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Protein

Ephrin type-A receptor 7

Gene

Epha7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7. Isoform 4 which lacks the kinase domain may regulate isoform 1 adhesive properties.3 Publications

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei665ATPPROSITE-ProRule annotation1
Active sitei758Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi639 – 647ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • axon guidance receptor activity Source: UniProtKB
  • chemorepellent activity Source: MGI
  • ephrin receptor binding Source: MGI
  • GPI-linked ephrin receptor activity Source: UniProtKB
  • protein tyrosine kinase activity Source: MGI
  • transmembrane-ephrin receptor activity Source: GO_Central
  • transmembrane receptor protein tyrosine kinase activity Source: GO_Central
  • transmembrane signaling receptor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase
Biological processApoptosis, Neurogenesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.1 3474
ReactomeiR-MMU-2682334 EPH-Ephrin signaling
R-MMU-3928663 EPHA-mediated growth cone collapse
R-MMU-3928665 EPH-ephrin mediated repulsion of cells

Names & Taxonomyi

Protein namesi
Recommended name:
Ephrin type-A receptor 7 (EC:2.7.10.1)
Alternative name(s):
Developmental kinase 1
Short name:
mDK-1
EPH homology kinase 3
Short name:
EHK-3
Embryonic brain kinase
Short name:
EBK
Gene namesi
Name:Epha7
Synonyms:Ebk, Ehk3, Mdk1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:95276 Epha7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 555ExtracellularSequence analysisAdd BLAST528
Transmembranei556 – 576HelicalSequence analysisAdd BLAST21
Topological domaini577 – 998CytoplasmicSequence analysisAdd BLAST422

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice are viable, fertile and show no gross morphological or behavioral defects. However, topographic targeting errors of nasal and temporal retinal axons appear during development of the retinocollicular projections in the visual system. 10 percent of the embryos also display exencephalic overgrowth of forebrain tissues which might be the result of reduced apoptosis.2 Publications

Chemistry databases

GuidetoPHARMACOLOGYi1827

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000001681928 – 998Ephrin type-A receptor 7Add BLAST971

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi343N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi410N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei608Phosphotyrosine; by autocatalysisSequence analysis1
Modified residuei614Phosphotyrosine; by autocatalysisSequence analysis1
Modified residuei791Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei940Phosphotyrosine; by autocatalysisSequence analysis1

Post-translational modificationi

Phosphorylated. Isoform 4 inhibits isoform 1 phosphorylation and may regulate its function in adhesion.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ61772
PeptideAtlasiQ61772
PRIDEiQ61772

PTM databases

iPTMnetiQ61772
PhosphoSitePlusiQ61772

Expressioni

Tissue specificityi

Widely expressed in embryo. In adult, expression restricted to hippocampus, testis and spleen. Expressed in myogenic progenitor cells (PubMed:27446912).1 Publication

Developmental stagei

During visual system development, expressed in an anterior to posterior decreasing gradient stretching through the entire midbrain. This gradient has the reverse orientation to the one defined by the expression of ephrins. Isoform 4 and isoform 5 are expressed at the edges of the embryonic cranial neural fold. In myogenic progenitor cells, highly expressed, at least as early as E11.5, expression decreases until 4 weeks after birth (PubMed:27446912).3 Publications

Gene expression databases

BgeeiENSMUSG00000028289 Expressed in 333 organ(s), highest expression level in dentate gyrus of hippocampal formation
CleanExiMM_EPHA7
ExpressionAtlasiQ61772 baseline and differential
GenevisibleiQ61772 MM

Interactioni

Subunit structurei

Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity). Interacts (via PDZ-binding motif) with GRIP1 and PICK1 (via PDZ domain).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199474, 1 interactor
STRINGi10090.ENSMUSP00000029964

Structurei

3D structure databases

ProteinModelPortaliQ61772
SMRiQ61772
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 210Eph LBDPROSITE-ProRule annotationAdd BLAST179
Domaini331 – 441Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST111
Domaini442 – 537Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96
Domaini633 – 894Protein kinasePROSITE-ProRule annotationAdd BLAST262
Domaini923 – 987SAMPROSITE-ProRule annotationAdd BLAST65

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi996 – 998PDZ-bindingSequence analysis3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi192 – 328Cys-richAdd BLAST137

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0196 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118975
HOGENOMiHOG000233856
HOVERGENiHBG062180
InParanoidiQ61772
KOiK05108
OrthoDBiEOG091G00W0
TreeFamiTF315608

Family and domain databases

CDDicd10485 EphR_LBD_A7, 1 hit
cd00063 FN3, 2 hits
Gene3Di2.60.120.260, 1 hit
2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR027936 Eph_TM
IPR034283 EphA7_rcpt_lig-bd
IPR001090 Ephrin_rcpt_lig-bd_dom
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR008979 Galactose-bd-like_sf
IPR009030 Growth_fac_rcpt_cys_sf
IPR013783 Ig-like_fold
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR016257 Tyr_kinase_ephrin_rcpt
IPR001426 Tyr_kinase_rcpt_V_CS
PfamiView protein in Pfam
PF14575 EphA2_TM, 1 hit
PF01404 Ephrin_lbd, 1 hit
PF00041 fn3, 2 hits
PF07714 Pkinase_Tyr, 1 hit
PF00536 SAM_1, 1 hit
PIRSFiPIRSF000666 TyrPK_ephrin_receptor, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00615 EPH_lbd, 1 hit
SM01411 Ephrin_rec_like, 1 hit
SM00060 FN3, 2 hits
SM00454 SAM, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF49265 SSF49265, 1 hit
SSF49785 SSF49785, 1 hit
SSF56112 SSF56112, 1 hit
SSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS01186 EGF_2, 1 hit
PS51550 EPH_LBD, 1 hit
PS50853 FN3, 2 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00790 RECEPTOR_TYR_KIN_V_1, 1 hit
PS00791 RECEPTOR_TYR_KIN_V_2, 1 hit
PS50105 SAM_DOMAIN, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q61772-1) [UniParc]FASTAAdd to basket
Also known as: MDK1, EPHA7-FL

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVVQTRFPSW IILCYIWLLG FAHTGEAQAA KEVLLLDSKA QQTELEWISS
60 70 80 90 100
PPSGWEEISG LDENYTPIRT YQVCQVMEPN QNNWLRTNWI SKGNAQRIFV
110 120 130 140 150
ELKFTLRDCN SLPGVLGTCK ETFNLYYYET DYDTGRNIRE NLYVKIDTIA
160 170 180 190 200
ADESFTQGDL GERKMKLNTE VREIGPLSKK GFYLAFQDVG ACIALVSVKV
210 220 230 240 250
YYKKCWSIVE NLAVFPDTVT GSEFSSLVEV RGTCVSSAEE EAENSPRMHC
260 270 280 290 300
SAEGEWLVPI GKCICKAGYQ QKGDTCEPCG RRFYKSSSQD LQCSRCPTHS
310 320 330 340 350
FSDREGSSRC ECEDGYYRAP SDPPYVACTR PPSAPQNLIF NINQTTVSLE
360 370 380 390 400
WSPPADNGGR NDVTYRILCK RCSWEQGECV PCGSNIGYMP QQTGLEDNYV
410 420 430 440 450
TVMDLLAHAN YTFEVEAVNG VSDLSRSQRL FAAVSITTGQ AAPSQVSGVM
460 470 480 490 500
KERVLQRSVQ LSWQEPEHPN GVITEYEIKY YEKDQRERTY STLKTKSTSA
510 520 530 540 550
SINNLKPGTV YVFQIRAVTA AGYGNYSPRL DVATLEEASG KMFEATAVSS
560 570 580 590 600
EQNPVIIIAV VAVAGTIILV FMVFGFIIGR RHCGYSKADQ EGDEELYFHF
610 620 630 640 650
KFPGTKTYID PETYEDPNRA VHQFAKELDA SCIKIERVIG AGEFGEVCSG
660 670 680 690 700
RLKLPGKRDV AVAIKTLKVG YTEKQRRDFL CEASIMGQFD HPNVVHLEGV
710 720 730 740 750
VTRGKPVMIV IEFMENGALD AFLRKHDGQF TVIQLVGMLR GIAAGMRYLA
760 770 780 790 800
DMGYVHRDLA ARNILVNSNL VCKVSDFGLS RVIEDDPEAV YTTTGGKIPV
810 820 830 840 850
RWTAPEAIQY RKFTSASDVW SYGIVMWEVM SYGERPYWDM SNQDVIKAIE
860 870 880 890 900
EGYRLPAPMD CPAGLHQLML DCWQKDRAER PKFEQIVGIL DKMIRNPSSL
910 920 930 940 950
KTPLGTCSRP LSPLLDQSTP DFTAFCSVGE WLQAIKMERY KDNFTAAGYN
960 970 980 990
SLESVARMTI DDVMSLGITL VGHQKKIMSS IQTMRAQMLH LHGTGIQV
Length:998
Mass (Da):111,860
Last modified:July 27, 2011 - v2
Checksum:iFCA1E83490E746E1
GO
Isoform 2 (identifier: Q61772-2) [UniParc]FASTAAdd to basket
Also known as: MDK1-1, Ebk-td1

The sequence of this isoform differs from the canonical sequence as follows:
     540-544: Missing.

Show »
Length:993
Mass (Da):111,268
Checksum:i2D1C811BCD1FA937
GO
Isoform 3 (identifier: Q61772-3) [UniParc]FASTAAdd to basket
Also known as: MDK1-2

The sequence of this isoform differs from the canonical sequence as follows:
     601-604: Missing.

Show »
Length:994
Mass (Da):111,431
Checksum:i25ADED280A8D9FBF
GO
Isoform 4 (identifier: Q61772-4) [UniParc]FASTAAdd to basket
Also known as: MDK1-T1, EPHA7-T1

The sequence of this isoform differs from the canonical sequence as follows:
     600-610: FKFPGTKTYID → SLVTNEHLSVL
     611-998: Missing.

Note: Truncated receptor lacking the kinase domain.
Show »
Length:610
Mass (Da):68,286
Checksum:iE61310A72FE1E739
GO
Isoform 5 (identifier: Q61772-5) [UniParc]FASTAAdd to basket
Also known as: MDK1-T2, EPHA7-T2

The sequence of this isoform differs from the canonical sequence as follows:
     600-626: FKFPGTKTYIDPETYEDPNRAVHQFAK → SLYRERGDGMEKTQHNKKWMIASCSRL
     627-998: Missing.

Note: Truncated receptor lacking the kinase domain.
Show »
Length:626
Mass (Da):70,300
Checksum:iF929755DC75B5664
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2BDQ4A2BDQ4_MOUSE
Eph receptor A7, isoform CRA_b
Epha7 mCG_14600
994Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti207S → T in CAA55687 (PubMed:7824284).Curated1
Sequence conflicti207S → T in CAA55688 (PubMed:7824284).Curated1
Sequence conflicti207S → T in CAA55689 (PubMed:7824284).Curated1
Sequence conflicti480Y → H in CAA57224 (PubMed:8541219).Curated1
Sequence conflicti657K → Q in CAA55687 (PubMed:7824284).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003006540 – 544Missing in isoform 2. 1 Publication5
Alternative sequenceiVSP_003010600 – 626FKFPG…HQFAK → SLYRERGDGMEKTQHNKKWM IASCSRL in isoform 5. CuratedAdd BLAST27
Alternative sequenceiVSP_003008600 – 610FKFPGTKTYID → SLVTNEHLSVL in isoform 4. CuratedAdd BLAST11
Alternative sequenceiVSP_003007601 – 604Missing in isoform 3. Curated4
Alternative sequenceiVSP_003009611 – 998Missing in isoform 4. CuratedAdd BLAST388
Alternative sequenceiVSP_003011627 – 998Missing in isoform 5. CuratedAdd BLAST372

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79082 mRNA Translation: CAA55687.1
X79083 mRNA Translation: CAA55688.1
X79084 mRNA Translation: CAA55689.1
AK030480 mRNA Translation: BAC26982.1
BX000989 Genomic DNA Translation: CAM21483.1
CH466538 Genomic DNA Translation: EDL05518.1
X81466 mRNA Translation: CAA57224.1
CCDSiCCDS18013.1 [Q61772-1]
CCDS51132.1 [Q61772-4]
CCDS71353.1 [Q61772-3]
PIRiI48612
I48614
JC5672
RefSeqiNP_001277363.1, NM_001290434.1
NP_034271.3, NM_010141.4 [Q61772-1]
XP_006537669.1, XM_006537606.3 [Q61772-2]
XP_006537670.1, XM_006537607.3 [Q61772-5]
UniGeneiMm.257266

Genome annotation databases

EnsembliENSMUST00000029964; ENSMUSP00000029964; ENSMUSG00000028289 [Q61772-1]
ENSMUST00000080934; ENSMUSP00000079735; ENSMUSG00000028289 [Q61772-4]
ENSMUST00000108194; ENSMUSP00000103829; ENSMUSG00000028289 [Q61772-5]
GeneIDi13841
KEGGimmu:13841
UCSCiuc008sen.3 mouse [Q61772-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79082 mRNA Translation: CAA55687.1
X79083 mRNA Translation: CAA55688.1
X79084 mRNA Translation: CAA55689.1
AK030480 mRNA Translation: BAC26982.1
BX000989 Genomic DNA Translation: CAM21483.1
CH466538 Genomic DNA Translation: EDL05518.1
X81466 mRNA Translation: CAA57224.1
CCDSiCCDS18013.1 [Q61772-1]
CCDS51132.1 [Q61772-4]
CCDS71353.1 [Q61772-3]
PIRiI48612
I48614
JC5672
RefSeqiNP_001277363.1, NM_001290434.1
NP_034271.3, NM_010141.4 [Q61772-1]
XP_006537669.1, XM_006537606.3 [Q61772-2]
XP_006537670.1, XM_006537607.3 [Q61772-5]
UniGeneiMm.257266

3D structure databases

ProteinModelPortaliQ61772
SMRiQ61772
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199474, 1 interactor
STRINGi10090.ENSMUSP00000029964

Chemistry databases

GuidetoPHARMACOLOGYi1827

PTM databases

iPTMnetiQ61772
PhosphoSitePlusiQ61772

Proteomic databases

PaxDbiQ61772
PeptideAtlasiQ61772
PRIDEiQ61772

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029964; ENSMUSP00000029964; ENSMUSG00000028289 [Q61772-1]
ENSMUST00000080934; ENSMUSP00000079735; ENSMUSG00000028289 [Q61772-4]
ENSMUST00000108194; ENSMUSP00000103829; ENSMUSG00000028289 [Q61772-5]
GeneIDi13841
KEGGimmu:13841
UCSCiuc008sen.3 mouse [Q61772-1]

Organism-specific databases

CTDi2045
MGIiMGI:95276 Epha7

Phylogenomic databases

eggNOGiKOG0196 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118975
HOGENOMiHOG000233856
HOVERGENiHBG062180
InParanoidiQ61772
KOiK05108
OrthoDBiEOG091G00W0
TreeFamiTF315608

Enzyme and pathway databases

BRENDAi2.7.10.1 3474
ReactomeiR-MMU-2682334 EPH-Ephrin signaling
R-MMU-3928663 EPHA-mediated growth cone collapse
R-MMU-3928665 EPH-ephrin mediated repulsion of cells

Miscellaneous databases

ChiTaRSiEpha7 mouse
PROiPR:Q61772
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028289 Expressed in 333 organ(s), highest expression level in dentate gyrus of hippocampal formation
CleanExiMM_EPHA7
ExpressionAtlasiQ61772 baseline and differential
GenevisibleiQ61772 MM

Family and domain databases

CDDicd10485 EphR_LBD_A7, 1 hit
cd00063 FN3, 2 hits
Gene3Di2.60.120.260, 1 hit
2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR027936 Eph_TM
IPR034283 EphA7_rcpt_lig-bd
IPR001090 Ephrin_rcpt_lig-bd_dom
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR008979 Galactose-bd-like_sf
IPR009030 Growth_fac_rcpt_cys_sf
IPR013783 Ig-like_fold
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR016257 Tyr_kinase_ephrin_rcpt
IPR001426 Tyr_kinase_rcpt_V_CS
PfamiView protein in Pfam
PF14575 EphA2_TM, 1 hit
PF01404 Ephrin_lbd, 1 hit
PF00041 fn3, 2 hits
PF07714 Pkinase_Tyr, 1 hit
PF00536 SAM_1, 1 hit
PIRSFiPIRSF000666 TyrPK_ephrin_receptor, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00615 EPH_lbd, 1 hit
SM01411 Ephrin_rec_like, 1 hit
SM00060 FN3, 2 hits
SM00454 SAM, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF49265 SSF49265, 1 hit
SSF49785 SSF49785, 1 hit
SSF56112 SSF56112, 1 hit
SSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS01186 EGF_2, 1 hit
PS51550 EPH_LBD, 1 hit
PS50853 FN3, 2 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00790 RECEPTOR_TYR_KIN_V_1, 1 hit
PS00791 RECEPTOR_TYR_KIN_V_2, 1 hit
PS50105 SAM_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEPHA7_MOUSE
AccessioniPrimary (citable) accession number: Q61772
Secondary accession number(s): Q61505
, Q61773, Q61774, Q8BSU8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 182 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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