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Protein

Meiosis-specific nuclear structural protein 1

Gene

Mns1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cilium organization Source: MGI
  • left/right axis specification Source: MGI
  • meiotic cell cycle Source: UniProtKB-KW
  • positive regulation of cilium assembly Source: CACAO
  • spermatogenesis Source: CACAO

Keywordsi

Biological processMeiosis

Names & Taxonomyi

Protein namesi
Recommended name:
Meiosis-specific nuclear structural protein 1
Gene namesi
Name:Mns1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:107933 Mns1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002989231 – 491Meiosis-specific nuclear structural protein 1Add BLAST491

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei188PhosphotyrosineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ61884
MaxQBiQ61884
PaxDbiQ61884
PRIDEiQ61884

PTM databases

iPTMnetiQ61884
PhosphoSitePlusiQ61884

Expressioni

Tissue specificityi

Testis and pachytene spermatocytes. Expressed at the pachytene stage during spermatogenesis.1 Publication

Gene expression databases

BgeeiENSMUSG00000032221
CleanExiMM_MNS1
ExpressionAtlasiQ61884 baseline and differential
GenevisibleiQ61884 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034746

Structurei

3D structure databases

ProteinModelPortaliQ61884
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili29 – 253Sequence analysisAdd BLAST225
Coiled coili287 – 410Sequence analysisAdd BLAST124

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi46 – 447Glu-richAdd BLAST402

Sequence similaritiesi

Belongs to the MNS1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFU7 Eukaryota
ENOG410YXPQ LUCA
GeneTreeiENSGT00730000111210
HOGENOMiHOG000006500
HOVERGENiHBG108140
InParanoidiQ61884
OMAiNAQKQRM
OrthoDBiEOG091G0CNW
PhylomeDBiQ61884
TreeFamiTF329219

Family and domain databases

InterProiView protein in InterPro
IPR026504 MNS1
PANTHERiPTHR19265 PTHR19265, 1 hit

Sequencei

Sequence statusi: Complete.

Q61884-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATKKRALSF SEKHQKLVDE KFRKSLNIQV MNKLERQAKN QVVQNENDEK
60 70 80 90 100
VERQRFLRVL QNEQFELDME EAIQKAEANK MLRDRQLEQE ERLANELARL
110 120 130 140 150
KHESLKDKKM RQQVRENSIE LRELEQKLKA AYMNKERAAQ IVEKDAMKYE
160 170 180 190 200
QMKRDAEIER IMMEEHDRLL KEESAKQERR NKERAQYYLD LEKQLEDQER
210 220 230 240 250
RKQEAYEQLL KEKLMIDEIV RKIYEEDQVE RQQKLEKKNA IQKYIEEFQR
260 270 280 290 300
AQDFWRQKKR EEMEEENRKI IEFANIQEQR EGERMARVHE IEEKRVQRQN
310 320 330 340 350
LLMKQLEETL RQRDDLEQVR QELYQEEQAE IIKLKVKEEA ELRLRRQREM
360 370 380 390 400
KQDFEDQMAL KELILQAAKE EEETFKKAML AKFAEDDRIE LMNAQKQRMK
410 420 430 440 450
QLEHKRAVEK LIEERRSQFL ADKQRELEEL QLQQRRQGCI NEIIEEERLR
460 470 480 490
LLKEHAAKLL GYLPKGVFKR EDDVDMLGEE FRKAYQKRDG V
Length:491
Mass (Da):60,236
Last modified:November 1, 1996 - v1
Checksum:i3B7BF9394C24376B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC046624 mRNA Translation: AAH46624.1
D14849 mRNA Translation: BAA03577.1
CCDSiCCDS40684.1
RefSeqiNP_032639.1, NM_008613.3
UniGeneiMm.387671

Genome annotation databases

EnsembliENSMUST00000034746; ENSMUSP00000034746; ENSMUSG00000032221
GeneIDi17427
KEGGimmu:17427
UCSCiuc009qpx.2 mouse

Similar proteinsi

Entry informationi

Entry nameiMNS1_MOUSE
AccessioniPrimary (citable) accession number: Q61884
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: November 1, 1996
Last modified: October 25, 2017
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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