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Protein

Beta-hexosaminidase A

Gene

hex-1

Organism
Caenorhabditis briggsae
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines. Degrades chitotriose (By similarity).By similarity

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei322Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-hexosaminidase A (EC:3.2.1.52)
Alternative name(s):
Beta-N-acetylhexosaminidase
N-acetyl-beta-glucosaminidase
Gene namesi
Name:hex-1By similarity
ORF Names:CBG14058
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000008549 Componentsi: Chromosome X, Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG14058 ; CBP29009 ; WBGene00034691 ; Cbr-hex-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_000031266416 – 552Beta-hexosaminidase AAdd BLAST537

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi44N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi348N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi409N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi457N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi6238.CBG14058

Structurei

3D structure databases

SMRiQ619W7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 20 family.Sequence analysis

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2499 Eukaryota
COG3525 LUCA
HOGENOMiHOG000157972
InParanoidiQ619W7
OMAiFAPWAHA
OrthoDBiEOG091G04NA

Family and domain databases

Gene3Di3.30.379.10, 1 hit
InterProiView protein in InterPro
IPR025705 Beta_hexosaminidase_sua/sub
IPR015883 Glyco_hydro_20_cat
IPR017853 Glycoside_hydrolase_SF
IPR029018 Hex-like_dom2
IPR029019 HEX_eukaryotic_N
PfamiView protein in Pfam
PF00728 Glyco_hydro_20, 1 hit
PF14845 Glycohydro_20b2, 1 hit
PIRSFiPIRSF001093 B-hxosamndse_ab_euk_, 1 hit
PRINTSiPR00738 GLHYDRLASE20
SUPFAMiSSF51445 SSF51445, 1 hit
SSF55545 SSF55545, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q619W7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLIVLSLLF TSTLAWFYGR DEPDRWSVGG VWPLPQKIIY GSKNRTLTYD
60 70 80 90 100
KIGIDLGDKK DCDVLLAMAD NYMNKWLFPY PVEMKTGGTE DFIITVTVKE
110 120 130 140 150
ECPGGPPVHG ASEEYLLRVS VSEAVINAQT VWGALRAMET LSHLVFYDQK
160 170 180 190 200
SQEYQIRTAE IFDKPRFPVR GIMIDSSRHF LSLNVIKRQL EIMSMNKLNV
210 220 230 240 250
LHWHLVDSES FPYTSQKFPE LHGVGAYSPR HVYSREDISE VIAFARLRGI
260 270 280 290 300
RVIPEFDLPG HTSSWKGRKG FLTECFDEKG EETFLPNLVD PMNDANFDFL
310 320 330 340 350
AEFLEEVTET FPDQFLHLGG DEVSDYIVEC WVRNKKIRKF MDEKGFGNNT
360 370 380 390 400
VLLENYFFEK LFSIVEKLKL KRKPIFWQEV FDNNIPDPNS IIHIWKGNTH
410 420 430 440 450
EEIYEQVKNI TSKNFPVIVS ACWYLNYIKY GADWRDEIRG TAPSNSRYYY
460 470 480 490 500
CDPTSFNGTD TQKNLVLGGI AAIWGELVDN TNIEARLWPR ASAAAERLWS
510 520 530 540 550
PAEKTQKAEN AWPRMHELRC RLVSRGYRIQ PNNNPDYCPF EFDEPPATKS

EL
Length:552
Mass (Da):63,880
Last modified:September 22, 2009 - v2
Checksum:iF51F5E37E49720A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE600983 Genomic DNA Translation: CAP32722.2

Genome annotation databases

EnsemblMetazoaiCBG14058; CBG14058; WBGene00034691

Similar proteinsi

Entry informationi

Entry nameiHEXA_CAEBR
AccessioniPrimary (citable) accession number: Q619W7
Secondary accession number(s): A8XJ97
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: September 22, 2009
Last modified: March 28, 2018
This is version 78 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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