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Protein

Inter-alpha-trypsin inhibitor heavy chain H1

Gene

Itih1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.By similarity

GO - Molecular functioni

GO - Biological processi

  • extracellular matrix organization Source: MGI
  • hyaluronan metabolic process Source: InterPro

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Inter-alpha-trypsin inhibitor heavy chain H1
Short name:
ITI heavy chain H1
Short name:
ITI-HC1
Short name:
Inter-alpha-inhibitor heavy chain 1
Gene namesi
Name:Itih1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:96618 Itih1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
PropeptideiPRO_000001650927 – 31By similarity5
ChainiPRO_000001651032 – 668Inter-alpha-trypsin inhibitor heavy chain H1Add BLAST637
PropeptideiPRO_0000016511669 – 907By similarityAdd BLAST239

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi57S-linked (Hex...) cysteineBy similarity1
Glycosylationi282N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi285N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei399PhosphothreonineBy similarity1
Modified residuei404PhosphothreonineBy similarity1
Glycosylationi585N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi650O-linked (GalNAc...) threonineBy similarity1
Modified residuei668Aspartate 1-(chondroitin 4-sulfate)-esterBy similarity1

Post-translational modificationi

Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal aspartate after propeptide cleavage.By similarity
The S-linked glycan is composed of two 6-carbon sugars, possibly Glc or Gal.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

MaxQBiQ61702
PaxDbiQ61702
PRIDEiQ61702

PTM databases

iPTMnetiQ61702
PhosphoSitePlusiQ61702
SwissPalmiQ61702

Expressioni

Tissue specificityi

Liver specific.

Gene expression databases

BgeeiENSMUSG00000006529 Expressed in 46 organ(s), highest expression level in liver
CleanExiMM_ITIH1
ExpressionAtlasiQ61702 baseline and differential
GenevisibleiQ61702 MM

Interactioni

Subunit structurei

I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (H1, H2 or H3) and one light chain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of H1, H2 and bikunin, inter-alpha-like inhibitor (I-alpha-LI) of H2 and bikunin, and pre-alpha-inhibitor (P-alpha-I) of H3 and bikunin.

Protein-protein interaction databases

BioGridi200836, 1 interactor
IntActiQ61702, 1 interactor
STRINGi10090.ENSMUSP00000126449

Structurei

3D structure databases

ProteinModelPortaliQ61702
SMRiQ61702
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 163VITPROSITE-ProRule annotationAdd BLAST130
Domaini287 – 447VWFAPROSITE-ProRule annotationAdd BLAST161

Sequence similaritiesi

Belongs to the ITIH family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IEJB Eukaryota
COG2304 LUCA
GeneTreeiENSGT00550000074468
HOVERGENiHBG057734
InParanoidiQ61702
KOiK19014
OMAiRHKQYYE
PhylomeDBiQ61702
TreeFamiTF328982

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR010600 ITI_HC_C
IPR013694 VIT
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF06668 ITI_HC_C, 1 hit
PF08487 VIT, 1 hit
PF00092 VWA, 1 hit
SMARTiView protein in SMART
SM00609 VIT, 1 hit
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS51468 VIT, 1 hit
PS50234 VWFA, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q61702-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGATGLRVL LCLLPLLTLQ ARPALGLATG RPRGSEKRHA VDTSVNGVSI
60 70 80 90 100
KSLKVNCKVT SRFAHYVITS QVVNNADKAR EVAFDVEIPK TAFISDFAIT
110 120 130 140 150
SDGKAFIGDI KDKVTAWKQY RKAAVLGESA GLVRASGRNM EQFTIHITVG
160 170 180 190 200
AQSKATFRLT YEEVLKRRLM QYDITIKVRP KQLVQHFEID VDIFEPQGIS
210 220 230 240 250
KLDAQASFLS EELAAQTIKK SFSGKKGHVL FRPTVSQQQS CPTCSTSLLN
260 270 280 290 300
GEFKVTYDVN RDKLCDLLVA NNYFTHFFAP KNLTNMSKNL VFVIDISGSM
310 320 330 340 350
EGQKVRQTKE ALLKILEDMR PVDNFDLVLF GSKVQSWKGS LVPASNANLQ
360 370 380 390 400
AAQDFVRRFS LAGATNLNGG LLRGIEILNK AQGSHPELSS PASILIMLTD
410 420 430 440 450
GEPTEGETDR SQILKNVRNA IRGRFPLYNL GFGHDLDFSF LEVMSTENNG
460 470 480 490 500
WAQRIYEDHD ATQQLQGFYN QVANPLLTDV ELQYPQDAVL ALTQHRHKQY
510 520 530 540 550
YDGSEIVVAG RIANHKLNTF KADVRARGEK QEFRATCLVD EEEMKKLLRE
560 570 580 590 600
RGHVLENHVE RLWAYLTIQE LLAKRMKTEG EERANLSSQV LKMSLDYHFV
610 620 630 640 650
TPLTSLTIRG LTDEDGLEPT IDKPLEDSQP LEMVGPRRTF VLSAIQPSPT
660 670 680 690 700
AHPIDSKLPL RVTGVDTDPH FIIYVPSKED SLCFNINEEP GVILNLVQDP
710 720 730 740 750
DTGFTVNGQL IGNKASSPGQ HESTYFGRLG ISSPTSDFQL EVTPQNITLN
760 770 780 790 800
PSSSGSMFSW RDQAVLQKDG VVVTINKKRN LVVSVDDGAT FEIVLHRTWK
810 820 830 840 850
GSAVHQDFLG FYVLDSFRMS ARTKGLLGQF FSPLDFEVFD LHPGSDPTKT
860 870 880 890 900
DATMVVKNRQ LTVTRGLQKD YSKDPRHGAE VPCWFVHDNG AGLIDGVHTD

YVVSDIF
Length:907
Mass (Da):101,067
Last modified:July 27, 2011 - v2
Checksum:iAF430E611C1755CD
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WJ05F8WJ05_MOUSE
Inter-alpha-trypsin inhibitor heavy...
Itih1
911Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti344A → V in CAA49841 (PubMed:7534067).Curated1
Sequence conflicti654I → T in CAA49841 (PubMed:7534067).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70391 mRNA Translation: CAA49841.1
AK149500 mRNA Translation: BAE28922.1
CH466573 Genomic DNA Translation: EDL24774.1
CCDSiCCDS49435.1
PIRiS54353
RefSeqiNP_001293007.1, NM_001306078.1
NP_032432.2, NM_008406.3
UniGeneiMm.3227

Genome annotation databases

EnsembliENSMUST00000163118; ENSMUSP00000126449; ENSMUSG00000006529
GeneIDi16424
KEGGimmu:16424
UCSCiuc007svz.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70391 mRNA Translation: CAA49841.1
AK149500 mRNA Translation: BAE28922.1
CH466573 Genomic DNA Translation: EDL24774.1
CCDSiCCDS49435.1
PIRiS54353
RefSeqiNP_001293007.1, NM_001306078.1
NP_032432.2, NM_008406.3
UniGeneiMm.3227

3D structure databases

ProteinModelPortaliQ61702
SMRiQ61702
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200836, 1 interactor
IntActiQ61702, 1 interactor
STRINGi10090.ENSMUSP00000126449

PTM databases

iPTMnetiQ61702
PhosphoSitePlusiQ61702
SwissPalmiQ61702

Proteomic databases

MaxQBiQ61702
PaxDbiQ61702
PRIDEiQ61702

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000163118; ENSMUSP00000126449; ENSMUSG00000006529
GeneIDi16424
KEGGimmu:16424
UCSCiuc007svz.1 mouse

Organism-specific databases

CTDi3697
MGIiMGI:96618 Itih1

Phylogenomic databases

eggNOGiENOG410IEJB Eukaryota
COG2304 LUCA
GeneTreeiENSGT00550000074468
HOVERGENiHBG057734
InParanoidiQ61702
KOiK19014
OMAiRHKQYYE
PhylomeDBiQ61702
TreeFamiTF328982

Miscellaneous databases

PROiPR:Q61702
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000006529 Expressed in 46 organ(s), highest expression level in liver
CleanExiMM_ITIH1
ExpressionAtlasiQ61702 baseline and differential
GenevisibleiQ61702 MM

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR010600 ITI_HC_C
IPR013694 VIT
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF06668 ITI_HC_C, 1 hit
PF08487 VIT, 1 hit
PF00092 VWA, 1 hit
SMARTiView protein in SMART
SM00609 VIT, 1 hit
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS51468 VIT, 1 hit
PS50234 VWFA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiITIH1_MOUSE
AccessioniPrimary (citable) accession number: Q61702
Secondary accession number(s): Q3UEI9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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