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Protein

Inter-alpha-trypsin inhibitor heavy chain H3

Gene

Itih3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Inter-alpha-trypsin inhibitor heavy chain H3
Short name:
ITI heavy chain H3
Short name:
ITI-HC3
Short name:
Inter-alpha-inhibitor heavy chain 3
Gene namesi
Name:Itih3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:96620 Itih3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000001653522 – 33By similarityAdd BLAST12
ChainiPRO_000001653634 – 649Inter-alpha-trypsin inhibitor heavy chain H3Add BLAST616
PropeptideiPRO_0000016537650 – 889By similarityAdd BLAST240

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi91N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi580N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei649Aspartate 1-(chondroitin 4-sulfate)-esterBy similarity1

Post-translational modificationi

Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal aspartate after propeptide cleavage.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Proteoglycan

Proteomic databases

MaxQBiQ61704
PaxDbiQ61704
PeptideAtlasiQ61704
PRIDEiQ61704

PTM databases

CarbonylDBiQ61704
GlyConnecti776
iPTMnetiQ61704
PhosphoSitePlusiQ61704

Expressioni

Tissue specificityi

Expressed in both liver and brain.

Gene expression databases

BgeeiENSMUSG00000006522 Expressed in 124 organ(s), highest expression level in liver
CleanExiMM_ITIH3
GenevisibleiQ61704 MM

Interactioni

Subunit structurei

I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (H1, H2 or H3) and one light chain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of H1, H2 and bikunin, inter-alpha-like inhibitor (I-alpha-LI) of H2 and bikunin, and pre-alpha-inhibitor (P-alpha-I) of H3 and bikunin.

Protein-protein interaction databases

IntActiQ61704, 3 interactors
MINTiQ61704
STRINGi10090.ENSMUSP00000006697

Structurei

3D structure databases

ProteinModelPortaliQ61704
SMRiQ61704
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 158VITPROSITE-ProRule annotationAdd BLAST130
Domaini284 – 467VWFAPROSITE-ProRule annotationAdd BLAST184

Sequence similaritiesi

Belongs to the ITIH family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IEJB Eukaryota
COG2304 LUCA
GeneTreeiENSGT00550000074468
HOGENOMiHOG000000680
HOVERGENiHBG057734
InParanoidiQ61704
OMAiKVACWFV
OrthoDBiEOG091G01HF
TreeFamiTF328982

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR010600 ITI_HC_C
IPR013694 VIT
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF06668 ITI_HC_C, 1 hit
PF08487 VIT, 1 hit
PF00092 VWA, 1 hit
SMARTiView protein in SMART
SM00609 VIT, 1 hit
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS51468 VIT, 1 hit
PS50234 VWFA, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q61704-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRTMWWPCLV LALLSGLETS GFPRSPLQLL GKRSLPEGVV DGIEVYSTKI
60 70 80 90 100
SCKVTSRFAH NVVTTRAVNR ADTAKEVSFD VELPKTAFIT NFTLTIDGVT
110 120 130 140 150
YPGNVKEKEV AQKQYEKAVS QGKTAGLVKA SGRKLEKFTV SVNVAAGSKV
160 170 180 190 200
TFELTYEELL KRNKGKYEMY LKVQPKQLVR HFEIDAHIFE PQGISMLDAE
210 220 230 240 250
ASFITNDLLG SALTKSFSGK KGHVSFKPSL DQQRSCPTCT DSLLNGDFTI
260 270 280 290 300
VYDVNRESPG NVQIVNGYFV HFFAPQGLPV VPKNIVFVID VSGSMSGRKI
310 320 330 340 350
QQTREALLKI LDDVKEDDYL NFILFSTDVT TWKDHLVQAT PANLKEAKTF
360 370 380 390 400
VKNIHDQSMT NINDGLLKGI EMLNKAREDH TVPERSTSII IMLTDGDANT
410 420 430 440 450
GESRPEKIQE NVRNAIGGKF PLYNLGFGNN LNYNFLETLA LENHGLARRI
460 470 480 490 500
YEDSDANLQL QGFYEEVANP LLTNVEVEYP ENAILDLTRN SYPHFYDGSE
510 520 530 540 550
IVVAGRLVDR NMDNFKADVK GHGALNDLTF TEEVDMEEMD AALKEQGYIF
560 570 580 590 600
GDYIERLWAY LTIEQLLEKR KNAKGDEKEN ITAEALDLSL KYHFVTPLTS
610 620 630 640 650
MVVTKPEDNE DQTSIADKPG EEAIAETTTM SFLTTQQSSQ SPYYYVDGDP
660 670 680 690 700
HFIIQIPGKN DSICFNIDEK PGTVLRLIQD PVTGITVTGQ IIGDKRSNAS
710 720 730 740 750
SRTGKTYFGK LGITNAWMDF RVEVTTEKII LGTGAELSTF SWLDTITVTQ
760 770 780 790 800
TGLSVTINRK KNMVVSFGDG ISFVIILHQV WKKHPVHQDF LGFYVVDSHR
810 820 830 840 850
MSAQTHGLLG QFFQPFDFKV FGIRPGSDPT KPDATMVVKN HRLTVTRGSQ
860 870 880
KDYRKDASVG TKVICWFVHN NGEGLIDGVH TDYIVPSLF
Length:889
Mass (Da):99,358
Last modified:July 27, 2011 - v3
Checksum:iCB3FF5F5062A27B9
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3BRQ3A0A2I3BRQ3_MOUSE
Inter-alpha-trypsin inhibitor heavy...
Itih3
699Annotation score:
A0A2I3BQM8A0A2I3BQM8_MOUSE
Inter-alpha-trypsin inhibitor heavy...
Itih3
224Annotation score:

Sequence cautioni

The sequence AAH15276 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA49843 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3T → A in CAA49843 (PubMed:7534067).Curated1
Sequence conflicti28Q → R in CAA49843 (PubMed:7534067).Curated1
Sequence conflicti28Q → R in AAH15276 (PubMed:15489334).Curated1
Sequence conflicti618 – 619KP → NA in CAA49843 (PubMed:7534067).Curated2
Sequence conflicti624I → F in CAA49843 (PubMed:7534067).Curated1
Sequence conflicti746I → V in CAA49843 (PubMed:7534067).Curated1
Sequence conflicti746I → V in AAH15276 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK146700 mRNA No translation available.
CT025528 Genomic DNA No translation available.
X70393 mRNA Translation: CAA49843.1 Different initiation.
BC015276 mRNA Translation: AAH15276.1 Different initiation.
CCDSiCCDS49434.1
PIRiS54355
RefSeqiNP_032433.2, NM_008407.2
UniGeneiMm.4517

Genome annotation databases

EnsembliENSMUST00000006697; ENSMUSP00000006697; ENSMUSG00000006522
GeneIDi16426
KEGGimmu:16426
UCSCiuc033goy.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK146700 mRNA No translation available.
CT025528 Genomic DNA No translation available.
X70393 mRNA Translation: CAA49843.1 Different initiation.
BC015276 mRNA Translation: AAH15276.1 Different initiation.
CCDSiCCDS49434.1
PIRiS54355
RefSeqiNP_032433.2, NM_008407.2
UniGeneiMm.4517

3D structure databases

ProteinModelPortaliQ61704
SMRiQ61704
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ61704, 3 interactors
MINTiQ61704
STRINGi10090.ENSMUSP00000006697

PTM databases

CarbonylDBiQ61704
GlyConnecti776
iPTMnetiQ61704
PhosphoSitePlusiQ61704

Proteomic databases

MaxQBiQ61704
PaxDbiQ61704
PeptideAtlasiQ61704
PRIDEiQ61704

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006697; ENSMUSP00000006697; ENSMUSG00000006522
GeneIDi16426
KEGGimmu:16426
UCSCiuc033goy.1 mouse

Organism-specific databases

CTDi3699
MGIiMGI:96620 Itih3

Phylogenomic databases

eggNOGiENOG410IEJB Eukaryota
COG2304 LUCA
GeneTreeiENSGT00550000074468
HOGENOMiHOG000000680
HOVERGENiHBG057734
InParanoidiQ61704
OMAiKVACWFV
OrthoDBiEOG091G01HF
TreeFamiTF328982

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation

Miscellaneous databases

PROiPR:Q61704
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000006522 Expressed in 124 organ(s), highest expression level in liver
CleanExiMM_ITIH3
GenevisibleiQ61704 MM

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR010600 ITI_HC_C
IPR013694 VIT
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF06668 ITI_HC_C, 1 hit
PF08487 VIT, 1 hit
PF00092 VWA, 1 hit
SMARTiView protein in SMART
SM00609 VIT, 1 hit
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS51468 VIT, 1 hit
PS50234 VWFA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiITIH3_MOUSE
AccessioniPrimary (citable) accession number: Q61704
Secondary accession number(s): E9QME9, Q91WG9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 140 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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