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Protein

Poly(rC)-binding protein 2

Gene

Pcbp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by MAVS signaling. It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitinationa and degradation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Ribonucleoprotein, RNA-binding
Biological processAntiviral defense, Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Poly(rC)-binding protein 2
Alternative name(s):
Alpha-CP2
CTBP
Short name:
CBP
Putative heterogeneous nuclear ribonucleoprotein X
Short name:
hnRNP X
Gene namesi
Name:Pcbp2
Synonyms:Cbp, Hnrnpx, Hnrpx
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:108202 Pcbp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000500911 – 362Poly(rC)-binding protein 2Add BLAST362

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki115Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei169PhosphoserineBy similarity1
Cross-linki181Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei185PhosphoserineBy similarity1
Modified residuei268PhosphoserineBy similarity1
Cross-linki319Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei361PhosphoserineBy similarity1
Modified residuei362PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ61990
PaxDbiQ61990
PeptideAtlasiQ61990
PRIDEiQ61990

2D gel databases

REPRODUCTION-2DPAGEiQ61990

PTM databases

iPTMnetiQ61990
PhosphoSitePlusiQ61990
SwissPalmiQ61990

Expressioni

Gene expression databases

BgeeiENSMUSG00000056851 Expressed in 304 organ(s), highest expression level in retina
CleanExiMM_PCBP2
ExpressionAtlasiQ61990 baseline and differential
GenevisibleiQ61990 MM

Interactioni

Subunit structurei

Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Interacts with IFIH1 and RNF135 (By similarity). Interacts with MAVS (via C-terminus) and ITCH (via WW domains) (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202043, 15 interactors
IntActiQ61990, 19 interactors
MINTiQ61990
STRINGi10090.ENSMUSP00000076294

Structurei

3D structure databases

ProteinModelPortaliQ61990
SMRiQ61990
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 75KH 1PROSITE-ProRule annotationAdd BLAST63
Domaini97 – 162KH 2PROSITE-ProRule annotationAdd BLAST66
Domaini284 – 348KH 3PROSITE-ProRule annotationAdd BLAST65

Domaini

The KH domains mediates poly(C) binding.By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2190 Eukaryota
ENOG410XNN8 LUCA
GeneTreeiENSGT00760000119144
HOGENOMiHOG000182823
HOVERGENiHBG053520
InParanoidiQ61990
KOiK13162
OMAiSIAKEPH
OrthoDBiEOG091G0DHI
PhylomeDBiQ61990
TreeFamiTF318292

Family and domain databases

Gene3Di3.30.1370.10, 3 hits
InterProiView protein in InterPro
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
PfamiView protein in Pfam
PF00013 KH_1, 3 hits
SMARTiView protein in SMART
SM00322 KH, 3 hits
SUPFAMiSSF54791 SSF54791, 3 hits
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 3 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 21 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q61990-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDTGVIEGGL NVTLTIRLLM HGKEVGSIIG KKGESVKKMR EESGARINIS
60 70 80 90 100
EGNCPERIIT LAGPTNAIFK AFAMIIDKLE EDISSSMTNS TAASRPPVTL
110 120 130 140 150
RLVVPASQCG SLIGKGGCKI KEIRESTGAQ VQVAGDMLPN STERAITIAG
160 170 180 190 200
IPQSIIECVK QICVVMLESP PKGVTIPYRP KPSSSPVIFA GGQDRYSTGS
210 220 230 240 250
DSASFPHTTP SMCLNPDLEG PPLEAYTIQG QYAIPQPDLT KLHQLAMQQS
260 270 280 290 300
HFPMTHGNTG FSGIESSSPE VKGYWAGLDA SAQTTSHELT IPNDLIGCII
310 320 330 340 350
GRQGAKINEI RQMSGAQIKI ANPVEGSTDR QVTITGSAAS ISLAQYLINV
360
RLSSETGGMG SS
Length:362
Mass (Da):38,222
Last modified:November 1, 1996 - v1
Checksum:i70C8AF710E3BF3C0
GO
Isoform 2 (identifier: Q61990-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     194-224: Missing.

Show »
Length:331
Mass (Da):34,917
Checksum:iE831D4BF718C26E3
GO
Isoform 3 (identifier: Q61990-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     263-275: Missing.

Show »
Length:349
Mass (Da):36,801
Checksum:iE0699D574B0B7DDA
GO

Computationally mapped potential isoform sequencesi

There are 21 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3TT81Q3TT81_MOUSE
Poly(rC)-binding protein 2
Pcbp2
322Annotation score:
B2M1R7B2M1R7_MOUSE
Poly(rC)-binding protein 2
Pcbp2
361Annotation score:
A0A2R8VHP9A0A2R8VHP9_MOUSE
Poly(rC)-binding protein 2
Pcbp2
335Annotation score:
A0A2R8VI25A0A2R8VI25_MOUSE
Poly(RC) binding protein 2, isoform...
Pcbp2 mCG_17573
316Annotation score:
A0A2R8VI71A0A2R8VI71_MOUSE
Poly(rC)-binding protein 2
Pcbp2
241Annotation score:
A0A2R8VJY1A0A2R8VJY1_MOUSE
Poly(rC)-binding protein 2
Pcbp2
205Annotation score:
A0A2R8VHI3A0A2R8VHI3_MOUSE
Poly(rC)-binding protein 2
Pcbp2
96Annotation score:
A0A2R8VHY9A0A2R8VHY9_MOUSE
Poly(rC)-binding protein 2
Pcbp2
249Annotation score:
A0A2R8W6L5A0A2R8W6L5_MOUSE
Poly(rC)-binding protein 2
Pcbp2
224Annotation score:
A0A2R8VI73A0A2R8VI73_MOUSE
Poly(rC)-binding protein 2
Pcbp2
264Annotation score:
There are more potential isoformsShow all

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002820194 – 224Missing in isoform 2. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_002821263 – 275Missing in isoform 3. CuratedAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19661 mRNA Translation: AAA03705.1
X75947 mRNA Translation: CAA53546.1
X97982 mRNA Translation: CAA66619.1
AF236845
, AF236842, AF236843, AF236844 Genomic DNA Translation: AAK14059.1
CCDSiCCDS27884.1 [Q61990-3]
CCDS49741.1 [Q61990-1]
CCDS49742.1 [Q61990-2]
PIRiS78515
RefSeqiNP_001096635.1, NM_001103165.1 [Q61990-1]
NP_001096636.1, NM_001103166.1 [Q61990-2]
NP_035172.2, NM_011042.2 [Q61990-3]
UniGeneiMm.236513

Genome annotation databases

EnsembliENSMUST00000077037; ENSMUSP00000076294; ENSMUSG00000056851 [Q61990-1]
ENSMUST00000078404; ENSMUSP00000077509; ENSMUSG00000056851 [Q61990-1]
ENSMUST00000229618; ENSMUSP00000155430; ENSMUSG00000056851 [Q61990-2]
ENSMUST00000229854; ENSMUSP00000155038; ENSMUSG00000056851 [Q61990-3]
GeneIDi18521
KEGGimmu:18521
UCSCiuc007xvy.2 mouse [Q61990-1]
uc007xvz.2 mouse [Q61990-2]
uc009vat.1 mouse [Q61990-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19661 mRNA Translation: AAA03705.1
X75947 mRNA Translation: CAA53546.1
X97982 mRNA Translation: CAA66619.1
AF236845
, AF236842, AF236843, AF236844 Genomic DNA Translation: AAK14059.1
CCDSiCCDS27884.1 [Q61990-3]
CCDS49741.1 [Q61990-1]
CCDS49742.1 [Q61990-2]
PIRiS78515
RefSeqiNP_001096635.1, NM_001103165.1 [Q61990-1]
NP_001096636.1, NM_001103166.1 [Q61990-2]
NP_035172.2, NM_011042.2 [Q61990-3]
UniGeneiMm.236513

3D structure databases

ProteinModelPortaliQ61990
SMRiQ61990
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202043, 15 interactors
IntActiQ61990, 19 interactors
MINTiQ61990
STRINGi10090.ENSMUSP00000076294

PTM databases

iPTMnetiQ61990
PhosphoSitePlusiQ61990
SwissPalmiQ61990

2D gel databases

REPRODUCTION-2DPAGEiQ61990

Proteomic databases

EPDiQ61990
PaxDbiQ61990
PeptideAtlasiQ61990
PRIDEiQ61990

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000077037; ENSMUSP00000076294; ENSMUSG00000056851 [Q61990-1]
ENSMUST00000078404; ENSMUSP00000077509; ENSMUSG00000056851 [Q61990-1]
ENSMUST00000229618; ENSMUSP00000155430; ENSMUSG00000056851 [Q61990-2]
ENSMUST00000229854; ENSMUSP00000155038; ENSMUSG00000056851 [Q61990-3]
GeneIDi18521
KEGGimmu:18521
UCSCiuc007xvy.2 mouse [Q61990-1]
uc007xvz.2 mouse [Q61990-2]
uc009vat.1 mouse [Q61990-3]

Organism-specific databases

CTDi5094
MGIiMGI:108202 Pcbp2

Phylogenomic databases

eggNOGiKOG2190 Eukaryota
ENOG410XNN8 LUCA
GeneTreeiENSGT00760000119144
HOGENOMiHOG000182823
HOVERGENiHBG053520
InParanoidiQ61990
KOiK13162
OMAiSIAKEPH
OrthoDBiEOG091G0DHI
PhylomeDBiQ61990
TreeFamiTF318292

Miscellaneous databases

ChiTaRSiPcbp2 mouse
PROiPR:Q61990
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000056851 Expressed in 304 organ(s), highest expression level in retina
CleanExiMM_PCBP2
ExpressionAtlasiQ61990 baseline and differential
GenevisibleiQ61990 MM

Family and domain databases

Gene3Di3.30.1370.10, 3 hits
InterProiView protein in InterPro
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
PfamiView protein in Pfam
PF00013 KH_1, 3 hits
SMARTiView protein in SMART
SM00322 KH, 3 hits
SUPFAMiSSF54791 SSF54791, 3 hits
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPCBP2_MOUSE
AccessioniPrimary (citable) accession number: Q61990
Secondary accession number(s): Q61383, Q62042
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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