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Entry version 141 (18 Sep 2019)
Sequence version 3 (27 Jul 2011)
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Protein

Retinoic acid-induced protein 1

Gene

Rai1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional regulator of the circadian clock components: CLOCK, ARNTL/BMAL1, ARNTL2/BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1762 – 1817C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST56
Zinc fingeri1837 – 1885PHD-typePROSITE-ProRule annotationAdd BLAST49

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processBiological rhythms
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Retinoic acid-induced protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rai1
Synonyms:Kiaa1820
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

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MGIi
MGI:103291 Rai1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Haploinsufficiency cause obesity and craniofacial abnormalities. Homozygous mice die during gastrulation and organogenesis. The few surviving mice experienced postnatal growth retardation and most of them died before weaning.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000971601 – 1889Retinoic acid-induced protein 1Add BLAST1889

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei322PhosphoserineBy similarity1
Modified residuei328PhosphoserineBy similarity1
Modified residuei455PhosphothreonineBy similarity1
Modified residuei551PhosphoserineBy similarity1
Modified residuei666PhosphoserineCombined sources1
Modified residuei679PhosphothreonineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki794Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki802Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Modified residuei863PhosphoserineBy similarity1
Modified residuei875PhosphoserineBy similarity1
Cross-linki884Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki884Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei1047PhosphoserineBy similarity1
Modified residuei1051PhosphothreonineBy similarity1
Modified residuei1105PhosphoserineCombined sources1
Modified residuei1332PhosphoserineBy similarity1
Modified residuei1343PhosphoserineCombined sources1
Cross-linki1394Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1400PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q61818

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q61818

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q61818

PRoteomics IDEntifications database

More...
PRIDEi
Q61818

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q61818

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q61818

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in all tissues examined with strong expression in the thymus and brain. Expressed in epithelial cells involved in organogenesis. No expression was seen in the corpus callosum of the brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000062115 Expressed in 282 organ(s), highest expression level in bone marrow

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q61818 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q61818 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
202577, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q61818, 3 interactors

Molecular INTeraction database

More...
MINTi
Q61818

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000070896

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q61818

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1143 – 1160Nuclear localization signalSequence analysisAdd BLAST18
Motifi1206 – 1223Nuclear localization signalSequence analysisAdd BLAST18

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi117 – 197Pro-richAdd BLAST81
Compositional biasi117 – 128Poly-ProAdd BLAST12
Compositional biasi1462 – 1465Poly-Gly4
Compositional biasi1597 – 1609Ser-richAdd BLAST13

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1762 – 1817C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST56
Zinc fingeri1837 – 1885PHD-typePROSITE-ProRule annotationAdd BLAST49

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IPTA Eukaryota
ENOG410Z8S8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156922

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000015259

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q61818

KEGG Orthology (KO)

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KOi
K19749

Identification of Orthologs from Complete Genome Data

More...
OMAi
PKAPLLC

Database of Orthologous Groups

More...
OrthoDBi
98385at2759

TreeFam database of animal gene trees

More...
TreeFami
TF331317

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR034732 EPHD
IPR001965 Znf_PHD
IPR013083 Znf_RING/FYVE/PHD

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00249 PHD, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51805 EPHD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q61818-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQSFRERCGF HGKQQNYPQT SQETSRLENY RQPGQAGLSC DRQRLLAKDY
60 70 80 90 100
YSPQPYTGYE GGTGTPSGTV ATAAADKYHR GSKSLQGRPA FPSYVQDSSP
110 120 130 140 150
YPGRYSGEEG LQTWGGPQPP PPQPQPLPGA VSKYEENLMK KTVVPPPNRQ
160 170 180 190 200
YPEQGPQLPF RTHSLHVPPP QPQQPLAYPK LQRQKPQNDL ASPLPFPQGS
210 220 230 240 250
HFPQHSQSFP TSSTYAPTVQ GGGQGAHSYK SCTAPSAQPH DRPMSANANL
260 270 280 290 300
APGQRVQNLH AYQPGRLGYE QQQQALQGRH HTQETLHYQN LAKYQHYGQQ
310 320 330 340 350
GQGYCPPDTA VRTPEQYYQT FSPSSSHSPA RSVGRSPSYS STPSPLMPNL
360 370 380 390 400
ENFPYSQQPL STGAFPTGIT DHSHFMPLLN PSPTDAASSV DPQAGNCKPL
410 420 430 440 450
QKEKLPDNLL SDLSLQSLTA LTSQVENISN TVQQLLLSKA TMPQKKGVKN
460 470 480 490 500
LVSRTPEQHK SQHCSPEGSG YSAEPAGTPL SEPPSSTPQS THAEPQDTDY
510 520 530 540 550
LSGSEDPLER SFLYCSQARG SPARVNSNSK AKPESVSTCS VTSPDDMSTK
560 570 580 590 600
SDDSFQSLHS TLPLDSFSKF VAGERDCPRL LLSALAQEDL ASEILGLQEA
610 620 630 640 650
IVEKADKAWA EASSLPKDNG KPPFSLENHG ACLDTVAKTS WSQPGEPETL
660 670 680 690 700
PEPLQLDKGG STKDFSPGLF EDPSVAFATT DPKKTSSPLS FGTKPLLGTA
710 720 730 740 750
TPDPTTAAFD CFPDTPTASS VDGANPFAWP EENLGDACPR WGLHPGELTK
760 770 780 790 800
GLEQGAKASD GVGKADAHEA SACMGFQEDH AIGKPAAALS GDFKQQEAEG
810 820 830 840 850
VKEEVGGLLQ CPEVAKANQW LEESRHCCSS TDFGDLPLLP PPGRKEDLEA
860 870 880 890 900
EEEYSSLCEL LGSPEQRPSL QDPLSPKAPL MCTKEEAEEA LDTKAGWVSP
910 920 930 940 950
CHLSGEPAVL LGPSVGAQSK VQSWFESSLS HMKPGEEGPE MERAPGSSGT
960 970 980 990 1000
SQGSLAPKPN KPAVPEGPIA KKEPVPRGKS LRSRRVHRGL PEAEDSPCRV
1010 1020 1030 1040 1050
PALPKDLLLP ESCTGPPQGQ AEGAGAPGRG LSEGLPRMCT RSLTALSEPQ
1060 1070 1080 1090 1100
TPGPPGLTTT PTPPDKLGGK QRAAFKSGKR VGKPSPKAAS SPSNPAALPV
1110 1120 1130 1140 1150
ASDSSPMGSK TKEPDSPSMP GKDQRSMVLR SRTKPQQVFH AKRRRPSESR
1160 1170 1180 1190 1200
IPDCRATKKL PANNHLPTAY KVSSGPQKEG RMNQRVKVPK PGTGNKLSDR
1210 1220 1230 1240 1250
PLHTLKRKSA FMAPVPAKKR SLILRSNNGS GGDGREERAE SSPGLLRRMA
1260 1270 1280 1290 1300
SPQRARPRGS GEPPPPPPLE PPAACMGLST QSSLPSAVRT KVLPPRKGRG
1310 1320 1330 1340 1350
LKLEAIVQKI TSPGLKKLAC RVAGAPPGTP RSPALPERRP GGSPAGAEEG
1360 1370 1380 1390 1400
LGGMGQMLPA ASGADPLCRN PASRSLKGKL LNSKKLSSAA DCPKAEAFMS
1410 1420 1430 1440 1450
PETLPSLGTA RAPKKRSRKG RTGTLGPSKG PLEKRPCPGQ PLLLAPHDRA
1460 1470 1480 1490 1500
SSTQGGGEDN SSGGGKKPKT EELGPASQPP EGRPCQPQTR AQKQPGQASY
1510 1520 1530 1540 1550
SSYSKRKRLS RGRGKTAHAS PCKGRATRRR QQQVLPLDPA EPEIRLKYIS
1560 1570 1580 1590 1600
SCKRLRADSR TPAFSPFVRV EKRDAYTTIC TVVNSPGDEP KPHWKPSSSA
1610 1620 1630 1640 1650
ASSSTSSSSL EPAGASLTTF PGGSVLQQRP SLPLSSTMHL GPVVSKALST
1660 1670 1680 1690 1700
SCLVCCLCQN PANFKDLGDL CGPYYPEHCL PKKKPKLKEK ARLEGTLEEA
1710 1720 1730 1740 1750
SLPLERTLKG LECSASTTAA APTTATITTP TALGRLSRPD GPADPAKQGP
1760 1770 1780 1790 1800
LRTSARGLSR RLQSCYCCDG QGDGGEEVAQ ADKSRKHECS KEAPTEPGGD
1810 1820 1830 1840 1850
TQEHWVHEAC AVWTSGVYLV AGKLFGLQEA MKVAVDMPCT SCHEPGATIS
1860 1870 1880
CSYKGCIHTY HYPCANDTGC TFIEENFTLK CPKHKRLPL
Length:1,889
Mass (Da):201,571
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i54F51C4CC901189E
GO
Isoform 2 (identifier: Q61818-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1838-1840: PCT → VRG
     1841-1889: Missing.

Show »
Length:1,840
Mass (Da):196,084
Checksum:iA9ACE15EE6EB48F8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AU85B1AU85_MOUSE
Retinoic acid-induced protein 1
Rai1
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti412 – 413DL → EV in BAA06184 (PubMed:7476016).Curated2
Sequence conflicti818N → D in BAA06184 (PubMed:7476016).Curated1
Sequence conflicti818N → D in BAC98259 (PubMed:14621295).Curated1
Sequence conflicti1170Y → F in BAA06184 (PubMed:7476016).Curated1
Sequence conflicti1170Y → F in BAC98259 (PubMed:14621295).Curated1
Sequence conflicti1183N → S in BAA06184 (PubMed:7476016).Curated1
Sequence conflicti1183N → S in BAC98259 (PubMed:14621295).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0110041838 – 1840PCT → VRG in isoform 2. 1 Publication3
Alternative sequenceiVSP_0110051841 – 1889Missing in isoform 2. 1 PublicationAdd BLAST49

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
D29801 mRNA Translation: BAA06184.1
AL669954 Genomic DNA No translation available.
AK129449 mRNA Translation: BAC98259.1
AK013909 mRNA Translation: BAC25417.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS24784.1 [Q61818-1]

Protein sequence database of the Protein Information Resource

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PIRi
T30250

NCBI Reference Sequences

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RefSeqi
NP_001032853.1, NM_001037764.1 [Q61818-1]
NP_033047.2, NM_009021.2 [Q61818-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000064190; ENSMUSP00000070896; ENSMUSG00000062115 [Q61818-1]
ENSMUST00000090806; ENSMUSP00000088315; ENSMUSG00000062115 [Q61818-2]
ENSMUST00000102688; ENSMUSP00000099749; ENSMUSG00000062115 [Q61818-1]
ENSMUST00000171108; ENSMUSP00000126183; ENSMUSG00000062115 [Q61818-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
19377

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:19377

UCSC genome browser

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UCSCi
uc007jfk.1 mouse [Q61818-1]
uc007jfl.1 mouse [Q61818-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D29801 mRNA Translation: BAA06184.1
AL669954 Genomic DNA No translation available.
AK129449 mRNA Translation: BAC98259.1
AK013909 mRNA Translation: BAC25417.1
CCDSiCCDS24784.1 [Q61818-1]
PIRiT30250
RefSeqiNP_001032853.1, NM_001037764.1 [Q61818-1]
NP_033047.2, NM_009021.2 [Q61818-1]

3D structure databases

SMRiQ61818
ModBaseiSearch...

Protein-protein interaction databases

BioGridi202577, 3 interactors
IntActiQ61818, 3 interactors
MINTiQ61818
STRINGi10090.ENSMUSP00000070896

PTM databases

iPTMnetiQ61818
PhosphoSitePlusiQ61818

Proteomic databases

EPDiQ61818
jPOSTiQ61818
PaxDbiQ61818
PRIDEiQ61818

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064190; ENSMUSP00000070896; ENSMUSG00000062115 [Q61818-1]
ENSMUST00000090806; ENSMUSP00000088315; ENSMUSG00000062115 [Q61818-2]
ENSMUST00000102688; ENSMUSP00000099749; ENSMUSG00000062115 [Q61818-1]
ENSMUST00000171108; ENSMUSP00000126183; ENSMUSG00000062115 [Q61818-1]
GeneIDi19377
KEGGimmu:19377
UCSCiuc007jfk.1 mouse [Q61818-1]
uc007jfl.1 mouse [Q61818-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10743
MGIiMGI:103291 Rai1

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiENOG410IPTA Eukaryota
ENOG410Z8S8 LUCA
GeneTreeiENSGT00940000156922
HOGENOMiHOG000015259
InParanoidiQ61818
KOiK19749
OMAiPKAPLLC
OrthoDBi98385at2759
TreeFamiTF331317

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Rai1 mouse

Protein Ontology

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PROi
PR:Q61818

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000062115 Expressed in 282 organ(s), highest expression level in bone marrow
ExpressionAtlasiQ61818 baseline and differential
GenevisibleiQ61818 MM

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR034732 EPHD
IPR001965 Znf_PHD
IPR013083 Znf_RING/FYVE/PHD
SMARTiView protein in SMART
SM00249 PHD, 1 hit
PROSITEiView protein in PROSITE
PS51805 EPHD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRAI1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q61818
Secondary accession number(s): B1AU87, Q6ZPH7, Q8CEV1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 27, 2011
Last modified: September 18, 2019
This is version 141 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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