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Protein

Zinc finger protein 354A

Gene

Znf354a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

It may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri184 – 206C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri212 – 234C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 290C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri321 – 343C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri349 – 371C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri377 – 399C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri405 – 427C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 455C2H2-type 9PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri461 – 483C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri489 – 511C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri517 – 539C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri545 – 567C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 354A
Alternative name(s):
Kidney, ischemia, and developmentally-regulated protein 1
Renal transcription factor Kid-1
Transcription factor 17
Short name:
TCF-17
Gene namesi
Name:Znf354a
Synonyms:Kid1, Tcf17, Zfp354a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:103172 Zfp354a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000472391 – 572Zinc finger protein 354AAdd BLAST572

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki121Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki155Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki238Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ61751
PRIDEiQ61751

PTM databases

iPTMnetiQ61751
PhosphoSitePlusiQ61751

Expressioni

Tissue specificityi

Highly expressed in eye and kidney. Detected at high levels in adult brain and kidney, and at lower levels in adult liver, lung, skeletal muscle, heart, salivary gland, testis and tongue. Detected in embryonic brain, heart, lung,kidney and gut.1 Publication

Gene expression databases

BgeeiENSMUSG00000020364 Expressed in 178 organ(s), highest expression level in ureter smooth muscle
CleanExiMM_ZFP354A
ExpressionAtlasiQ61751 baseline and differential
GenevisibleiQ61751 MM

Interactioni

Protein-protein interaction databases

BioGridi204002, 3 interactors
STRINGi10090.ENSMUSP00000020628

Structurei

3D structure databases

ProteinModelPortaliQ61751
SMRiQ61751
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 85KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri184 – 206C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri212 – 234C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 290C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri321 – 343C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri349 – 371C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri377 – 399C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri405 – 427C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 455C2H2-type 9PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri461 – 483C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri489 – 511C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri517 – 539C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri545 – 567C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150883
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ61751
KOiK09228
OMAiRNVPWDL

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 11 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q61751-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPEQWEATS QVSLTFEDVA VLFTRDEWKK LVPSQRSLYR EVMLENYSNL
60 70 80 90 100
ASLGFPFTKP KVISLLQQGE DPWKVEEEGP GGFSLGLKCS QRTTKSTQTQ
110 120 130 140 150
DSSFRELIMR KSKRKEPWNM KSENLSIHEG KLEEKWDVNA STIERSYKSN
160 170 180 190 200
ELSPKSHREK RSSECEKQIS YLSNPLGITP DKRYKCSMCE KTFINTSSLR
210 220 230 240 250
KHEKNHSGEK LFKCKECSKA FSQSSALIQH QITHTGEKPY VCKECGKAFT
260 270 280 290 300
LSTSLYKHLR THTVEKSYRC KECGKSFGRR SGLFIHQKVH AGENPYKYNP
310 320 330 340 350
GRKASTSLSG CQRIHSRKKT YLCNECGNTF KSSSSLRYHQ RIHTGEKPFK
360 370 380 390 400
CSECGRAFSQ SASLIQHERI HTGEKPYRCS ECGKGFTSIS RLNRHRIIHT
410 420 430 440 450
GEKFYNCNEC GKALSSHSTL IIHERIHTGE KPCKCKVCGK AFRQSSALIQ
460 470 480 490 500
HQRMHTGERP YKCNECGKTF RCNSSLSNHQ RTHTGEKPYR CQECGMSFGQ
510 520 530 540 550
SSALIQHRRI HTGEKPFKCN TCGKTFRQSS SRIAHQRIHT GEKPYECNTC
560 570
GKLFNHRSSL TNHYKIHVDE DP
Length:572
Mass (Da):65,662
Last modified:July 27, 2011 - v2
Checksum:i1BB5DDFAA51AA9B3
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1ATG3B1ATG3_MOUSE
Zinc finger protein 354A
Zfp354a
573Annotation score:
Q5PPR4Q5PPR4_MOUSE
Zfp354a protein
Zfp354a mCG_1040691
571Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti82G → D in AAA96309 (PubMed:9176064).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77247 mRNA Translation: AAA96309.1
AF184111 mRNA Translation: AAF01033.1
AL645962 Genomic DNA Translation: CAI24599.1
CH466575 Genomic DNA Translation: EDL33680.1
BC050843 mRNA Translation: AAH50843.1
CCDSiCCDS24648.1
RefSeqiNP_001313495.1, NM_001326566.1
NP_033355.2, NM_009329.4
XP_006532853.1, XM_006532790.1
UniGeneiMm.4792

Genome annotation databases

EnsembliENSMUST00000020628; ENSMUSP00000020628; ENSMUSG00000020364
ENSMUST00000102766; ENSMUSP00000099827; ENSMUSG00000020364
GeneIDi21408
KEGGimmu:21408
UCSCiuc007itl.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77247 mRNA Translation: AAA96309.1
AF184111 mRNA Translation: AAF01033.1
AL645962 Genomic DNA Translation: CAI24599.1
CH466575 Genomic DNA Translation: EDL33680.1
BC050843 mRNA Translation: AAH50843.1
CCDSiCCDS24648.1
RefSeqiNP_001313495.1, NM_001326566.1
NP_033355.2, NM_009329.4
XP_006532853.1, XM_006532790.1
UniGeneiMm.4792

3D structure databases

ProteinModelPortaliQ61751
SMRiQ61751
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204002, 3 interactors
STRINGi10090.ENSMUSP00000020628

PTM databases

iPTMnetiQ61751
PhosphoSitePlusiQ61751

Proteomic databases

PaxDbiQ61751
PRIDEiQ61751

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020628; ENSMUSP00000020628; ENSMUSG00000020364
ENSMUST00000102766; ENSMUSP00000099827; ENSMUSG00000020364
GeneIDi21408
KEGGimmu:21408
UCSCiuc007itl.1 mouse

Organism-specific databases

CTDi21408
MGIiMGI:103172 Zfp354a

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150883
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ61751
KOiK09228
OMAiRNVPWDL

Enzyme and pathway databases

ReactomeiR-MMU-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRSiPim3 mouse
PROiPR:Q61751
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020364 Expressed in 178 organ(s), highest expression level in ureter smooth muscle
CleanExiMM_ZFP354A
ExpressionAtlasiQ61751 baseline and differential
GenevisibleiQ61751 MM

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 11 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZ354A_MOUSE
AccessioniPrimary (citable) accession number: Q61751
Secondary accession number(s): Q9QXU0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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