Kif3b

Functionⁱ

Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity).By similarity

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	96 – 103	ATPPROSITE-ProRule annotation		8

GO - Molecular functionⁱ

ATPase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
ATP binding Source: UniProtKB-KW
intraciliary transport particle B binding
Source: MGI
Inferred from direct assayⁱ
- 12821668
microtubule binding Source: MGI
microtubule motor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
Rho GTPase binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

microtubule-based movement
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
mitotic spindle assembly Source: MGI
positive regulation of cytokinesis Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Motor protein
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2132295 MHC class II antigen presentation R-MMU-5620924 Intraflagellar transport R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic R-MMU-983189 Kinesins

Reactomeⁱ

R-MMU-2132295 MHC class II antigen presentation
R-MMU-5620924 Intraflagellar transport
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-MMU-983189 Kinesins

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Kinesin-like protein KIF3B Alternative name(s): Microtubule plus end-directed kinesin motor 3B Cleaved into the following chain: Kinesin-like protein KIF3B, N-terminally processed
Gene namesⁱ	Name:Kif3b
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 2

Organism-specific databases

MGIⁱ	MGI:107688 Kif3b

Keywords - Cellular componentⁱ

Cell projection, Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
ChainⁱPRO_0000424496	1 – 747	Kinesin-like protein KIF3BAdd BLAST	747
Initiator methionineⁱ		Removed; alternateBy similarity
ChainⁱPRO_0000125396	2 – 747	Kinesin-like protein KIF3B, N-terminally processedAdd BLAST	746

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	1	N-acetylmethionineBy similarity		1
Modified residueⁱ	2	N-acetylserine; in Kinesin-like protein KIF3B, N-terminally processedBy similarity		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	Q61771
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q61771
PaxDbⁱ	Q61771
PRIDEⁱ	Q61771

PTM databases

iPTMnetⁱ	Q61771
PhosphoSitePlusⁱ	Q61771

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000027475 Expressed in 261 organ(s), highest expression level in testis
CleanExⁱ	MM_KIF3B
ExpressionAtlasⁱ	Q61771 baseline and differential
Genevisibleⁱ	Q61771 MM

Interactionⁱ

Subunit structureⁱ

Interacts with the SMC3 subunit of the cohesin complex (By similarity). Heterodimer of KIF3A and KIF3B (PubMed:7559760). Interacts directly with IFT20 (PubMed:12821668).By similarity2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Kif3a	P28741	5	EBI-6395332,EBI-6169413
Trim60	Q8VI40	3	EBI-6395332,EBI-6395249

GO - Molecular functionⁱ

microtubule binding Source: MGI
Rho GTPase binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	200942, 5 interactors
ComplexPortalⁱ	CPX-3203 KIF3 complex variant AB CPX-3204 KIF3 complex variant AB-KAP3
CORUMⁱ	Q61771
IntActⁱ	Q61771, 6 interactors
Molecular INTeraction database More...MINTⁱ	Q61771
STRINGⁱ	10090.ENSMUSP00000028977

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q61771
SMRⁱ	Q61771
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	9 – 340	Kinesin motorPROSITE-ProRule annotationAdd BLAST		332

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	580 – 747	GlobularAdd BLAST		168

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	346 – 579	Sequence analysisAdd BLAST		234

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	386 – 393	Poly-Gly	8
Compositional biasⁱ	394 – 405	Poly-GluAdd BLAST	12
Compositional biasⁱ	723 – 730	Poly-Ser	8

Sequence similaritiesⁱ

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG0240 Eukaryota COG5059 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150817
HOVERGENⁱ	HBG052255
InParanoidⁱ	Q61771
KEGG Orthology (KO) More...KOⁱ	K20196
OMAⁱ	DMPARTT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03RO
TreeFamⁱ	TF105223

Family and domain databases

Gene3Dⁱ	3.40.850.10, 1 hit
InterProⁱ	View protein in InterPro IPR027640 Kinesin-like_fam IPR019821 Kinesin_motor_CS IPR001752 Kinesin_motor_dom IPR036961 Kinesin_motor_dom_sf IPR027417 P-loop_NTPase
PANTHERⁱ	PTHR24115 PTHR24115, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00225 Kinesin, 1 hit
PRINTSⁱ	PR00380 KINESINHEAVY
SMARTⁱ	View protein in SMART SM00129 KISc, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS00411 KINESIN_MOTOR_1, 1 hit PS50067 KINESIN_MOTOR_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q61771-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSKLKSSESV RVVVRCRPMN GKEKAASYDK VVDVDVKLGQ VSVKNPKGTS 
        60         70         80         90        100
HEMPKTFTFD AVYDWNAKQF ELYDETFRPL VDSVLQGFNG TIFAYGQTGT 
       110        120        130        140        150
GKTYTMEGVR GDPEKRGVIP NSFDHIFTHI SRSQNQQYLV RASYLEIYQE 
       160        170        180        190        200
EIRDLLSKDQ TKRLELKERP DTGVYVKDLS SFVTKSVKEI EHVMNVGNQN 
       210        220        230        240        250
RSVGATNMNE HSSRSHAIFV ITIECSEVGL DGENHIRVGK LNLVDLAGSE 
       260        270        280        290        300
RQAKTGAQGE RLKEATKINL SLSALGNVIS ALVDGKSTHI PYRDSKLTRL 
       310        320        330        340        350
LQDSLGGNAK TVMVANVGPA SYNVEETLTT LRYANRAKNI KNKPRVNEDP 
       360        370        380        390        400
KDALLREFQE EIARLKAQLE KRSIGRRKRR EKRREGGGSG GGGEEEEEEG 
       410        420        430        440        450
EEGEEDGDDK DDYWREQQEK LEIEKRAIVE DHSLVAEEKM RLLKEKEKKM 
       460        470        480        490        500
EDLRREKDAA EMLGAKIKAM ESKLLVGGKN IVDHTNEQQK ILEQKRQEIA 
       510        520        530        540        550
EQKRREREIQ QQMESRDEET LELKETYTSL QQEVDIKTKK LKKLFSKLQA 
       560        570        580        590        600
VKAEIHDLQE EHIKERQELE QTQNELTREL KLKHLIIENF IPLEEKNKIM 
       610        620        630        640        650
NRSFFDDEED HWKLHPITRL ENQQMMKRPV SAVGYKRPLS QHARMSMMIR 
       660        670        680        690        700
PEPRYRAENI MLLELDMPSR TTRDYEGPAI SPKVQAALDA ALQDEDEIQV 
       710        720        730        740 
DASSFESTAS RKPKARPKSG RKSGSSSSSS GNPASQFYPQ SRGLVPK

Length:747

Mass (Da):85,288

Last modified:November 1, 1996 - v1

Checksum:ⁱFA369A4190EC8B47

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D26077 mRNA Translation: BAA05070.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS16911.1
PIRⁱ	A57107
NCBI Reference Sequences More...RefSeqⁱ	NP_032470.3, NM_008444.4
UniGeneⁱ	Mm.315560

Genome annotation databases

Ensemblⁱ	ENSMUST00000028977; ENSMUSP00000028977; ENSMUSG00000027475
GeneIDⁱ	16569
KEGGⁱ	mmu:16569
UCSC genome browser More...UCSCⁱ	uc008nhp.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q61771	Kinesin-like protein (Fragment)		MOUSE		757	UniRef100_Q61771
Kinesin-like protein		MOUSE		747

Protein	Similar proteins		Species	Score	Length	Source
Q61771	Kinesin-like protein KIF3B	)	HUMAN		747	UniRef90_O15066
Kinesin-like protein		PANTR		747
Kinesin-like protein		COLAP		747
Kinesin-like protein		CERAT		747
Kinesin-like protein		PAPAN		747
+229

Protein	Similar proteins		Species	Score	Length	Source
Q61771	Kinesin-like protein KIF3B	)	HUMAN		747	UniRef50_O15066
Kinesin-like protein		PANTR		747
Kinesin-like protein		COLAP		747
Kinesin-like protein		CERAT		747
Kinesin-like protein		PAPAN		747
+287

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D26077 mRNA Translation: BAA05070.1
CCDSⁱ	CCDS16911.1
PIRⁱ	A57107
RefSeqⁱ	NP_032470.3, NM_008444.4
UniGeneⁱ	Mm.315560

3D structure databases

ProteinModelPortalⁱ	Q61771
SMRⁱ	Q61771
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	200942, 5 interactors
ComplexPortalⁱ	CPX-3203 KIF3 complex variant AB CPX-3204 KIF3 complex variant AB-KAP3
CORUMⁱ	Q61771
IntActⁱ	Q61771, 6 interactors
MINTⁱ	Q61771
STRINGⁱ	10090.ENSMUSP00000028977

PTM databases

iPTMnetⁱ	Q61771
PhosphoSitePlusⁱ	Q61771

Proteomic databases

EPDⁱ	Q61771
MaxQBⁱ	Q61771
PaxDbⁱ	Q61771
PRIDEⁱ	Q61771

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000028977; ENSMUSP00000028977; ENSMUSG00000027475
GeneIDⁱ	16569
KEGGⁱ	mmu:16569
UCSCⁱ	uc008nhp.2 mouse

Organism-specific databases

CTDⁱ	9371
MGIⁱ	MGI:107688 Kif3b

Phylogenomic databases

eggNOGⁱ	KOG0240 Eukaryota COG5059 LUCA
GeneTreeⁱ	ENSGT00930000150817
HOVERGENⁱ	HBG052255
InParanoidⁱ	Q61771
KOⁱ	K20196
OMAⁱ	DMPARTT
OrthoDBⁱ	EOG091G03RO
TreeFamⁱ	TF105223

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2132295 MHC class II antigen presentation R-MMU-5620924 Intraflagellar transport R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic R-MMU-983189 Kinesins

Reactomeⁱ

R-MMU-2132295 MHC class II antigen presentation
R-MMU-5620924 Intraflagellar transport
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-MMU-983189 Kinesins

Miscellaneous databases

ChiTaRSⁱ	Kif3b mouse
Protein Ontology More...PROⁱ	PR:Q61771
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000027475 Expressed in 261 organ(s), highest expression level in testis
CleanExⁱ	MM_KIF3B
ExpressionAtlasⁱ	Q61771 baseline and differential
Genevisibleⁱ	Q61771 MM

Family and domain databases

Gene3Dⁱ	3.40.850.10, 1 hit
InterProⁱ	View protein in InterPro IPR027640 Kinesin-like_fam IPR019821 Kinesin_motor_CS IPR001752 Kinesin_motor_dom IPR036961 Kinesin_motor_dom_sf IPR027417 P-loop_NTPase
PANTHERⁱ	PTHR24115 PTHR24115, 1 hit
Pfamⁱ	View protein in Pfam PF00225 Kinesin, 1 hit
PRINTSⁱ	PR00380 KINESINHEAVY
SMARTⁱ	View protein in SMART SM00129 KISc, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS00411 KINESIN_MOTOR_1, 1 hit PS50067 KINESIN_MOTOR_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KIF3B_MOUSE
Accessionⁱ	Q61771Primary (citable) accession number: Q61771
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
	Last sequence update:	November 1, 1996
	Last modified:	November 7, 2018
	This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q61771 (KIF3B_MOUSE)

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Kinesin-like protein KIF3B

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Other locations

Cytoskeleton

Cytosol

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Coiled coil

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ