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UniProtKB - Q61789 (LAMA3_MOUSE)

Entry version 190 (07 Apr 2021)
Sequence version 4 (16 Oct 2013)
Previous versions | rss
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Protein

Laminin subunit alpha-3

Gene

Lama3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Laminin-5 is thought to be involved in (1) cell adhesion via integrin alpha-3/beta-1 in focal adhesion and integrin alpha-6/beta-4 in hemidesmosomes, (2) signal transduction via tyrosine phosphorylation of pp125-FAK and p80, (3) differentiation of keratinocytes.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-1474228, Degradation of the extracellular matrix
R-MMU-2022090, Assembly of collagen fibrils and other multimeric structures
R-MMU-2214320, Anchoring fibril formation
R-MMU-3000157, Laminin interactions
R-MMU-446107, Type I hemidesmosome assembly
R-MMU-8874081, MET activates PTK2 signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Laminin subunit alpha-3
Alternative name(s):
Epiligrin subunit alpha
Kalinin subunit alpha
Laminin-5 subunit alpha
Laminin-6 subunit alpha
Laminin-7 subunit alpha
Nicein subunit alpha
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Lama3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:99909, Lama3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 311 PublicationAdd BLAST31
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001705932 – 3330Laminin subunit alpha-3Add BLAST3299

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi139N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi296 ↔ 305By similarity
Disulfide bondi298 ↔ 316By similarity
Disulfide bondi318 ↔ 327By similarity
Disulfide bondi330 ↔ 350By similarity
Disulfide bondi353 ↔ 362By similarity
Disulfide bondi355 ↔ 387By similarity
Disulfide bondi390 ↔ 399By similarity
Disulfide bondi402 ↔ 420By similarity
Disulfide bondi423 ↔ 433By similarity
Disulfide bondi425 ↔ 440By similarity
Disulfide bondi442 ↔ 451By similarity
Glycosylationi445N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi454 ↔ 464By similarity
Disulfide bondi488 ↔ 500By similarity
Disulfide bondi490 ↔ 506By similarity
Disulfide bondi508 ↔ 517By similarity
Disulfide bondi520 ↔ 530By similarity
Disulfide bondi533 ↔ 545By similarity
Disulfide bondi535 ↔ 552By similarity
Disulfide bondi554 ↔ 563By similarity
Disulfide bondi566 ↔ 583By similarity
Disulfide bondi628 ↔ 642By similarity
Disulfide bondi630 ↔ 649By similarity
Disulfide bondi651 ↔ 660By similarity
Disulfide bondi663 ↔ 678By similarity
Disulfide bondi681 ↔ 693By similarity
Disulfide bondi683 ↔ 700By similarity
Disulfide bondi702 ↔ 711By similarity
Disulfide bondi1309 ↔ 1316By similarity
Disulfide bondi1311 ↔ 1323By similarity
Disulfide bondi1325 ↔ 1334By similarity
Disulfide bondi1337 ↔ 1350By similarity
Disulfide bondi1353 ↔ 1368By similarity
Glycosylationi1354N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1355 ↔ 1375By similarity
Disulfide bondi1377 ↔ 1386By similarity
Disulfide bondi1389 ↔ 1399By similarity
Disulfide bondi1402 ↔ 1414By similarity
Disulfide bondi1404 ↔ 1421By similarity
Disulfide bondi1423 ↔ 1432By similarity
Disulfide bondi1435 ↔ 1450By similarity
Glycosylationi1673N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1684 ↔ 1693By similarity
Disulfide bondi1686 ↔ 1700By similarity
Disulfide bondi1703 ↔ 1712By similarity
Disulfide bondi1715 ↔ 1728By similarity
Disulfide bondi1731 ↔ 1743By similarity
Disulfide bondi1733 ↔ 1752By similarity
Disulfide bondi1754 ↔ 1763By similarity
Disulfide bondi1766 ↔ 1781By similarity
Disulfide bondi1819InterchainCurated
Disulfide bondi1822InterchainCurated
Glycosylationi2159N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2261N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2332N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2361N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2498N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2557 ↔ 2587By similarity
Glycosylationi2580N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2733 ↔ 2756By similarity
Glycosylationi2747N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2891 ↔ 2923By similarity
Glycosylationi3094N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3124 ↔ 3147By similarity
Glycosylationi3270N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3299 ↔ 3327By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q61789

PeptideAtlas

More...PeptideAtlasi		Q61789

PRoteomics IDEntifications database

More...PRIDEi		Q61789

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		264908 [Q61789-1]
264909 [Q61789-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q61789, 13 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q61789

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q61789

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Basal membrane of the upper alimentary tract and urinary and nasal epithelia, salivary glands and teeth (both variants). Isoform A is predominantly expressed in skin, hair follicles and developing neurons of the trigeminal ganglion. Isoform B was found in bronchi, alveoli, stomach, intestinal crypts, whisker pads, CNS, telencephalic neuroectoderm, thalamus, Rathke pouch and periventricular subependymal germinal layer.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000024421, Expressed in molar tooth and 143 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q61789, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Alpha-3 is a subunit of laminin-5 (laminin-332 or epiligrin/kalinin/nicein), laminin-6 (laminin-311 or K-laminin) and laminin-7 (laminin-321 or KS-laminin).

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		201098, 8 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-3012, Laminin-332 complex variant A [Q61789-2]
CPX-3013, Laminin-311 complex variant A [Q61789-2]
CPX-3014, Laminin-321 complex [Q61789-2]
CPX-3164, Laminin-332 complex variant B [Q61789-1]
CPX-3167, Laminin-311 complex variant B [Q61789-1]

Protein interaction database and analysis system

More...IntActi		Q61789, 1 interactor

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000089703

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q61789, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q61789

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini40 – 295Laminin N-terminalPROSITE-ProRule annotationAdd BLAST256
Domaini296 – 350Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST55
Domaini353 – 420Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST68
Domaini423 – 464Laminin EGF-like 3PROSITE-ProRule annotationAdd BLAST42
Domaini488 – 530Laminin EGF-like 4PROSITE-ProRule annotationAdd BLAST43
Domaini533 – 576Laminin EGF-like 5PROSITE-ProRule annotationAdd BLAST44
Domaini582 – 625Laminin EGF-like 6PROSITE-ProRule annotationAdd BLAST44
Domaini628 – 678Laminin EGF-like 7PROSITE-ProRule annotationAdd BLAST51
Domaini681 – 725Laminin EGF-like 8PROSITE-ProRule annotationAdd BLAST45
Domaini1309 – 1352Laminin EGF-like 9PROSITE-ProRule annotationAdd BLAST44
Domaini1353 – 1401Laminin EGF-like 10PROSITE-ProRule annotationAdd BLAST49
Domaini1402 – 1452Laminin EGF-like 11PROSITE-ProRule annotationAdd BLAST51
Domaini1453 – 1462Laminin EGF-like 12; first partPROSITE-ProRule annotation10
Domaini1466 – 1650Laminin IV type APROSITE-ProRule annotationAdd BLAST185
Domaini1651 – 1683Laminin EGF-like 12; second partPROSITE-ProRule annotationAdd BLAST33
Domaini1684 – 1730Laminin EGF-like 13PROSITE-ProRule annotationAdd BLAST47
Domaini1731 – 1783Laminin EGF-like 14PROSITE-ProRule annotationAdd BLAST53
Domaini1784 – 1818Laminin EGF-like 15; truncatedPROSITE-ProRule annotationAdd BLAST35
Domaini2386 – 2587Laminin G-like 1PROSITE-ProRule annotationAdd BLAST202
Domaini2594 – 2756Laminin G-like 2PROSITE-ProRule annotationAdd BLAST163
Domaini2763 – 2923Laminin G-like 3PROSITE-ProRule annotationAdd BLAST161
Domaini2983 – 3147Laminin G-like 4PROSITE-ProRule annotationAdd BLAST165
Domaini3154 – 3327Laminin G-like 5PROSITE-ProRule annotationAdd BLAST174

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni295 – 725Domain VAdd BLAST431
Regioni793 – 1262Domain IV 1 (domain IV B)Add BLAST470
Regioni1263 – 1462Domain III BAdd BLAST200
Regioni1651 – 1818Domain III AAdd BLAST168
Regioni1819 – 2385Domain II and IAdd BLAST567

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1851 – 1980Sequence analysisAdd BLAST130
Coiled coili2012 – 2057Sequence analysisAdd BLAST46
Coiled coili2088 – 2165Sequence analysisAdd BLAST78
Coiled coili2211 – 2238Sequence analysisAdd BLAST28
Coiled coili2318 – 2383Sequence analysisAdd BLAST66

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi2274 – 2276Cell attachment siteSequence analysis3

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
Domains IV and G are globular.

Keywords - Domaini

Coiled coil, Laminin EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1836, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155638

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000301_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q61789

Identification of Orthologs from Complete Genome Data

More...OMAi		IRANYWE

Database of Orthologous Groups

More...OrthoDBi		2342at2759

TreeFam database of animal gene trees

More...TreeFami		TF335359

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.120.1490, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013320, ConA-like_dom_sf
IPR000742, EGF-like_dom
IPR009254, Laminin_aI
IPR010307, Laminin_dom_II
IPR002049, Laminin_EGF
IPR001791, Laminin_G
IPR000034, Laminin_IV
IPR008211, Laminin_N
IPR038684, Laminin_N_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00052, Laminin_B, 1 hit
PF00053, Laminin_EGF, 12 hits
PF00054, Laminin_G_1, 1 hit
PF02210, Laminin_G_2, 4 hits
PF06008, Laminin_I, 1 hit
PF06009, Laminin_II, 1 hit
PF00055, Laminin_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00181, EGF, 8 hits
SM00180, EGF_Lam, 14 hits
SM00281, LamB, 1 hit
SM00282, LamG, 5 hits
SM00136, LamNT, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49899, SSF49899, 5 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00022, EGF_1, 11 hits
PS01186, EGF_2, 1 hit
PS01248, EGF_LAM_1, 12 hits
PS50027, EGF_LAM_2, 13 hits
PS50025, LAM_G_DOMAIN, 5 hits
PS51115, LAMININ_IVA, 1 hit
PS51117, LAMININ_NTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform B (identifier: Q61789-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVALGRAPR SLPLLLTLLL LLLLRMSPSW SVVGQDHPMS SRSLHPPYFN 
        60         70         80         90        100
LAQAARIWAT ATCGERDPEV SRPRPELFCK LVGGPAAQGS GHTIQGQFCD 
       110        120        130        140        150
YCNSEDSRKA HPASHAIDGS ERWWQSPPLS SGTQYNQVNL TLDLGQLFHV 
       160        170        180        190        200
AYILIKFANS PRPDLWILER SVDFGSTYSP WQYFAHSRRD CVEQFGQEAN 
       210        220        230        240        250
MAITQDDQML CVTEYSRIVP LENGEIVVSL INGRPGAKKF AFSDTLREFT 
       260        270        280        290        300
KATNIRLRFL RTNTLLGHLI SKAERDPTVT RRYYYSIKDI SVGGRCVCNG 
       310        320        330        340        350
HAEACSADNP EKQFRCECQH HTCGDTCNRC CAGYNQRRWQ PAGQEQHNEC 
       360        370        380        390        400
EACNCHGHAV DCYYDPDVEH QQASLNSKGV YAGGGVCINC QHNTAGVNCE 
       410        420        430        440        450
KCAKGYFRPH GVPVDALHGC IPCSCDPERA DDCDQGSGHC HCKPNFSGDY 
       460        470        480        490        500
CETCADGYYN FPFCLRIPVF PNYTPSPEDP VAGNIKGCDC NLEGVLPEIC 
       510        520        530        540        550
DDRGRCLCRP GVEGPQCDSC RSGSYSFPIC QACQCSTIGS YPVPCDPGNG 
       560        570        580        590        600
QCDCLPGITG RQCDRCLSGA YDFPYCQGSG SVCHPAGTLD SSLGYCQCKQ 
       610        620        630        640        650
HVASPTCSVC KPLYWNLAKE NPRGCSECQC HEAGTLSGIG ECGQEDGDCS 
       660        670        680        690        700
CKAHVTGDAC DTCEDGFFSL EKSNYFGCQG CQCDIGGALT TMCSGPSGVC 
       710        720        730        740        750
QCREHVEGKQ CQRPENNYYF PDLHHMKYEV EDGTGPNGRN LRFGFDPLVF 
       760        770        780        790        800
PEFSWRGYAP MTSVQNEVRV RLSVRQSSLS LFRIVLRYIS PGTEAISGRI 
       810        820        830        840        850
TLYSSQGDSD ALQSRKITFP PSKEPAFVTV PGNGFAGPFS ITPGTWIACI 
       860        870        880        890        900
QVEGVLLDYL VLLPRDYYEA FTLQVPVTEP CAHTGSPQDN CLLYQHLPLT 
       910        920        930        940        950
AFSCTLACEA RHFLLDGELR PLAMRQPTPT HPAMVDLSGR EVELQLRLRV 
       960        970        980        990       1000
PQVGHYVVLL EYATEVEQLF VVDVNLKSSG SALAGQVNIY SCKYSIPCRS 
      1010       1020       1030       1040       1050
VVIDSLSRTA VHELLADADI QLKAHMAHFL LYHICIIPAE EFSTEYLRPQ 
      1060       1070       1080       1090       1100
VHCIASYRQH ANPSASCVSL AHETPPTASI LDATSRGLFS ALPHEPSSPA 
      1110       1120       1130       1140       1150
DGVTLKAPQS QVTLKGLIPH LGRHVFVIHF YQAEHPGFPT EVIVNGGRQW 
      1160       1170       1180       1190       1200
SGSFLASFCP HLLGCRDQVI SDGQVEFDIS EAEVAVTVKI PDGKSLTLVR 
      1210       1220       1230       1240       1250
VLVVPAENYD YQILHKTTVD KSSEFISSCG GDSFYIDPQA ASGFCKNSAR 
      1260       1270       1280       1290       1300
SLVAFYHNGA IPCECDPAGT AGHHCSPEGG QCPCRPNVIG RQCSRCATGY 
      1310       1320       1330       1340       1350
YGFPYCKPCN CGRRLCEEVT GKCLCPPHTV RPQCEVCEMN SFNFHPVAGC 
      1360       1370       1380       1390       1400
DVCNCSRKGT IEAAVSECDR DSGQCRCKPR VTGQQCDKCA PGFYQFPECV 
      1410       1420       1430       1440       1450
PCSCNRDGTE PSVCDPETGA CMCKENVEGP QCQLCREGSF YLDPTNPKGC 
      1460       1470       1480       1490       1500
TKCFCFGVNT DCQSSHKQRA KFVDMMGWRL ETADGVDVPV SFNPGSNSMV 
      1510       1520       1530       1540       1550
ADLQELPPSV HSASWVAPPS YLGDKVSSYG GYLTYHAKSF GLPGDMVLLG 
      1560       1570       1580       1590       1600
KQPDVQLTGQ HMSLIHKEPS DPRPDRLHHG RVQVIEGNFR HEGSSAPVSR 
      1610       1620       1630       1640       1650
EELMTVLSRL ERLHIRGLHF TETQRLTLGE VGLEEASDTG SGPRAHLVEM 
      1660       1670       1680       1690       1700
CACPPDYTGD SCQGCRPGYY WDNKSLPVGR CVPCNCNGHS NRCQDGSGIC 
      1710       1720       1730       1740       1750
INCQHNTAGE HCERCQAGHY GNAIHGSCRV CPCPHTNSFA TGCAVDGGAV 
      1760       1770       1780       1790       1800
RCACKPGYTG TQCERCAPGY FGNPQKFGGS CQPCNCNSNG QLGPCDPLTG 
      1810       1820       1830       1840       1850
DCVNQEPKDG SPAEECDDCD SCVMTLLNDL ASMGEELRLV KSKLQGLSVS 
      1860       1870       1880       1890       1900
TGALEQIRHM ETQAKDLRNQ LLGFRSATSS HGSKMDDLEK ELSHLNREFE 
      1910       1920       1930       1940       1950
TLQEKAQVNS RKAQTLYNNI DQTIQSAKEL DMKIKNIVQN VHILLKQMAR 
      1960       1970       1980       1990       2000
PGGEGTDLPV GDWSRELAEA QRMMRDLRSR DFKKHLQEAE AEKMEAQLLL 
      2010       2020       2030       2040       2050
HRIRTWLESH QVENNGLLKN IRDSLNDYED KLQDLRSILQ EAAAQAKQAT 
      2060       2070       2080       2090       2100
GINHENEGVL GAIQRQMKEM DSLKNDFTKY LATADSSLLQ TNNLLQQMDK 
      2110       2120       2130       2140       2150
SQKEYESLAA ALNGARQELS DRVRELSRSG GKAPLVVEAE KHAQSLQELA 
      2160       2170       2180       2190       2200
KQLEEIKRNT SGDELVRCAV DAATAYENIL NAIRAAEDAA SKATSASKSA 
      2210       2220       2230       2240       2250
FQTVIKEDLP KRAKTLSSDS EELLNEAKMT QKRLQQVSPA LNSLQQTLKT 
      2260       2270       2280       2290       2300
VSVQKDLLDA NLTVARDDLH GIQRGDIDSV VIGAKSMVRE ANGITSEVLD 
      2310       2320       2330       2340       2350
GLNPIQTDLG RIKDSYESAR REDFSKALVD ANNSVKKLTR KLPDLFIKIE 
      2360       2370       2380       2390       2400
SINQQLLPLG NISDNVDRIR ELIQQARDAA NKVAIPMRFN GKSGVEVRLP 
      2410       2420       2430       2440       2450
NDLEDLKGYT SLSLFLQRPD LRENGGTEDM FVMYLGNKDA SKDYIGMAVV 
      2460       2470       2480       2490       2500
DGQLTCVYNL GDREAEVQID QVLTESESQE AVMDRVKFQR IYQFAKLNYT 
      2510       2520       2530       2540       2550
KEATSTKPKA PGVYDMESAS SNTLLNLDPE NAVFYVGGYP PGFELPRRLR 
      2560       2570       2580       2590       2600
FPPYKGCIEL DDLNENVLSL YNFKTTFNLN TTEVEPCRRR KEESDKNYFE 
      2610       2620       2630       2640       2650
GTGYARIPTQ PNAPFPNFMQ TIQTTVDRGL LFFAENQDNF ISLNIEDGNL 
      2660       2670       2680       2690       2700
MVKYKLNSEP PKEKGIRDTI NNGRDHMILI SIGKSQKRML INMNKHSIII 
      2710       2720       2730       2740       2750
EGEIFDFSTY YLGGIPIAIR ERFNISTPAF QGCMKNLKKT SGVVRLNDTV 
      2760       2770       2780       2790       2800
GVTKKCSEDW KLVRTASFSR GGQMSFTNLD VPSLDRFQLS FGFQTFQPSG 
      2810       2820       2830       2840       2850
TLLNHQTRTS SLLVTLEDGH IALSTRDSSS PIFKSPGTYM DGLLHHVSVI 
      2860       2870       2880       2890       2900
SDTSGLRLLI DDQVLRRNQR LASFSNAQQS LSMGGGYFEG CISNVFVQRM 
      2910       2920       2930       2940       2950
SQSPEVLDMA SKSTKRDAFL GGCSLNKPPF LMLFKSPKGF NKARSFNVNQ 
      2960       2970       2980       2990       3000
LLQDAPQAAR SIEAWQDGKS CLPPLNTKAT HRALQFGDSP TSHLLFKLPQ 
      3010       3020       3030       3040       3050
ELLKPRLQFS LDIQTTSSRG LVFHTGTRDS FVALYLSEGH VIFALGAGGK 
      3060       3070       3080       3090       3100
KLRLRSKERY HDGKWHSVVF GLSGRKVHLV VDGLRAQEGS LPGNSTISPR 
      3110       3120       3130       3140       3150
EQVYLGLSPS RKSKSLPQHS FVGCLRNFQL DSKPLDSPSA RSGVSPCLGG 
      3160       3170       3180       3190       3200
SLEKGIYFSQ GGGHVVLANS VSLEPALTLT LSIRPRSLTG VLIHIASQSG 
      3210       3220       3230       3240       3250
EHLSVYMEAG KVTTSMNSEA GGTVTSITPK RSLCDGQWHS VTVSIKQHTL 
      3260       3270       3280       3290       3300
HLELDTDNSY TAGQLSFPPN STRGSLHIGG VPDKLKMLTL PVWNSFFGCL 
      3310       3320       3330
KNIQVNHIPV PITEATDVQG SVSLNGCPDH
Length:3,330
Mass (Da):366,227
Last modified:October 16, 2013 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i993EB20BACDD6C59
GO
Isoform A (identifier: Q61789-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1619: Missing.
     1620-1662: FTETQRLTLG...CPPDYTGDSC → MLPAVRWSAW...QASYMELRPS

Show »
Length:1,724
Mass (Da):190,610
Checksum:i01153704F6DC87C3
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA58837 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti982A → R in CAA58837 (PubMed:7665604).Curated1
Sequence conflicti1150W → R in CAA58837 (PubMed:7665604).Curated1
Sequence conflicti1224E → K in CAA58837 (PubMed:7665604).Curated1
Sequence conflicti1272G → GH in CAA58837 (PubMed:7665604).Curated1
Sequence conflicti1291R → S in CAA58837 (PubMed:7665604).Curated1
Sequence conflicti1398E → K in CAA58837 (PubMed:7665604).Curated1
Sequence conflicti1466H → R in CAA58837 (PubMed:7665604).Curated1
Sequence conflicti1479R → V in CAA58837 (PubMed:7665604).Curated1
Sequence conflicti1488V → F in CAA58837 (PubMed:7665604).Curated1
Sequence conflicti1527 – 1528SS → II in CAA58837 (PubMed:7665604).Curated2
Sequence conflicti1608S → P in CAA58837 (PubMed:7665604).Curated1
Sequence conflicti1983 – 1984KK → QN in CAA58836 (PubMed:7665604).Curated2
Sequence conflicti1983 – 1984KK → QN in CAA58837 (PubMed:7665604).Curated2
Sequence conflicti1983 – 1984KK → QN in AAA68091 (PubMed:8012114).Curated2
Sequence conflicti1987Q → G in CAA58836 (PubMed:7665604).Curated1
Sequence conflicti1987Q → G in CAA58837 (PubMed:7665604).Curated1
Sequence conflicti1987Q → G in AAA68091 (PubMed:8012114).Curated1
Sequence conflicti2463R → G in CAA58836 (PubMed:7665604).Curated1
Sequence conflicti2463R → G in CAA58837 (PubMed:7665604).Curated1
Sequence conflicti2463R → G in AAA68091 (PubMed:8012114).Curated1
Sequence conflicti2488F → S in CAA58836 (PubMed:7665604).Curated1
Sequence conflicti2488F → S in CAA58837 (PubMed:7665604).Curated1
Sequence conflicti2488F → S in AAA68091 (PubMed:8012114).Curated1
Sequence conflicti2617 – 2620NFMQ → KLSW in CAA58836 (PubMed:7665604).Curated4
Sequence conflicti2617 – 2620NFMQ → KLSW in CAA58837 (PubMed:7665604).Curated4
Sequence conflicti2724 – 2725NI → PL in CAA58836 (PubMed:7665604).Curated2
Sequence conflicti2724 – 2725NI → PL in CAA58837 (PubMed:7665604).Curated2
Sequence conflicti3257D → Y in CAA58836 (PubMed:7665604).Curated1
Sequence conflicti3257D → Y in CAA58837 (PubMed:7665604).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0030381 – 1619Missing in isoform A. 1 PublicationAdd BLAST1619
Alternative sequenceiVSP_0030391620 – 1662FTETQ…TGDSC → MLPAVRWSAWSTGWLWIFGA ALGQCLGYGSEQQRVAFLQR PSQNHLQASYMELRPS in isoform A. 1 PublicationAdd BLAST43

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X84013 mRNA Translation: CAA58836.1
X84014 mRNA Translation: CAA58837.1 Frameshift.
AC102131 Genomic DNA No translation available.
AC102248 Genomic DNA No translation available.
AC139027 Genomic DNA No translation available.
AC157909 Genomic DNA No translation available.
AJ293592 mRNA Translation: CAB99254.2
U88353 mRNA Translation: AAC53179.1
L20478 mRNA Translation: AAA68091.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS50222.1 [Q61789-1]
CCDS84360.1 [Q61789-2]

NCBI Reference Sequences

More...RefSeqi		NP_001334390.1, NM_001347461.1 [Q61789-2]
NP_034810.1, NM_010680.1 [Q61789-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000092070; ENSMUSP00000089703; ENSMUSG00000024421 [Q61789-1]
ENSMUST00000188815; ENSMUSP00000140104; ENSMUSG00000024421 [Q61789-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		16774

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:16774

UCSC genome browser

More...UCSCi		uc008ecf.2, mouse [Q61789-1]
uc008ech.1, mouse [Q61789-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84013 mRNA Translation: CAA58836.1
X84014 mRNA Translation: CAA58837.1 Frameshift.
AC102131 Genomic DNA No translation available.
AC102248 Genomic DNA No translation available.
AC139027 Genomic DNA No translation available.
AC157909 Genomic DNA No translation available.
AJ293592 mRNA Translation: CAB99254.2
U88353 mRNA Translation: AAC53179.1
L20478 mRNA Translation: AAA68091.1
CCDSiCCDS50222.1 [Q61789-1]
CCDS84360.1 [Q61789-2]
RefSeqiNP_001334390.1, NM_001347461.1 [Q61789-2]
NP_034810.1, NM_010680.1 [Q61789-1]

3D structure databases

SMRiQ61789
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi201098, 8 interactors
ComplexPortaliCPX-3012, Laminin-332 complex variant A [Q61789-2]
CPX-3013, Laminin-311 complex variant A [Q61789-2]
CPX-3014, Laminin-321 complex [Q61789-2]
CPX-3164, Laminin-332 complex variant B [Q61789-1]
CPX-3167, Laminin-311 complex variant B [Q61789-1]
IntActiQ61789, 1 interactor
STRINGi10090.ENSMUSP00000089703

PTM databases

GlyGeniQ61789, 13 sites
iPTMnetiQ61789
PhosphoSitePlusiQ61789

Proteomic databases

PaxDbiQ61789
PeptideAtlasiQ61789
PRIDEiQ61789
ProteomicsDBi264908 [Q61789-1]
264909 [Q61789-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1948, 192 antibodies

Genome annotation databases

EnsembliENSMUST00000092070; ENSMUSP00000089703; ENSMUSG00000024421 [Q61789-1]
ENSMUST00000188815; ENSMUSP00000140104; ENSMUSG00000024421 [Q61789-2]
GeneIDi16774
KEGGimmu:16774
UCSCiuc008ecf.2, mouse [Q61789-1]
uc008ech.1, mouse [Q61789-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3909
MGIiMGI:99909, Lama3

Phylogenomic databases

eggNOGiKOG1836, Eukaryota
GeneTreeiENSGT00940000155638
HOGENOMiCLU_000301_1_0_1
InParanoidiQ61789
OMAiIRANYWE
OrthoDBi2342at2759
TreeFamiTF335359

Enzyme and pathway databases

ReactomeiR-MMU-1474228, Degradation of the extracellular matrix
R-MMU-2022090, Assembly of collagen fibrils and other multimeric structures
R-MMU-2214320, Anchoring fibril formation
R-MMU-3000157, Laminin interactions
R-MMU-446107, Type I hemidesmosome assembly
R-MMU-8874081, MET activates PTK2 signaling

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		16774, 1 hit in 53 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Lama3, mouse

Protein Ontology

More...PROi		PR:Q61789
RNActiQ61789, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000024421, Expressed in molar tooth and 143 other tissues
GenevisibleiQ61789, MM

Family and domain databases

Gene3Di2.60.120.1490, 1 hit
InterProiView protein in InterPro
IPR013320, ConA-like_dom_sf
IPR000742, EGF-like_dom
IPR009254, Laminin_aI
IPR010307, Laminin_dom_II
IPR002049, Laminin_EGF
IPR001791, Laminin_G
IPR000034, Laminin_IV
IPR008211, Laminin_N
IPR038684, Laminin_N_sf
PfamiView protein in Pfam
PF00052, Laminin_B, 1 hit
PF00053, Laminin_EGF, 12 hits
PF00054, Laminin_G_1, 1 hit
PF02210, Laminin_G_2, 4 hits
PF06008, Laminin_I, 1 hit
PF06009, Laminin_II, 1 hit
PF00055, Laminin_N, 1 hit
SMARTiView protein in SMART
SM00181, EGF, 8 hits
SM00180, EGF_Lam, 14 hits
SM00281, LamB, 1 hit
SM00282, LamG, 5 hits
SM00136, LamNT, 1 hit
SUPFAMiSSF49899, SSF49899, 5 hits
PROSITEiView protein in PROSITE
PS00022, EGF_1, 11 hits
PS01186, EGF_2, 1 hit
PS01248, EGF_LAM_1, 12 hits
PS50027, EGF_LAM_2, 13 hits
PS50025, LAM_G_DOMAIN, 5 hits
PS51115, LAMININ_IVA, 1 hit
PS51117, LAMININ_NTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLAMA3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q61789
Secondary accession number(s): E9PUR4
, O08751, Q61788, Q61966, Q9JHQ7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 16, 2013
Last modified: April 7, 2021
This is version 190 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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