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UniProtKB - Q62000 (MIME_MOUSE)
Protein
Mimecan
Gene
Ogn
Organism
Mus musculus (Mouse)
Status
Functioni
Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.
By similarityGO - Molecular functioni
- growth factor activity Source: UniProtKB-KW
GO - Biological processi
Keywordsi
Molecular function | Growth factor |
Enzyme and pathway databases
Reactomei | R-MMU-2022854, Keratan sulfate biosynthesis R-MMU-2022857, Keratan sulfate degradation |
Names & Taxonomyi
Protein namesi | Recommended name: MimecanAlternative name(s): Osteoglycin |
Gene namesi | Name:Ogn Synonyms:Og |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:109278, Ogn |
VEuPathDBi | HostDB:ENSMUSG00000021390 |
Subcellular locationi
Extracellular region or secreted
- extracellular matrix By similarity
Extracellular region or secreted
- extracellular space Source: BHF-UCL
Other locations
- collagen-containing extracellular matrix Source: BHF-UCL
Keywords - Cellular componenti
Extracellular matrix, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000032761 | 20 – 298 | MimecanAdd BLAST | 279 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 255 ↔ 288 | By similarity | ||
Glycosylationi | 258 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
CPTACi | non-CPTAC-4048 |
MaxQBi | Q62000 |
PaxDbi | Q62000 |
PeptideAtlasi | Q62000 |
PRIDEi | Q62000 |
ProteomicsDBi | 295606 |
PTM databases
GlyGeni | Q62000, 1 site |
iPTMneti | Q62000 |
PhosphoSitePlusi | Q62000 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000021390, Expressed in sciatic nerve and 279 other tissues |
Genevisiblei | Q62000, MM |
Interactioni
GO - Molecular functioni
- growth factor activity Source: UniProtKB-KW
Protein-protein interaction databases
IntActi | Q62000, 15 interactors |
STRINGi | 10090.ENSMUSP00000021822 |
Miscellaneous databases
RNActi | Q62000, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 112 – 131 | LRR 1Add BLAST | 20 | |
Repeati | 132 – 155 | LRR 2Add BLAST | 24 | |
Repeati | 156 – 179 | LRR 3Add BLAST | 24 | |
Repeati | 180 – 199 | LRR 4Add BLAST | 20 | |
Repeati | 200 – 225 | LRR 5Add BLAST | 26 | |
Repeati | 226 – 246 | LRR 6Add BLAST | 21 | |
Repeati | 247 – 277 | LRR 7Add BLAST | 31 |
Sequence similaritiesi
Keywords - Domaini
Leucine-rich repeat, Repeat, SignalPhylogenomic databases
eggNOGi | KOG0619, Eukaryota |
GeneTreei | ENSGT00940000157238 |
HOGENOMi | CLU_067583_1_0_1 |
InParanoidi | Q62000 |
OMAi | RILHLQY |
OrthoDBi | 927103at2759 |
PhylomeDBi | Q62000 |
TreeFami | TF351924 |
Family and domain databases
Gene3Di | 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR027211, Mimecan IPR043547, Mimecan/Epiphycan |
PANTHERi | PTHR46269, PTHR46269, 1 hit PTHR46269:SF1, PTHR46269:SF1, 1 hit |
Pfami | View protein in Pfam PF13855, LRR_8, 1 hit |
SMARTi | View protein in SMART SM00369, LRR_TYP, 4 hits |
PROSITEi | View protein in PROSITE PS51450, LRR, 4 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q62000-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
METVHSTFLL LLFVPLTQQA PQSQLDSHVN YEYATGNSEE TKFSQDYEDK
60 70 80 90 100
YLDGKSIKEK ETMIIPDEKS LQLQKDEVIP SLPTKKENDE MPTCLLCVCL
110 120 130 140 150
SGSVYCEEVD IDAVPPLPKE SAYLYARFNK IKKLTAKDFA DMPNLRRLDF
160 170 180 190 200
TGNLIEDIED GTFSKLSLLE ELTLAENQLL RLPVLPPKLT LLNAKHNKIK
210 220 230 240 250
SKGIKANTFK KLNKLSFLYL DHNDLESVPP NLPESLRVIH LQFNSISSLT
260 270 280 290
DDTFCKANDT RYIRERIEEI RLEGNPIALG KHPNSFICLK RLPIGSYF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D31951 mRNA Translation: BAA06721.1 BC021939 mRNA Translation: AAH21939.1 |
CCDSi | CCDS26505.1 |
PIRi | JC4130 |
RefSeqi | NP_032786.1, NM_008760.4 |
Genome annotation databases
Ensembli | ENSMUST00000021822; ENSMUSP00000021822; ENSMUSG00000021390 |
GeneIDi | 18295 |
KEGGi | mmu:18295 |
UCSCi | uc007qjr.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D31951 mRNA Translation: BAA06721.1 BC021939 mRNA Translation: AAH21939.1 |
CCDSi | CCDS26505.1 |
PIRi | JC4130 |
RefSeqi | NP_032786.1, NM_008760.4 |
3D structure databases
AlphaFoldDBi | Q62000 |
SMRi | Q62000 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q62000, 15 interactors |
STRINGi | 10090.ENSMUSP00000021822 |
PTM databases
GlyGeni | Q62000, 1 site |
iPTMneti | Q62000 |
PhosphoSitePlusi | Q62000 |
Proteomic databases
CPTACi | non-CPTAC-4048 |
MaxQBi | Q62000 |
PaxDbi | Q62000 |
PeptideAtlasi | Q62000 |
PRIDEi | Q62000 |
ProteomicsDBi | 295606 |
Protocols and materials databases
Antibodypediai | 2122, 306 antibodies from 34 providers |
DNASUi | 18295 |
Genome annotation databases
Ensembli | ENSMUST00000021822; ENSMUSP00000021822; ENSMUSG00000021390 |
GeneIDi | 18295 |
KEGGi | mmu:18295 |
UCSCi | uc007qjr.1, mouse |
Organism-specific databases
CTDi | 4969 |
MGIi | MGI:109278, Ogn |
VEuPathDBi | HostDB:ENSMUSG00000021390 |
Phylogenomic databases
eggNOGi | KOG0619, Eukaryota |
GeneTreei | ENSGT00940000157238 |
HOGENOMi | CLU_067583_1_0_1 |
InParanoidi | Q62000 |
OMAi | RILHLQY |
OrthoDBi | 927103at2759 |
PhylomeDBi | Q62000 |
TreeFami | TF351924 |
Enzyme and pathway databases
Reactomei | R-MMU-2022854, Keratan sulfate biosynthesis R-MMU-2022857, Keratan sulfate degradation |
Miscellaneous databases
BioGRID-ORCSi | 18295, 1 hit in 72 CRISPR screens |
ChiTaRSi | Ogn, mouse |
PROi | PR:Q62000 |
RNActi | Q62000, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000021390, Expressed in sciatic nerve and 279 other tissues |
Genevisiblei | Q62000, MM |
Family and domain databases
Gene3Di | 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR027211, Mimecan IPR043547, Mimecan/Epiphycan |
PANTHERi | PTHR46269, PTHR46269, 1 hit PTHR46269:SF1, PTHR46269:SF1, 1 hit |
Pfami | View protein in Pfam PF13855, LRR_8, 1 hit |
SMARTi | View protein in SMART SM00369, LRR_TYP, 4 hits |
PROSITEi | View protein in PROSITE PS51450, LRR, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | MIME_MOUSE | |
Accessioni | Q62000Primary (citable) accession number: Q62000 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 8, 2002 |
Last sequence update: | November 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 172 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families