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Protein

Oviduct-specific glycoprotein

Gene

Ovgp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development.

GO - Molecular functioni

  • chitinase activity Source: GO_Central
  • chitin binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processFertilization

Enzyme and pathway databases

ReactomeiR-MMU-1300644 Interaction With The Zona Pellucida

Protein family/group databases

CAZyiGH18 Glycoside Hydrolase Family 18

Names & Taxonomyi

Protein namesi
Recommended name:
Oviduct-specific glycoprotein
Alternative name(s):
Estrogen-dependent oviduct protein
Oviductal glycoprotein
Oviductin
Gene namesi
Name:Ovgp1
Synonyms:Chit5, Ogp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:106661 Ovgp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001197522 – 721Oviduct-specific glycoproteinAdd BLAST700

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi402N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi442N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi469N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ62010
PaxDbiQ62010
PRIDEiQ62010

PTM databases

iPTMnetiQ62010
PhosphoSitePlusiQ62010

Expressioni

Tissue specificityi

Epithelial cells of the oviduct.

Gene expression databases

BgeeiENSMUSG00000074340 Expressed in 237 organ(s), highest expression level in female gonad
CleanExiMM_OVGP1
ExpressionAtlasiQ62010 baseline and differential
GenevisibleiQ62010 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000573

Structurei

3D structure databases

ProteinModelPortaliQ62010
SMRiQ62010
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati486 – 49217
Repeati493 – 49927
Repeati500 – 50637
Repeati507 – 51347
Repeati514 – 52057
Repeati521 – 52767
Repeati528 – 53477
Repeati535 – 54187
Repeati542 – 54897
Repeati549 – 555107
Repeati556 – 562117
Repeati563 – 569127
Repeati570 – 576137
Repeati577 – 583147
Repeati584 – 590157
Repeati591 – 597167
Repeati598 – 604177
Repeati605 – 611187
Repeati612 – 618197
Repeati619 – 625207
Repeati626 – 632217

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni486 – 63221 X 7 AA tandem repeats of S-K-[TAI]-[TI]-[TAP]-[GED]-[IVM]Add BLAST147

Sequence similaritiesi

Belongs to the glycosyl hydrolase 18 family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG2806 Eukaryota
COG3325 LUCA
GeneTreeiENSGT00550000074323
HOGENOMiHOG000111109
HOVERGENiHBG011684
InParanoidiQ62010
KOiK17526
OrthoDBiEOG091G014W
PhylomeDBiQ62010
TreeFamiTF315610

Family and domain databases

Gene3Di3.10.50.10, 1 hit
InterProiView protein in InterPro
IPR011583 Chitinase_II
IPR029070 Chitinase_insertion_sf
IPR001223 Glyco_hydro18_cat
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF00704 Glyco_hydro_18, 1 hit
SMARTiView protein in SMART
SM00636 Glyco_18, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit
SSF54556 SSF54556, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q62010-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRLLLLAGL VLLMKHSDGT AYKLVCYFTN WAHSRPGPAS IMPHDLDPFL
60 70 80 90 100
CTHLIFAFAS MSNNQIVAKN LQDENVLYPE FNKLKERNRE LKTLLSIGGW
110 120 130 140 150
NFGTSRFTAM LSTLANREKF IDSVISFLRI HGFDGLDLFF LYPGLRGSPP
160 170 180 190 200
HDRWNFLFLI EELQFAFERE ALLTQHPRLL LSAAVSGIPS IIHTSYDALL
210 220 230 240 250
LGRRLDFINV LSYDLHGSWE KFTGHNSPLF SLPEDSKSSA YAMNYWRKLG
260 270 280 290 300
TPADKLIMGF PTYGRNFYLL KESKNGLQTA SMGPASPGKY TKQAGFLAYY
310 320 330 340 350
EVCSFVQRAK KHWIDYQYVP YAFKGKEWLG YDDTISFSYK AMYVKREHFG
360 370 380 390 400
GAMVWTLDMD DVRGTFCGNG PFPLVHILNE LLVQTESNST PLPQFWFTSS
410 420 430 440 450
VNASGPGSEN TALTEVLTTD TIKILPPGGE AMTTEVHRRY ENMTTVPSDG
460 470 480 490 500
SVTPGGTASP RKHAVTPENN TMAAEAKTMS TLDFFSKTTT GVSKTTTGIS
510 520 530 540 550
KTTTGVSKTT TGVSKATAGI SKTIPEISKA TAGVSKTTTG VSKTTTGISK
560 570 580 590 600
TITGVSKTTT GISKTTTGIS KTTTGVSKIT TGVSKTTTGI SKTTTGISQT
610 620 630 640 650
TTGISKTTTD ISKTTTGISK TTPGISKTTP GMTVIVQTQA NEAETTATMD
660 670 680 690 700
HQSVTPTEMD TTLFYLKTMT PSEKETSRKK TMVLEKATVS PREMSATPNG
710 720
QSKTLKWASL ITEVETYSQD G
Length:721
Mass (Da):78,808
Last modified:November 1, 1997 - v1
Checksum:i37246C8F01665652
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q099E9Q099_MOUSE
Oviduct-specific glycoprotein
Ovgp1
232Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D32137 mRNA Translation: BAA06863.1
CCDSiCCDS17716.1
RefSeqiNP_031722.1, NM_007696.2
UniGeneiMm.431947

Genome annotation databases

EnsembliENSMUST00000000573; ENSMUSP00000000573; ENSMUSG00000074340
GeneIDi12659
KEGGimmu:12659
UCSCiuc008qvq.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D32137 mRNA Translation: BAA06863.1
CCDSiCCDS17716.1
RefSeqiNP_031722.1, NM_007696.2
UniGeneiMm.431947

3D structure databases

ProteinModelPortaliQ62010
SMRiQ62010
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000573

Protein family/group databases

CAZyiGH18 Glycoside Hydrolase Family 18

PTM databases

iPTMnetiQ62010
PhosphoSitePlusiQ62010

Proteomic databases

MaxQBiQ62010
PaxDbiQ62010
PRIDEiQ62010

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000573; ENSMUSP00000000573; ENSMUSG00000074340
GeneIDi12659
KEGGimmu:12659
UCSCiuc008qvq.1 mouse

Organism-specific databases

CTDi5016
MGIiMGI:106661 Ovgp1

Phylogenomic databases

eggNOGiKOG2806 Eukaryota
COG3325 LUCA
GeneTreeiENSGT00550000074323
HOGENOMiHOG000111109
HOVERGENiHBG011684
InParanoidiQ62010
KOiK17526
OrthoDBiEOG091G014W
PhylomeDBiQ62010
TreeFamiTF315610

Enzyme and pathway databases

ReactomeiR-MMU-1300644 Interaction With The Zona Pellucida

Miscellaneous databases

PROiPR:Q62010
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000074340 Expressed in 237 organ(s), highest expression level in female gonad
CleanExiMM_OVGP1
ExpressionAtlasiQ62010 baseline and differential
GenevisibleiQ62010 MM

Family and domain databases

Gene3Di3.10.50.10, 1 hit
InterProiView protein in InterPro
IPR011583 Chitinase_II
IPR029070 Chitinase_insertion_sf
IPR001223 Glyco_hydro18_cat
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF00704 Glyco_hydro_18, 1 hit
SMARTiView protein in SMART
SM00636 Glyco_18, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit
SSF54556 SSF54556, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOVGP1_MOUSE
AccessioniPrimary (citable) accession number: Q62010
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 7, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
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Main funding by: National Institutes of Health

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