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Protein

Endoplasmic reticulum membrane sensor NFE2L1

Gene

Nfe2l1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Endoplasmic reticulum membrane sensor NFE2L1: Endoplasmic reticulum membrane sensor that translocates into the nucleus in response to various stresses to act as a transcription factor (PubMed:20385086, PubMed:21536885, PubMed:23816881, PubMed:29149604). Constitutes a precursor of the transcription factor NRF1. Able to detect various cellular stresses, such as cholesterol excess, oxidative stress or proteasome inhibition (PubMed:20385086, PubMed:21536885, PubMed:23816881, PubMed:29149604). In response to stress, it is released from the endoplasmic reticulum membrane following cleavage by the protease DDI2 and translocates into the nucleus to form the transcription factor NRF1 (PubMed:29149604). Acts as a key sensor of cholesterol excess: in excess cholesterol conditions, the endoplasmic reticulum membrane form of the protein directly binds cholesterol via its CRAC motif, preventing cleavage and release of the transcription factor NRF1, thereby allowing expression of genes promoting cholesterol removal, such as CD36 (PubMed:29149604). Involved in proteasome homeostasis: in response to proteasome inhibition, it is released from the endoplasmic reticulum membrane, translocates to the nucleus and activates expression of genes encoding proteasome subunits (PubMed:20385086, PubMed:21536885, PubMed:23816881).4 Publications
Transcription factor NRF1: CNC-type bZIP family transcription factor that translocates to the nucleus and regulates expression of target genes in response to various stresses (PubMed:10601325, PubMed:11342101, PubMed:23144760, PubMed:16872277, PubMed:21911472, PubMed:23816881, PubMed:29149604). Heterodimerizes with small-Maf proteins (MAFF, MAFG or MAFK) and binds DNA motifs including the antioxidant response elements (AREs), which regulate expression of genes involved in oxidative stress response (PubMed:12808106, PubMed:15738389, PubMed:23144760, PubMed:16872277, PubMed:21911472, PubMed:23816881). Activates or represses expression of target genes, depending on the context (PubMed:12808106, PubMed:15738389, PubMed:23144760, PubMed:16872277, PubMed:21911472, PubMed:23816881). Plays a key role in cholesterol homeostasis by acting as a sensor of cholesterol excess: in low cholesterol conditions, translocates into the nucleus and represses expression of genes involved in defense against cholesterol excess, such as CD36 (PubMed:29149604). In excess cholesterol conditions, the endoplasmic reticulum membrane form of the protein directly binds cholesterol via its CRAC motif, preventing cleavage and release of the transcription factor NRF1, thereby allowing expression of genes promoting cholesterol removal (PubMed:29149604). Critical for redox balance in response to oxidative stress: acts by binding the AREs motifs on promoters and mediating activation of oxidative stress response genes, such as GCLC, GCLM, GSS, MT1 and MT2 (PubMed:10601325, PubMed:11342101, PubMed:12968018, PubMed:15738389, PubMed:18826952). Plays an essential role during fetal liver hematopoiesis: probably has a protective function against oxidative stress and is involved in lipid homeostasis in the liver (PubMed:9501099, PubMed:12808106, PubMed:15738389, PubMed:18826952, PubMed:22586274). Involved in proteasome homeostasis: in response to proteasome inhibition, mediates the 'bounce-back' of proteasome subunits by translocating into the nucleus and activating expression of genes encoding proteasome subunits (PubMed:20385086, PubMed:21536885, PubMed:23816881). Also involved in regulating glucose flux (PubMed:25041126). Together with CEBPB; represses expression of DSPP during odontoblast differentiation (By similarity). In response to ascorbic acid induction, activates expression of SP7/Osterix in osteoblasts (PubMed:17510056).By similarity17 Publications
Isoform 2: Transcription factor that binds the antioxidant response elements (ARE) consensus sequence on promoters and activates their expression.2 Publications
Isoform 3: Transcription factor that binds the extended kappa 3 site of the TNF-alpha promoter after Fc gamma RIII stimulation and participates in the induction of this cytokine (PubMed:9580677).1 Publication

Caution

Endoplasmic reticulum membrane sensor NFE2L1: its topology is subject to discussion. According to some groups, it has a single-pass type II membrane protein in normal conditions and is retrotranslocated into a single-pass type III membrane protein in response to stress. According to other reports, it is integrated into the endoplasmic reticulum membrane via multiple membrane-spanning alpha-helices (PubMed:20629635, PubMed:26268886).2 Publications
Endoplasmic reticulum membrane sensor NFE2L1: Was initially thought to be either inactive as transcription factor or to repress transcriptional activation mediated by other isoforms (PubMed:9580677). The presence of the transmembrane region at the N-terminus may explain the inability to observe transcription factor activity.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processCholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism, Transcription, Transcription regulation
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Endoplasmic reticulum membrane sensor NFE2L1Curated
Alternative name(s):
Locus control region-factor 11 Publication
Short name:
LCR-F11 Publication
Nuclear factor erythroid 2-related factor 1Curated
Short name:
NF-E2-related factor 11 Publication
Short name:
NFE2-related factor 11 Publication
Nuclear factor, erythroid derived 2, like 1
Cleaved into the following chain:
Gene namesi
Name:Nfe2l11 PublicationImported
Synonyms:Nrf11 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:99421 Nfe2l1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 24Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane, Nucleus

Pathology & Biotechi

Disruption phenotypei

Embryonic lethality: embryos progress normally to the late egg cylinder stage at approximately 6.5 days post coitus (dpc), but development is arrested before 7.5 dpc (PubMed:9087432, PubMed:9501099). Mutant embryos fail to form a primitive streak and lack detectable mesoderm (PubMed:9087432). Homozygous embryos suffer from anemia as a result of abnormal fetal liver erythropoiesis (PubMed:9501099). No defect in globin gene expression are detected; abnormal red cell production being the result of a defect in the fetal liver microenvironment specific for erythroid cells (PubMed:9501099). Mice lacking both Nfe2l1 and Nfe2l2 die early between embryonic days 9 and 10 and exhibit extensive apoptosis due to marked oxidative stress in cells that is indicated by elevated intracellular reactive oxygen species levels and cell death (PubMed:12968018). Conditional knockout mice lacking Nfe2l1 in the liver do not show any liver damage when they are maintained in an unstressed condition (PubMed:15738389). In oxidative stress condition, they develop hepatic cancer following steatosis, apoptosis, necrosis, inflammation, and fibrosis (PubMed:15738389). Hepatocyte-specific deletion causes liver damage resembling the human disease non-alcoholic steatohepatitis (PubMed:18826952). Liver of conditional knockout mice lacking Nfe2l1 show massive hepatic cholesterol accumulation and damage due to inability to mediate response to cholesterol excess (PubMed:29149604). Conditional knockout mice lacking Nfe2l1 in the brain show proteasome impairment and progressive degeneration in cortical neurons (PubMed:21554501, PubMed:21536885).8 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi350 – 354Missing : Abolishes interaction with FBXW7. 1 Publication5
Mutagenesisi448 – 451SGLS → AGLA: Abolishes ubiquitination and degradation by the SCF(BTRC) complex. 1 Publication4
Mutagenesisi496S → A: Does not affect phosphorylation by CK2. 1 Publication1
Mutagenesisi497S → A: Abolishes phosphorylation by CK2. 1 Publication1
Mutagenesisi499S → A: Does not affect phosphorylation by CK2. 1 Publication1
Mutagenesisi501T → A: Does not affect phosphorylation by CK2. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000764481 – 741Endoplasmic reticulum membrane sensor NFE2L1Add BLAST741
ChainiPRO_0000443104104 – 741Transcription factor NRF1By similarityAdd BLAST638

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi319N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi331N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi394N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei497Phosphoserine; by CK21 Publication1
Modified residuei568PhosphoserineBy similarity1

Post-translational modificationi

Endoplasmic reticulum membrane sensor NFE2L1: Cleaved at Leu-104 by the aspartyl protease DDI2 following retrotranslocation, releasing the protein from the endoplasmic reticulum membrane and forming the transcription factor NRF1 that translocates into the nucleus. Ubiquitination is prerequisite for cleavage by aspartyl protease DDI2.By similarity
Endoplasmic reticulum membrane sensor NFE2L1: N-glycosylated in normal conditions, when it has a single-pass type II membrane protein topology, with the DNA-binding domain facing the endoplasmic reticulum lumen (PubMed:17705787, PubMed:18990090). Deglycosylated during retrotranslocation to the cytosolic side of the membrane, to have a single-pass type III membrane protein topology with the major part of the protein facing the cytosol (By similarity).By similarity2 Publications
Endoplasmic reticulum membrane sensor NFE2L1: Ubiquitinated by the SCF(FBXW7) complex and SYVN1/HRD1, leading to its degradation by the proteasome (PubMed:21953459, PubMed:21911472). Ubiquitinated during retrotranslocation to the cytosolic side of the membrane: ubiquitination does not lead to degradation and is required for processing by the aspartyl protease DDI2 and subsequent release from the endoplasmic reticulum membrane (By similarity).By similarity2 Publications
Transcription factor NRF1: Phosphorylation by CK2 at Ser-497 inhibits transcription factor activity, possibly by affecting DNA-binding activity (PubMed:9580677, PubMed:23816881). Phosphorylation at Ser-568 is required for interaction with CEBPB (By similarity).By similarity2 Publications
Transcription factor NRF1: Ubiquitinated by the SCF(BTRC) complex in the nucleus, leading to its degradation by the proteasome.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei103 – 104Cleavage; by DDI2By similarity2

Keywords - PTMi

Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ61985
PRIDEiQ61985

PTM databases

iPTMnetiQ61985
PhosphoSitePlusiQ61985

Expressioni

Tissue specificityi

Isoform 1: Widely expressed including kidney, brown fat, white fat, large intestine, small intestine, stomach, lung, brain and liver (PubMed:23144760). Isoform 1: Expressed in mouse embryonic fibroblasts (MEF) (PubMed:23144760). Isoform 2: Widely expressed including kidney, brown fat, white fat, large intestine, small intestine, stomach, lung, brain and liver (PubMed:23144760). Isoform 2: levels in white fat, lung and liver are increased compared to isoform 1 (at protein level) (PubMed:23144760). Isoform 2: levels are elevated in brown fat and brain, but are reduced in liver compared to isoform 1 levels (PubMed:23144760). Isoform 2: Expressed in mouse embryonic fibroblasts (MEF) (PubMed:23144760).1 Publication

Gene expression databases

BgeeiENSMUSG00000038615 Expressed in 320 organ(s), highest expression level in soleus muscle
CleanExiMM_NFE2L1
MM_NRF1
ExpressionAtlasiQ61985 baseline and differential
GenevisibleiQ61985 MM

Interactioni

Subunit structurei

Interacts with KEAP1 (By similarity). Endoplasmic reticulum membrane sensor NFE2L1: Interacts (via CPD region) with FBXW7; leading to its ubiquitination and degradation (PubMed:21953459). Endoplasmic reticulum membrane sensor NFE2L1: Interacts with SYVN1/HRD1; leading to its ubiquitination and degradation (PubMed:21911472). Endoplasmic reticulum membrane sensor NFE2L1: Interacts (when ubiquitinated) with DDI2; leading to its cleavage (By similarity). Transcription factor NRF1: Interacts (via the bZIP domain) with small MAF protein (MAFF, MAFG or MAFK); required for binding to antioxidant response elements (AREs) on DNA (PubMed:11342101, PubMed:23144760). Transcription factor NRF1: Interacts (via Destruction motif) with BTRC; leading to its ubiquitination and degradation (PubMed:21911472). Transcription factor NRF1: Interacts with CEBPB; the heterodimer represses expression of DSPP during odontoblast differentiation (By similarity).By similarity5 Publications

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080467

Structurei

3D structure databases

ProteinModelPortaliQ61985
SMRiQ61985
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini623 – 686bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni191 – 199Cholesterol recognition/amino acid consensus (CRAC) region1 Publication9
Regioni350 – 354CPD1 Publication5
Regioni625 – 644Basic motifPROSITE-ProRule annotationAdd BLAST20
Regioni651 – 665Leucine-zipperPROSITE-ProRule annotationAdd BLAST15

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi447 – 451Destruction motif1 Publication5
Motifi730 – 737Nuclear localization signalSequence analysis8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi125 – 259Asp/Glu-rich (acidic)Add BLAST135
Compositional biasi414 – 447Asp/Glu-rich (acidic)Add BLAST34
Compositional biasi467 – 486Poly-SerAdd BLAST20

Domaini

The cholesterol recognition/amino acid consensus (CRAC) region directly binds cholesterol, as well as campesterol and 27-hydroxycholesterol (PubMed:29149604). Has much lower affinity for epicholesterol (PubMed:29149604).1 Publication

Sequence similaritiesi

Belongs to the bZIP family. CNC subfamily.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3863 Eukaryota
ENOG410ZGMS LUCA
GeneTreeiENSGT00930000150911
HOGENOMiHOG000185844
HOVERGENiHBG052609
InParanoidiQ61985
KOiK09040
OMAiHKHSGPS

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR004826 bZIP_Maf
IPR029847 Nrf1_NFE2L1
IPR008917 TF_DNA-bd_sf
PANTHERiPTHR24411:SF31 PTHR24411:SF31, 2 hits
PfamiView protein in Pfam
PF03131 bZIP_Maf, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
SUPFAMiSSF47454 SSF47454, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q61985-1) [UniParc]FASTAAdd to basket
Also known as: Long1 Publication, Nrf1a1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLSLKKYLTE GLLQFTILLS LIGVRVDVDT YLTSQLPPLR EIILGPSSAY
60 70 80 90 100
TQTQFHNLRN TLDGYGIHPK SIDLDNYFTA RRLLSQVRAL DRFQVPTTEV
110 120 130 140 150
NAWLVHRDPE GSVSGSQPNS GLALESSSGL QDVTGPDNGV RESETEQGFG
160 170 180 190 200
EDLEDLGAVA PPVSGDLTKE DIDLIDILWR QDIDLGAGRE VFDYSHRQKE
210 220 230 240 250
QDVDKELQDG REREDTWSGE GAEALARDLL VDGETGESFP AQFPADVSSI
260 270 280 290 300
PEAVPSESES PALQNSLLSP LLTGTESPFD LEQQWQDLMS IMEMQAMEVN
310 320 330 340 350
TSASEILYNA PPGDPLSTNY SLAPNTPINQ NVSLHQASLG GCSQDFSLFS
360 370 380 390 400
PEVESLPVAS SSTLLPLVPS NSTSLNSTFG STNLAGLFFP SQLNGTANDT
410 420 430 440 450
SGPELPDPLG GLLDEAMLDE ISLMDLAIEE GFNPVQASQL EEEFDSDSGL
460 470 480 490 500
SLDSSHSPSS LSSSEGSSSS SSSSSSSSAS SSASSSFSEE GAVGYSSDSE
510 520 530 540 550
TLDLEEAEGA VGYQPEYSKF CRMSYQDPSQ LSCLPYLEHV GHNHTYNMAP
560 570 580 590 600
SALDSADLPP PSTLKKGSKE KQADFLDKQM SRDEHRARAM KIPFTNDKII
610 620 630 640 650
NLPVEEFNEL LSKYQLSEAQ LSLIRDIRRR GKNKMAAQNC RKRKLDTILN
660 670 680 690 700
LERDVEDLQR DKARLLREKV EFLRSLRQMK QKVQSLYQEV FGRLRDEHGR
710 720 730 740
PYSPSQYALQ YAGDGSVLLI PRTMADQQAR RQERKPKDRR K
Note: Produced by alternative promoter usage.
Length:741
Mass (Da):81,575
Last modified:May 29, 2013 - v2
Checksum:iDDB267F32CD2A92C
GO
Isoform 2 (identifier: Q61985-3) [UniParc]FASTAAdd to basket
Also known as: Nrf1b1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-158: Missing.
     159-170: VAPPVSGDLTKE → MGWESRLTAASA

Note: Produced by alternative promoter usage.
Show »
Length:583
Mass (Da):64,269
Checksum:iFA621B98FA01E566
GO
Isoform 3 (identifier: Q61985-2) [UniParc]FASTAAdd to basket
Also known as: Short1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-158: Missing.
     159-291: Missing.
     447-583: Missing.

Note: Produced by alternative splicing of isoform 1.
Show »
Length:313
Mass (Da):35,158
Checksum:iE204C4337A71E365
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A6D2A2A6D2_MOUSE
Endoplasmic reticulum membrane sens...
Nfe2l1
742Annotation score:
Q3V3M1Q3V3M1_MOUSE
Endoplasmic reticulum membrane sens...
Nfe2l1
453Annotation score:
A2A6D1A2A6D1_MOUSE
Endoplasmic reticulum membrane sens...
Nfe2l1
152Annotation score:
A2A6D0A2A6D0_MOUSE
Endoplasmic reticulum membrane sens...
Nfe2l1
148Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti318T → S in CAA55362 (PubMed:7759107).Curated1
Sequence conflicti387L → P in CAA55362 (PubMed:7759107).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0005801 – 158Missing in isoform 2 and isoform 3. CuratedAdd BLAST158
Alternative sequenceiVSP_046523159 – 291Missing in isoform 3. CuratedAdd BLAST133
Alternative sequenceiVSP_046524159 – 170VAPPV…DLTKE → MGWESRLTAASA in isoform 2. CuratedAdd BLAST12
Alternative sequenceiVSP_000581447 – 583Missing in isoform 3. CuratedAdd BLAST137

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78709 mRNA Translation: CAA55362.1
AF015881 Genomic DNA Translation: AAC40108.1
AL596384 Genomic DNA No translation available.
CCDSiCCDS25304.1 [Q61985-1]
CCDS48894.1 [Q61985-3]
PIRiI48694
RefSeqiNP_001123922.1, NM_001130450.1 [Q61985-1]
NP_032712.2, NM_008686.3 [Q61985-1]
UniGeneiMm.6743

Genome annotation databases

EnsembliENSMUST00000081775; ENSMUSP00000080467; ENSMUSG00000038615 [Q61985-1]
ENSMUST00000107657; ENSMUSP00000103284; ENSMUSG00000038615 [Q61985-1]
ENSMUST00000107658; ENSMUSP00000103285; ENSMUSG00000038615 [Q61985-1]
ENSMUST00000167110; ENSMUSP00000127804; ENSMUSG00000038615 [Q61985-3]
ENSMUST00000167149; ENSMUSP00000128527; ENSMUSG00000038615 [Q61985-1]
GeneIDi18023
KEGGimmu:18023
UCSCiuc007lcq.2 mouse [Q61985-1]
uc011ydl.1 mouse [Q61985-3]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78709 mRNA Translation: CAA55362.1
AF015881 Genomic DNA Translation: AAC40108.1
AL596384 Genomic DNA No translation available.
CCDSiCCDS25304.1 [Q61985-1]
CCDS48894.1 [Q61985-3]
PIRiI48694
RefSeqiNP_001123922.1, NM_001130450.1 [Q61985-1]
NP_032712.2, NM_008686.3 [Q61985-1]
UniGeneiMm.6743

3D structure databases

ProteinModelPortaliQ61985
SMRiQ61985
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080467

PTM databases

iPTMnetiQ61985
PhosphoSitePlusiQ61985

Proteomic databases

PaxDbiQ61985
PRIDEiQ61985

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000081775; ENSMUSP00000080467; ENSMUSG00000038615 [Q61985-1]
ENSMUST00000107657; ENSMUSP00000103284; ENSMUSG00000038615 [Q61985-1]
ENSMUST00000107658; ENSMUSP00000103285; ENSMUSG00000038615 [Q61985-1]
ENSMUST00000167110; ENSMUSP00000127804; ENSMUSG00000038615 [Q61985-3]
ENSMUST00000167149; ENSMUSP00000128527; ENSMUSG00000038615 [Q61985-1]
GeneIDi18023
KEGGimmu:18023
UCSCiuc007lcq.2 mouse [Q61985-1]
uc011ydl.1 mouse [Q61985-3]

Organism-specific databases

CTDi4779
MGIiMGI:99421 Nfe2l1

Phylogenomic databases

eggNOGiKOG3863 Eukaryota
ENOG410ZGMS LUCA
GeneTreeiENSGT00930000150911
HOGENOMiHOG000185844
HOVERGENiHBG052609
InParanoidiQ61985
KOiK09040
OMAiHKHSGPS

Miscellaneous databases

ChiTaRSiNfe2l1 mouse
PROiPR:Q61985
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038615 Expressed in 320 organ(s), highest expression level in soleus muscle
CleanExiMM_NFE2L1
MM_NRF1
ExpressionAtlasiQ61985 baseline and differential
GenevisibleiQ61985 MM

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR004826 bZIP_Maf
IPR029847 Nrf1_NFE2L1
IPR008917 TF_DNA-bd_sf
PANTHERiPTHR24411:SF31 PTHR24411:SF31, 2 hits
PfamiView protein in Pfam
PF03131 bZIP_Maf, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
SUPFAMiSSF47454 SSF47454, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNF2L1_MOUSE
AccessioniPrimary (citable) accession number: Q61985
Secondary accession number(s): E9Q038, O70234
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 29, 2013
Last modified: November 7, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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