UniProtKB - Q61771 (KIF3B_MOUSE)
Kinesin-like protein KIF3B
Kif3b
Functioni
Microtubule-based molecular motor that transport intracellular cargos, such as vesicles, organelles and protein complexes. Uses ATP hydrolysis to generate force to bind and move along the microtubule (PubMed:7559760).
Plays a role in cilia formation (PubMed:9865700).
Involved in photoreceptor integrity and opsin trafficking in rod photoreceptors (By similarity).
Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit GRIN2A into neuronal dendrites (PubMed:31746486).
By similarity3 PublicationsRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 96 – 103 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- ATP hydrolysis activity Source: GO_Central
- intraciliary transport particle B binding Source: MGI
- microtubule binding Source: MGI
- microtubule motor activity Source: GO_Central
- small GTPase binding Source: MGI
GO - Biological processi
- anterograde dendritic transport of neurotransmitter receptor complex Source: UniProtKB
- cilium assembly Source: UniProtKB
- intraciliary transport Source: UniProtKB
- microtubule-based movement Source: GO_Central
- mitotic spindle assembly Source: MGI
- opsin transport Source: UniProtKB
- positive regulation of cytokinesis Source: MGI
- vesicle-mediated transport Source: UniProtKB
Keywordsi
Molecular function | Motor protein |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-MMU-2132295, MHC class II antigen presentation R-MMU-5620924, Intraflagellar transport R-MMU-6811434, COPI-dependent Golgi-to-ER retrograde traffic R-MMU-983189, Kinesins |
Names & Taxonomyi
Protein namesi | Recommended name: Kinesin-like protein KIF3BAlternative name(s): Microtubule plus end-directed kinesin motor 3B Cleaved into the following chain: |
Gene namesi | Name:Kif3bImported |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:107688, Kif3b |
VEuPathDBi | HostDB:ENSMUSG00000027475 |
Subcellular locationi
Cytoskeleton
- cytoskeleton Curated
Other locations
- cilium 2 Publications
- dendritic spine 1 Publication
Note: Colocalized with GRIN2A in dendritic shafts and in DLG4-positive spines.1 Publication
Cytoskeleton
- centrosome Source: MGI
- kinesin complex Source: GO_Central
- kinesin II complex Source: MGI
- microtubule Source: GO_Central
- microtubule cytoskeleton Source: MGI
- spindle Source: MGI
Cytosol
- cytosol Source: Reactome
Other locations
- axon Source: MGI
- cilium Source: UniProtKB
- dendrite Source: UniProtKB
- dendrite cytoplasm Source: GOC
- dendritic spine Source: UniProtKB-SubCell
- midbody Source: MGI
Keywords - Cellular componenti
Cell junction, Cell projection, Cytoplasm, Cytoskeleton, Microtubule, SynapsePathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000424496 | 1 – 747 | Kinesin-like protein KIF3BAdd BLAST | 747 | |
Initiator methioninei | Removed; alternateBy similarity | |||
ChainiPRO_0000125396 | 2 – 747 | Kinesin-like protein KIF3B, N-terminally processedAdd BLAST | 746 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 2 | N-acetylserine; in Kinesin-like protein KIF3B, N-terminally processedBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q61771 |
MaxQBi | Q61771 |
PaxDbi | Q61771 |
PRIDEi | Q61771 |
ProteomicsDBi | 269219 |
PTM databases
iPTMneti | Q61771 |
PhosphoSitePlusi | Q61771 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000027475, Expressed in spermatocyte and 287 other tissues |
ExpressionAtlasi | Q61771, baseline and differential |
Genevisiblei | Q61771, MM |
Interactioni
Subunit structurei
Heterodimer of KIF3A and KIF3B (PubMed:7559760). KIF3A/KIF3B heterodimer interacts with KIFAP3 forming a heterotrimeric (KIF3A/KIF3B/KIFAP3) complex (PubMed:8710890).
Interacts with the SMC3 subunit of the cohesin complex (By similarity).
Interacts directly with IFT20 (PubMed:12821668).
Interacts with FLCN (By similarity).
By similarity3 PublicationsBinary interactionsi
GO - Molecular functioni
- microtubule binding Source: MGI
- small GTPase binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 200942, 14 interactors |
ComplexPortali | CPX-3203, KIF3 complex variant AB CPX-3204, KIF3 complex variant AB-KAP3 |
CORUMi | Q61771 |
IntActi | Q61771, 8 interactors |
MINTi | Q61771 |
STRINGi | 10090.ENSMUSP00000028977 |
Miscellaneous databases
RNActi | Q61771, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 9 – 340 | Kinesin motorPROSITE-ProRule annotationAdd BLAST | 332 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 374 – 412 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 580 – 747 | GlobularAdd BLAST | 168 | |
Regioni | 698 – 747 | DisorderedSequence analysisAdd BLAST | 50 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 346 – 579 | Sequence analysisAdd BLAST | 234 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 392 – 412 | Acidic residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 720 – 739 | Polar residuesSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG4280, Eukaryota |
GeneTreei | ENSGT00940000153739 |
HOGENOMi | CLU_001485_22_4_1 |
InParanoidi | Q61771 |
OMAi | LESKMLC |
OrthoDBi | 862274at2759 |
PhylomeDBi | Q61771 |
TreeFami | TF105223 |
Family and domain databases
Gene3Di | 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR027640, Kinesin-like_fam IPR019821, Kinesin_motor_CS IPR001752, Kinesin_motor_dom IPR036961, Kinesin_motor_dom_sf IPR027417, P-loop_NTPase |
PANTHERi | PTHR24115, PTHR24115, 1 hit |
Pfami | View protein in Pfam PF00225, Kinesin, 1 hit |
PRINTSi | PR00380, KINESINHEAVY |
SMARTi | View protein in SMART SM00129, KISc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00411, KINESIN_MOTOR_1, 1 hit PS50067, KINESIN_MOTOR_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MSKLKSSESV RVVVRCRPMN GKEKAASYDK VVDVDVKLGQ VSVKNPKGTS
60 70 80 90 100
HEMPKTFTFD AVYDWNAKQF ELYDETFRPL VDSVLQGFNG TIFAYGQTGT
110 120 130 140 150
GKTYTMEGVR GDPEKRGVIP NSFDHIFTHI SRSQNQQYLV RASYLEIYQE
160 170 180 190 200
EIRDLLSKDQ TKRLELKERP DTGVYVKDLS SFVTKSVKEI EHVMNVGNQN
210 220 230 240 250
RSVGATNMNE HSSRSHAIFV ITIECSEVGL DGENHIRVGK LNLVDLAGSE
260 270 280 290 300
RQAKTGAQGE RLKEATKINL SLSALGNVIS ALVDGKSTHI PYRDSKLTRL
310 320 330 340 350
LQDSLGGNAK TVMVANVGPA SYNVEETLTT LRYANRAKNI KNKPRVNEDP
360 370 380 390 400
KDALLREFQE EIARLKAQLE KRSIGRRKRR EKRREGGGSG GGGEEEEEEG
410 420 430 440 450
EEGEEDGDDK DDYWREQQEK LEIEKRAIVE DHSLVAEEKM RLLKEKEKKM
460 470 480 490 500
EDLRREKDAA EMLGAKIKAM ESKLLVGGKN IVDHTNEQQK ILEQKRQEIA
510 520 530 540 550
EQKRREREIQ QQMESRDEET LELKETYTSL QQEVDIKTKK LKKLFSKLQA
560 570 580 590 600
VKAEIHDLQE EHIKERQELE QTQNELTREL KLKHLIIENF IPLEEKNKIM
610 620 630 640 650
NRSFFDDEED HWKLHPITRL ENQQMMKRPV SAVGYKRPLS QHARMSMMIR
660 670 680 690 700
PEPRYRAENI MLLELDMPSR TTRDYEGPAI SPKVQAALDA ALQDEDEIQV
710 720 730 740
DASSFESTAS RKPKARPKSG RKSGSSSSSS GNPASQFYPQ SRGLVPK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 13 | V → M in BAE28411 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 34 | V → A in BAC38996 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 710 | S → N in BAE28411 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D26077 mRNA Translation: BAA05070.1 AK148200 mRNA Translation: BAE28411.1 AK083700 mRNA Translation: BAC38996.1 |
CCDSi | CCDS16911.1 |
PIRi | A57107 |
RefSeqi | NP_032470.3, NM_008444.4 |
Genome annotation databases
Ensembli | ENSMUST00000028977; ENSMUSP00000028977; ENSMUSG00000027475 |
GeneIDi | 16569 |
KEGGi | mmu:16569 |
UCSCi | uc008nhp.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D26077 mRNA Translation: BAA05070.1 AK148200 mRNA Translation: BAE28411.1 AK083700 mRNA Translation: BAC38996.1 |
CCDSi | CCDS16911.1 |
PIRi | A57107 |
RefSeqi | NP_032470.3, NM_008444.4 |
3D structure databases
AlphaFoldDBi | Q61771 |
SMRi | Q61771 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 200942, 14 interactors |
ComplexPortali | CPX-3203, KIF3 complex variant AB CPX-3204, KIF3 complex variant AB-KAP3 |
CORUMi | Q61771 |
IntActi | Q61771, 8 interactors |
MINTi | Q61771 |
STRINGi | 10090.ENSMUSP00000028977 |
PTM databases
iPTMneti | Q61771 |
PhosphoSitePlusi | Q61771 |
Proteomic databases
EPDi | Q61771 |
MaxQBi | Q61771 |
PaxDbi | Q61771 |
PRIDEi | Q61771 |
ProteomicsDBi | 269219 |
Protocols and materials databases
Antibodypediai | 1560, 115 antibodies from 22 providers |
DNASUi | 16569 |
Genome annotation databases
Ensembli | ENSMUST00000028977; ENSMUSP00000028977; ENSMUSG00000027475 |
GeneIDi | 16569 |
KEGGi | mmu:16569 |
UCSCi | uc008nhp.2, mouse |
Organism-specific databases
CTDi | 9371 |
MGIi | MGI:107688, Kif3b |
VEuPathDBi | HostDB:ENSMUSG00000027475 |
Phylogenomic databases
eggNOGi | KOG4280, Eukaryota |
GeneTreei | ENSGT00940000153739 |
HOGENOMi | CLU_001485_22_4_1 |
InParanoidi | Q61771 |
OMAi | LESKMLC |
OrthoDBi | 862274at2759 |
PhylomeDBi | Q61771 |
TreeFami | TF105223 |
Enzyme and pathway databases
Reactomei | R-MMU-2132295, MHC class II antigen presentation R-MMU-5620924, Intraflagellar transport R-MMU-6811434, COPI-dependent Golgi-to-ER retrograde traffic R-MMU-983189, Kinesins |
Miscellaneous databases
BioGRID-ORCSi | 16569, 6 hits in 72 CRISPR screens |
ChiTaRSi | Kif3b, mouse |
PROi | PR:Q61771 |
RNActi | Q61771, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000027475, Expressed in spermatocyte and 287 other tissues |
ExpressionAtlasi | Q61771, baseline and differential |
Genevisiblei | Q61771, MM |
Family and domain databases
Gene3Di | 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR027640, Kinesin-like_fam IPR019821, Kinesin_motor_CS IPR001752, Kinesin_motor_dom IPR036961, Kinesin_motor_dom_sf IPR027417, P-loop_NTPase |
PANTHERi | PTHR24115, PTHR24115, 1 hit |
Pfami | View protein in Pfam PF00225, Kinesin, 1 hit |
PRINTSi | PR00380, KINESINHEAVY |
SMARTi | View protein in SMART SM00129, KISc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00411, KINESIN_MOTOR_1, 1 hit PS50067, KINESIN_MOTOR_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | KIF3B_MOUSE | |
Accessioni | Q61771Primary (citable) accession number: Q61771 Secondary accession number(s): Q3UFZ8, Q8BNH4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | November 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 156 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families