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Protein

FXYD domain-containing ion transport regulator 3

Gene

Fxyd3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na+ out of the cell and K+ into the cell (PubMed:15743908). Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1 (By similarity). Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes (By similarity).By similarity1 Publication

Miscellaneous

Marker of a cell type preferentially transformed by neu or ras oncoprotein.

GO - Molecular functioni

  • ATPase binding Source: MGI
  • ion channel activity Source: InterPro
  • sodium channel regulator activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processIon transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport
LigandPotassium, Sodium

Enzyme and pathway databases

ReactomeiR-MMU-5578775 Ion homeostasis
R-MMU-936837 Ion transport by P-type ATPases

Protein family/group databases

TCDBi1.A.27.1.2 the phospholemman (plm) family

Names & Taxonomyi

Protein namesi
Recommended name:
FXYD domain-containing ion transport regulator 3
Alternative name(s):
Chloride conductance inducer protein Mat-8
Mammary tumor 8 kDa protein
Phospholemman-like
Sodium/potassium-transporting ATPase subunit FXYD3Curated
Gene namesi
Name:Fxyd3
Synonyms:Mat8, Plml
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:107497 Fxyd3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38ExtracellularSequence analysisAdd BLAST38
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Topological domaini60 – 88CytoplasmicSequence analysisAdd BLAST29

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi5V → N: Does not lead to glycosylation, suggesting that the non-cleavable signal sequence remains partly or entirely embedded in the membrane. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000103631 – 88FXYD domain-containing ion transport regulator 3Add BLAST88
Signal peptidei1 – 20Not cleaved1 PublicationAdd BLAST20

Post-translational modificationi

Glutathionylated.By similarity

Keywords - PTMi

Glutathionylation

Proteomic databases

PaxDbiQ61835
PRIDEiQ61835

PTM databases

PhosphoSitePlusiQ61835

Expressioni

Tissue specificityi

Expressed at high levels in heart, skeletal muscle and liver with low levels of expression in breast, brain, lung, stomach and colon (PubMed:7836447). In the gastric gland, mainly expressed in the mucus cells forming the upper part of the gland and is absent from the parietal cells (PubMed:15743908).2 Publications

Gene expression databases

BgeeiENSMUSG00000057092 Expressed in 172 organ(s), highest expression level in urinary bladder urothelium
CleanExiMM_FXYD3
ExpressionAtlasiQ61835 baseline and differential
GenevisibleiQ61835 MM

Interactioni

Subunit structurei

Regulatory subunit of the sodium/potassium-transporting ATPase which is composed of a catalytic alpha subunit, a non-catalytic beta subunit and an additional regulatory subunit (PubMed:15743908). Interacts with catalytic alpha subunit ATP1A1 (PubMed:15743908). Also interacts with non-catalytic beta subunit ATP1B1 (PubMed:15743908). Interacts with the ATP1A1-ATP1B1, ATP1A2-ATP1B1 and ATP1A3-ATP1B1 NKA isozymes (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201318, 2 interactors
STRINGi10090.ENSMUSP00000130245

Structurei

3D structure databases

ProteinModelPortaliQ61835
SMRiQ61835
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FXYD family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J4PQ Eukaryota
ENOG4111AWX LUCA
GeneTreeiENSGT00530000063998
HOGENOMiHOG000234469
HOVERGENiHBG008212
InParanoidiQ61835
KOiK13361
OMAiIVLMSEW
OrthoDBiEOG091G14HJ
PhylomeDBiQ61835
TreeFamiTF333443

Family and domain databases

InterProiView protein in InterPro
IPR000272 Ion-transport_regulator_FXYD
PfamiView protein in Pfam
PF02038 ATP1G1_PLM_MAT8, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005989 PD005989, 1 hit
PROSITEiView protein in PROSITE
PS01310 FXYD, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q61835-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQEVVLSLLV LLAGLPTLDA NDPENKNDPF YYDWYSLRVG GLICAGILCA
60 70 80
LGIIVLMSGK CKCKFRQKPS HRPGEGPPLI TPGSAHNC
Length:88
Mass (Da):9,526
Last modified:November 1, 1996 - v1
Checksum:i9CD61684B856E35D
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q966E9Q966_MOUSE
FXYD domain-containing ion transpor...
Fxyd3
71Annotation score:
A0A0J9YV80A0A0J9YV80_MOUSE
FXYD domain-containing ion transpor...
Fxyd3
32Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X93038 mRNA Translation: CAA63606.1
BC002039 mRNA Translation: AAH02039.1
BC056223 mRNA Translation: AAH56223.1
CCDSiCCDS21125.1
PIRiS61552
RefSeqiNP_032583.1, NM_008557.2
UniGeneiMm.263847

Genome annotation databases

EnsembliENSMUST00000167369; ENSMUSP00000130245; ENSMUSG00000057092
GeneIDi17178
KEGGimmu:17178
UCSCiuc009gia.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X93038 mRNA Translation: CAA63606.1
BC002039 mRNA Translation: AAH02039.1
BC056223 mRNA Translation: AAH56223.1
CCDSiCCDS21125.1
PIRiS61552
RefSeqiNP_032583.1, NM_008557.2
UniGeneiMm.263847

3D structure databases

ProteinModelPortaliQ61835
SMRiQ61835
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201318, 2 interactors
STRINGi10090.ENSMUSP00000130245

Protein family/group databases

TCDBi1.A.27.1.2 the phospholemman (plm) family

PTM databases

PhosphoSitePlusiQ61835

Proteomic databases

PaxDbiQ61835
PRIDEiQ61835

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000167369; ENSMUSP00000130245; ENSMUSG00000057092
GeneIDi17178
KEGGimmu:17178
UCSCiuc009gia.2 mouse

Organism-specific databases

CTDi5349
MGIiMGI:107497 Fxyd3

Phylogenomic databases

eggNOGiENOG410J4PQ Eukaryota
ENOG4111AWX LUCA
GeneTreeiENSGT00530000063998
HOGENOMiHOG000234469
HOVERGENiHBG008212
InParanoidiQ61835
KOiK13361
OMAiIVLMSEW
OrthoDBiEOG091G14HJ
PhylomeDBiQ61835
TreeFamiTF333443

Enzyme and pathway databases

ReactomeiR-MMU-5578775 Ion homeostasis
R-MMU-936837 Ion transport by P-type ATPases

Miscellaneous databases

ChiTaRSiFxyd3 mouse
PROiPR:Q61835
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000057092 Expressed in 172 organ(s), highest expression level in urinary bladder urothelium
CleanExiMM_FXYD3
ExpressionAtlasiQ61835 baseline and differential
GenevisibleiQ61835 MM

Family and domain databases

InterProiView protein in InterPro
IPR000272 Ion-transport_regulator_FXYD
PfamiView protein in Pfam
PF02038 ATP1G1_PLM_MAT8, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005989 PD005989, 1 hit
PROSITEiView protein in PROSITE
PS01310 FXYD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFXYD3_MOUSE
AccessioniPrimary (citable) accession number: Q61835
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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