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Entry version 168 (08 May 2019)
Sequence version 3 (01 May 2007)
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Protein

Protein HIRA

Gene

Hira

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for the periodic repression of histone gene transcription during the cell cycle (By similarity). Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • transcription corepressor activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein HIRA
Alternative name(s):
TUP1-like enhancer of split protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Hira
Synonyms:Tuple1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:99430 Hira

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Embryonic stem cells (ES cells) exhibit accelerated differentiation in the early stages which may be attributable to increased availability of soluble histones.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000510201 – 1015Protein HIRAAdd BLAST1015

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei111PhosphoserineBy similarity1
Modified residuei548PhosphoserineBy similarity1
Modified residuei554Phosphothreonine1 Publication1
Modified residuei556PhosphoserineBy similarity1
Modified residuei575PhosphothreonineBy similarity1
Modified residuei583PhosphoserineBy similarity1
Modified residuei608PhosphoserineBy similarity1
Modified residuei609PhosphoserineBy similarity1
Modified residuei610PhosphoserineBy similarity1
Modified residuei612PhosphoserineBy similarity1
Modified residuei659PhosphoserineBy similarity1
Modified residuei673PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sumoylated.By similarity
Phosphorylated by CDK2/CCNA1 and CDK2/CCNE1 on Thr-554 in vitro (By similarity). Also phosphorylated on Thr-554 in vivo.By similarity1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q61666

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q61666

PeptideAtlas

More...
PeptideAtlasi
Q61666

PRoteomics IDEntifications database

More...
PRIDEi
Q61666

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q61666

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q61666

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in cerebrum, cerebellum, heart, kidney, liver, lung and spleen.

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Throughout development the long isoform is more abundant. In embryos, ubiquitously expressed with high levels detected in cranial neural folds, subregions of pharyngeal arches 1 and 2, circumpharyngeal neural crest and limb buds.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000022702 Expressed in 219 organ(s), highest expression level in embryonic stem cell

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q61666 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q61666 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CCNA1, HIRIP3 and NFU1/HIRIP5. Part of a complex which includes ASF1A, CABIN1, histone H3.3, histone H4 and UBN1 (By similarity). Interacts with histone H2B, histone H3F3B, PAX3 and PAX7.By similarity1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
200309, 10 interactors

Protein interaction database and analysis system

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IntActi
Q61666, 8 interactors

Molecular INTeraction database

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MINTi
Q61666

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000004222

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q61666

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati11 – 53WD 1Add BLAST43
Repeati68 – 107WD 2Add BLAST40
Repeati129 – 168WD 3Add BLAST40
Repeati172 – 211WD 4Add BLAST40
Repeati220 – 263WD 5Add BLAST44
Repeati266 – 322WD 6Add BLAST57
Repeati326 – 367WD 7Add BLAST42

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni421 – 727Interaction with CCNA1By similarityAdd BLAST307
Regioni421 – 479Interaction with ASF1ABy similarityAdd BLAST59
Regioni439 – 475Required for repression of histone gene transcriptionBy similarityAdd BLAST37
Regioni593 – 737Interaction with PAX31 PublicationAdd BLAST145
Regioni594 – 824Interaction with histone H2BBy similarityAdd BLAST231
Regioni736 – 1015Interaction with histone H4By similarityAdd BLAST280
Regioni738 – 826Interaction with PAX31 PublicationAdd BLAST89

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi408 – 412Poly-Gln5
Compositional biasi638 – 641Poly-Lys4
Compositional biasi803 – 806Poly-Val4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat HIR1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0973 Eukaryota
ENOG410XP1H LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00550000074919

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000007670

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q61666

KEGG Orthology (KO)

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KOi
K11293

Identification of Orthologs from Complete Genome Data

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OMAi
DVQDLGW

Database of Orthologous Groups

More...
OrthoDBi
685536at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q61666

TreeFam database of animal gene trees

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TreeFami
TF323161

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031120 HIR1
IPR011494 Hira
IPR019015 HIRA_B_motif
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR13831 PTHR13831, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF07569 Hira, 1 hit
PF09453 HIRA_B, 1 hit
PF00400 WD40, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform Long (identifier: Q61666-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKLLKPTWVN HNGKPIFSVD IHPDGTKFAT GGQGQDSGKV VIWNMSPVLQ
60 70 80 90 100
EDDEKDENIP KMLCQMDNHL ACVNCVRWSN SGMYLASGGD DKLIMVWKRA
110 120 130 140 150
TYIGPSTVFG SSGKLANVEQ WRCVSILRSH SGDVMDVAWS PHDAWLASCS
160 170 180 190 200
VDNTVVIWNA VKFPEILATL RGHSGLVKGL TWDPVGKYIA SQADDRSLKV
210 220 230 240 250
WRTLDWQLET SITKPFDECG GTTHVLRLSW SPDGHYLVSA HAMNNSGPTA
260 270 280 290 300
QIIEREGWKT NMDFVGHRKA VTVVKFNPKI FKKKQKNGSS TKPSCPYCCC
310 320 330 340 350
AVGSKDRSLS VWLTCLKRPL VVIHELFDKS IMDISWTLNG LGILVCSMDG
360 370 380 390 400
SVAFLDFSQD ELGDPLSEEE KSRIHQSTYG KSLAIMTEAQ LSTAVIENPE
410 420 430 440 450
MLKYQRRQQQ QQLDQKNATT RETSSASSVT GVVNGESLED IRKNLLKKQV
460 470 480 490 500
ETRTADGRRR ITPLCIAQLD TGDFSTAFFN SIPLSSSLAG TMLSSPSGQQ
510 520 530 540 550
LLPLDSSTPS FGASKPCTEP VAATSARPTG ESVSKDSMNA TSTPAASSPS
560 570 580 590 600
VLTTPSKIEP MKAFDSRFTE RSKATPGAPS LTSVIPTAVE RLKEQNLVKE
610 620 630 640 650
LRSRELESSS DSDEKVHLAK PSSLSKRKLE LEVETVEKKK KGRPRKDSRL
660 670 680 690 700
LPMSLSVQSP AALSTEKEAM CLSAPALALK LPIPGPQRAF TLQVSSDPSM
710 720 730 740 750
YIEVENEVTT VGGIRLSRLK CNREGKEWET VLSSRVLTAA GSCDVVCVAC
760 770 780 790 800
EKRMLSVFST CGRRLLPPIL LPSPISTLHC TGPYVMALTA AATLSVWDVH
810 820 830 840 850
RQVVVVKEES LHSILSGSDM TVSQILLTQH GIPVMNLSDG KAYCFNPSLS
860 870 880 890 900
TWNLVSDKQD SLAQCADFRN SLPSQDAMLC SGPLAIIQGR TSNSGRQAAR
910 920 930 940 950
LFSVPHVVQQ ETTLAYLENQ VAAALTLQSS HEYRHWLLLY ARYLVNEGFE
960 970 980 990 1000
YRLREICKDL LGPVHCSTGS QWESTVVGLR KRELLKELLP VIGQNLRFQR
1010
LFTECQEQLD ILRDK
Length:1,015
Mass (Da):111,767
Last modified:May 1, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2D84294D45B7A967
GO
Isoform Short (identifier: Q61666-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     556-562: SKIEPMK → PQYIICSP
     563-1015: Missing.

Show »
Length:563
Mass (Da):61,642
Checksum:i7F687DA1201815BD
GO
Isoform 3 (identifier: Q61666-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-44: Missing.
     473-497: DFSTAFFNSIPLSSSLAGTMLSSPS → YSLLHQAFCGLVWGGLLFFCCQLAS
     498-1015: Missing.

Show »
Length:453
Mass (Da):50,449
Checksum:iFF189AF5E97CF083
GO
Isoform 4 (identifier: Q61666-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-652: Missing.

Note: No experimental confirmation available.
Show »
Length:363
Mass (Da):40,090
Checksum:iFD785BD8473346A1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RE52D6RE52_MOUSE
Protein HIRA
Hira
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A338P6E9A0A338P6E9_MOUSE
Protein HIRA
Hira
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A338P737A0A338P737_MOUSE
Protein HIRA
Hira
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti216F → C in CAA63334 (PubMed:8611624).Curated1
Sequence conflicti400E → G in AAH52856 (PubMed:15489334).Curated1
Sequence conflicti459R → S in CAA63334 (PubMed:8611624).Curated1
Sequence conflicti650L → F in CAA63334 (PubMed:8611624).Curated1
Sequence conflicti712G → R in CAA68049 (PubMed:9063745).Curated1
Sequence conflicti1007E → G in CAA63334 (PubMed:8611624).Curated1
Sequence conflicti1013 – 1014RD → WG in CAA63334 (PubMed:8611624).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0250491 – 652Missing in isoform 4. 1 PublicationAdd BLAST652
Alternative sequenceiVSP_0250501 – 44Missing in isoform 3. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_025051473 – 497DFSTA…LSSPS → YSLLHQAFCGLVWGGLLFFC CQLAS in isoform 3. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_025052498 – 1015Missing in isoform 3. 1 PublicationAdd BLAST518
Alternative sequenceiVSP_006773556 – 562SKIEPMK → PQYIICSP in isoform Short. 1 Publication7
Alternative sequenceiVSP_006774563 – 1015Missing in isoform Short. 1 PublicationAdd BLAST453

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X92590 mRNA Translation: CAA63334.1
X99712 mRNA Translation: CAA68049.1
X75295 mRNA Translation: CAA53043.1
AK135928 mRNA Translation: BAE22728.1
AK168963 mRNA Translation: BAE40768.1
BC052856 mRNA Translation: AAH52856.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS28031.1 [Q61666-1]

Protein sequence database of the Protein Information Resource

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PIRi
S45345
S68141

NCBI Reference Sequences

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RefSeqi
NP_034565.2, NM_010435.2 [Q61666-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000004222; ENSMUSP00000004222; ENSMUSG00000022702 [Q61666-1]
ENSMUST00000120532; ENSMUSP00000112614; ENSMUSG00000022702 [Q61666-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
15260

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:15260

UCSC genome browser

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UCSCi
uc007yoq.1 mouse [Q61666-1]
uc007yor.1 mouse [Q61666-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92590 mRNA Translation: CAA63334.1
X99712 mRNA Translation: CAA68049.1
X75295 mRNA Translation: CAA53043.1
AK135928 mRNA Translation: BAE22728.1
AK168963 mRNA Translation: BAE40768.1
BC052856 mRNA Translation: AAH52856.1
CCDSiCCDS28031.1 [Q61666-1]
PIRiS45345
S68141
RefSeqiNP_034565.2, NM_010435.2 [Q61666-1]

3D structure databases

SMRiQ61666
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200309, 10 interactors
IntActiQ61666, 8 interactors
MINTiQ61666
STRINGi10090.ENSMUSP00000004222

PTM databases

iPTMnetiQ61666
PhosphoSitePlusiQ61666

Proteomic databases

EPDiQ61666
PaxDbiQ61666
PeptideAtlasiQ61666
PRIDEiQ61666

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
15260
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000004222; ENSMUSP00000004222; ENSMUSG00000022702 [Q61666-1]
ENSMUST00000120532; ENSMUSP00000112614; ENSMUSG00000022702 [Q61666-3]
GeneIDi15260
KEGGimmu:15260
UCSCiuc007yoq.1 mouse [Q61666-1]
uc007yor.1 mouse [Q61666-3]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7290
MGIiMGI:99430 Hira

Phylogenomic databases

eggNOGiKOG0973 Eukaryota
ENOG410XP1H LUCA
GeneTreeiENSGT00550000074919
HOGENOMiHOG000007670
InParanoidiQ61666
KOiK11293
OMAiDVQDLGW
OrthoDBi685536at2759
PhylomeDBiQ61666
TreeFamiTF323161

Enzyme and pathway databases

ReactomeiR-MMU-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF)

Miscellaneous databases

Protein Ontology

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PROi
PR:Q61666

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000022702 Expressed in 219 organ(s), highest expression level in embryonic stem cell
ExpressionAtlasiQ61666 baseline and differential
GenevisibleiQ61666 MM

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR031120 HIR1
IPR011494 Hira
IPR019015 HIRA_B_motif
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR13831 PTHR13831, 1 hit
PfamiView protein in Pfam
PF07569 Hira, 1 hit
PF09453 HIRA_B, 1 hit
PF00400 WD40, 4 hits
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHIRA_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q61666
Secondary accession number(s): O08845
, Q3TFY0, Q3UX35, Q62365, Q7TMW4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 2007
Last modified: May 8, 2019
This is version 168 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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