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Protein

DnaJ homolog subfamily C member 1

Gene

Dnajc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May modulate protein synthesis.By similarity

GO - Molecular functioni

  • chaperone binding Source: MGI
  • DNA binding Source: UniProtKB-KW
  • ribosome binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionChaperone, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 1
Alternative name(s):
DnaJ protein homolog MTJ1
Gene namesi
Name:Dnajc1
Synonyms:Dnajl1, Mtj1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:103268 Dnajc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini44 – 149LumenalBy similarityAdd BLAST106
Transmembranei150 – 170HelicalSequence analysisAdd BLAST21
Topological domaini171 – 552CytoplasmicBy similarityAdd BLAST382

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 43Sequence analysisAdd BLAST43
ChainiPRO_000007104344 – 552DnaJ homolog subfamily C member 1Add BLAST509

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei379PhosphoserineBy similarity1
Modified residuei477PhosphoserineCombined sources1
Modified residuei478PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ61712
MaxQBiQ61712
PaxDbiQ61712
PeptideAtlasiQ61712
PRIDEiQ61712

PTM databases

iPTMnetiQ61712
PhosphoSitePlusiQ61712

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiENSMUSG00000026740 Expressed in 287 organ(s), highest expression level in saliva-secreting gland
CleanExiMM_DNAJC1
ExpressionAtlasiQ61712 baseline and differential
GenevisibleiQ61712 MM

Interactioni

Subunit structurei

Interacts (via J domain) with HSPA5. Interacts (via cytosolic domain) with ribosomes. Interacts (via SANT 2 domain) with SERPINA3; the interaction delays the formation of the covalent inhibitory complex SERPINA3-chymotrypsin, but does not alter the catalytic activity of SERPINA3. Interacts (via SANT 2 domain) with ITIH4 (via C-terminus); the interaction protects ITIH4 against in vitro cleavage by kallikrein (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199250, 3 interactors
DIPiDIP-60498N
IntActiQ61712, 1 interactor
STRINGi10090.ENSMUSP00000088980

Structurei

3D structure databases

ProteinModelPortaliQ61712
SMRiQ61712
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 129JPROSITE-ProRule annotationAdd BLAST74
Domaini323 – 377SANT 1PROSITE-ProRule annotationAdd BLAST55
Domaini490 – 545SANT 2PROSITE-ProRule annotationAdd BLAST56

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410INV7 Eukaryota
COG2214 LUCA
GeneTreeiENSGT00530000063419
HOGENOMiHOG000231867
HOVERGENiHBG051374
InParanoidiQ61712
KOiK09521
OMAiPNWRSAV
OrthoDBiEOG091G0I6J
PhylomeDBiQ61712
TreeFamiTF105161

Family and domain databases

CDDicd06257 DnaJ, 1 hit
cd00167 SANT, 2 hits
Gene3Di1.10.287.110, 1 hit
InterProiView protein in InterPro
IPR001623 DnaJ_domain
IPR018253 DnaJ_domain_CS
IPR009057 Homeobox-like_sf
IPR036869 J_dom_sf
IPR017877 Myb-like_dom
IPR001005 SANT/Myb
IPR017884 SANT_dom
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PF00249 Myb_DNA-binding, 1 hit
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SM00717 SANT, 2 hits
SUPFAMiSSF46565 SSF46565, 1 hit
SSF46689 SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS00636 DNAJ_1, 1 hit
PS50076 DNAJ_2, 1 hit
PS51293 SANT, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q61712-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWVPGFGSAR LPQRRRSGLE SSSVRPLWLL LLFLLAAVRP VRAWESGDLE
60 70 80 90 100
LFDLVEEVQL NFYEFLGVQQ DASSADIRKA YRKLSLTLHP DKNKDENAET
110 120 130 140 150
QFRQLVAIYE VLKDDERRQR YDDVLINGLP DWRQPVFYYR RVRKMSNAEL
160 170 180 190 200
ALLLFIILTV GHYAVVWSIY LEKQLDELLG RKKRERKKKT GSKSVDAAKL
210 220 230 240 250
GASEKNERLL IKPQWHDLLP CKLGIWFCLT LKALPHLIQD AGQFYAKYKE
260 270 280 290 300
TKLKEKEDAL ARIEIETLQK QKKVKVKKPK PEFPVYMPLE NTYIQSYDHG
310 320 330 340 350
TSIEEIEEQM DDWLENRKRT QKRQAPEWTE EDLSQLTRSM VKFPGGTPGR
360 370 380 390 400
WDKIAHELGR SVTDVTTKAK ELKDSVTSSP GMTRLSELKS NGQNSRPIKI
410 420 430 440 450
ATALPDDIIT QREDSAGAME DEEHEAAEGE QESATTEARP RRRKSARAAE
460 470 480 490 500
AVTRVEPEEK LRGKRQKDFD ISEQNDSSDE EKQRKERTRA AEEAWTQSQQ
510 520 530 540 550
KLLELALQQY PKGASDRWDK IAKCVPSKSK EDCIARYKLL VELVQKKKQA

KS
Length:552
Mass (Da):63,870
Last modified:November 1, 1996 - v1
Checksum:i8DFABB217717ECDA
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6ZL86F6ZL86_MOUSE
DnaJ homolog subfamily C member 1
Dnajc1
357Annotation score:
F6WEH1F6WEH1_MOUSE
DnaJ homolog subfamily C member 1
Dnajc1
58Annotation score:
F8WH68F8WH68_MOUSE
DnaJ homolog subfamily C member 1
Dnajc1
105Annotation score:
F6YK70F6YK70_MOUSE
DnaJ homolog subfamily C member 1
Dnajc1
79Annotation score:
F7C8U2F7C8U2_MOUSE
DnaJ homolog subfamily C member 1
Dnajc1
34Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L16953 mRNA Translation: AAA66349.1
BC080300 mRNA No translation available.
CCDSiCCDS15709.1
PIRiJC4030
RefSeqiNP_001177746.1, NM_001190817.1
NP_031895.1, NM_007869.3
UniGeneiMm.246674

Genome annotation databases

EnsembliENSMUST00000091418; ENSMUSP00000088980; ENSMUSG00000026740
ENSMUST00000166495; ENSMUSP00000126321; ENSMUSG00000026740
GeneIDi13418
KEGGimmu:13418
UCSCiuc008ilt.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L16953 mRNA Translation: AAA66349.1
BC080300 mRNA No translation available.
CCDSiCCDS15709.1
PIRiJC4030
RefSeqiNP_001177746.1, NM_001190817.1
NP_031895.1, NM_007869.3
UniGeneiMm.246674

3D structure databases

ProteinModelPortaliQ61712
SMRiQ61712
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199250, 3 interactors
DIPiDIP-60498N
IntActiQ61712, 1 interactor
STRINGi10090.ENSMUSP00000088980

PTM databases

iPTMnetiQ61712
PhosphoSitePlusiQ61712

Proteomic databases

EPDiQ61712
MaxQBiQ61712
PaxDbiQ61712
PeptideAtlasiQ61712
PRIDEiQ61712

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000091418; ENSMUSP00000088980; ENSMUSG00000026740
ENSMUST00000166495; ENSMUSP00000126321; ENSMUSG00000026740
GeneIDi13418
KEGGimmu:13418
UCSCiuc008ilt.2 mouse

Organism-specific databases

CTDi64215
MGIiMGI:103268 Dnajc1

Phylogenomic databases

eggNOGiENOG410INV7 Eukaryota
COG2214 LUCA
GeneTreeiENSGT00530000063419
HOGENOMiHOG000231867
HOVERGENiHBG051374
InParanoidiQ61712
KOiK09521
OMAiPNWRSAV
OrthoDBiEOG091G0I6J
PhylomeDBiQ61712
TreeFamiTF105161

Miscellaneous databases

ChiTaRSiDnajc1 mouse
PROiPR:Q61712
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026740 Expressed in 287 organ(s), highest expression level in saliva-secreting gland
CleanExiMM_DNAJC1
ExpressionAtlasiQ61712 baseline and differential
GenevisibleiQ61712 MM

Family and domain databases

CDDicd06257 DnaJ, 1 hit
cd00167 SANT, 2 hits
Gene3Di1.10.287.110, 1 hit
InterProiView protein in InterPro
IPR001623 DnaJ_domain
IPR018253 DnaJ_domain_CS
IPR009057 Homeobox-like_sf
IPR036869 J_dom_sf
IPR017877 Myb-like_dom
IPR001005 SANT/Myb
IPR017884 SANT_dom
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PF00249 Myb_DNA-binding, 1 hit
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SM00717 SANT, 2 hits
SUPFAMiSSF46565 SSF46565, 1 hit
SSF46689 SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS00636 DNAJ_1, 1 hit
PS50076 DNAJ_2, 1 hit
PS51293 SANT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDNJC1_MOUSE
AccessioniPrimary (citable) accession number: Q61712
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 12, 2018
This is version 160 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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