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Protein

Inter-alpha-trypsin inhibitor heavy chain H2

Gene

Itih2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Inter-alpha-trypsin inhibitor heavy chain H2
Short name:
ITI heavy chain H2
Short name:
ITI-HC2
Short name:
Inter-alpha-inhibitor heavy chain 2
Gene namesi
Name:Itih2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:96619 Itih2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000001652019 – 54By similarityAdd BLAST36
ChainiPRO_000001652155 – 702Inter-alpha-trypsin inhibitor heavy chain H2Add BLAST648
PropeptideiPRO_0000016522703 – 946By similarityAdd BLAST244

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei60PhosphoserineCombined sources1
Glycosylationi118N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi263N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei2824-carboxyglutamateBy similarity1
Modified residuei2834-carboxyglutamateBy similarity1
Glycosylationi445N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei466PhosphoserineBy similarity1
Modified residuei702Aspartate 1-(chondroitin 4-sulfate)-esterBy similarity1
Modified residuei886PhosphoserineBy similarity1

Post-translational modificationi

Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal aspartate after propeptide cleavage.By similarity
Phosphorylated by FAM20C in the extracellular medium.By similarity

Keywords - PTMi

Gamma-carboxyglutamic acid, Glycoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

MaxQBiQ61703
PaxDbiQ61703
PRIDEiQ61703

PTM databases

iPTMnetiQ61703
PhosphoSitePlusiQ61703

Expressioni

Tissue specificityi

Expressed in both liver and brain.

Gene expression databases

CleanExiMM_ITIH2

Interactioni

Subunit structurei

I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (H1, H2 or H3) and one light chain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of H1, H2 and bikunin, inter-alpha-like inhibitor (I-alpha-LI) of H2 and bikunin, and pre-alpha-inhibitor (P-alpha-I) of H3 and bikunin.

Protein-protein interaction databases

IntActiQ61703, 4 interactors
MINTiQ61703
STRINGi10090.ENSMUSP00000046530

Structurei

3D structure databases

ProteinModelPortaliQ61703
SMRiQ61703
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 185VITPROSITE-ProRule annotationAdd BLAST130
Domaini308 – 468VWFAPROSITE-ProRule annotationAdd BLAST161

Sequence similaritiesi

Belongs to the ITIH family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IEJB Eukaryota
COG2304 LUCA
HOGENOMiHOG000000680
HOVERGENiHBG057734
InParanoidiQ61703
KOiK19015
PhylomeDBiQ61703

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR010600 ITI_HC_C
IPR013694 VIT
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF06668 ITI_HC_C, 1 hit
PF08487 VIT, 1 hit
PF00092 VWA, 1 hit
SMARTiView protein in SMART
SM00609 VIT, 1 hit
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS51468 VIT, 1 hit
PS50234 VWFA, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q61703-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQRPVCLLIW LFLLEAQAFE IPINGNSEFA EYSDLVELAP DKLPFVQENG
60 70 80 90 100
RHQRSLPEES GEETDTVDPV TLYSYKVQST ITSRVATTTI QSKLVNNSPL
110 120 130 140 150
PQSVVFDVQI PKGAFISNFT MTVNGMTFTS SIKEKTVGRA LYSQARAKGK
160 170 180 190 200
TAGWVRSRTL DMENFNTEVN IPPGAKVQFE LHYQEVKWRK LGSYEHKIHL
210 220 230 240 250
QPGKLAKHLE VNVWIIEPQG MRFLHVPDTF EGHFQGVPVI SKGQQKAHVS
260 270 280 290 300
FKPTVAQQRK CPNCTETAVN GELVVMYDVN REEKAGELEV FNGYFVHFFA
310 320 330 340 350
PENLDPIPKN ILFVIDVSGS MWGIKMKQTV EAMKTILDDL RTDDQFSVVD
360 370 380 390 400
FNHNVRTWRN DLVSATKTQI ADAKRYIEKI QPSGGTNINE ALLRAIFILN
410 420 430 440 450
EASNMGLLNP DSVSLIILVS DGDPTVGELK LSKIQKNVKQ SIQDNISLFS
460 470 480 490 500
LGIGFDVDYD FLKRLSNENR GIAQRIYGNQ DTSSQLKKFY NQVSTPLLRN
510 520 530 540 550
VQFNYPQASV TDVTQNNFHN YFGGSEIVVA GKFDPSKLTE VQSIITATSA
560 570 580 590 600
NTELVLETLS QMDDLEEFLS KDKHADPDFT KKLWAYLTIN QLLAERSLAP
610 620 630 640 650
TAAIKRKITK TILQMSLDHH IVTPLTAMVI ENDAGDERML ADSPPQDHSC
660 670 680 690 700
CSGALYYGTK VASGPIPSWA NPSPTPMSAM LAVGAKPLES TPPTHLNQVE
710 720 730 740 750
NDPHFIIYLP KSKRNICFNI DSEPGKILSL VSDPESGIVV NGQLIGAKRA
760 770 780 790 800
ENGKLSTYFG KLGFYFQKEG MKIEISTETI TLSSGSSTSR LSWSDTAHLG
810 820 830 840 850
NSRVLISVKK EKSVTLTLNK ELFFSVLLHR VWRKHPVNVD FLGIYAPPID
860 870 880 890 900
KFSPRVHGLL GQFMQEPAIH IFNERPGKEP GKPEASMEVK GHKLTVTRGL
910 920 930 940
QKDYRTDIVF GTDVPCWFVH NSGKGFIDGH YKDYFVPQLY SFLKRP
Length:946
Mass (Da):105,928
Last modified:November 1, 1996 - v1
Checksum:i40DB6716433ED9DC
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3X977G3X977_MOUSE
Inter-alpha trypsin inhibitor, heav...
Itih2 mCG_5023
950Annotation score:
Q3UEG7Q3UEG7_MOUSE
Inter-alpha-trypsin inhibitor heavy...
Itih2
452Annotation score:
E0CX69E0CX69_MOUSE
Inter-alpha-trypsin inhibitor heavy...
Itih2
81Annotation score:

Sequence cautioni

The sequence BAE21837 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti833R → G in BAE21837 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70392 mRNA Translation: CAA49842.1
AK133782 mRNA Translation: BAE21837.1 Different initiation.
AL772367 Genomic DNA No translation available.
PIRiS54354
RefSeqiNP_034712.2, NM_010582.3
UniGeneiMm.182043

Genome annotation databases

GeneIDi16425
KEGGimmu:16425

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70392 mRNA Translation: CAA49842.1
AK133782 mRNA Translation: BAE21837.1 Different initiation.
AL772367 Genomic DNA No translation available.
PIRiS54354
RefSeqiNP_034712.2, NM_010582.3
UniGeneiMm.182043

3D structure databases

ProteinModelPortaliQ61703
SMRiQ61703
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ61703, 4 interactors
MINTiQ61703
STRINGi10090.ENSMUSP00000046530

PTM databases

iPTMnetiQ61703
PhosphoSitePlusiQ61703

Proteomic databases

MaxQBiQ61703
PaxDbiQ61703
PRIDEiQ61703

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi16425
KEGGimmu:16425

Organism-specific databases

CTDi3698
MGIiMGI:96619 Itih2

Phylogenomic databases

eggNOGiENOG410IEJB Eukaryota
COG2304 LUCA
HOGENOMiHOG000000680
HOVERGENiHBG057734
InParanoidiQ61703
KOiK19015
PhylomeDBiQ61703

Miscellaneous databases

ChiTaRSiItih2 mouse
PROiPR:Q61703
SOURCEiSearch...

Gene expression databases

CleanExiMM_ITIH2

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR010600 ITI_HC_C
IPR013694 VIT
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF06668 ITI_HC_C, 1 hit
PF08487 VIT, 1 hit
PF00092 VWA, 1 hit
SMARTiView protein in SMART
SM00609 VIT, 1 hit
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS51468 VIT, 1 hit
PS50234 VWFA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiITIH2_MOUSE
AccessioniPrimary (citable) accession number: Q61703
Secondary accession number(s): A2AKU6, Q3UZM0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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