Transcription factor HES-3

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Generation of structurally and functionally distinct factors from the basic helix-loop-helix gene Hes3 by alternative first exons."
    Hirata H., Ohtsuka T., Bessho Y., Kageyama R.
    J. Biol. Chem. 275:19083-19089(2000) [PubMed] [Europe PMC] [Abstract]
• protein dimerization activity Source: InterPro
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Generation of structurally and functionally distinct factors from the basic helix-loop-helix gene Hes3 by alternative first exons."
    Hirata H., Ohtsuka T., Bessho Y., Kageyama R.
    J. Biol. Chem. 275:19083-19089(2000) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II regulatory region sequence-specific DNA binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• transcription factor binding Source: UniProtKB <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • "Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer."
    Katoh M., Katoh M.
    Int. J. Oncol. 31:461-466(2007) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• anterior/posterior pattern specification Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cell differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• hindbrain morphogenesis Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain."
    Hirata H., Tomita K., Bessho Y., Kageyama R.
    EMBO J. 20:4454-4466(2001) [PubMed] [Europe PMC] [Abstract]
• in utero embryonic development Source: MGIInferred from genetic interactionⁱ
  • "Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain."
    Hirata H., Tomita K., Bessho Y., Kageyama R.
    EMBO J. 20:4454-4466(2001) [PubMed] [Europe PMC] [Abstract]
• midbrain development Source: MGIInferred from genetic interactionⁱ
  • "Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain."
    Hirata H., Tomita K., Bessho Y., Kageyama R.
    EMBO J. 20:4454-4466(2001) [PubMed] [Europe PMC] [Abstract]
• midbrain-hindbrain boundary morphogenesis Source: MGIInferred from genetic interactionⁱ
  • "Secondary lymphoid organ chemokine reduces pulmonary tumor burden in spontaneous murine bronchoalveolar cell carcinoma."
    Sharma S., Stolina M., Zhu L., Lin Y., Batra R., Huang M., Strieter R., Dubinett S.M.
    Cancer Res. 61:6406-6412(2001) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription, DNA-templated Source: MGI
• negative regulation of transcription by RNA polymerase II Source: NTNU_SBInferred from direct assayⁱ
  • "Generation of structurally and functionally distinct factors from the basic helix-loop-helix gene Hes3 by alternative first exons."
    Hirata H., Ohtsuka T., Bessho Y., Kageyama R.
    J. Biol. Chem. 275:19083-19089(2000) [PubMed] [Europe PMC] [Abstract]
• neural tube development Source: MGIInferred from genetic interactionⁱ
  • "Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain."
    Hirata H., Tomita K., Bessho Y., Kageyama R.
    EMBO J. 20:4454-4466(2001) [PubMed] [Europe PMC] [Abstract]
• oculomotor nerve development Source: MGIInferred from genetic interactionⁱ
  • "Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain."
    Hirata H., Tomita K., Bessho Y., Kageyama R.
    EMBO J. 20:4454-4466(2001) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: MGIInferred from genetic interactionⁱ
  • "Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain."
    Hirata H., Tomita K., Bessho Y., Kageyama R.
    EMBO J. 20:4454-4466(2001) [PubMed] [Europe PMC] [Abstract]
  • "Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis."
    Kinameri E., Inoue T., Aruga J., Imayoshi I., Kageyama R., Shimogori T., Moore A.W.
    PLoS ONE 3:e3859-e3859(2008) [PubMed] [Europe PMC] [Abstract]
• regulation of neurogenesis Source: MGIInferred from genetic interactionⁱ
  • "Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis."
    Kinameri E., Inoue T., Aruga J., Imayoshi I., Kageyama R., Shimogori T., Moore A.W.
    PLoS ONE 3:e3859-e3859(2008) [PubMed] [Europe PMC] [Abstract]
• regulation of timing of neuron differentiation Source: MGIInferred from genetic interactionⁱ
  • "Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain."
    Hirata H., Tomita K., Bessho Y., Kageyama R.
    EMBO J. 20:4454-4466(2001) [PubMed] [Europe PMC] [Abstract]
• trochlear nerve development Source: MGIInferred from genetic interactionⁱ
  • "Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain."
    Hirata H., Tomita K., Bessho Y., Kageyama R.
    EMBO J. 20:4454-4466(2001) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• protein dimerization activity Source: InterPro
• transcription factor binding Source: UniProtKBNon-traceable author statementⁱ
  • "Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer."
    Katoh M., Katoh M.
    Int. J. Oncol. 31:461-466(2007) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Motif

Compositional bias

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MEKKRRARIN VSLEQLRSLL ERHYSHQIRK RKLEKADILE LSVKYMRSLQ 
        60         70         80         90        100
NSLQGLWPVP SGVDYPSGFQ GGLRGVSQRL RPGEGDSGLR CPLLLQRREG 
       110        120        130        140        150
STTDSANPQA TSVLNPCLPA IWAPSRAAGG SHSPQSPLPL PGGLLESSTD 
       160        170 
VVAPHPASNC QAESTRPGFR VWRPW                            

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot