Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

LIM and SH3 domain protein 1

Gene

Lasp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity).By similarity

GO - Molecular functioni

  • actin filament binding Source: MGI
  • ion transmembrane transporter activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionActin-binding
Biological processIon transport, Transport
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LIM and SH3 domain protein 1
Short name:
LASP-1
Alternative name(s):
Metastatic lymph node gene 50 protein
Short name:
MLN 50
Gene namesi
Name:Lasp1
Synonyms:Mln50
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:109656 Lasp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000757621 – 263LIM and SH3 domain protein 1Add BLAST263

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei42N6-acetyllysineBy similarity1
Modified residuei68PhosphothreonineBy similarity1
Modified residuei75N6-methyllysineBy similarity1
Modified residuei99PhosphoserineBy similarity1
Modified residuei104PhosphothreonineCombined sources1
Modified residuei112N6-succinyllysineCombined sources1
Modified residuei118PhosphoserineBy similarity1
Modified residuei134PhosphoserineBy similarity1
Modified residuei156Phosphothreonine; by PKA1 Publication1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ61792
MaxQBiQ61792
PaxDbiQ61792
PRIDEiQ61792

PTM databases

iPTMnetiQ61792
PhosphoSitePlusiQ61792
SwissPalmiQ61792

Expressioni

Gene expression databases

BgeeiENSMUSG00000038366 Expressed in 305 organ(s), highest expression level in conjunctival fornix
CleanExiMM_LASP1
ExpressionAtlasiQ61792 baseline and differential
GenevisibleiQ61792 MM

Interactioni

Subunit structurei

Interacts with F-actin. Interacts with KBTBD10 (By similarity). Interacts with ANKRD54.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201111, 8 interactors
ELMiQ61792
IntActiQ61792, 3 interactors
MINTiQ61792
STRINGi10090.ENSMUSP00000042123

Structurei

3D structure databases

ProteinModelPortaliQ61792
SMRiQ61792
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 56LIM zinc-bindingPROSITE-ProRule annotationAdd BLAST52
Repeati61 – 95Nebulin 1Add BLAST35
Repeati97 – 131Nebulin 2Add BLAST35
Domaini204 – 263SH3PROSITE-ProRule annotationAdd BLAST60

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi174 – 180Poly-Gln7
Compositional biasi203 – 206Poly-Gly4

Keywords - Domaini

LIM domain, Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG1702 Eukaryota
ENOG4111GQ8 LUCA
GeneTreeiENSGT00530000062924
HOGENOMiHOG000006616
HOVERGENiHBG054636
InParanoidiQ61792
OMAiYGYKEPA
OrthoDBiEOG091G0U2O
PhylomeDBiQ61792
TreeFamiTF319104

Family and domain databases

CDDicd11934 SH3_Lasp1_C, 1 hit
InterProiView protein in InterPro
IPR035630 Lasp1_SH3
IPR000900 Nebulin_repeat
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 1 hit
PF00880 Nebulin, 2 hits
PF14604 SH3_9, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00132 LIM, 1 hit
SM00227 NEBU, 2 hits
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit
PS51216 NEBULIN, 2 hits
PS50002 SH3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All

Q61792-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNPNCARCGK IVYPTEKVNC LDKYWHKACF HCETCKMTLN MKNYKGYEKK
60 70 80 90 100
PYCNAHYPKQ SFTMVADTPE NLRLKQQSEL QSQVRYKEEF EKNKGKGFSV
110 120 130 140 150
VADTPELQRI KKTQDQISNI KYHEEFEKSR MGPSGGEGVE PERREAQDSS
160 170 180 190 200
SYRRPTEQQQ PQPHHIPTSA PVYQQPQQQQ MTSSYGGYKE PAAPVSIQRS
210 220 230 240 250
APGGGGKRYR AVYDYSAADE DEVSFQDGDT IVNVQQIDDG WMYGTVERTG
260
DTGMLPANYV EAI
Length:263
Mass (Da):29,994
Last modified:November 1, 1996 - v1
Checksum:iA6CA2FC2E451433E
GO

Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A6G9A2A6G9_MOUSE
LIM and SH3 domain protein 1
Lasp1
129Annotation score:
A2A6H0A2A6H0_MOUSE
LIM and SH3 domain protein 1
Lasp1
186Annotation score:
A2A6G8A2A6G8_MOUSE
LIM and SH3 domain protein 1
Lasp1
103Annotation score:
A2A6G6A2A6G6_MOUSE
LIM and SH3 domain protein 1
Lasp1
89Annotation score:
A2A6G5A2A6G5_MOUSE
LIM and SH3 domain protein 1
Lasp1
69Annotation score:
A2A6H1A2A6H1_MOUSE
LIM and SH3 domain protein 1
Lasp1
56Annotation score:
E9Q0N6E9Q0N6_MOUSE
LIM and SH3 domain protein 1
Lasp1
70Annotation score:
A2A6G7A2A6G7_MOUSE
LIM and SH3 domain protein 1
Lasp1
99Annotation score:
A2A6G0A2A6G0_MOUSE
LIM and SH3 domain protein 1
Lasp1
28Annotation score:
A2A6G4A2A6G4_MOUSE
LIM and SH3 domain protein 1
Lasp1
47Annotation score:
There are more potential isoformsShow all

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96973 mRNA Translation: CAA65659.1
AK078445 mRNA Translation: BAC37278.1
BC010840 mRNA Translation: AAH10840.1
U58882 mRNA Translation: AAC52639.1
CCDSiCCDS25332.1
RefSeqiNP_034818.1, NM_010688.4
XP_006532404.1, XM_006532341.1
UniGeneiMm.271967
Mm.470698

Genome annotation databases

EnsembliENSMUST00000043843; ENSMUSP00000042123; ENSMUSG00000038366
GeneIDi16796
KEGGimmu:16796
UCSCiuc007lew.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96973 mRNA Translation: CAA65659.1
AK078445 mRNA Translation: BAC37278.1
BC010840 mRNA Translation: AAH10840.1
U58882 mRNA Translation: AAC52639.1
CCDSiCCDS25332.1
RefSeqiNP_034818.1, NM_010688.4
XP_006532404.1, XM_006532341.1
UniGeneiMm.271967
Mm.470698

3D structure databases

ProteinModelPortaliQ61792
SMRiQ61792
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201111, 8 interactors
ELMiQ61792
IntActiQ61792, 3 interactors
MINTiQ61792
STRINGi10090.ENSMUSP00000042123

PTM databases

iPTMnetiQ61792
PhosphoSitePlusiQ61792
SwissPalmiQ61792

Proteomic databases

EPDiQ61792
MaxQBiQ61792
PaxDbiQ61792
PRIDEiQ61792

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043843; ENSMUSP00000042123; ENSMUSG00000038366
GeneIDi16796
KEGGimmu:16796
UCSCiuc007lew.1 mouse

Organism-specific databases

CTDi3927
MGIiMGI:109656 Lasp1

Phylogenomic databases

eggNOGiKOG1702 Eukaryota
ENOG4111GQ8 LUCA
GeneTreeiENSGT00530000062924
HOGENOMiHOG000006616
HOVERGENiHBG054636
InParanoidiQ61792
OMAiYGYKEPA
OrthoDBiEOG091G0U2O
PhylomeDBiQ61792
TreeFamiTF319104

Miscellaneous databases

ChiTaRSiLasp1 mouse
PROiPR:Q61792
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038366 Expressed in 305 organ(s), highest expression level in conjunctival fornix
CleanExiMM_LASP1
ExpressionAtlasiQ61792 baseline and differential
GenevisibleiQ61792 MM

Family and domain databases

CDDicd11934 SH3_Lasp1_C, 1 hit
InterProiView protein in InterPro
IPR035630 Lasp1_SH3
IPR000900 Nebulin_repeat
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 1 hit
PF00880 Nebulin, 2 hits
PF14604 SH3_9, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00132 LIM, 1 hit
SM00227 NEBU, 2 hits
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit
PS51216 NEBULIN, 2 hits
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLASP1_MOUSE
AccessioniPrimary (citable) accession number: Q61792
Secondary accession number(s): Q62416
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: September 12, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again