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Protein

Homeobox expressed in ES cells 1

Gene

Hesx1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi108 – 167HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox expressed in ES cells 1
Alternative name(s):
Anterior-restricted homeobox protein
Homeobox protein ANF
Rathke pouch homeo box
Gene namesi
Name:Hesx1
Synonyms:Hes-1, Rpx
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:96071 Hesx1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000489231 – 185Homeobox expressed in ES cells 1Add BLAST185

Proteomic databases

PaxDbiQ61658
PRIDEiQ61658

PTM databases

PhosphoSitePlusiQ61658

Expressioni

Tissue specificityi

High levels found in the embryonic liver, lower level expression seen in the viscera, amnion and yolk sac.

Developmental stagei

Early expression seen in the anterior midline endoderm and prechordal plate precursor, subsequently activated in the overlying ectoderm of the cephalic neural plate. Later disappears in the mesendoderm while remaining in the prospective prosencephalic region of the neural plate ectoderm, ultimately expression is restricted to Rathke pouch, the primordium of the pituitary. Expressed in embryonic stem cells.1 Publication

Inductioni

Down-regulated during embryonic stem (ES) cell differentiation.

Gene expression databases

BgeeiENSMUSG00000040726 Expressed in 46 organ(s), highest expression level in remnant of Rathke's pouch
CleanExiMM_HESX1
GenevisibleiQ61658 MM

Interactioni

Subunit structurei

Can form heterodimers with PROP1 in binding to DNA Interacts with TLE1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200279, 5 interactors
STRINGi10090.ENSMUSP00000041999

Structurei

3D structure databases

ProteinModelPortaliQ61658
SMRiQ61658
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ANF homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
GeneTreeiENSGT00920000149119
HOGENOMiHOG000112889
HOVERGENiHBG004226
InParanoidiQ61658
KOiK09354
OMAiDGNLCLH
OrthoDBiEOG091G112W
TreeFamiTF335506

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q61658-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSPSLREGAQ LRESKPAPCS FSIESILGLD QKKDCTTSVR PHRPWTDTCG
60 70 80 90 100
DSEKGGNPPL HAPDLPSETS FPCPVDHPRP EERAPKYENY FSASETRSLK
110 120 130 140 150
RELSWYRGRR PRTAFTQNQV EVLENVFRVN CYPGIDIRED LAQKLNLEED
160 170 180
RIQIWFQNRR AKMKRSRRES QFLMAKKPFN PDLLK
Length:185
Mass (Da):21,504
Last modified:October 3, 2012 - v2
Checksum:i5C18A524BF281246
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti51D → N in CAA56344 (PubMed:7876132).Curated1
Sequence conflicti51D → N in AAA97869 (PubMed:8565852).Curated1
Sequence conflicti55G → D in CAA56344 (PubMed:7876132).Curated1
Sequence conflicti55G → D in AAA97869 (PubMed:8565852).Curated1
Sequence conflicti176K → R in CAA56344 (PubMed:7876132).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80040 mRNA Translation: CAA56344.1
U40720 mRNA Translation: AAA97869.1
AK082831 mRNA Translation: BAC38643.1
AC124603 Genomic DNA No translation available.
BC132051 mRNA Translation: AAI32052.1
BC132053 mRNA Translation: AAI32054.1
BC145262 mRNA Translation: AAI45263.1
CCDSiCCDS26884.1
PIRiA55882
RefSeqiNP_034550.2, NM_010420.2
XP_006518633.1, XM_006518570.3
UniGeneiMm.4802

Genome annotation databases

EnsembliENSMUST00000035433; ENSMUSP00000041999; ENSMUSG00000040726
ENSMUST00000224331; ENSMUSP00000152952; ENSMUSG00000040726
GeneIDi15209
KEGGimmu:15209
UCSCiuc007stj.1 mouse

Similar proteinsi

Entry informationi

Entry nameiHESX1_MOUSE
AccessioniPrimary (citable) accession number: Q61658
Secondary accession number(s): Q61047, Q8C477
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 3, 2012
Last modified: September 12, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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