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Protein

Leucine-rich repeat neuronal protein 1

Gene

Lrrn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • positive regulation of synapse assembly Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat neuronal protein 1
Alternative name(s):
Neuronal leucine-rich repeat protein 1
Short name:
NLRR-1
Gene namesi
Name:Lrrn1
Synonyms:Kiaa1497
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:106038 Lrrn1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 631ExtracellularSequence analysisAdd BLAST606
Transmembranei632 – 652HelicalSequence analysisAdd BLAST21
Topological domaini653 – 716CytoplasmicSequence analysisAdd BLAST64

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25By similarityAdd BLAST25
ChainiPRO_000001484826 – 716Leucine-rich repeat neuronal protein 1Add BLAST691

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi69N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi96N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi117N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi385N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi447 ↔ 499PROSITE-ProRule annotation
Glycosylationi517N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ61809
PaxDbiQ61809
PRIDEiQ61809

PTM databases

iPTMnetiQ61809
PhosphoSitePlusiQ61809

Expressioni

Tissue specificityi

Expressed in brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000034648 Expressed in 261 organ(s), highest expression level in islet of Langerhans
CleanExiMM_LRRN1
GenevisibleiQ61809 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037096

Structurei

3D structure databases

ProteinModelPortaliQ61809
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 72LRRNTAdd BLAST47
Repeati73 – 95LRR 1Add BLAST23
Repeati96 – 117LRR 2Add BLAST22
Repeati120 – 141LRR 3Add BLAST22
Repeati144 – 165LRR 4Add BLAST22
Repeati168 – 189LRR 5Add BLAST22
Repeati192 – 213LRR 6Add BLAST22
Repeati216 – 237LRR 7Add BLAST22
Repeati240 – 261LRR 8Add BLAST22
Repeati264 – 285LRR 9Add BLAST22
Domaini371 – 424LRRCTAdd BLAST54
Domaini424 – 515Ig-like C2-typeAdd BLAST92
Domaini525 – 619Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST95

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000118831
HOGENOMiHOG000252914
HOVERGENiHBG052361
InParanoidiQ61809
OMAiHDTFPNH
OrthoDBiEOG091G066E
PhylomeDBiQ61809
TreeFamiTF334360

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 2 hits
3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF13855 LRR_8, 3 hits
PF01463 LRRCT, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00369 LRR_TYP, 9 hits
SM00082 LRRCT, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF49265 SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit
PS50835 IG_LIKE, 1 hit
PS51450 LRR, 9 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61809-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARLSTGKAA CQVVLGLLIT SLTESSILTS ECPQLCVCEI RPWFTPQSTY
60 70 80 90 100
REATTVDCND LRLTRIPGNL SSDTQVLLLQ SNNIAKTVDE LQQLFNLTEL
110 120 130 140 150
DFSQNNFTNI KEVGLANLTQ LTTLHLEENQ ISEMTDYCLQ DLSNLQELYI
160 170 180 190 200
NHNQISTISA NAFSGLKNLL RLHLNSNKLK VIDSRWFDST PNLEILMIGE
210 220 230 240 250
NPVIGILDMN FRPLSNLRSL VLAGMYLTDV PGNALVGLDS LESLSFYDNK
260 270 280 290 300
LIKVPQLALQ KVPNLKFLDL NKNPIHKIQE GDFKNMLRLK ELGINNMGEL
310 320 330 340 350
VSVDRYALDN LPELTKLEAT NNPKLSYIHR LAFRSVPALE SLMLNNNALN
360 370 380 390 400
AVYQKTVESL PNLREISIHS NPLRCDCVIH WINSNKTNIR FMEPLSMFCA
410 420 430 440 450
MPPEYRGQQV KEVLIQDSSE QCLPMISHDT FPNHLNMDIG TTLFLDCRAM
460 470 480 490 500
AEPEPEIYWV TPIGNKITVE TLSDKYKLSS EGTLEIANIQ IEDSGRYTCV
510 520 530 540 550
AQNVQGADTR VATIKVNGTL LDGAQVLKIY VKQTESHSIL VSWKVNSNVM
560 570 580 590 600
TSNLKWSSAT MKIDNPHITY TARVPVDVHE YNLTHLQPST DYEVCLTVSN
610 620 630 640 650
IHQQTQKSCV NVTTKTAAFA LDISDHETST ALAAVMGSMF AVISLASIAI
660 670 680 690 700
YIAKRFKRKN YHHSLKKYMQ KTSSIPLNEL YPPLINLWEA DSDKDKDGSA
710
DTKPTQVDTS RSYYMW
Length:716
Mass (Da):80,548
Last modified:November 1, 1996 - v1
Checksum:i5073FB4801D08F58
GO

Sequence cautioni

The sequence BAD32464 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D45913 mRNA Translation: BAA08341.1
AK173186 mRNA Translation: BAD32464.1 Different initiation.
AK139355 mRNA Translation: BAE23973.1
AK139965 mRNA Translation: BAE24199.1
AK160841 mRNA Translation: BAE36040.1
BC031122 mRNA Translation: AAH31122.1
BC058701 mRNA Translation: AAH58701.1
CCDSiCCDS20399.1
RefSeqiNP_032542.1, NM_008516.4
UniGeneiMm.428543
Mm.488119

Genome annotation databases

EnsembliENSMUST00000049285; ENSMUSP00000037096; ENSMUSG00000034648
GeneIDi16979
KEGGimmu:16979
UCSCiuc009ddd.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D45913 mRNA Translation: BAA08341.1
AK173186 mRNA Translation: BAD32464.1 Different initiation.
AK139355 mRNA Translation: BAE23973.1
AK139965 mRNA Translation: BAE24199.1
AK160841 mRNA Translation: BAE36040.1
BC031122 mRNA Translation: AAH31122.1
BC058701 mRNA Translation: AAH58701.1
CCDSiCCDS20399.1
RefSeqiNP_032542.1, NM_008516.4
UniGeneiMm.428543
Mm.488119

3D structure databases

ProteinModelPortaliQ61809
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037096

PTM databases

iPTMnetiQ61809
PhosphoSitePlusiQ61809

Proteomic databases

MaxQBiQ61809
PaxDbiQ61809
PRIDEiQ61809

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049285; ENSMUSP00000037096; ENSMUSG00000034648
GeneIDi16979
KEGGimmu:16979
UCSCiuc009ddd.2 mouse

Organism-specific databases

CTDi57633
MGIiMGI:106038 Lrrn1
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000118831
HOGENOMiHOG000252914
HOVERGENiHBG052361
InParanoidiQ61809
OMAiHDTFPNH
OrthoDBiEOG091G066E
PhylomeDBiQ61809
TreeFamiTF334360

Miscellaneous databases

ChiTaRSiLrrn1 mouse
PROiPR:Q61809
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034648 Expressed in 261 organ(s), highest expression level in islet of Langerhans
CleanExiMM_LRRN1
GenevisibleiQ61809 MM

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 2 hits
3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF13855 LRR_8, 3 hits
PF01463 LRRCT, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00369 LRR_TYP, 9 hits
SM00082 LRRCT, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF49265 SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit
PS50835 IG_LIKE, 1 hit
PS51450 LRR, 9 hits
ProtoNetiSearch...

Entry informationi

Entry nameiLRRN1_MOUSE
AccessioniPrimary (citable) accession number: Q61809
Secondary accession number(s): Q3USY1, Q69ZI0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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