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Protein

Neuronatin

Gene

Nnat

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May participate in the maintenance of segment identity in the hindbrain and pituitary development, and maturation or maintenance of the overall structure of the nervous system.

GO - Biological processi

  • brain development Source: GO_Central
  • positive regulation of insulin secretion Source: MGI
  • regulation of protein localization Source: MGI
  • response to glucose Source: MGI

Keywordsi

Molecular functionDevelopmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronatin
Gene namesi
Name:Nnat
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:104716 Nnat

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000968831 – 81NeuronatinAdd BLAST81

Proteomic databases

PaxDbiQ61979
PRIDEiQ61979

PTM databases

iPTMnetiQ61979
PhosphoSitePlusiQ61979

Expressioni

Tissue specificityi

Highest in brain and ovary.

Developmental stagei

Expressed in rhombomeres 3 and 5 during early hindbrain development and in the floor of the foregut pocket. Also expressed in the early Rathke pouch, derived adenohypophysis, and developing inner ear. During later embryogenesis, strongly expressed in the major part of the central and peripheral nervous system.

Gene expression databases

BgeeiENSMUSG00000067786 Expressed in 300 organ(s), highest expression level in cochlea
CleanExiMM_NNAT
ExpressionAtlasiQ61979 baseline and differential
GenevisibleiQ61979 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105152

Structurei

3D structure databases

SMRiQ61979
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the neuronatin family.Curated

Phylogenomic databases

eggNOGiENOG410JDHY Eukaryota
ENOG41117T6 LUCA
GeneTreeiENSGT00390000007412
HOGENOMiHOG000113807
HOVERGENiHBG001605
InParanoidiQ61979
OMAiMGERRQR
PhylomeDBiQ61979
TreeFamiTF338710

Family and domain databases

InterProiView protein in InterPro
IPR024885 Neuronatin
PANTHERiPTHR15285 PTHR15285, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q61979-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAVAAASAE LLIIGWYIFR VLLQVFLECC IYWVGFAFRN PPGTQPIARS
60 70 80
EVFRYSLQKL AHTVSRTGRQ VLGERRQRAP N
Length:81
Mass (Da):9,211
Last modified:February 1, 1997 - v2
Checksum:i067086DB0A4E3D20
GO
Isoform 2 (identifier: Q61979-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-51: Missing.

Show »
Length:54
Mass (Da):6,127
Checksum:i184E7C8A2E706C87
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UWR7G3UWR7_MOUSE
Neuronatin
Nnat
125Annotation score:
G3UWR4G3UWR4_MOUSE
Neuronatin
Nnat
63Annotation score:
G3X9K1G3X9K1_MOUSE
Neuronatin
Nnat mCG_21985
129Annotation score:
G3UZA6G3UZA6_MOUSE
Neuronatin
Nnat
112Annotation score:
G3UYJ4G3UYJ4_MOUSE
Neuronatin
Nnat
79Annotation score:

Sequence cautioni

The sequence CAA58551 differs from that shown. Incorrect N-terminal sequence due to reversal of the first 22 base pairs of the cDNA.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00433325 – 51Missing in isoform 2. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83568 mRNA Translation: CAA58551.1 Sequence problems.
X83569 mRNA Translation: CAA58552.1
X83570 mRNA Translation: CAA58553.1
AF303656 Genomic DNA Translation: AAL01185.1
AK160626 mRNA Translation: BAE35925.1
AL672259 Genomic DNA Translation: CAM16145.1
BC036984 mRNA Translation: AAH36984.1
CCDSiCCDS38306.1 [Q61979-1]
CCDS38307.1 [Q61979-3]
PIRiS51082
S51083
S51084
RefSeqiNP_001278057.1, NM_001291128.1
NP_001278058.1, NM_001291129.1
NP_001278059.1, NM_001291130.1
NP_035053.1, NM_010923.3 [Q61979-1]
NP_851291.1, NM_180960.3 [Q61979-3]
UniGeneiMm.34330
Mm.486979

Genome annotation databases

EnsembliENSMUST00000109526; ENSMUSP00000105152; ENSMUSG00000067786 [Q61979-1]
ENSMUST00000153739; ENSMUSP00000129821; ENSMUSG00000067786 [Q61979-3]
GeneIDi18111
KEGGimmu:18111
UCSCiuc008npe.2 mouse [Q61979-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83568 mRNA Translation: CAA58551.1 Sequence problems.
X83569 mRNA Translation: CAA58552.1
X83570 mRNA Translation: CAA58553.1
AF303656 Genomic DNA Translation: AAL01185.1
AK160626 mRNA Translation: BAE35925.1
AL672259 Genomic DNA Translation: CAM16145.1
BC036984 mRNA Translation: AAH36984.1
CCDSiCCDS38306.1 [Q61979-1]
CCDS38307.1 [Q61979-3]
PIRiS51082
S51083
S51084
RefSeqiNP_001278057.1, NM_001291128.1
NP_001278058.1, NM_001291129.1
NP_001278059.1, NM_001291130.1
NP_035053.1, NM_010923.3 [Q61979-1]
NP_851291.1, NM_180960.3 [Q61979-3]
UniGeneiMm.34330
Mm.486979

3D structure databases

SMRiQ61979
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105152

PTM databases

iPTMnetiQ61979
PhosphoSitePlusiQ61979

Proteomic databases

PaxDbiQ61979
PRIDEiQ61979

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000109526; ENSMUSP00000105152; ENSMUSG00000067786 [Q61979-1]
ENSMUST00000153739; ENSMUSP00000129821; ENSMUSG00000067786 [Q61979-3]
GeneIDi18111
KEGGimmu:18111
UCSCiuc008npe.2 mouse [Q61979-1]

Organism-specific databases

CTDi4826
MGIiMGI:104716 Nnat

Phylogenomic databases

eggNOGiENOG410JDHY Eukaryota
ENOG41117T6 LUCA
GeneTreeiENSGT00390000007412
HOGENOMiHOG000113807
HOVERGENiHBG001605
InParanoidiQ61979
OMAiMGERRQR
PhylomeDBiQ61979
TreeFamiTF338710

Miscellaneous databases

PROiPR:Q61979
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000067786 Expressed in 300 organ(s), highest expression level in cochlea
CleanExiMM_NNAT
ExpressionAtlasiQ61979 baseline and differential
GenevisibleiQ61979 MM

Family and domain databases

InterProiView protein in InterPro
IPR024885 Neuronatin
PANTHERiPTHR15285 PTHR15285, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNNAT_MOUSE
AccessioniPrimary (citable) accession number: Q61979
Secondary accession number(s): Q548Q0, Q61980, Q61981
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 7, 2018
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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