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Entry version 167 (07 Oct 2020)
Sequence version 2 (04 Apr 2006)
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Protein

RNA polymerase-associated protein CTR9 homolog

Gene

Ctr9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3) and dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription (By similarity). Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of the SET1 complex. Involved in transcriptional regulation of IL6-responsive genes and in JAK-STAT pathway; may regulate DNA-association of STAT3.By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation, Wnt signaling pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-112382, Formation of RNA Pol II elongation complex
R-MMU-674695, RNA Polymerase II Pre-transcription Events
R-MMU-75955, RNA Polymerase II Transcription Elongation
R-MMU-8866654, E3 ubiquitin ligases ubiquitinate target proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA polymerase-associated protein CTR9 homolog
Alternative name(s):
SH2 domain-binding protein 1
Tetratricopeptide repeat-containing, SH2-binding phosphoprotein of 150 kDa
Short name:
TPR-containing, SH2-binding phosphoprotein of 150 kDa
Short name:
p150TSP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ctr9
Synonyms:Kiaa0155, Sh2bp1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:109345, Ctr9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002315891 – 1173RNA polymerase-associated protein CTR9 homologAdd BLAST1173

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei925PhosphothreonineCombined sources1
Modified residuei932PhosphoserineBy similarity1
Modified residuei941PhosphoserineCombined sources1
Modified residuei943PhosphoserineBy similarity1
Modified residuei970PhosphoserineCombined sources1
Modified residuei1020PhosphoserineBy similarity1
Modified residuei1021PhosphoserineBy similarity1
Modified residuei1037PhosphoserineCombined sources1
Modified residuei1039PhosphoserineCombined sources1
Modified residuei1041PhosphoserineCombined sources1
Modified residuei1079PhosphoserineCombined sources1
Modified residuei1083PhosphoserineCombined sources1
Modified residuei1085PhosphoserineCombined sources1
Modified residuei1095PhosphoserineBy similarity1
Modified residuei1100PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q62018

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q62018

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q62018

PeptideAtlas

More...
PeptideAtlasi
Q62018

PRoteomics IDEntifications database

More...
PRIDEi
Q62018

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q62018

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q62018

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000005609, Expressed in urinary bladder and 300 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q62018, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the PAF1 complex, which consists of CDC73, PAF1, LEO1, CTR9, RTF1 and WDR61 (By similarity). The PAF1 complex interacts with PHF5A (PubMed:27749823).

Interacts with KMT2A/MLL1 (By similarity).

Interacts with STAT3 (PubMed:17911113).

Interacts with SETD5 (PubMed:27864380).

Interacts with ERCC6 (By similarity).

By similarity3 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
204339, 19 interactors

Protein interaction database and analysis system

More...
IntActi
Q62018, 7 interactors

Molecular INTeraction database

More...
MINTi
Q62018

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000005749

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q62018, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q62018

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati41 – 75TPR 1Add BLAST35
Repeati129 – 162TPR 2Add BLAST34
Repeati163 – 196TPR 3Add BLAST34
Repeati198 – 231TPR 4Add BLAST34
Repeati235 – 268TPR 5Add BLAST34
Repeati306 – 339TPR 6Add BLAST34
Repeati341 – 374TPR 7Add BLAST34
Repeati412 – 444TPR 8Add BLAST33
Repeati451 – 484TPR 9Add BLAST34
Repeati497 – 530TPR 10Add BLAST34
Repeati531 – 564TPR 11Add BLAST34
Repeati566 – 598TPR 12Add BLAST33
Repeati613 – 646TPR 13Add BLAST34
Repeati647 – 680TPR 14Add BLAST34
Repeati681 – 714TPR 15Add BLAST34
Repeati717 – 750TPR 16Add BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi904 – 908Poly-Gly5
Compositional biasi933 – 936Poly-Lys4
Compositional biasi944 – 951Poly-Glu8
Compositional biasi959 – 962Poly-Arg4
Compositional biasi971 – 976Poly-Glu6
Compositional biasi1015 – 1172Ser-richAdd BLAST158

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2002, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000005097

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006386_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q62018

KEGG Orthology (KO)

More...
KOi
K15176

Identification of Orthologs from Complete Genome Data

More...
OMAi
MLAAHYV

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q62018

TreeFam database of animal gene trees

More...
TreeFami
TF314342

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031101, Ctr9
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat

The PANTHER Classification System

More...
PANTHERi
PTHR14027, PTHR14027, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13181, TPR_8, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00028, TPR, 10 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452, SSF48452, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50005, TPR, 10 hits
PS50293, TPR_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q62018-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRGSIEIPL RDTDEVIELD FDQLPEGDEV ISILKQEHTQ LHIWIALALE
60 70 80 90 100
YYKQGKTEEF VKLLEAARID GNLDYRDHEK DQMTCLDTLA AYYVQQARKE
110 120 130 140 150
KNKDNKKDLI TQATLLYTMA DKIIMYDQNH LLGRACFCLL EGDKMDQADA
160 170 180 190 200
QFHFVLNQSP NNIPALLGKA CISFNKKDYR GALAYYKKAL RTNPGCPAEV
210 220 230 240 250
RLGMGHCFVK LNKLEKARLA FSRALELNSK CVGALVGLAV LELNNKEADS
260 270 280 290 300
IKNGVQLLSR AYTIDPSNPM VLNHLANHFF FKKDYSKVQH LALHAFHNTE
310 320 330 340 350
VEAMQAESCY QLARSFHVQE DYDQAFQYYY QATQFASSSF VLPFFGLGQM
360 370 380 390 400
YIYRGDKENA SQCFEKVLKA YPNNYETMKI LGSLYAASED QEKRDIAKGH
410 420 430 440 450
LKKVTEQYPD DVEAWIELAQ ILEQTDIQGA LSAYGTATRI LQEKVQADVP
460 470 480 490 500
PEILNNVGAL HFRLGNLGEA KKYFLASLDR AKAEAEHDEH YYNAISVTTS
510 520 530 540 550
YNLARLYEAM CEFHEAEKLY KNILREHPNY VDCYLRLGAM ARDKGNFYEA
560 570 580 590 600
SDWFKEALQI NQDHPDAWSL IGNLHLAKQE WGPGQKKFER ILKQPATQSD
610 620 630 640 650
TYSMLALGNV WLQTLHQPTR DREKEKRHQD RALAIYKQVL RNDAKNLYAA
660 670 680 690 700
NGIGAVLAHK GYFREARDVF AQVREATADI SDVWLNLAHI YVEQKQYISA
710 720 730 740 750
VQMYENCLRK FYKHQNTEVV LYLARALFKC GKLQECKQTL LKARHVAPSD
760 770 780 790 800
TVLMFNVALV LQRLATSVLK DEKSNLKEVL NAVKELELAH RYFSYLSKVG
810 820 830 840 850
DKMRFDLALA ASEARQCSDL LSQAQYHVAR ARKQDEEERE LRAKQEQEKE
860 870 880 890 900
LLRQKLLKEQ EEKRLREKEE QKKLLEQRAQ YVEKTKNILM FTGETEATKE
910 920 930 940 950
KKRGGGGGRR SKKGGEFDEF VNDDTDDDLP VSKKKKRRKG SGSEQEGEEE
960 970 980 990 1000
EGGERKKKRR RRPPKGEEGS EEEETENGPK PKKRRPPRAE KKKAPKPERL
1010 1020 1030 1040 1050
PPSMKGKIKS KAIISSSDDS SDEDKLKIAD EGHPRNSNSD SDDDERPNRR
1060 1070 1080 1090 1100
ASSESDSDDN QNKSGSEAGS PRRSGRQESD EDSDSDQPSR KRRRSGSEQS
1110 1120 1130 1140 1150
DNESVQSGRS PSGASENEND SRPASPSAES DHESEQGSDN EGSGQGSGNE
1160 1170
SEPEGSNNEA SDRGSEHGSD DSD
Length:1,173
Mass (Da):133,408
Last modified:April 4, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2FB84564F1BEFD79
GO
Isoform 2 (identifier: Q62018-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     704-721: YENCLRKFYKHQNTEVVL → VTSLLLRIVACNVEPWLP
     722-1173: Missing.

Show »
Length:721
Mass (Da):82,546
Checksum:i6D0600A36B09374F
GO
Isoform 3 (identifier: Q62018-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     816-860: Missing.
     995-1032: Missing.

Show »
Length:1,090
Mass (Da):123,864
Checksum:i022D322BACADB17B
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH53910 differs from that shown. Contaminating sequence. Potential poly-A sequence starting in position 937.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti144K → Q in AAC42083 (PubMed:8636124).Curated1
Sequence conflicti223R → S in AAH53910 (PubMed:15489334).Curated1
Sequence conflicti242E → Q in BAC32223 (PubMed:16141072).Curated1
Sequence conflicti390D → Y in AAH53910 (PubMed:15489334).Curated1
Sequence conflicti719V → I in BAE22373 (PubMed:16141072).Curated1
Sequence conflicti877Q → R in AAH80719 (PubMed:15489334).Curated1
Sequence conflicti900E → K in AAH80719 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_017846704 – 721YENCL…TEVVL → VTSLLLRIVACNVEPWLP in isoform 2. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_017847722 – 1173Missing in isoform 2. 1 PublicationAdd BLAST452
Alternative sequenceiVSP_017848816 – 860Missing in isoform 3. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_017849995 – 1032Missing in isoform 3. 1 PublicationAdd BLAST38

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L49502 mRNA Translation: AAC42083.1
AK040205 mRNA Translation: BAC30540.1
AK040331 mRNA Translation: BAC30566.1
AK045101 mRNA Translation: BAC32223.1
AK083921 mRNA Translation: BAC39065.2
AK134990 mRNA Translation: BAE22373.1
AK148536 mRNA Translation: BAE28606.1
BC053910 mRNA Translation: AAH53910.1 Sequence problems.
BC080719 mRNA Translation: AAH80719.1
AB093211 Transcribed RNA Translation: BAC41395.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS21750.1 [Q62018-1]

Protein sequence database of the Protein Information Resource

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PIRi
T42719

NCBI Reference Sequences

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RefSeqi
NP_033457.2, NM_009431.2 [Q62018-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000005749; ENSMUSP00000005749; ENSMUSG00000005609 [Q62018-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
22083

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:22083

UCSC genome browser

More...
UCSCi
uc009jfw.1, mouse [Q62018-2]
uc009jfx.1, mouse [Q62018-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L49502 mRNA Translation: AAC42083.1
AK040205 mRNA Translation: BAC30540.1
AK040331 mRNA Translation: BAC30566.1
AK045101 mRNA Translation: BAC32223.1
AK083921 mRNA Translation: BAC39065.2
AK134990 mRNA Translation: BAE22373.1
AK148536 mRNA Translation: BAE28606.1
BC053910 mRNA Translation: AAH53910.1 Sequence problems.
BC080719 mRNA Translation: AAH80719.1
AB093211 Transcribed RNA Translation: BAC41395.1
CCDSiCCDS21750.1 [Q62018-1]
PIRiT42719
RefSeqiNP_033457.2, NM_009431.2 [Q62018-1]

3D structure databases

SMRiQ62018
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi204339, 19 interactors
IntActiQ62018, 7 interactors
MINTiQ62018
STRINGi10090.ENSMUSP00000005749

PTM databases

iPTMnetiQ62018
PhosphoSitePlusiQ62018

Proteomic databases

EPDiQ62018
jPOSTiQ62018
PaxDbiQ62018
PeptideAtlasiQ62018
PRIDEiQ62018

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
24416, 165 antibodies

Genome annotation databases

EnsembliENSMUST00000005749; ENSMUSP00000005749; ENSMUSG00000005609 [Q62018-1]
GeneIDi22083
KEGGimmu:22083
UCSCiuc009jfw.1, mouse [Q62018-2]
uc009jfx.1, mouse [Q62018-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9646
MGIiMGI:109345, Ctr9

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiKOG2002, Eukaryota
GeneTreeiENSGT00390000005097
HOGENOMiCLU_006386_0_0_1
InParanoidiQ62018
KOiK15176
OMAiMLAAHYV
PhylomeDBiQ62018
TreeFamiTF314342

Enzyme and pathway databases

ReactomeiR-MMU-112382, Formation of RNA Pol II elongation complex
R-MMU-674695, RNA Polymerase II Pre-transcription Events
R-MMU-75955, RNA Polymerase II Transcription Elongation
R-MMU-8866654, E3 ubiquitin ligases ubiquitinate target proteins

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
22083, 7 hits in 20 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Ctr9, mouse

Protein Ontology

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PROi
PR:Q62018
RNActiQ62018, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000005609, Expressed in urinary bladder and 300 other tissues
GenevisibleiQ62018, MM

Family and domain databases

Gene3Di1.25.40.10, 3 hits
InterProiView protein in InterPro
IPR031101, Ctr9
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat
PANTHERiPTHR14027, PTHR14027, 1 hit
PfamiView protein in Pfam
PF13181, TPR_8, 3 hits
SMARTiView protein in SMART
SM00028, TPR, 10 hits
SUPFAMiSSF48452, SSF48452, 3 hits
PROSITEiView protein in PROSITE
PS50005, TPR, 10 hits
PS50293, TPR_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCTR9_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q62018
Secondary accession number(s): Q3UFF5
, Q3UY40, Q66JX4, Q7TPS6, Q8BND9, Q8BRD1, Q8C9W7, Q8C9Y3, Q8CHI1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: October 7, 2020
This is version 167 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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