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UniProtKB - Q61657 (HES3_MOUSE)
Protein
Transcription factor HES-3
Gene
Hes3
Organism
Mus musculus (Mouse)
Status
Functioni
Transcriptional repressor of genes that require a bHLH protein for their transcription.
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SB
- E-box binding Source: GO_Central
- N-box binding Source: GO_Central
- protein dimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
GO - Biological processi
- anterior/posterior pattern specification Source: GO_Central
- hindbrain morphogenesis Source: MGI
- in utero embryonic development Source: MGI
- midbrain development Source: MGI
- midbrain-hindbrain boundary morphogenesis Source: MGI
- negative regulation of neuron differentiation Source: GO_Central
- negative regulation of transcription, DNA-templated Source: MGI
- negative regulation of transcription by RNA polymerase II Source: NTNU_SB
- neural tube development Source: MGI
- Notch signaling pathway Source: GO_Central
- oculomotor nerve development Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- regulation of neurogenesis Source: MGI
- regulation of timing of neuron differentiation Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
- trochlear nerve development Source: MGI
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor HES-3Alternative name(s): Hairy and enhancer of split 3 |
Gene namesi | Name:Hes3 Synonyms:Hes-3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:104877, Hes3 |
VEuPathDBi | HostDB:ENSMUSG00000028946 |
Subcellular locationi
Nucleus
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000127209 | 1 – 175 | Transcription factor HES-3Add BLAST | 175 |
Proteomic databases
PaxDbi | Q61657 |
PRIDEi | Q61657 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000028946, Expressed in adipose tissue and 144 other tissues |
ExpressionAtlasi | Q61657, baseline and differential |
Genevisiblei | Q61657, MM |
Interactioni
Subunit structurei
Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.
By similarityGO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
ELMi | Q61657 |
STRINGi | 10090.ENSMUSP00000092006 |
Miscellaneous databases
RNActi | Q61657, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 49 | bHLHPROSITE-ProRule annotationAdd BLAST | 49 | |
Domaini | 65 – 98 | OrangePROSITE-ProRule annotationAdd BLAST | 34 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 126 – 166 | DisorderedSequence analysisAdd BLAST | 41 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 172 – 175 | WRPW motif | 4 |
Domaini
Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.By similarity
Phylogenomic databases
eggNOGi | KOG4304, Eukaryota |
GeneTreei | ENSGT00730000111482 |
HOGENOMi | CLU_068550_4_0_1 |
InParanoidi | Q61657 |
OrthoDBi | 1095795at2759 |
PhylomeDBi | Q61657 |
TreeFami | TF351373 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR003650, Orange_dom |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS51054, ORANGE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q61657-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEKKRRARIN VSLEQLRSLL ERHYSHQIRK RKLEKADILE LSVKYMRSLQ
60 70 80 90 100
NSLQGLWPVP SGVDYPSGFQ GGLRGVSQRL RPGEGDSGLR CPLLLQRREG
110 120 130 140 150
STTDSANPQA TSVLNPCLPA IWAPSRAAGG SHSPQSPLPL PGGLLESSTD
160 170
VVAPHPASNC QAESTRPGFR VWRPW
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A1W2P7Y8 | A0A1W2P7Y8_MOUSE | Transcription factor HES-3 | Hes3 | 200 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 70 | Q → H (PubMed:8074710).Curated | 1 | |
Sequence conflicti | 70 | Q → H (Ref. 2) Curated | 1 | |
Sequence conflicti | 155 | H → Q (PubMed:8074710).Curated | 1 | |
Sequence conflicti | 155 | H → Q (Ref. 2) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D32200 Genomic DNA Translation: BAA06899.1 D85169 Genomic DNA Translation: BAA19799.1 AK090218 mRNA Translation: BAC41140.1 BC116444 mRNA Translation: AAI16445.1 |
CCDSi | CCDS18997.1 |
RefSeqi | NP_032263.2, NM_008237.4 XP_011248495.1, XM_011250193.2 |
Genome annotation databases
Ensembli | ENSMUST00000094438; ENSMUSP00000092006; ENSMUSG00000028946 |
GeneIDi | 15207 |
KEGGi | mmu:15207 |
UCSCi | uc008wac.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D32200 Genomic DNA Translation: BAA06899.1 D85169 Genomic DNA Translation: BAA19799.1 AK090218 mRNA Translation: BAC41140.1 BC116444 mRNA Translation: AAI16445.1 |
CCDSi | CCDS18997.1 |
RefSeqi | NP_032263.2, NM_008237.4 XP_011248495.1, XM_011250193.2 |
3D structure databases
AlphaFoldDBi | Q61657 |
SMRi | Q61657 |
ModBasei | Search... |
Protein-protein interaction databases
ELMi | Q61657 |
STRINGi | 10090.ENSMUSP00000092006 |
Proteomic databases
PaxDbi | Q61657 |
PRIDEi | Q61657 |
Protocols and materials databases
Antibodypediai | 62181, 52 antibodies from 14 providers |
DNASUi | 15207 |
Genome annotation databases
Ensembli | ENSMUST00000094438; ENSMUSP00000092006; ENSMUSG00000028946 |
GeneIDi | 15207 |
KEGGi | mmu:15207 |
UCSCi | uc008wac.1, mouse |
Organism-specific databases
CTDi | 390992 |
MGIi | MGI:104877, Hes3 |
VEuPathDBi | HostDB:ENSMUSG00000028946 |
Phylogenomic databases
eggNOGi | KOG4304, Eukaryota |
GeneTreei | ENSGT00730000111482 |
HOGENOMi | CLU_068550_4_0_1 |
InParanoidi | Q61657 |
OrthoDBi | 1095795at2759 |
PhylomeDBi | Q61657 |
TreeFami | TF351373 |
Miscellaneous databases
BioGRID-ORCSi | 15207, 1 hit in 70 CRISPR screens |
PROi | PR:Q61657 |
RNActi | Q61657, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000028946, Expressed in adipose tissue and 144 other tissues |
ExpressionAtlasi | Q61657, baseline and differential |
Genevisiblei | Q61657, MM |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR003650, Orange_dom |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS51054, ORANGE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HES3_MOUSE | |
Accessioni | Q61657Primary (citable) accession number: Q61657 Secondary accession number(s): O09083, O09150, Q8BTI2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | December 12, 2006 | |
Last modified: | May 25, 2022 | |
This is version 148 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot