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Protein

Integrin alpha-7

Gene

Itga7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. Involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Mice carrying a ITGA7 null allele are viable and fertile, but show progressive muscular dystrophy starting soon after birth, but with a distinct variability in different muscle types. Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells. Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi372 – 380Sequence analysis9
Calcium bindingi434 – 442Sequence analysis9
Calcium bindingi492 – 500Sequence analysis9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIntegrin, Receptor
Biological processCell adhesion, Cell shape
LigandCalcium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Integrin alpha-7
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Itga7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:102700 Itga7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini34 – 1076ExtracellularSequence analysisAdd BLAST1043
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1077 – 1102HelicalSequence analysisAdd BLAST26
Topological domaini1103 – 1179CytoplasmicSequence analysisAdd BLAST77

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 331 PublicationAdd BLAST33
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001627034 – 1179Integrin alpha-7Add BLAST1146
ChainiPRO_000001627134 – 955Integrin alpha-7 heavy chainSequence analysisAdd BLAST922
ChainiPRO_0000016272959 – 1179Integrin alpha-7 light chainSequence analysisAdd BLAST221

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi86N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi94 ↔ 103By similarity
Disulfide bondi140 ↔ 163By similarity
Disulfide bondi184 ↔ 197By similarity
Disulfide bondi539 ↔ 546By similarity
Disulfide bondi552 ↔ 615By similarity
Disulfide bondi681 ↔ 687By similarity
Disulfide bondi781 ↔ 792By similarity
Glycosylationi784N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi939 ↔ 993Interchain (between heavy and light chains)By similarity
Glycosylationi988N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi999 ↔ 1004By similarity
Glycosylationi1023N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1043N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

ADP-ribosylated on at least two sites of the extracellular domain in skeletal myotubes (in vitro).
No proteolytic cleavage to produce the 70 kDa form is seen due to the presence of a Gly instead of an arginine residue at position 647.

Keywords - PTMi

ADP-ribosylation, Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q61738

PeptideAtlas

More...
PeptideAtlasi
Q61738

PRoteomics IDEntifications database

More...
PRIDEi
Q61738

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q61738

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q61738

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoforms containing segment X2 are found in adult heart, lung and skeletal muscle. Isoforms containing segment X1 are expressed in adult heart, lung and in proliferating skeletal myoblasts but not in adult skeletal muscle. Isoforms containing segment a are exclusively found in skeletal muscle. Isoforms containing segment B are widely expressed. In muscle fibers isoforms containing segment A and B are expressed at myotendinous and neuromuscular junctions; isoforms containing segment C are expressed at neuromuscular junctions and at extrasynaptic sites.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Isoforms are developmentally regulated during the formation of skeletal muscle. Undifferentiated (replicating) myoblasts express isoforms containing segment B only, whereas differentiated myoblasts express isoforms containing segments A or B.

Gene expression databases

CleanEx database of gene expression profiles

More...
CleanExi
MM_ITGA7

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-7 associates with beta-1. Interacts with COMP. Interacts (via C-terminus intracellular tail region) with CIB1; the interaction is stabilized/increased in a calcium- and magnesium-dependent manner (By similarity).By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-3121 Integrin alpha7-beta1 complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q61738

Protein interaction database and analysis system

More...
IntActi
Q61738, 5 interactors

Molecular INTeraction database

More...
MINTi
Q61738

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000096712

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati38 – 103FG-GAP 1PROSITE-ProRule annotationAdd BLAST66
Repeati110 – 175FG-GAP 2PROSITE-ProRule annotationAdd BLAST66
Repeati185 – 238FG-GAP 3PROSITE-ProRule annotationAdd BLAST54
Repeati292 – 349FG-GAP 4PROSITE-ProRule annotationAdd BLAST58
Repeati350 – 411FG-GAP 5PROSITE-ProRule annotationAdd BLAST62
Repeati412 – 467FG-GAP 6PROSITE-ProRule annotationAdd BLAST56
Repeati471 – 530FG-GAP 7PROSITE-ProRule annotationAdd BLAST60
Repeati1155 – 115814
Repeati1163 – 116624
Repeati1171 – 117434

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1155 – 11743 X 4 AA repeats of D-X-H-PAdd BLAST20

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1105 – 1109GFFKR motif5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi953 – 958Poly-Arg6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IPBB Eukaryota
ENOG410XVGZ LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000015786

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG108011

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q61738

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q61738

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.130, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01839 FG-GAP, 2 hits
PF08441 Integrin_alpha2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01185 INTEGRINA

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00191 Int_alpha, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF69179 SSF69179, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51470 FG_GAP, 7 hits
PS00242 INTEGRIN_ALPHA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist. There is a combination of at least four alternatively spliced domains, two extracellular (X1 and X2) and two cytoplasmic (A and B). A third potential alternatively spliced cytoplasmic domain (C) doesn't appear to be expressed. So far detected are isoform alpha-7X1A, isoform alpha-7X1B and isoform alpha-7X2B. Experimental confirmation may be lacking for some isoforms.

This entry has 6 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform Alpha-7X1X2B (identifier: Q61738-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARIPRCDFL RPPGIYYLIT SLLAGLFLPP AIAFNLDVMG AIRKEGEPGS
60 70 80 90 100
LFGFSVALHR QLQPRPQSWL LVGAPQALAL PGQQANRTGG LFACPLSLEE
110 120 130 140 150
TDCYRVDIDR GANVQKESKE NQWLGVSVRS QGAGGKIVTC AHRYESRQRV
160 170 180 190 200
DQALETRDVI GRCFVLSQDL AIRDELDGGE WKFCEGRPQG HEQFGFCQQG
210 220 230 240 250
TAATFSPDSH YLVFGAPGTY NWKGTARVEL CAQGSPDLAH LDDGPYEAGG
260 270 280 290 300
EKEQDPRLIP VPANSYLGLL FVTNIDSSDP DQLVYKTLDP ADRLTGPAGD
310 320 330 340 350
LTLNSYLGFS IDSGKGLMRS EELSFVAGAP RANHKGAVVI LRKDSATRLI
360 370 380 390 400
PEVVLSGERL TSGFGYSLAV TDLNNDGWAD LIVGAPYFFE RQEELGGAVY
410 420 430 440 450
VYMNQGGHWA DISPLRICGS PDSMFGISLA VLGDLNQDGF PDIAVGAPFD
460 470 480 490 500
GDGKVFIYHG SSLGVVVKPS QVLEGEAVGI KSFGYSLSGG LDVDGNHYPD
510 520 530 540 550
LLVGSLADTA ALFRARPVLH VSQEIFIDPR AIDLEQPNCA DGRLVCVDIK
560 570 580 590 600
ICFSYVAVPS SYSPSVALDY MLDGDTDRRL RGQVPRVTFL SRGLDDLRHQ
610 620 630 640 650
SSGTVWLKHQ HDRVCGDTVF QLQENVKDKL RAIVVTLSYG LRTPPLGRQA
660 670 680 690 700
PGQELPTVAP ILNAHQPSTQ RTEIHFLKQG CGQDKICQSN LQLERYQFCS
710 720 730 740 750
RISDTEFQAL PMDLDGRTAL FALSGQPFIG LELTVTNLPS DPSRPQADGD
760 770 780 790 800
DAHEAQLLVT LPASLRYSGV RALDSVEKPL CLSNDSASHV ECELGNPMKR
810 820 830 840 850
GAQVTFYLIL STSGITIETT ELEVKLLLAT ISEQELDPVS VRAHVFIELP
860 870 880 890 900
LSISGVATPQ QLFFSGEVKG ESAMRSEREL GRKVKYEVTV SNQGQSLNTL
910 920 930 940 950
GSANLNIMWP HEIANGKWLL YPMRVELEGG QGPGKRGICS PRPNILQLDV
960 970 980 990 1000
DSRDRRRREL GQPEPQEPPE KVEPSTSWWP VSSAEKRNMT LDCPRTAKCV
1010 1020 1030 1040 1050
VFSCPLYSFD RAAVLHVWGR LWNSTFLEEY MAVKSLEVIV RANITVKSSI
1060 1070 1080 1090 1100
KNLLLRDAST VIPVMVYLDP MAVVVEGVPW WVILLGVLAG LLVLALLVLL
1110 1120 1130 1140 1150
LWKLGFFKRA KHPEATVPQY HAVKIPREDR QQFKEEKTGT IQRSNWGNSQ
1160 1170
WEGSDAHPIL AADWHPELGP DGHPVPATA
Length:1,179
Mass (Da):129,329
Last modified:October 5, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3C26D5BABF2E463D
GO
Isoform Alpha-7X1A (identifier: Q61738-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     268-307: Missing.
     1104-1179: LGFFKRAKHP...PDGHPVPATA → CGFFRRNSPS...PRPPCPSTTQ

Show »
Length:1,120
Mass (Da):122,492
Checksum:iC47BD71A00A96C14
GO
Isoform Alpha-7X1B (identifier: Q61738-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     268-307: Missing.

Show »
Length:1,139
Mass (Da):125,037
Checksum:i318EE0ED64709E7B
GO
Isoform Alpha-7X2A (identifier: Q61738-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     224-267: Missing.
     1104-1179: LGFFKRAKHP...PDGHPVPATA → CGFFRRNSPS...PRPPCPSTTQ

Show »
Length:1,116
Mass (Da):122,151
Checksum:iF9ED8397C6373324
GO
Isoform Alpha-7X2B (identifier: Q61738-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     224-267: Missing.

Show »
Length:1,135
Mass (Da):124,696
Checksum:iB4C1D6D65C7E3676
GO
Isoform Alpha-7X1X2A (identifier: Q61738-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1104-1179: LGFFKRAKHP...PDGHPVPATA → CGFFRRNSPS...PRPPCPSTTQ

Show »
Length:1,160
Mass (Da):126,784
Checksum:iCAF7035497AAA400
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3X9Q1G3X9Q1_MOUSE
Integrin alpha-7
Itga7 mCG_18693
1,136Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q3TZS3Q3TZS3_MOUSE
Integrin alpha-7
Itga7
1,140Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2P7M9A0A1W2P7M9_MOUSE
Integrin alpha-7
Itga7
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti133A → P in CAA73023 (Ref. 2) Curated1
Sequence conflicti133A → P in CAA73024 (Ref. 2) Curated1
Sequence conflicti347T → Q in AAA16599 (PubMed:8253814).Curated1
Sequence conflicti347T → S in CAA73023 (Ref. 2) Curated1
Sequence conflicti347T → S in CAA73024 (Ref. 2) Curated1
Sequence conflicti647G → R in AAA16600 (PubMed:8253814).Curated1
Sequence conflicti879 – 880EL → DV in CAA73023 (Ref. 2) Curated2
Sequence conflicti879 – 880EL → DV in CAA73024 (Ref. 2) Curated2
Sequence conflicti882R → S in CAA73023 (Ref. 2) Curated1
Sequence conflicti882R → S in CAA73024 (Ref. 2) Curated1
Sequence conflicti904N → F in CAA73023 (Ref. 2) Curated1
Sequence conflicti904N → F in CAA73024 (Ref. 2) Curated1
Sequence conflicti989M → V in CAA73023 (Ref. 2) Curated1
Sequence conflicti989M → V in CAA73024 (Ref. 2) Curated1
Sequence conflicti994 – 995PR → AQG in CAA73023 (Ref. 2) Curated2
Sequence conflicti994 – 995PR → AQG in CAA73024 (Ref. 2) Curated2
Sequence conflicti1031 – 1034MAVK → LLIN in AAA16598 (PubMed:8253814).Curated4
Sequence conflicti1086G → A in CAA73023 (Ref. 2) Curated1
Sequence conflicti1086G → A in CAA73024 (Ref. 2) Curated1
Isoform Alpha-7X2A (identifier: Q61738-4)
Sequence conflicti1042G → A in L16544 (PubMed:8360188).Curated1
Sequence conflicti1115 – 1116TQ → T in AAA16598 (PubMed:8253814).Curated2
Isoform Alpha-7X1A (identifier: Q61738-2)
Sequence conflicti1046G → A in L16544 (PubMed:8360188).Curated1
Sequence conflicti1119 – 1120TQ → T in AAA16598 (PubMed:8253814).Curated2
Isoform Alpha-7X1X2A (identifier: Q61738-6)
Sequence conflicti1086G → A in L16544 (PubMed:8360188).Curated1
Sequence conflicti1159 – 1160TQ → T in AAA16598 (PubMed:8253814).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_002731224 – 267Missing in isoform Alpha-7X2A and isoform Alpha-7X2B. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_002732268 – 307Missing in isoform Alpha-7X1A and isoform Alpha-7X1B. CuratedAdd BLAST40
Alternative sequenceiVSP_0027331104 – 1179LGFFK…VPATA → CGFFRRNSPSSSFPTNYHRA HLAVQPSAMEAGGPGTVGWD SSSGRSTPRPPCPSTTQ in isoform Alpha-7X1A, isoform Alpha-7X2A and isoform Alpha-7X1X2A. CuratedAdd BLAST76

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L23423 mRNA Translation: AAA16600.1
Y12380
, Y12383, Y12384, Y12385, Y12386, Y12387, Y12388, Y12389, Y12390, Y12382 Genomic DNA Translation: CAA73023.1
L23422 Genomic DNA Translation: AAA16599.1
Y12380
, Y12383, Y12384, Y12385, Y12386, Y12387, Y12388, Y12389, Y12390, Y12381, Y12382 Genomic DNA Translation: CAA73024.1
U60419 Genomic DNA Translation: AAC52772.1
L23421 mRNA Translation: AAA16598.1
L16544 mRNA No translation available.

Protein sequence database of the Protein Information Resource

More...
PIRi
I61186
I61187

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.179747

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23423 mRNA Translation: AAA16600.1
Y12380
, Y12383, Y12384, Y12385, Y12386, Y12387, Y12388, Y12389, Y12390, Y12382 Genomic DNA Translation: CAA73023.1
L23422 Genomic DNA Translation: AAA16599.1
Y12380
, Y12383, Y12384, Y12385, Y12386, Y12387, Y12388, Y12389, Y12390, Y12381, Y12382 Genomic DNA Translation: CAA73024.1
U60419 Genomic DNA Translation: AAC52772.1
L23421 mRNA Translation: AAA16598.1
L16544 mRNA No translation available.
PIRiI61186
I61187
UniGeneiMm.179747

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

ComplexPortaliCPX-3121 Integrin alpha7-beta1 complex
CORUMiQ61738
IntActiQ61738, 5 interactors
MINTiQ61738
STRINGi10090.ENSMUSP00000096712

PTM databases

iPTMnetiQ61738
PhosphoSitePlusiQ61738

Proteomic databases

PaxDbiQ61738
PeptideAtlasiQ61738
PRIDEiQ61738

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:102700 Itga7

Phylogenomic databases

eggNOGiENOG410IPBB Eukaryota
ENOG410XVGZ LUCA
HOGENOMiHOG000015786
HOVERGENiHBG108011
InParanoidiQ61738
PhylomeDBiQ61738

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q61738

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

CleanExiMM_ITGA7

Family and domain databases

Gene3Di2.130.10.130, 2 hits
InterProiView protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
PfamiView protein in Pfam
PF01839 FG-GAP, 2 hits
PF08441 Integrin_alpha2, 1 hit
PRINTSiPR01185 INTEGRINA
SMARTiView protein in SMART
SM00191 Int_alpha, 5 hits
SUPFAMiSSF69179 SSF69179, 3 hits
PROSITEiView protein in PROSITE
PS51470 FG_GAP, 7 hits
PS00242 INTEGRIN_ALPHA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiITA7_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q61738
Secondary accession number(s): O88731
, O88732, P70350, Q61737, Q61741
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: October 5, 2010
Last modified: June 20, 2018
This is version 150 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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