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Protein

Secretory phospholipase A2 receptor

Gene

Pla2r1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipases sPLA2-IB/PLA2G1B, sPLA2-X/PLA2G10 and, with lower affinity, sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B and sPLA2-X/PLA2G10.11 Publications

GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB-KW
  • phospholipase binding Source: UniProtKB
  • signaling receptor activity Source: UniProtKB
  • transmembrane signaling receptor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processEndocytosis
LigandLectin

Enzyme and pathway databases

ReactomeiR-MMU-1482788 Acyl chain remodelling of PC
R-MMU-1482801 Acyl chain remodelling of PS
R-MMU-1482839 Acyl chain remodelling of PE
R-MMU-1482922 Acyl chain remodelling of PI
R-MMU-1482925 Acyl chain remodelling of PG
R-MMU-1483166 Synthesis of PA

Names & Taxonomyi

Protein namesi
Recommended name:
Secretory phospholipase A2 receptor
Short name:
PLA2-R
Short name:
PLA2R
Alternative name(s):
180 kDa secretory phospholipase A2 receptor
M-type receptor
Cleaved into the following chain:
Soluble secretory phospholipase A2 receptor
Short name:
Soluble PLA2-R
Short name:
Soluble PLA2R
Gene namesi
Name:Pla2r1
Synonyms:Pla2g1br
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:102468 Pla2r1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 1396ExtracellularSequence analysisAdd BLAST1370
Transmembranei1397 – 1417HelicalSequence analysisAdd BLAST21
Topological domaini1418 – 1487CytoplasmicSequence analysisAdd BLAST70

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Disruption phenotypei

Mice are viable, fertile and without evident histopathological abnormalities. After challenge with bacterial lipopolysaccharide (LPS), they exhibit longer survival than wild-type mice. They are also resistant to lethal effects of exogenous sPLA2-IB/PLA2G1B after sensitization with sublethal dose of LPS, suggesting a potential role in the progression of endotoxic shock.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26By similarityAdd BLAST26
ChainiPRO_500013980427 – 1487Secretory phospholipase A2 receptorAdd BLAST1461
ChainiPRO_000031125127 – ?Soluble secretory phospholipase A2 receptorCurated

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi55 ↔ 68By similarity
Disulfide bondi93 ↔ 110By similarity
Glycosylationi97N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi181 ↔ 207By similarity
Disulfide bondi195 ↔ 222By similarity
Glycosylationi239N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi263 ↔ 356By similarity
Disulfide bondi333 ↔ 348By similarity
Disulfide bondi408 ↔ 503By similarity
Disulfide bondi480 ↔ 495By similarity
Disulfide bondi617 ↔ 634By similarity
Disulfide bondi699 ↔ 796By similarity
Disulfide bondi774 ↔ 788By similarity
Disulfide bondi840 ↔ 937By similarity
Disulfide bondi914 ↔ 929By similarity
Glycosylationi928N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1066 ↔ 1086By similarity
Glycosylationi1107N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1122N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1131N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1208 ↔ 1222By similarity
Disulfide bondi1279 ↔ 1376By similarity
Disulfide bondi1353 ↔ 1368By similarity

Post-translational modificationi

The secretory phospholipase A2 receptor form may be produced by the action of metalloproteinases. It contains all extracellular domains and only lacks transmembrane and cytosolic regions. It is however unclear whether this form is produced by proteolytic cleavage as suggested by some experiments reported by PubMed:11830583, or by alternative splicing.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ62028
PeptideAtlasiQ62028
PRIDEiQ62028

PTM databases

PhosphoSitePlusiQ62028

Expressioni

Tissue specificityi

Widely expressed. Present in type II alveolar epithelial cells and a subset of splenic lymphocytes. Present at the surface of polymorphonuclear neutrophils (at protein level).3 Publications

Inductioni

Following exposure to endotoxin (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000054580 Expressed in 218 organ(s), highest expression level in retina
CleanExiMM_PLA2R1
GenevisibleiQ62028 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ62028, 1 interactor
MINTiQ62028
STRINGi10090.ENSMUSP00000065205

Structurei

3D structure databases

ProteinModelPortaliQ62028
SMRiQ62028
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 165Ricin B-type lectinPROSITE-ProRule annotationAdd BLAST124
Domaini176 – 224Fibronectin type-IIPROSITE-ProRule annotationAdd BLAST49
Domaini241 – 357C-type lectin 1PROSITE-ProRule annotationAdd BLAST117
Domaini387 – 504C-type lectin 2PROSITE-ProRule annotationAdd BLAST118
Domaini524 – 643C-type lectin 3PROSITE-ProRule annotationAdd BLAST120
Domaini673 – 797C-type lectin 4PROSITE-ProRule annotationAdd BLAST125
Domaini819 – 938C-type lectin 5PROSITE-ProRule annotationAdd BLAST120
Domaini964 – 1095C-type lectin 6PROSITE-ProRule annotationAdd BLAST132
Domaini1120 – 1231C-type lectin 7PROSITE-ProRule annotationAdd BLAST112
Domaini1256 – 1377C-type lectin 8PROSITE-ProRule annotationAdd BLAST122

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1435 – 1441Endocytosis signal7

Domaini

C-type lectin domains 3-5 mediate the interaction with phospholipase PLA2G1B.1 Publication
The endocytosis signal probably mediates endocytosis via clathrin-coated pits.By similarity

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IS42 Eukaryota
ENOG4111FAE LUCA
GeneTreeiENSGT00720000108514
HOGENOMiHOG000231191
HOVERGENiHBG108261
InParanoidiQ62028
KOiK06560
OMAiKGIFIIQ
OrthoDBiEOG091G0CY8
PhylomeDBiQ62028
TreeFamiTF316663

Family and domain databases

CDDicd00062 FN2, 1 hit
cd00161 RICIN, 1 hit
Gene3Di2.10.10.10, 1 hit
3.10.100.10, 8 hits
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
IPR000562 FN_type2_dom
IPR036943 FN_type2_sf
IPR035992 Ricin_B-like_lectins
IPR000772 Ricin_B_lectin
PfamiView protein in Pfam
PF00040 fn2, 1 hit
PF00059 Lectin_C, 8 hits
SMARTiView protein in SMART
SM00034 CLECT, 8 hits
SM00059 FN2, 1 hit
SM00458 RICIN, 1 hit
SUPFAMiSSF50370 SSF50370, 1 hit
SSF56436 SSF56436, 8 hits
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 2 hits
PS50041 C_TYPE_LECTIN_2, 8 hits
PS00023 FN2_1, 1 hit
PS51092 FN2_2, 1 hit
PS50231 RICIN_B_LECTIN, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q62028-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVQWLAMLQL LWLQQLLLLG IHQGIAQDLT HIQEPSLEWR DKGIFIIQSE
60 70 80 90 100
SLKTCIQAGK SVLTLENCKQ PNEHMLWKWV SDDHLFNVGG SGCLGLNISA
110 120 130 140 150
LEQPLKLYEC DSTLISLRWH CDRKMIEGPL QYKVQVKSDN TVVARKQIHR
160 170 180 190 200
WIAYTSSGGD ICEHPSRDLY TLKGNAHGMP CVFPFQFKGH WHHDCIREGQ
210 220 230 240 250
KEHLLWCATT SRYEEDEKWG FCPDPTSMKV FCDATWQRNG SSRICYQFNL
260 270 280 290 300
LSSLSWNQAH SSCLMQGGAL LSIADEDEED FIRKHLSKVV KEVWIGLNQL
310 320 330 340 350
DEKAGWQWSD GTPLSYLNWS QEITPGPFVE HHCGTLEVVS AAWRSRDCES
360 370 380 390 400
TLPYICKRDL NHTAQGILEK DSWKYHATHC DPDWTPFNRK CYKLKKDRKS
410 420 430 440 450
WLGALHSCQS NDSVLMDVAS LAEVEFLVSL LRDENASETW IGLSSNKIPV
460 470 480 490 500
SFEWSSGSSV IFTNWYPLEP RILPNRRQLC VSAEESDGRW KVKDCKERLF
510 520 530 540 550
YICKKAGQVP ADEQSGCPAG WERHGRFCYK IDTVLRSFEE ASSGYYCSPA
560 570 580 590 600
LLTITSRFEQ AFITSLISSV AEKDSYFWIA LQDQNNTGEY TWKTVGQREP
610 620 630 640 650
VQYTYWNTRQ PSNRGGCVVV RGGSSLGRWE VKDCSDFKAM SLCKTPVKIW
660 670 680 690 700
EKTELEERWP FHPCYMDWES ATGLASCFKV FHSEKVLMKR SWREAEAFCE
710 720 730 740 750
EFGAHLASFA HIEEENFVNE LLHSKFNWTQ ERQFWIGFNR RNPLNAGSWA
760 770 780 790 800
WSDGSPVVSS FLDNAYFEED AKNCAVYKAN KTLLPSNCAS KHEWICRIPR
810 820 830 840 850
DVRPKFPDWY QYDAPWLFYQ NAEYLFHTHP AEWATFEFVC GWLRSDFLTI
860 870 880 890 900
YSAQEQEFIH SKIKGLTKYG VKWWIGLEEG GARDQIQWSN GSPVIFQNWD
910 920 930 940 950
KGREERVDSQ RKRCVFISSI TGLWGTENCS VPLPSICKRV KIWVIEKEKP
960 970 980 990 1000
PTQPGTCPKG WLYFNYKCFL VTIPKDPREL KTWTGAQEFC VAKGGTLVSI
1010 1020 1030 1040 1050
KSELEQAFIT MNLFGQTTNV WIGLQSTNHE KWVNGKPLVY SNWSPSDIIN
1060 1070 1080 1090 1100
IPSYNTTEFQ KHIPLCALMS SNPNFHFTGK WYFDDCGKEG YGFVCEKMQD
1110 1120 1130 1140 1150
TLEHHVNVSD TSAIPSTLEY GNRTYKIIRG NMTWYAAGKS CRMHRAELAS
1160 1170 1180 1190 1200
IPDAFHQAFL TVLLSRLGHT HWIGLSTTDN GQTFDWSDGT KSPFTYWKDE
1210 1220 1230 1240 1250
ESAFLGDCAF ADTNGRWHST ACESFLQGAI CHVVTETKAF EHPGLCSETS
1260 1270 1280 1290 1300
VPWIKFKGNC YSFSTVLDSR SFEDAHEFCK SEGSNLLAIR DAAENSFLLE
1310 1320 1330 1340 1350
ELLAFGSSVQ MVWLNAQFDN NNKTLRWFDG TPTEQSNWGL RKPDMDHLKP
1360 1370 1380 1390 1400
HPCVVLRIPE GIWHFTPCED KKGFICKMEA GIPAVTAQPE KGLSHSIVPV
1410 1420 1430 1440 1450
TVTLTLIIAL GIFMLCFWIY KQKSDIFQRL TGSRGSYYPT LNFSTAHLEE
1460 1470 1480
NILISDLEKN TNDEEVRDAP ATESKRGHKG RPICISP
Length:1,487
Mass (Da):170,512
Last modified:November 1, 1996 - v1
Checksum:iAD8D905859B0EDE8
GO
Isoform 2 (identifier: Q62028-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     680-689: VFHSEKVLMK → DTGKAVLDWI
     690-1487: Missing.

Note: No experimental confirmation available.
Show »
Length:689
Mass (Da):79,127
Checksum:i846ED8D4A79573B4
GO

Sequence cautioni

The sequence CAM22305 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAM23630 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_029495680 – 689VFHSEKVLMK → DTGKAVLDWI in isoform 2. 1 Publication10
Alternative sequenceiVSP_029496690 – 1487Missing in isoform 2. 1 PublicationAdd BLAST798

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D30779 mRNA Translation: BAA06443.1
BX679662, AL928546 Genomic DNA Translation: CAM22305.1 Different initiation.
AL928546, BX679662 Genomic DNA Translation: CAM23630.1 Different initiation.
BC048780 mRNA Translation: AAH48780.1
BC141355 mRNA Translation: AAI41356.1
BC141356 mRNA Translation: AAI41357.1
CCDSiCCDS16059.1 [Q62028-1]
PIRiS48719
RefSeqiNP_032893.1, NM_008867.2 [Q62028-1]
UniGeneiMm.5092

Genome annotation databases

EnsembliENSMUST00000112525; ENSMUSP00000108144; ENSMUSG00000054580 [Q62028-1]
GeneIDi18779
KEGGimmu:18779
UCSCiuc008jug.2 mouse [Q62028-1]
uc008juh.2 mouse [Q62028-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Phospholipase A2 receptor

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D30779 mRNA Translation: BAA06443.1
BX679662, AL928546 Genomic DNA Translation: CAM22305.1 Different initiation.
AL928546, BX679662 Genomic DNA Translation: CAM23630.1 Different initiation.
BC048780 mRNA Translation: AAH48780.1
BC141355 mRNA Translation: AAI41356.1
BC141356 mRNA Translation: AAI41357.1
CCDSiCCDS16059.1 [Q62028-1]
PIRiS48719
RefSeqiNP_032893.1, NM_008867.2 [Q62028-1]
UniGeneiMm.5092

3D structure databases

ProteinModelPortaliQ62028
SMRiQ62028
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ62028, 1 interactor
MINTiQ62028
STRINGi10090.ENSMUSP00000065205

PTM databases

PhosphoSitePlusiQ62028

Proteomic databases

PaxDbiQ62028
PeptideAtlasiQ62028
PRIDEiQ62028

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000112525; ENSMUSP00000108144; ENSMUSG00000054580 [Q62028-1]
GeneIDi18779
KEGGimmu:18779
UCSCiuc008jug.2 mouse [Q62028-1]
uc008juh.2 mouse [Q62028-2]

Organism-specific databases

CTDi22925
MGIiMGI:102468 Pla2r1

Phylogenomic databases

eggNOGiENOG410IS42 Eukaryota
ENOG4111FAE LUCA
GeneTreeiENSGT00720000108514
HOGENOMiHOG000231191
HOVERGENiHBG108261
InParanoidiQ62028
KOiK06560
OMAiKGIFIIQ
OrthoDBiEOG091G0CY8
PhylomeDBiQ62028
TreeFamiTF316663

Enzyme and pathway databases

ReactomeiR-MMU-1482788 Acyl chain remodelling of PC
R-MMU-1482801 Acyl chain remodelling of PS
R-MMU-1482839 Acyl chain remodelling of PE
R-MMU-1482922 Acyl chain remodelling of PI
R-MMU-1482925 Acyl chain remodelling of PG
R-MMU-1483166 Synthesis of PA

Miscellaneous databases

PROiPR:Q62028
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000054580 Expressed in 218 organ(s), highest expression level in retina
CleanExiMM_PLA2R1
GenevisibleiQ62028 MM

Family and domain databases

CDDicd00062 FN2, 1 hit
cd00161 RICIN, 1 hit
Gene3Di2.10.10.10, 1 hit
3.10.100.10, 8 hits
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
IPR000562 FN_type2_dom
IPR036943 FN_type2_sf
IPR035992 Ricin_B-like_lectins
IPR000772 Ricin_B_lectin
PfamiView protein in Pfam
PF00040 fn2, 1 hit
PF00059 Lectin_C, 8 hits
SMARTiView protein in SMART
SM00034 CLECT, 8 hits
SM00059 FN2, 1 hit
SM00458 RICIN, 1 hit
SUPFAMiSSF50370 SSF50370, 1 hit
SSF56436 SSF56436, 8 hits
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 2 hits
PS50041 C_TYPE_LECTIN_2, 8 hits
PS00023 FN2_1, 1 hit
PS51092 FN2_2, 1 hit
PS50231 RICIN_B_LECTIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPLA2R_MOUSE
AccessioniPrimary (citable) accession number: Q62028
Secondary accession number(s): A2AS64, B9EJ68, Q80ZL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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