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UniProtKB - Q61672 (S29A2_MOUSE)
Protein
Equilibrative nucleoside transporter 2
Gene
Slc29a2
Organism
Mus musculus (Mouse)
Status
Functioni
Mediates equilibrative transport of purine and pyrimidine nucleosides, and the purine base hypoxanthine.
Kineticsi
- KM=0.75 mM for adenosine
GO - Molecular functioni
- neurotransmitter transmembrane transporter activity Source: ARUK-UCL
- nucleoside transmembrane transporter activity Source: MGI
- purine nucleoside transmembrane transporter activity Source: ARUK-UCL
- uridine transmembrane transporter activity Source: MGI
GO - Biological processi
- adenine transport Source: MGI
- adenosine transport Source: ARUK-UCL
- cellular response to insulin stimulus Source: Ensembl
- guanine transport Source: MGI
- hypoxanthine transport Source: MGI
- lactation Source: Ensembl
- neurotransmitter reuptake Source: MGI
- neurotransmitter transport Source: MGI
- neurotransmitter uptake Source: ARUK-UCL
- nucleoside transmembrane transport Source: MGI
- nucleoside transport Source: MGI
- purine nucleoside transmembrane transport Source: ARUK-UCL
- pyrimidine-containing compound transmembrane transport Source: MGI
- thymine transport Source: MGI
- uridine transport Source: MGI
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
Reactomei | R-MMU-83936, Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane |
Protein family/group databases
TCDBi | 2.A.57.1.2, the equilibrative nucleoside transporter (ent) family |
Names & Taxonomyi
Protein namesi | Recommended name: Equilibrative nucleoside transporter 2Alternative name(s): 36 kDa hydrophobic nucleolar protein 36 kDa nucleolar protein HNP36 Delayed-early response protein 12 Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter Short name: Equilibrative NBMPR-insensitive nucleoside transporter Nucleoside transporter, ei-type Solute carrier family 29 member 2 |
Gene namesi | Name:Slc29a2 Synonyms:Der12, Ent2, Hnp36 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1345278, Slc29a2 |
VEuPathDBi | HostDB:ENSMUSG00000024891 |
Subcellular locationi
Nucleus
Plasma membrane
- Basolateral cell membrane By similarity; Multi-pass membrane protein By similarity
Nucleus
- nuclear membrane Source: UniProtKB-SubCell
Plasma Membrane
- basolateral plasma membrane Source: UniProtKB
- integral component of plasma membrane Source: InterPro
- plasma membrane Source: MGI
Other locations
- integral component of membrane Source: GO_Central
- presynapse Source: GOC
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 13 – 33 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 69 – 89 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 98 – 118 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 123 – 143 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 161 – 181 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 192 – 212 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 288 – 308 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 323 – 343 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 360 – 380 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 396 – 416 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 432 – 452 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, Membrane, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000209341 | 1 – 456 | Equilibrative nucleoside transporter 2Add BLAST | 456 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 56 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 252 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q61672 |
MaxQBi | Q61672 |
PaxDbi | Q61672 |
PeptideAtlasi | Q61672 |
PRIDEi | Q61672 |
ProteomicsDBi | 253379 |
PTM databases
GlyGeni | Q61672, 1 site |
iPTMneti | Q61672 |
PhosphoSitePlusi | Q61672 |
Expressioni
Inductioni
By platelet derived growth factor (PDGF) and fibroblast growth factor (FGF).
Gene expression databases
Bgeei | ENSMUSG00000024891, Expressed in ectoplacental cone and 131 other tissues |
ExpressionAtlasi | Q61672, baseline and differential |
Genevisiblei | Q61672, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000025826 |
Miscellaneous databases
RNActi | Q61672, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 248 – 277 | DisorderedSequence analysisAdd BLAST | 30 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1479, Eukaryota |
GeneTreei | ENSGT00950000182898 |
HOGENOMi | CLU_021611_6_0_1 |
InParanoidi | Q61672 |
OMAi | FNIMDWV |
OrthoDBi | 559763at2759 |
PhylomeDBi | Q61672 |
TreeFami | TF313950 |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR034764, ENT1/ENT2 IPR030197, ENT2 IPR002259, Eqnu_transpt IPR036259, MFS_trans_sf |
PANTHERi | PTHR10332, PTHR10332, 1 hit PTHR10332:SF8, PTHR10332:SF8, 1 hit |
Pfami | View protein in Pfam PF01733, Nucleoside_tran, 1 hit |
PIRSFi | PIRSF016379, ENT, 1 hit |
PRINTSi | PR01130, DERENTRNSPRT |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00939, 2a57, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q61672-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MARGNAPRDS YHLVGISFFI LGLGTLLPWN FFITAIPYFQ GRLAGTNSSA
60 70 80 90 100
ETMGTNHTSP TDTFNFNNWV TLLSQLPLLL FTLLNSFLYQ CIPESVRILG
110 120 130 140 150
SLLAILLLFA LTAALVKVDL SPGLFFSVTM ASVWFINSFC AVLQGSLFGQ
160 170 180 190 200
LGTMPSTYST LFLSGQGLAG IFAALAMLMS LASGVDAQTS ALGYFITPCV
210 220 230 240 250
GILLSIVCYL SLPHLKFARY YLTEKLSQAP TQELETKAEL LQADEKNGVP
260 270 280 290 300
ISPQQASPTL DLDPEKEPEP EEPQKPGKPS VFVVFRKIWL TALCLVLVFT
310 320 330 340 350
VTLSVFPAIT AMVTTSSNSP GKWGLFFNPI CCFLLFNVMD WLGRSLTSYF
360 370 380 390 400
LWPDEDSQQL LPLLVCLRFL FVPLFMLCHV PQHARLPIIF RQDAYFITFM
410 420 430 440 450
LLFAVSNGYL VSLTMCLAPR QVLPHEREVA GALMTFFLAL GLSCGASLSF
LFKALL
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A494BAC3 | A0A494BAC3_MOUSE | Equilibrative nucleoside transporte... | Slc29a2 | 404 | Annotation score: | ||
A0A498WFQ1 | A0A498WFQ1_MOUSE | Equilibrative nucleoside transporte... | Slc29a2 | 427 | Annotation score: | ||
A0A494BAD2 | A0A494BAD2_MOUSE | Equilibrative nucleoside transporte... | Slc29a2 | 228 | Annotation score: |
Sequence cautioni
The sequence CAA60381 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF183397 mRNA Translation: AAF78477.1 CH466612 Genomic DNA Translation: EDL33088.1 BC048958 mRNA Translation: AAH48958.1 X86682 mRNA Translation: CAA60381.1 Different initiation. |
CCDSi | CCDS50354.1 |
PIRi | JC4195 |
RefSeqi | NP_031880.2, NM_007854.3 |
Genome annotation databases
Ensembli | ENSMUST00000236152; ENSMUSP00000157780; ENSMUSG00000024891 |
GeneIDi | 13340 |
KEGGi | mmu:13340 |
UCSCi | uc008gbv.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF183397 mRNA Translation: AAF78477.1 CH466612 Genomic DNA Translation: EDL33088.1 BC048958 mRNA Translation: AAH48958.1 X86682 mRNA Translation: CAA60381.1 Different initiation. |
CCDSi | CCDS50354.1 |
PIRi | JC4195 |
RefSeqi | NP_031880.2, NM_007854.3 |
3D structure databases
SMRi | Q61672 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000025826 |
Chemistry databases
ChEMBLi | CHEMBL1287612 |
Protein family/group databases
TCDBi | 2.A.57.1.2, the equilibrative nucleoside transporter (ent) family |
PTM databases
GlyGeni | Q61672, 1 site |
iPTMneti | Q61672 |
PhosphoSitePlusi | Q61672 |
Proteomic databases
EPDi | Q61672 |
MaxQBi | Q61672 |
PaxDbi | Q61672 |
PeptideAtlasi | Q61672 |
PRIDEi | Q61672 |
ProteomicsDBi | 253379 |
Protocols and materials databases
Antibodypediai | 16257, 140 antibodies from 23 providers |
DNASUi | 13340 |
Genome annotation databases
Ensembli | ENSMUST00000236152; ENSMUSP00000157780; ENSMUSG00000024891 |
GeneIDi | 13340 |
KEGGi | mmu:13340 |
UCSCi | uc008gbv.2, mouse |
Organism-specific databases
CTDi | 3177 |
MGIi | MGI:1345278, Slc29a2 |
VEuPathDBi | HostDB:ENSMUSG00000024891 |
Phylogenomic databases
eggNOGi | KOG1479, Eukaryota |
GeneTreei | ENSGT00950000182898 |
HOGENOMi | CLU_021611_6_0_1 |
InParanoidi | Q61672 |
OMAi | FNIMDWV |
OrthoDBi | 559763at2759 |
PhylomeDBi | Q61672 |
TreeFami | TF313950 |
Enzyme and pathway databases
Reactomei | R-MMU-83936, Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane |
Miscellaneous databases
BioGRID-ORCSi | 13340, 1 hit in 66 CRISPR screens |
PROi | PR:Q61672 |
RNActi | Q61672, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000024891, Expressed in ectoplacental cone and 131 other tissues |
ExpressionAtlasi | Q61672, baseline and differential |
Genevisiblei | Q61672, MM |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR034764, ENT1/ENT2 IPR030197, ENT2 IPR002259, Eqnu_transpt IPR036259, MFS_trans_sf |
PANTHERi | PTHR10332, PTHR10332, 1 hit PTHR10332:SF8, PTHR10332:SF8, 1 hit |
Pfami | View protein in Pfam PF01733, Nucleoside_tran, 1 hit |
PIRSFi | PIRSF016379, ENT, 1 hit |
PRINTSi | PR01130, DERENTRNSPRT |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00939, 2a57, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | S29A2_MOUSE | |
Accessioni | Q61672Primary (citable) accession number: Q61672 Secondary accession number(s): Q9JIT8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | March 8, 2011 | |
Last modified: | February 23, 2022 | |
This is version 148 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families