UniProtKB - Q61771 (KIF3B_MOUSE)
Protein
Kinesin-like protein KIF3B
Gene
Kif3b
Organism
Mus musculus (Mouse)
Status
Functioni
Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity).By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 96 – 103 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATPase activity Source: GO_Central
- ATP binding Source: UniProtKB-KW
- intraciliary transport particle B binding Source: MGI
- microtubule binding Source: MGI
- microtubule motor activity Source: GO_Central
- Rho GTPase binding Source: MGI
GO - Biological processi
- microtubule-based movement Source: GO_Central
- mitotic spindle assembly Source: MGI
- positive regulation of cytokinesis Source: MGI
Keywordsi
Molecular function | Motor protein |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-MMU-2132295, MHC class II antigen presentation R-MMU-5620924, Intraflagellar transport R-MMU-6811434, COPI-dependent Golgi-to-ER retrograde traffic R-MMU-983189, Kinesins |
Names & Taxonomyi
Protein namesi | Recommended name: Kinesin-like protein KIF3BAlternative name(s): Microtubule plus end-directed kinesin motor 3B Cleaved into the following chain: |
Gene namesi | Name:Kif3b |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:107688, Kif3b |
Subcellular locationi
Cytoskeleton
- cytoskeleton Curated
Other locations
- cilium 1 Publication
Cytoskeleton
- centrosome Source: MGI
- kinesin complex Source: GO_Central
- kinesin II complex Source: MGI
- microtubule Source: GO_Central
- microtubule cytoskeleton Source: MGI
- spindle Source: MGI
Cytosol
- cytosol Source: Reactome
Other locations
Keywords - Cellular componenti
Cell projection, Cytoplasm, Cytoskeleton, MicrotubulePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000424496 | 1 – 747 | Kinesin-like protein KIF3BAdd BLAST | 747 | |
Initiator methioninei | Removed; alternateBy similarity | |||
ChainiPRO_0000125396 | 2 – 747 | Kinesin-like protein KIF3B, N-terminally processedAdd BLAST | 746 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 2 | N-acetylserine; in Kinesin-like protein KIF3B, N-terminally processedBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q61771 |
MaxQBi | Q61771 |
PaxDbi | Q61771 |
PRIDEi | Q61771 |
PTM databases
iPTMneti | Q61771 |
PhosphoSitePlusi | Q61771 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000027475, Expressed in spermatocyte and 281 other tissues |
ExpressionAtlasi | Q61771, baseline and differential |
Genevisiblei | Q61771, MM |
Interactioni
Subunit structurei
Binary interactionsi
Hide detailsGO - Molecular functioni
- microtubule binding Source: MGI
- Rho GTPase binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 200942, 13 interactors |
ComplexPortali | CPX-3203, KIF3 complex variant AB CPX-3204, KIF3 complex variant AB-KAP3 |
CORUMi | Q61771 |
IntActi | Q61771, 6 interactors |
MINTi | Q61771 |
STRINGi | 10090.ENSMUSP00000028977 |
Miscellaneous databases
RNActi | Q61771, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 9 – 340 | Kinesin motorPROSITE-ProRule annotationAdd BLAST | 332 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 580 – 747 | GlobularAdd BLAST | 168 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 346 – 579 | Sequence analysisAdd BLAST | 234 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 386 – 393 | Poly-Gly | 8 | |
Compositional biasi | 394 – 405 | Poly-GluAdd BLAST | 12 | |
Compositional biasi | 723 – 730 | Poly-Ser | 8 |
Sequence similaritiesi
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.PROSITE-ProRule annotation
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG4280, Eukaryota |
GeneTreei | ENSGT00940000153739 |
HOGENOMi | CLU_001485_22_4_1 |
InParanoidi | Q61771 |
OMAi | LESKMLC |
OrthoDBi | 862274at2759 |
TreeFami | TF105223 |
Family and domain databases
Gene3Di | 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR027640, Kinesin-like_fam IPR019821, Kinesin_motor_CS IPR001752, Kinesin_motor_dom IPR036961, Kinesin_motor_dom_sf IPR027417, P-loop_NTPase |
PANTHERi | PTHR24115, PTHR24115, 1 hit |
Pfami | View protein in Pfam PF00225, Kinesin, 1 hit |
PRINTSi | PR00380, KINESINHEAVY |
SMARTi | View protein in SMART SM00129, KISc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00411, KINESIN_MOTOR_1, 1 hit PS50067, KINESIN_MOTOR_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q61771-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSKLKSSESV RVVVRCRPMN GKEKAASYDK VVDVDVKLGQ VSVKNPKGTS
60 70 80 90 100
HEMPKTFTFD AVYDWNAKQF ELYDETFRPL VDSVLQGFNG TIFAYGQTGT
110 120 130 140 150
GKTYTMEGVR GDPEKRGVIP NSFDHIFTHI SRSQNQQYLV RASYLEIYQE
160 170 180 190 200
EIRDLLSKDQ TKRLELKERP DTGVYVKDLS SFVTKSVKEI EHVMNVGNQN
210 220 230 240 250
RSVGATNMNE HSSRSHAIFV ITIECSEVGL DGENHIRVGK LNLVDLAGSE
260 270 280 290 300
RQAKTGAQGE RLKEATKINL SLSALGNVIS ALVDGKSTHI PYRDSKLTRL
310 320 330 340 350
LQDSLGGNAK TVMVANVGPA SYNVEETLTT LRYANRAKNI KNKPRVNEDP
360 370 380 390 400
KDALLREFQE EIARLKAQLE KRSIGRRKRR EKRREGGGSG GGGEEEEEEG
410 420 430 440 450
EEGEEDGDDK DDYWREQQEK LEIEKRAIVE DHSLVAEEKM RLLKEKEKKM
460 470 480 490 500
EDLRREKDAA EMLGAKIKAM ESKLLVGGKN IVDHTNEQQK ILEQKRQEIA
510 520 530 540 550
EQKRREREIQ QQMESRDEET LELKETYTSL QQEVDIKTKK LKKLFSKLQA
560 570 580 590 600
VKAEIHDLQE EHIKERQELE QTQNELTREL KLKHLIIENF IPLEEKNKIM
610 620 630 640 650
NRSFFDDEED HWKLHPITRL ENQQMMKRPV SAVGYKRPLS QHARMSMMIR
660 670 680 690 700
PEPRYRAENI MLLELDMPSR TTRDYEGPAI SPKVQAALDA ALQDEDEIQV
710 720 730 740
DASSFESTAS RKPKARPKSG RKSGSSSSSS GNPASQFYPQ SRGLVPK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D26077 mRNA Translation: BAA05070.1 |
CCDSi | CCDS16911.1 |
PIRi | A57107 |
RefSeqi | NP_032470.3, NM_008444.4 |
Genome annotation databases
Ensembli | ENSMUST00000028977; ENSMUSP00000028977; ENSMUSG00000027475 |
GeneIDi | 16569 |
KEGGi | mmu:16569 |
UCSCi | uc008nhp.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D26077 mRNA Translation: BAA05070.1 |
CCDSi | CCDS16911.1 |
PIRi | A57107 |
RefSeqi | NP_032470.3, NM_008444.4 |
3D structure databases
SMRi | Q61771 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 200942, 13 interactors |
ComplexPortali | CPX-3203, KIF3 complex variant AB CPX-3204, KIF3 complex variant AB-KAP3 |
CORUMi | Q61771 |
IntActi | Q61771, 6 interactors |
MINTi | Q61771 |
STRINGi | 10090.ENSMUSP00000028977 |
PTM databases
iPTMneti | Q61771 |
PhosphoSitePlusi | Q61771 |
Proteomic databases
EPDi | Q61771 |
MaxQBi | Q61771 |
PaxDbi | Q61771 |
PRIDEi | Q61771 |
Protocols and materials databases
Antibodypediai | 1560, 112 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000028977; ENSMUSP00000028977; ENSMUSG00000027475 |
GeneIDi | 16569 |
KEGGi | mmu:16569 |
UCSCi | uc008nhp.2, mouse |
Organism-specific databases
CTDi | 9371 |
MGIi | MGI:107688, Kif3b |
Phylogenomic databases
eggNOGi | KOG4280, Eukaryota |
GeneTreei | ENSGT00940000153739 |
HOGENOMi | CLU_001485_22_4_1 |
InParanoidi | Q61771 |
OMAi | LESKMLC |
OrthoDBi | 862274at2759 |
TreeFami | TF105223 |
Enzyme and pathway databases
Reactomei | R-MMU-2132295, MHC class II antigen presentation R-MMU-5620924, Intraflagellar transport R-MMU-6811434, COPI-dependent Golgi-to-ER retrograde traffic R-MMU-983189, Kinesins |
Miscellaneous databases
BioGRID-ORCSi | 16569, 5 hits in 17 CRISPR screens |
ChiTaRSi | Kif3b, mouse |
PROi | PR:Q61771 |
RNActi | Q61771, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000027475, Expressed in spermatocyte and 281 other tissues |
ExpressionAtlasi | Q61771, baseline and differential |
Genevisiblei | Q61771, MM |
Family and domain databases
Gene3Di | 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR027640, Kinesin-like_fam IPR019821, Kinesin_motor_CS IPR001752, Kinesin_motor_dom IPR036961, Kinesin_motor_dom_sf IPR027417, P-loop_NTPase |
PANTHERi | PTHR24115, PTHR24115, 1 hit |
Pfami | View protein in Pfam PF00225, Kinesin, 1 hit |
PRINTSi | PR00380, KINESINHEAVY |
SMARTi | View protein in SMART SM00129, KISc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00411, KINESIN_MOTOR_1, 1 hit PS50067, KINESIN_MOTOR_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KIF3B_MOUSE | |
Accessioni | Q61771Primary (citable) accession number: Q61771 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | November 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families