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Protein

Kinesin-like protein KIF3B

Gene

Kif3b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi96 – 103ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity Source: GO_Central
  • ATP binding Source: UniProtKB-KW
  • intraciliary transport particle B binding Source: MGI
  • microtubule binding Source: MGI
  • microtubule motor activity Source: GO_Central
  • Rho GTPase binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-2132295 MHC class II antigen presentation
R-MMU-5620924 Intraflagellar transport
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-MMU-983189 Kinesins

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF3B
Alternative name(s):
Microtubule plus end-directed kinesin motor 3B
Cleaved into the following chain:
Gene namesi
Name:Kif3b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:107688 Kif3b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004244961 – 747Kinesin-like protein KIF3BAdd BLAST747
Initiator methionineiRemoved; alternateBy similarity
ChainiPRO_00001253962 – 747Kinesin-like protein KIF3B, N-terminally processedAdd BLAST746

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei2N-acetylserine; in Kinesin-like protein KIF3B, N-terminally processedBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ61771
MaxQBiQ61771
PaxDbiQ61771
PRIDEiQ61771

PTM databases

iPTMnetiQ61771
PhosphoSitePlusiQ61771

Expressioni

Gene expression databases

BgeeiENSMUSG00000027475 Expressed in 261 organ(s), highest expression level in testis
CleanExiMM_KIF3B
ExpressionAtlasiQ61771 baseline and differential
GenevisibleiQ61771 MM

Interactioni

Subunit structurei

Interacts with the SMC3 subunit of the cohesin complex (By similarity). Heterodimer of KIF3A and KIF3B (PubMed:7559760). Interacts directly with IFT20 (PubMed:12821668).By similarity2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200942, 5 interactors
ComplexPortaliCPX-3203 KIF3 complex variant AB
CPX-3204 KIF3 complex variant AB-KAP3
CORUMiQ61771
IntActiQ61771, 6 interactors
MINTiQ61771
STRINGi10090.ENSMUSP00000028977

Structurei

3D structure databases

ProteinModelPortaliQ61771
SMRiQ61771
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 340Kinesin motorPROSITE-ProRule annotationAdd BLAST332

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni580 – 747GlobularAdd BLAST168

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili346 – 579Sequence analysisAdd BLAST234

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi386 – 393Poly-Gly8
Compositional biasi394 – 405Poly-GluAdd BLAST12
Compositional biasi723 – 730Poly-Ser8

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0240 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00930000150817
HOVERGENiHBG052255
InParanoidiQ61771
KOiK20196
OMAiDMPARTT
OrthoDBiEOG091G03RO
TreeFamiTF105223

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61771-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKLKSSESV RVVVRCRPMN GKEKAASYDK VVDVDVKLGQ VSVKNPKGTS
60 70 80 90 100
HEMPKTFTFD AVYDWNAKQF ELYDETFRPL VDSVLQGFNG TIFAYGQTGT
110 120 130 140 150
GKTYTMEGVR GDPEKRGVIP NSFDHIFTHI SRSQNQQYLV RASYLEIYQE
160 170 180 190 200
EIRDLLSKDQ TKRLELKERP DTGVYVKDLS SFVTKSVKEI EHVMNVGNQN
210 220 230 240 250
RSVGATNMNE HSSRSHAIFV ITIECSEVGL DGENHIRVGK LNLVDLAGSE
260 270 280 290 300
RQAKTGAQGE RLKEATKINL SLSALGNVIS ALVDGKSTHI PYRDSKLTRL
310 320 330 340 350
LQDSLGGNAK TVMVANVGPA SYNVEETLTT LRYANRAKNI KNKPRVNEDP
360 370 380 390 400
KDALLREFQE EIARLKAQLE KRSIGRRKRR EKRREGGGSG GGGEEEEEEG
410 420 430 440 450
EEGEEDGDDK DDYWREQQEK LEIEKRAIVE DHSLVAEEKM RLLKEKEKKM
460 470 480 490 500
EDLRREKDAA EMLGAKIKAM ESKLLVGGKN IVDHTNEQQK ILEQKRQEIA
510 520 530 540 550
EQKRREREIQ QQMESRDEET LELKETYTSL QQEVDIKTKK LKKLFSKLQA
560 570 580 590 600
VKAEIHDLQE EHIKERQELE QTQNELTREL KLKHLIIENF IPLEEKNKIM
610 620 630 640 650
NRSFFDDEED HWKLHPITRL ENQQMMKRPV SAVGYKRPLS QHARMSMMIR
660 670 680 690 700
PEPRYRAENI MLLELDMPSR TTRDYEGPAI SPKVQAALDA ALQDEDEIQV
710 720 730 740
DASSFESTAS RKPKARPKSG RKSGSSSSSS GNPASQFYPQ SRGLVPK
Length:747
Mass (Da):85,288
Last modified:November 1, 1996 - v1
Checksum:iFA369A4190EC8B47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26077 mRNA Translation: BAA05070.1
CCDSiCCDS16911.1
PIRiA57107
RefSeqiNP_032470.3, NM_008444.4
UniGeneiMm.315560

Genome annotation databases

EnsembliENSMUST00000028977; ENSMUSP00000028977; ENSMUSG00000027475
GeneIDi16569
KEGGimmu:16569
UCSCiuc008nhp.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26077 mRNA Translation: BAA05070.1
CCDSiCCDS16911.1
PIRiA57107
RefSeqiNP_032470.3, NM_008444.4
UniGeneiMm.315560

3D structure databases

ProteinModelPortaliQ61771
SMRiQ61771
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200942, 5 interactors
ComplexPortaliCPX-3203 KIF3 complex variant AB
CPX-3204 KIF3 complex variant AB-KAP3
CORUMiQ61771
IntActiQ61771, 6 interactors
MINTiQ61771
STRINGi10090.ENSMUSP00000028977

PTM databases

iPTMnetiQ61771
PhosphoSitePlusiQ61771

Proteomic databases

EPDiQ61771
MaxQBiQ61771
PaxDbiQ61771
PRIDEiQ61771

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028977; ENSMUSP00000028977; ENSMUSG00000027475
GeneIDi16569
KEGGimmu:16569
UCSCiuc008nhp.2 mouse

Organism-specific databases

CTDi9371
MGIiMGI:107688 Kif3b

Phylogenomic databases

eggNOGiKOG0240 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00930000150817
HOVERGENiHBG052255
InParanoidiQ61771
KOiK20196
OMAiDMPARTT
OrthoDBiEOG091G03RO
TreeFamiTF105223

Enzyme and pathway databases

ReactomeiR-MMU-2132295 MHC class II antigen presentation
R-MMU-5620924 Intraflagellar transport
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-MMU-983189 Kinesins

Miscellaneous databases

ChiTaRSiKif3b mouse
PROiPR:Q61771
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027475 Expressed in 261 organ(s), highest expression level in testis
CleanExiMM_KIF3B
ExpressionAtlasiQ61771 baseline and differential
GenevisibleiQ61771 MM

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKIF3B_MOUSE
AccessioniPrimary (citable) accession number: Q61771
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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