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Protein

Kallikrein 1-related peptidase b24

Gene

Klk1b24

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.Curated

Catalytic activityi

Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei65Charge relay systemBy similarity1
Active sitei122Charge relay systemBy similarity1
Active sitei215Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

  • proteolysis Source: UniProtKB

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.069

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein 1-related peptidase b24 (EC:3.4.21.35)
Alternative name(s):
Glandular kallikrein K24
Short name:
mGK-24
Tissue kallikrein 24
Gene namesi
Name:Klk1b24
Synonyms:Klk-24, Klk24
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:892021 Klk1b24

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
PropeptideiPRO_000002799118 – 24Activation peptideBy similarity7
ChainiPRO_000002799225 – 263Kallikrein 1-related peptidase b24Add BLAST239

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 175PROSITE-ProRule annotationBy similarity
Disulfide bondi50 ↔ 66PROSITE-ProRule annotationBy similarity
Glycosylationi69N-linked (GlcNAc...) asparagineCurated1
Glycosylationi105N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi154 ↔ 221PROSITE-ProRule annotationBy similarity
Glycosylationi185N-linked (GlcNAc...) asparagineCurated1
Disulfide bondi186 ↔ 200PROSITE-ProRule annotationBy similarity
Disulfide bondi211 ↔ 236PROSITE-ProRule annotationBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

MaxQBiQ61754
PaxDbiQ61754
PRIDEiQ61754

PTM databases

iPTMnetiQ61754
PhosphoSitePlusiQ61754

Expressioni

Gene expression databases

BgeeiENSMUSG00000063713
CleanExiMM_KLK1B24
GenevisibleiQ61754 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000073392

Structurei

3D structure databases

ProteinModelPortaliQ61754
SMRiQ61754
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 260Peptidase S1PROSITE-ProRule annotationAdd BLAST236

Sequence similaritiesi

Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00920000149111
HOGENOMiHOG000251820
HOVERGENiHBG013304
InParanoidiQ61754
KOiK01325
OMAiLPNENCT
OrthoDBiEOG091G0DF7
PhylomeDBiQ61754
TreeFamiTF331065

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61754-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWFLILFLAL SLGGIDAAPP VQSRVVGGFK CEKNSQPWHV AVFRYNKYIC
60 70 80 90 100
GGVLLNPNWV LTAAHCYGNA TSQYNVWLGK NKLFQREPSA QHRWVSKSFP
110 120 130 140 150
HPDYNMSLLN DDIPQPKDKS NDLMLLRLSE PADITDAVKP IDLPTEEPKL
160 170 180 190 200
GSTCLASGWG SITPTKWQKP NDLQCVFIKL LPNENCTKPY LHKVTDVMLC
210 220 230 240 250
AGEMGGGKDT CAGDSGGPLI CDGILHGITS WGPVPCGKPN APAIYTKLIK
260
FASWIKDTMA KNP
Length:263
Mass (Da):28,926
Last modified:June 7, 2004 - v3
Checksum:i4EE052242B7A415F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB039277 mRNA Translation: BAA92320.1
BC146015 mRNA Translation: AAI46016.1
BC146019 mRNA Translation: AAI46020.1
M18619, M18599 Genomic DNA Translation: AAG11390.1
CCDSiCCDS21198.1
PIRiI70016
I70017
RefSeqiNP_034773.1, NM_010643.2
UniGeneiMm.483098

Genome annotation databases

EnsembliENSMUST00000073713; ENSMUSP00000073392; ENSMUSG00000063713
GeneIDi16617
KEGGimmu:16617
UCSCiuc009gok.1 mouse

Similar proteinsi

Entry informationi

Entry nameiK1B24_MOUSE
AccessioniPrimary (citable) accession number: Q61754
Secondary accession number(s): A6H6V7, Q61755, Q9JM69
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: June 20, 2018
This is version 125 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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