UniProtKB - Q61772 (EPHA7_MOUSE)
Ephrin type-A receptor 7
Epha7
Functioni
Catalytic activityi
- EC:2.7.10.1PROSITE-ProRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 665 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 758 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 639 – 647 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- axon guidance receptor activity Source: UniProtKB
- chemorepellent activity Source: MGI
- ephrin receptor binding Source: MGI
- GPI-linked ephrin receptor activity Source: UniProtKB
- protein tyrosine kinase activity Source: MGI
- transmembrane-ephrin receptor activity Source: GO_Central
- transmembrane receptor protein tyrosine kinase activity Source: GO_Central
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- axon guidance Source: GO_Central
- brain development Source: UniProtKB
- branching morphogenesis of a nerve Source: MGI
- ephrin receptor signaling pathway Source: UniProtKB
- multicellular organism development Source: GO_Central
- negative regulation of collateral sprouting Source: BHF-UCL
- negative regulation of synapse assembly Source: BHF-UCL
- nephric duct morphogenesis Source: MGI
- phosphorylation Source: UniProtKB
- positive regulation of apoptotic process Source: MGI
- positive regulation of kinase activity Source: GO_Central
- positive regulation of neuron apoptotic process Source: MGI
- positive regulation of protein phosphorylation Source: BHF-UCL
- regulation of cell-cell adhesion Source: UniProtKB
- regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
- regulation of ERK1 and ERK2 cascade Source: UniProtKB
- regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
- regulation of postsynapse organization Source: SynGO
- regulation of protein autophosphorylation Source: UniProtKB
- retinal ganglion cell axon guidance Source: MGI
- transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Keywordsi
Molecular function | Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase |
Biological process | Apoptosis, Neurogenesis |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.10.1, 3474 |
Reactomei | R-MMU-2682334, EPH-Ephrin signaling R-MMU-3928663, EPHA-mediated growth cone collapse R-MMU-3928665, EPH-ephrin mediated repulsion of cells |
Names & Taxonomyi
Protein namesi | Recommended name: Ephrin type-A receptor 7 (EC:2.7.10.1)Alternative name(s): Developmental kinase 1 Short name: mDK-1 EPH homology kinase 3 Short name: EHK-3 Embryonic brain kinase Short name: EBK |
Gene namesi | Name:Epha7 Synonyms:Ebk, Ehk3, Mdk1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:95276, Epha7 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- integral component of postsynaptic density membrane Source: MGI
- integral component of postsynaptic specialization membrane Source: MGI
- postsynaptic membrane Source: MGI
Other locations
- dendrite Source: MGI
- glutamatergic synapse Source: SynGO
- hippocampal mossy fiber to CA3 synapse Source: MGI
- neuromuscular junction Source: MGI
- neuron projection Source: GO_Central
- neuronal cell body Source: MGI
- receptor complex Source: GO_Central
- Schaffer collateral - CA1 synapse Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 28 – 555 | ExtracellularSequence analysisAdd BLAST | 528 | |
Transmembranei | 556 – 576 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 577 – 998 | CytoplasmicSequence analysisAdd BLAST | 422 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
Chemistry databases
GuidetoPHARMACOLOGYi | 1827 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 27 | Sequence analysisAdd BLAST | 27 | |
ChainiPRO_0000016819 | 28 – 998 | Ephrin type-A receptor 7Add BLAST | 971 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 343 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 410 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 608 | Phosphotyrosine; by autocatalysisSequence analysis | 1 | |
Modified residuei | 614 | Phosphotyrosine; by autocatalysisSequence analysis | 1 | |
Modified residuei | 791 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 940 | Phosphotyrosine; by autocatalysisSequence analysis | 1 |
Post-translational modificationi
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | Q61772 |
PeptideAtlasi | Q61772 |
PRIDEi | Q61772 |
PTM databases
GlyGeni | Q61772, 2 sites |
iPTMneti | Q61772 |
PhosphoSitePlusi | Q61772 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSMUSG00000028289, Expressed in dentate gyrus of hippocampal formation and 352 other tissues |
ExpressionAtlasi | Q61772, baseline and differential |
Genevisiblei | Q61772, MM |
Interactioni
Subunit structurei
Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity).
Interacts (via PDZ-binding motif) with GRIP1 and PICK1 (via PDZ domain).
By similarity1 PublicationGO - Molecular functioni
- chemorepellent activity Source: MGI
- ephrin receptor binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 199474, 1 interactor |
STRINGi | 10090.ENSMUSP00000029964 |
Miscellaneous databases
RNActi | Q61772, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 32 – 210 | Eph LBDPROSITE-ProRule annotationAdd BLAST | 179 | |
Domaini | 331 – 441 | Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST | 111 | |
Domaini | 442 – 537 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 633 – 894 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 262 | |
Domaini | 923 – 987 | SAMPROSITE-ProRule annotationAdd BLAST | 65 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 996 – 998 | PDZ-bindingSequence analysis | 3 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 192 – 328 | Cys-richAdd BLAST | 137 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0196, Eukaryota |
GeneTreei | ENSGT00940000160189 |
HOGENOMi | CLU_000288_141_3_1 |
InParanoidi | Q61772 |
TreeFami | TF315608 |
Family and domain databases
CDDi | cd10485, EphR_LBD_A7, 1 hit cd00063, FN3, 2 hits |
Gene3Di | 1.10.150.50, 1 hit 2.60.120.260, 1 hit 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR027936, Eph_TM IPR034283, EphA7_rcpt_lig-bd IPR001090, Ephrin_rcpt_lig-bd_dom IPR003961, FN3_dom IPR036116, FN3_sf IPR008979, Galactose-bd-like_sf IPR009030, Growth_fac_rcpt_cys_sf IPR013783, Ig-like_fold IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001660, SAM IPR013761, SAM/pointed_sf IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR011641, Tyr-kin_ephrin_A/B_rcpt-like IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR016257, Tyr_kinase_ephrin_rcpt IPR001426, Tyr_kinase_rcpt_V_CS |
Pfami | View protein in Pfam PF14575, EphA2_TM, 1 hit PF01404, Ephrin_lbd, 1 hit PF00041, fn3, 2 hits PF07714, PK_Tyr_Ser-Thr, 1 hit PF00536, SAM_1, 1 hit |
PIRSFi | PIRSF000666, TyrPK_ephrin_receptor, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00615, EPH_lbd, 1 hit SM01411, Ephrin_rec_like, 1 hit SM00060, FN3, 2 hits SM00454, SAM, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit SSF49265, SSF49265, 1 hit SSF49785, SSF49785, 1 hit SSF56112, SSF56112, 1 hit SSF57184, SSF57184, 1 hit |
PROSITEi | View protein in PROSITE PS01186, EGF_2, 1 hit PS51550, EPH_LBD, 1 hit PS50853, FN3, 2 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS00790, RECEPTOR_TYR_KIN_V_1, 1 hit PS00791, RECEPTOR_TYR_KIN_V_2, 1 hit PS50105, SAM_DOMAIN, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVVQTRFPSW IILCYIWLLG FAHTGEAQAA KEVLLLDSKA QQTELEWISS
60 70 80 90 100
PPSGWEEISG LDENYTPIRT YQVCQVMEPN QNNWLRTNWI SKGNAQRIFV
110 120 130 140 150
ELKFTLRDCN SLPGVLGTCK ETFNLYYYET DYDTGRNIRE NLYVKIDTIA
160 170 180 190 200
ADESFTQGDL GERKMKLNTE VREIGPLSKK GFYLAFQDVG ACIALVSVKV
210 220 230 240 250
YYKKCWSIVE NLAVFPDTVT GSEFSSLVEV RGTCVSSAEE EAENSPRMHC
260 270 280 290 300
SAEGEWLVPI GKCICKAGYQ QKGDTCEPCG RRFYKSSSQD LQCSRCPTHS
310 320 330 340 350
FSDREGSSRC ECEDGYYRAP SDPPYVACTR PPSAPQNLIF NINQTTVSLE
360 370 380 390 400
WSPPADNGGR NDVTYRILCK RCSWEQGECV PCGSNIGYMP QQTGLEDNYV
410 420 430 440 450
TVMDLLAHAN YTFEVEAVNG VSDLSRSQRL FAAVSITTGQ AAPSQVSGVM
460 470 480 490 500
KERVLQRSVQ LSWQEPEHPN GVITEYEIKY YEKDQRERTY STLKTKSTSA
510 520 530 540 550
SINNLKPGTV YVFQIRAVTA AGYGNYSPRL DVATLEEASG KMFEATAVSS
560 570 580 590 600
EQNPVIIIAV VAVAGTIILV FMVFGFIIGR RHCGYSKADQ EGDEELYFHF
610 620 630 640 650
KFPGTKTYID PETYEDPNRA VHQFAKELDA SCIKIERVIG AGEFGEVCSG
660 670 680 690 700
RLKLPGKRDV AVAIKTLKVG YTEKQRRDFL CEASIMGQFD HPNVVHLEGV
710 720 730 740 750
VTRGKPVMIV IEFMENGALD AFLRKHDGQF TVIQLVGMLR GIAAGMRYLA
760 770 780 790 800
DMGYVHRDLA ARNILVNSNL VCKVSDFGLS RVIEDDPEAV YTTTGGKIPV
810 820 830 840 850
RWTAPEAIQY RKFTSASDVW SYGIVMWEVM SYGERPYWDM SNQDVIKAIE
860 870 880 890 900
EGYRLPAPMD CPAGLHQLML DCWQKDRAER PKFEQIVGIL DKMIRNPSSL
910 920 930 940 950
KTPLGTCSRP LSPLLDQSTP DFTAFCSVGE WLQAIKMERY KDNFTAAGYN
960 970 980 990
SLESVARMTI DDVMSLGITL VGHQKKIMSS IQTMRAQMLH LHGTGIQV
The sequence of this isoform differs from the canonical sequence as follows:
600-626: FKFPGTKTYIDPETYEDPNRAVHQFAK → SLYRERGDGMEKTQHNKKWMIASCSRL
627-998: Missing.
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA2BDQ4 | A2BDQ4_MOUSE | Receptor protein-tyrosine kinase | Epha7 | 994 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 207 | S → T in CAA55687 (PubMed:7824284).Curated | 1 | |
Sequence conflicti | 207 | S → T in CAA55688 (PubMed:7824284).Curated | 1 | |
Sequence conflicti | 207 | S → T in CAA55689 (PubMed:7824284).Curated | 1 | |
Sequence conflicti | 480 | Y → H in CAA57224 (PubMed:8541219).Curated | 1 | |
Sequence conflicti | 657 | K → Q in CAA55687 (PubMed:7824284).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_003006 | 540 – 544 | Missing in isoform 2. 1 Publication | 5 | |
Alternative sequenceiVSP_003010 | 600 – 626 | FKFPG…HQFAK → SLYRERGDGMEKTQHNKKWM IASCSRL in isoform 5. CuratedAdd BLAST | 27 | |
Alternative sequenceiVSP_003008 | 600 – 610 | FKFPGTKTYID → SLVTNEHLSVL in isoform 4. CuratedAdd BLAST | 11 | |
Alternative sequenceiVSP_003007 | 601 – 604 | Missing in isoform 3. Curated | 4 | |
Alternative sequenceiVSP_003009 | 611 – 998 | Missing in isoform 4. CuratedAdd BLAST | 388 | |
Alternative sequenceiVSP_003011 | 627 – 998 | Missing in isoform 5. CuratedAdd BLAST | 372 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X79082 mRNA Translation: CAA55687.1 X79083 mRNA Translation: CAA55688.1 X79084 mRNA Translation: CAA55689.1 AK030480 mRNA Translation: BAC26982.1 BX000989 Genomic DNA No translation available. CH466538 Genomic DNA Translation: EDL05518.1 X81466 mRNA Translation: CAA57224.1 |
CCDSi | CCDS18013.1 [Q61772-1] CCDS51132.1 [Q61772-4] CCDS71353.1 [Q61772-3] |
PIRi | I48612 I48614 JC5672 |
RefSeqi | NP_001277363.1, NM_001290434.1 NP_034271.3, NM_010141.4 [Q61772-1] XP_006537669.1, XM_006537606.3 [Q61772-2] XP_006537670.1, XM_006537607.3 [Q61772-5] |
Genome annotation databases
Ensembli | ENSMUST00000029964; ENSMUSP00000029964; ENSMUSG00000028289 [Q61772-1] ENSMUST00000080934; ENSMUSP00000079735; ENSMUSG00000028289 [Q61772-4] ENSMUST00000108194; ENSMUSP00000103829; ENSMUSG00000028289 [Q61772-5] |
GeneIDi | 13841 |
KEGGi | mmu:13841 |
UCSCi | uc008sen.3, mouse [Q61772-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X79082 mRNA Translation: CAA55687.1 X79083 mRNA Translation: CAA55688.1 X79084 mRNA Translation: CAA55689.1 AK030480 mRNA Translation: BAC26982.1 BX000989 Genomic DNA No translation available. CH466538 Genomic DNA Translation: EDL05518.1 X81466 mRNA Translation: CAA57224.1 |
CCDSi | CCDS18013.1 [Q61772-1] CCDS51132.1 [Q61772-4] CCDS71353.1 [Q61772-3] |
PIRi | I48612 I48614 JC5672 |
RefSeqi | NP_001277363.1, NM_001290434.1 NP_034271.3, NM_010141.4 [Q61772-1] XP_006537669.1, XM_006537606.3 [Q61772-2] XP_006537670.1, XM_006537607.3 [Q61772-5] |
3D structure databases
SMRi | Q61772 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 199474, 1 interactor |
STRINGi | 10090.ENSMUSP00000029964 |
Chemistry databases
GuidetoPHARMACOLOGYi | 1827 |
PTM databases
GlyGeni | Q61772, 2 sites |
iPTMneti | Q61772 |
PhosphoSitePlusi | Q61772 |
Proteomic databases
PaxDbi | Q61772 |
PeptideAtlasi | Q61772 |
PRIDEi | Q61772 |
Protocols and materials databases
Antibodypediai | 642, 515 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000029964; ENSMUSP00000029964; ENSMUSG00000028289 [Q61772-1] ENSMUST00000080934; ENSMUSP00000079735; ENSMUSG00000028289 [Q61772-4] ENSMUST00000108194; ENSMUSP00000103829; ENSMUSG00000028289 [Q61772-5] |
GeneIDi | 13841 |
KEGGi | mmu:13841 |
UCSCi | uc008sen.3, mouse [Q61772-1] |
Organism-specific databases
CTDi | 2045 |
MGIi | MGI:95276, Epha7 |
Phylogenomic databases
eggNOGi | KOG0196, Eukaryota |
GeneTreei | ENSGT00940000160189 |
HOGENOMi | CLU_000288_141_3_1 |
InParanoidi | Q61772 |
TreeFami | TF315608 |
Enzyme and pathway databases
BRENDAi | 2.7.10.1, 3474 |
Reactomei | R-MMU-2682334, EPH-Ephrin signaling R-MMU-3928663, EPHA-mediated growth cone collapse R-MMU-3928665, EPH-ephrin mediated repulsion of cells |
Miscellaneous databases
BioGRID-ORCSi | 13841, 0 hits in 17 CRISPR screens |
ChiTaRSi | Epha7, mouse |
PROi | PR:Q61772 |
RNActi | Q61772, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000028289, Expressed in dentate gyrus of hippocampal formation and 352 other tissues |
ExpressionAtlasi | Q61772, baseline and differential |
Genevisiblei | Q61772, MM |
Family and domain databases
CDDi | cd10485, EphR_LBD_A7, 1 hit cd00063, FN3, 2 hits |
Gene3Di | 1.10.150.50, 1 hit 2.60.120.260, 1 hit 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR027936, Eph_TM IPR034283, EphA7_rcpt_lig-bd IPR001090, Ephrin_rcpt_lig-bd_dom IPR003961, FN3_dom IPR036116, FN3_sf IPR008979, Galactose-bd-like_sf IPR009030, Growth_fac_rcpt_cys_sf IPR013783, Ig-like_fold IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001660, SAM IPR013761, SAM/pointed_sf IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR011641, Tyr-kin_ephrin_A/B_rcpt-like IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR016257, Tyr_kinase_ephrin_rcpt IPR001426, Tyr_kinase_rcpt_V_CS |
Pfami | View protein in Pfam PF14575, EphA2_TM, 1 hit PF01404, Ephrin_lbd, 1 hit PF00041, fn3, 2 hits PF07714, PK_Tyr_Ser-Thr, 1 hit PF00536, SAM_1, 1 hit |
PIRSFi | PIRSF000666, TyrPK_ephrin_receptor, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00615, EPH_lbd, 1 hit SM01411, Ephrin_rec_like, 1 hit SM00060, FN3, 2 hits SM00454, SAM, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit SSF49265, SSF49265, 1 hit SSF49785, SSF49785, 1 hit SSF56112, SSF56112, 1 hit SSF57184, SSF57184, 1 hit |
PROSITEi | View protein in PROSITE PS01186, EGF_2, 1 hit PS51550, EPH_LBD, 1 hit PS50853, FN3, 2 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS00790, RECEPTOR_TYR_KIN_V_1, 1 hit PS00791, RECEPTOR_TYR_KIN_V_2, 1 hit PS50105, SAM_DOMAIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EPHA7_MOUSE | |
Accessioni | Q61772Primary (citable) accession number: Q61772 Secondary accession number(s): Q61505 Q8BSU8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | July 27, 2011 | |
Last modified: | December 2, 2020 | |
This is version 195 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human and mouse protein kinases
Human and mouse protein kinases: classification and index