 165 | Ricin B-type lectinPROSITE-ProRule annotationAdd BLAST | 124 | |
Domaini | 176 – 224 | Fibronectin type-IIPROSITE-ProRule annotationAdd BLAST | 49 | |
Domaini | 241 – 357 | C-type lectin 1PROSITE-ProRule annotationAdd BLAST | 117 | |
Domaini | 387 – 504 | C-type lectin 2PROSITE-ProRule annotationAdd BLAST | 118 | |
Domaini | 524 – 643 | C-type lectin 3PROSITE-ProRule annotationAdd BLAST | 120 | |
Domaini | 673 – 797 | C-type lectin 4PROSITE-ProRule annotationAdd BLAST | 125 | |
Domaini | 819 – 938 | C-type lectin 5PROSITE-ProRule annotationAdd BLAST | 120 | |
Domaini | 964 – 1095 | C-type lectin 6PROSITE-ProRule annotationAdd BLAST | 132 | |
Domaini | 1120 – 1231 | C-type lectin 7PROSITE-ProRule annotationAdd BLAST | 112 | |
Domaini | 1256 – 1377 | C-type lectin 8PROSITE-ProRule annotationAdd BLAST | 122 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 1435 – 1441 | Endocytosis signal | 7 |
Domaini
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4297, Eukaryota |
GeneTreei | ENSGT00990000203637 |
HOGENOMi | CLU_002069_2_0_1 |
InParanoidi | Q62028 |
OMAi | KYHATHC |
PhylomeDBi | Q62028 |
TreeFami | TF316663 |
Family and domain databases
CDDi | cd00062, FN2, 1 hit cd00161, RICIN, 1 hit |
Gene3Di | 2.10.10.10, 1 hit 3.10.100.10, 8 hits |
InterProi | View protein in InterPro IPR001304, C-type_lectin-like IPR016186, C-type_lectin-like/link_sf IPR018378, C-type_lectin_CS IPR016187, CTDL_fold IPR000562, FN_type2_dom IPR036943, FN_type2_sf IPR035992, Ricin_B-like_lectins IPR000772, Ricin_B_lectin |
Pfami | View protein in Pfam PF00040, fn2, 1 hit PF00059, Lectin_C, 8 hits |
SMARTi | View protein in SMART SM00034, CLECT, 8 hits SM00059, FN2, 1 hit SM00458, RICIN, 1 hit |
SUPFAMi | SSF50370, SSF50370, 1 hit SSF56436, SSF56436, 8 hits |
PROSITEi | View protein in PROSITE PS00615, C_TYPE_LECTIN_1, 2 hits PS50041, C_TYPE_LECTIN_2, 8 hits PS00023, FN2_1, 1 hit PS51092, FN2_2, 1 hit PS50231, RICIN_B_LECTIN, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVQWLAMLQL LWLQQLLLLG IHQGIAQDLT HIQEPSLEWR DKGIFIIQSE
60 70 80 90 100
SLKTCIQAGK SVLTLENCKQ PNEHMLWKWV SDDHLFNVGG SGCLGLNISA
110 120 130 140 150
LEQPLKLYEC DSTLISLRWH CDRKMIEGPL QYKVQVKSDN TVVARKQIHR
160 170 180 190 200
WIAYTSSGGD ICEHPSRDLY TLKGNAHGMP CVFPFQFKGH WHHDCIREGQ
210 220 230 240 250
KEHLLWCATT SRYEEDEKWG FCPDPTSMKV FCDATWQRNG SSRICYQFNL
260 270 280 290 300
LSSLSWNQAH SSCLMQGGAL LSIADEDEED FIRKHLSKVV KEVWIGLNQL
310 320 330 340 350
DEKAGWQWSD GTPLSYLNWS QEITPGPFVE HHCGTLEVVS AAWRSRDCES
360 370 380 390 400
TLPYICKRDL NHTAQGILEK DSWKYHATHC DPDWTPFNRK CYKLKKDRKS
410 420 430 440 450
WLGALHSCQS NDSVLMDVAS LAEVEFLVSL LRDENASETW IGLSSNKIPV
460 470 480 490 500
SFEWSSGSSV IFTNWYPLEP RILPNRRQLC VSAEESDGRW KVKDCKERLF
510 520 530 540 550
YICKKAGQVP ADEQSGCPAG WERHGRFCYK IDTVLRSFEE ASSGYYCSPA
560 570 580 590 600
LLTITSRFEQ AFITSLISSV AEKDSYFWIA LQDQNNTGEY TWKTVGQREP
610 620 630 640 650
VQYTYWNTRQ PSNRGGCVVV RGGSSLGRWE VKDCSDFKAM SLCKTPVKIW
660 670 680 690 700
EKTELEERWP FHPCYMDWES ATGLASCFKV FHSEKVLMKR SWREAEAFCE
710 720 730 740 750
EFGAHLASFA HIEEENFVNE LLHSKFNWTQ ERQFWIGFNR RNPLNAGSWA
760 770 780 790 800
WSDGSPVVSS FLDNAYFEED AKNCAVYKAN KTLLPSNCAS KHEWICRIPR
810 820 830 840 850
DVRPKFPDWY QYDAPWLFYQ NAEYLFHTHP AEWATFEFVC GWLRSDFLTI
860 870 880 890 900
YSAQEQEFIH SKIKGLTKYG VKWWIGLEEG GARDQIQWSN GSPVIFQNWD
910 920 930 940 950
KGREERVDSQ RKRCVFISSI TGLWGTENCS VPLPSICKRV KIWVIEKEKP
960 970 980 990 1000
PTQPGTCPKG WLYFNYKCFL VTIPKDPREL KTWTGAQEFC VAKGGTLVSI
1010 1020 1030 1040 1050
KSELEQAFIT MNLFGQTTNV WIGLQSTNHE KWVNGKPLVY SNWSPSDIIN
1060 1070 1080 1090 1100
IPSYNTTEFQ KHIPLCALMS SNPNFHFTGK WYFDDCGKEG YGFVCEKMQD
1110 1120 1130 1140 1150
TLEHHVNVSD TSAIPSTLEY GNRTYKIIRG NMTWYAAGKS CRMHRAELAS
1160 1170 1180 1190 1200
IPDAFHQAFL TVLLSRLGHT HWIGLSTTDN GQTFDWSDGT KSPFTYWKDE
1210 1220 1230 1240 1250
ESAFLGDCAF ADTNGRWHST ACESFLQGAI CHVVTETKAF EHPGLCSETS
1260 1270 1280 1290 1300
VPWIKFKGNC YSFSTVLDSR SFEDAHEFCK SEGSNLLAIR DAAENSFLLE
1310 1320 1330 1340 1350
ELLAFGSSVQ MVWLNAQFDN NNKTLRWFDG TPTEQSNWGL RKPDMDHLKP
1360 1370 1380 1390 1400
HPCVVLRIPE GIWHFTPCED KKGFICKMEA GIPAVTAQPE KGLSHSIVPV
1410 1420 1430 1440 1450
TVTLTLIIAL GIFMLCFWIY KQKSDIFQRL TGSRGSYYPT LNFSTAHLEE
1460 1470 1480
NILISDLEKN TNDEEVRDAP ATESKRGHKG RPICISP
Sequence cautioni
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_029495 | 680 – 689 | VFHSEKVLMK → DTGKAVLDWI in isoform 2. 1 Publication | 10 | |
Alternative sequenceiVSP_029496 | 690 – 1487 | Missing in isoform 2. 1 PublicationAdd BLAST | 798 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D30779 mRNA Translation: BAA06443.1 BX679662, AL928546 Genomic DNA Translation: CAM22305.1 Different initiation. AL928546, BX679662 Genomic DNA Translation: CAM23630.1 Different initiation. BC048780 mRNA Translation: AAH48780.1 BC141355 mRNA Translation: AAI41356.1 BC141356 mRNA Translation: AAI41357.1 |
CCDSi | CCDS16059.1 [Q62028-1] |
PIRi | S48719 |
RefSeqi | NP_032893.1, NM_008867.2 [Q62028-1] |
Genome annotation databases
Ensembli | ENSMUST00000112525; ENSMUSP00000108144; ENSMUSG00000054580 [Q62028-1] |
GeneIDi | 18779 |
KEGGi | mmu:18779 |
UCSCi | uc008jug.2, mouse [Q62028-1] uc008juh.2, mouse [Q62028-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Functional Glycomics Gateway - Glycan Binding Phospholipase A2 receptor |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D30779 mRNA Translation: BAA06443.1 BX679662, AL928546 Genomic DNA Translation: CAM22305.1 Different initiation. AL928546, BX679662 Genomic DNA Translation: CAM23630.1 Different initiation. BC048780 mRNA Translation: AAH48780.1 BC141355 mRNA Translation: AAI41356.1 BC141356 mRNA Translation: AAI41357.1 |
CCDSi | CCDS16059.1 [Q62028-1] |
PIRi | S48719 |
RefSeqi | NP_032893.1, NM_008867.2 [Q62028-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q62028, 1 interactor |
MINTi | Q62028 |
STRINGi | 10090.ENSMUSP00000108144 |
PTM databases
GlyGeni | Q62028, 6 sites |
PhosphoSitePlusi | Q62028 |
Proteomic databases
PaxDbi | Q62028 |
PeptideAtlasi | Q62028 |
PRIDEi | Q62028 |
Protocols and materials databases
Antibodypediai | 2544, 230 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000112525; ENSMUSP00000108144; ENSMUSG00000054580 [Q62028-1] |
GeneIDi | 18779 |
KEGGi | mmu:18779 |
UCSCi | uc008jug.2, mouse [Q62028-1] uc008juh.2, mouse [Q62028-2] |
Organism-specific databases
CTDi | 22925 |
MGIi | MGI:102468, Pla2r1 |
Phylogenomic databases
eggNOGi | KOG4297, Eukaryota |
GeneTreei | ENSGT00990000203637 |
HOGENOMi | CLU_002069_2_0_1 |
InParanoidi | Q62028 |
OMAi | KYHATHC |
PhylomeDBi | Q62028 |
TreeFami | TF316663 |
Enzyme and pathway databases
Reactomei | R-MMU-1482788, Acyl chain remodelling of PC R-MMU-1482801, Acyl chain remodelling of PS R-MMU-1482839, Acyl chain remodelling of PE R-MMU-1482922, Acyl chain remodelling of PI R-MMU-1482925, Acyl chain remodelling of PG R-MMU-1483166, Synthesis of PA |
Miscellaneous databases
BioGRID-ORCSi | 18779, 1 hit in 17 CRISPR screens |
ChiTaRSi | Pla2r1, mouse |
PROi | PR:Q62028 |
RNActi | Q62028, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000054580, Expressed in retina and 235 other tissues |
Genevisiblei | Q62028, MM |
Family and domain databases
CDDi | cd00062, FN2, 1 hit cd00161, RICIN, 1 hit |
Gene3Di | 2.10.10.10, 1 hit 3.10.100.10, 8 hits |
InterProi | View protein in InterPro IPR001304, C-type_lectin-like IPR016186, C-type_lectin-like/link_sf IPR018378, C-type_lectin_CS IPR016187, CTDL_fold IPR000562, FN_type2_dom IPR036943, FN_type2_sf IPR035992, Ricin_B-like_lectins IPR000772, Ricin_B_lectin |
Pfami | View protein in Pfam PF00040, fn2, 1 hit PF00059, Lectin_C, 8 hits |
SMARTi | View protein in SMART SM00034, CLECT, 8 hits SM00059, FN2, 1 hit SM00458, RICIN, 1 hit |
SUPFAMi | SSF50370, SSF50370, 1 hit SSF56436, SSF56436, 8 hits |
PROSITEi | View protein in PROSITE PS00615, C_TYPE_LECTIN_1, 2 hits PS50041, C_TYPE_LECTIN_2, 8 hits PS00023, FN2_1, 1 hit PS51092, FN2_2, 1 hit PS50231, RICIN_B_LECTIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PLA2R_MOUSE | |
Accessioni | Q62028Primary (citable) accession number: Q62028 Secondary accession number(s): A2AS64, B9EJ68, Q80ZL5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 13, 2007 |
Last sequence update: | November 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 148 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot