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Protein

Protein CBFA2T1

Gene

Runx1t1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Can repress the expression of MMP7 in a ZBTB33-dependent manner. Can repress transactivation mediated by TCF12 (By similarity). Acts as a negative regulator of adipogenesis (PubMed:23527555).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri488 – 524MYND-typePROSITE-ProRule annotationAdd BLAST37

GO - Molecular functioni

GO - Biological processi

  • fat cell differentiation Source: MGI
  • negative regulation of fat cell differentiation Source: UniProtKB
  • negative regulation of neuron projection development Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • regulation of DNA binding Source: MGI
  • regulation of transcription, DNA-templated Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CBFA2T1
Alternative name(s):
Protein MTG8
Gene namesi
Name:Runx1t1
Synonyms:Cbfa2t1, Cbfa2t1h, Mtg8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:104793 Runx1t1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002183001 – 577Protein CBFA2T1Add BLAST577

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineBy similarity1
Modified residuei390PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ61909
PaxDbiQ61909
PRIDEiQ61909

PTM databases

iPTMnetiQ61909
PhosphoSitePlusiQ61909

Expressioni

Gene expression databases

BgeeiENSMUSG00000006586
ExpressionAtlasiQ61909 baseline and differential
GenevisibleiQ61909 MM

Interactioni

Subunit structurei

Homotetramer (By similarity). Heterotetramer with CBFA2T2 and CBFA2T3 (By similarity). Interacts with TCF12, SIN3A, HDAC1, HDAC2, HDAC3, NCOR1 and NCOR2. Interacts with ATN1 (via its N-terminus); the interaction enhances the transcriptional repression (By similarity).By similarity

GO - Molecular functioni

  • protein homodimerization activity Source: MGI

Protein-protein interaction databases

BioGridi198520, 7 interactors
IntActiQ61909, 2 interactors
MINTiQ61909
STRINGi10090.ENSMUSP00000095857

Structurei

3D structure databases

ProteinModelPortaliQ61909
SMRiQ61909
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini93 – 188TAFHPROSITE-ProRule annotationAdd BLAST96

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni310 – 356Important for oligomerizationBy similarityAdd BLAST47
Regioni310 – 356Nervy homology region 2 (NHR2)By similarityAdd BLAST47
Regioni416 – 465Nervy homology region 3 (NHR3)By similarityAdd BLAST50

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi30 – 33Poly-Pro4
Compositional biasi75 – 81Poly-Ser7
Compositional biasi263 – 270Poly-Pro8
Compositional biasi380 – 386Poly-Ser7

Domaini

The TAFH domain mediates interaction with transcription regulators.By similarity
Nervy homology region 2 (NHR2) mediates homo- and possibly heterotypic oligomerization by forming a four-helix bundle tetrameric structure.By similarity

Sequence similaritiesi

Belongs to the CBFA2T family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri488 – 524MYND-typePROSITE-ProRule annotationAdd BLAST37

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IG1Z Eukaryota
ENOG410XR30 LUCA
GeneTreeiENSGT00390000013479
HOGENOMiHOG000049245
HOVERGENiHBG000169
InParanoidiQ61909
KOiK10053

Family and domain databases

Gene3Di1.20.120.1110, 1 hit
InterProiView protein in InterPro
IPR013290 CBFA2T1
IPR013289 CBFA2T1/2/3
IPR014896 NHR2
IPR037249 TAFH/NHR1_dom_sf
IPR003894 TAFH_NHR1
IPR002893 Znf_MYND
PANTHERiPTHR10379 PTHR10379, 1 hit
PTHR10379:SF5 PTHR10379:SF5, 1 hit
PfamiView protein in Pfam
PF08788 NHR2, 1 hit
PF07531 TAFH, 1 hit
PF01753 zf-MYND, 1 hit
PRINTSiPR01875 ETOFAMILY
PR01876 MTG8PROTEIN
SMARTiView protein in SMART
SM00549 TAFH, 1 hit
SUPFAMiSSF158553 SSF158553, 1 hit
PROSITEiView protein in PROSITE
PS51119 TAFH, 1 hit
PS01360 ZF_MYND_1, 1 hit
PS50865 ZF_MYND_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q61909-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDRTEKHST MPDSPVDVKT QSRLTPPAMP PPPTTQGAPR TSSFTPTTLT
60 70 80 90 100
NGTSHSPTAL NGAPSPPNGF SNGPSSSSSS SLANQQLPPA CGARQLSKLK
110 120 130 140 150
RFLTTLQQFG NDISPEIGER VRTLVLGLVN STLTIEEFHS KLQEATNFPL
160 170 180 190 200
RPFVIPFLKA NLPLLQRELL HCARLAKQNP AQYLAQHEQL LLDASTTSPV
210 220 230 240 250
DSSELLLDVN ENGKRRTPDR TKENGFDREP LHSEHPSKRP CTISPGQRYS
260 270 280 290 300
PNNGLSYQPN GLPHPTPPPP QHYRLDDMAI AHHYRDSYRH PSHRDLRDRN
310 320 330 340 350
RPMGLHGTRQ EEMIDHRLTD REWAEEWKHL DHLLNCIMDM VEKTRRSLTV
360 370 380 390 400
LRRCQEADRE ELNYWIRRYS DAEDLKKGGS SSSSHSRQQS PVNPDPVALD
410 420 430 440 450
AHREFLHRPA SGYVPEEIWK KAEEAVNEVK RQAMTELQKA VSEAERKAHD
460 470 480 490 500
MITTERAKME RTVAEAKRQA AEDALAVINQ QEDSSESCWN CGRKASETCS
510 520 530 540 550
GCNTARYCGS FCQHKDWEKH HHICGQTLQA PQQGDTPAVS SSVTPSSGAG
560 570
SPMDTPPAAT PRSTTPGTPS TIETTPR
Length:577
Mass (Da):64,338
Last modified:November 1, 1996 - v1
Checksum:i2656F185318C4B11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D32007 mRNA Translation: BAA06774.1
CCDSiCCDS17978.1
RefSeqiNP_033952.1, NM_009822.3
UniGeneiMm.470961
Mm.4909

Genome annotation databases

EnsembliENSMUST00000098256; ENSMUSP00000095856; ENSMUSG00000006586
GeneIDi12395
KEGGimmu:12395
UCSCiuc008sax.3 mouse

Similar proteinsi

Entry informationi

Entry nameiMTG8_MOUSE
AccessioniPrimary (citable) accession number: Q61909
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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