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Entry version 130 (02 Jun 2021)
Sequence version 2 (22 Jul 2015)
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Protein

Interferon alpha-11

Gene

Ifna11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has antiviral and antiproliferative activities (PubMed:15254193).

Produced by macrophages and stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase (By similarity).

During viral infection, mediates antiviral effect, either directly by inducing interferon-stimulated genes, either indirectly through stimulation of natural killer cells enabling them to control viral replication (PubMed:22912583).

By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine
Biological processAntiviral defense

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-909733, Interferon alpha/beta signaling
R-MMU-912694, Regulation of IFNA signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interferon alpha-11
Short name:
IFN-alpha-11
Alternative name(s):
Limitin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ifna11
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:109210, Ifna11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000031763424 – 190Interferon alpha-11Add BLAST167

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi24 ↔ 122By similarity
Disulfide bondi52 ↔ 162By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi101N-linked (GlcNAc...) asparagineCurated1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated (PubMed:15254193).1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q61716

PRoteomics IDEntifications database

More...
PRIDEi
Q61716

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
273104

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q61716, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q61716

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q61716

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000100549, Expressed in skeletal muscle tissue and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000127921

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q61716, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q61716

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502SQAC, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT01000000214430

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q61716

Identification of Orthologs from Complete Genome Data

More...
OMAi
RKYSPCA

Database of Orthologous Groups

More...
OrthoDBi
1358010at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q61716

TreeFam database of animal gene trees

More...
TreeFami
TF336177

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00095, IFab, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009079, 4_helix_cytokine-like_core
IPR000471, Interferon_alpha/beta/delta

The PANTHER Classification System

More...
PANTHERi
PTHR11691, PTHR11691, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00143, Interferon, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00266, INTERFERONAB

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00076, IFabd, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47266, SSF47266, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00252, INTERFERON_A_B_D, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q61716-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARLCAFLMI LIVMSYWSTC SLGCDLPHTY NLRNKRALKV LAQMRRLTPL
60 70 80 90 100
SCLKDRKDFG FPLEKVDAQQ IQKAQSIPVL RDLTQQILNL FASKDSSAAW
110 120 130 140 150
NATLLDSFCN DLHQQLNDLQ GCLMQQVGVQ ESPLTQEDSL LAVRIYFHRI
160 170 180 190
TVFLREKKHS PCAWEVVRAE VWRALSSSAN VLGRLREEKA
Length:190
Mass (Da):21,736
Last modified:July 22, 2015 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i87BB8781552A94D1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti48T → S in AAI16871 (PubMed:15489334).Curated1
Sequence conflicti48T → S in AAI16873 (PubMed:15489334).Curated1
Sequence conflicti48T → S in AAA37883 (PubMed:1655578).Curated1
Sequence conflicti57K → Q in AAI16871 (PubMed:15489334).Curated1
Sequence conflicti57K → Q in AAI16873 (PubMed:15489334).Curated1
Sequence conflicti57K → Q in AAA37883 (PubMed:1655578).Curated1
Sequence conflicti72 – 76QKAQS → KKAQA in AAI16871 (PubMed:15489334).Curated5
Sequence conflicti72 – 76QKAQS → KKAQA in AAI16873 (PubMed:15489334).Curated5
Sequence conflicti72 – 76QKAQS → KKAQA in AAA37883 (PubMed:1655578).Curated5
Sequence conflicti92 – 95ASKD → TSKA in AAI16871 (PubMed:15489334).Curated4
Sequence conflicti92 – 95ASKD → TSKA in AAI16873 (PubMed:15489334).Curated4
Sequence conflicti92 – 95ASKD → TSKA in AAA37883 (PubMed:1655578).Curated4
Sequence conflicti132S → P in AAI16871 (PubMed:15489334).Curated1
Sequence conflicti132S → P in AAI16873 (PubMed:15489334).Curated1
Sequence conflicti132S → P in AAA37883 (PubMed:1655578).Curated1
Sequence conflicti139S → A in AAI16871 (PubMed:15489334).Curated1
Sequence conflicti139S → A in AAI16873 (PubMed:15489334).Curated1
Sequence conflicti139S → A in AAA37883 (PubMed:1655578).Curated1
Sequence conflicti149R → S in AAI16871 (PubMed:15489334).Curated1
Sequence conflicti149R → S in AAI16873 (PubMed:15489334).Curated1
Sequence conflicti149R → S in AAA37883 (PubMed:1655578).Curated1
Sequence conflicti179 – 186ANVLGRLR → VNLLARLS in AAI16871 (PubMed:15489334).Curated8
Sequence conflicti179 – 186ANVLGRLR → VNLLARLS in AAI16873 (PubMed:15489334).Curated8
Sequence conflicti179 – 186ANVLGRLR → VNLLARLS in AAA37883 (PubMed:1655578).Curated8

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M68944 Genomic DNA Translation: AAA37883.1
AY225954 Genomic DNA Translation: AAO63596.1
AL928605 Genomic DNA No translation available.
BC116870 mRNA Translation: AAI16871.1
BC116872 mRNA Translation: AAI16873.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS38810.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JH0468

NCBI Reference Sequences

More...
RefSeqi
NP_032359.2, NM_008333.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000170428; ENSMUSP00000127921; ENSMUSG00000100549

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
15964

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:15964

UCSC genome browser

More...
UCSCi
uc008tny.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M68944 Genomic DNA Translation: AAA37883.1
AY225954 Genomic DNA Translation: AAO63596.1
AL928605 Genomic DNA No translation available.
BC116870 mRNA Translation: AAI16871.1
BC116872 mRNA Translation: AAI16873.1
CCDSiCCDS38810.1
PIRiJH0468
RefSeqiNP_032359.2, NM_008333.2

3D structure databases

SMRiQ61716
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000127921

PTM databases

GlyGeniQ61716, 1 site
iPTMnetiQ61716
PhosphoSitePlusiQ61716

Proteomic databases

PaxDbiQ61716
PRIDEiQ61716
ProteomicsDBi273104

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
15964

Genome annotation databases

EnsembliENSMUST00000170428; ENSMUSP00000127921; ENSMUSG00000100549
GeneIDi15964
KEGGimmu:15964
UCSCiuc008tny.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
15964
MGIiMGI:109210, Ifna11

Phylogenomic databases

eggNOGiENOG502SQAC, Eukaryota
GeneTreeiENSGT01000000214430
InParanoidiQ61716
OMAiRKYSPCA
OrthoDBi1358010at2759
PhylomeDBiQ61716
TreeFamiTF336177

Enzyme and pathway databases

ReactomeiR-MMU-909733, Interferon alpha/beta signaling
R-MMU-912694, Regulation of IFNA signaling

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
15964, 1 hit in 20 CRISPR screens

Protein Ontology

More...
PROi
PR:Q61716
RNActiQ61716, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000100549, Expressed in skeletal muscle tissue and 14 other tissues

Family and domain databases

CDDicd00095, IFab, 1 hit
InterProiView protein in InterPro
IPR009079, 4_helix_cytokine-like_core
IPR000471, Interferon_alpha/beta/delta
PANTHERiPTHR11691, PTHR11691, 1 hit
PfamiView protein in Pfam
PF00143, Interferon, 1 hit
PRINTSiPR00266, INTERFERONAB
SMARTiView protein in SMART
SM00076, IFabd, 1 hit
SUPFAMiSSF47266, SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00252, INTERFERON_A_B_D, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIFNAB_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q61716
Secondary accession number(s): Q810G4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 22, 2015
Last modified: June 2, 2021
This is version 130 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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