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Protein

Lysine-specific demethylase hairless

Gene

Hr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Histone demethylase that specifically demethylates both mono- and dimethylated 'Lys-9' of histone H3. May act as a transcription regulator controlling hair biology (via targeting of collagens), neural activity, and cell cycle (By similarity).By similarity

Cofactori

Fe2+By similarityNote: Binds 1 Fe2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi1000Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi1002Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi1118Iron; catalyticPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri595 – 620C6-typeAdd BLAST26

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Oxidoreductase
Biological processTranscription, Transcription regulation
LigandIron, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine-specific demethylase hairless (EC:1.14.11.-)
Gene namesi
Name:Hr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:96223 Hr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Defects in Hr are the cause of a number of pleiotropic effects including structural abnormalities of epithelial cells in the hair follicles, hair loss towards the end of the first hair growth cycle, and the failure of subsequent hair growth cycles. Older mice carrying a hr mutation have been reported to possess altered ratios of T-cell-dependent B-cell responses. Mice homozygous for hr mutation are uniquely sensitive to UV and chemically induced skin tumors.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000838911 – 1182Lysine-specific demethylase hairlessAdd BLAST1182

Proteomic databases

PaxDbiQ61645
PRIDEiQ61645

PTM databases

iPTMnetiQ61645
PhosphoSitePlusiQ61645

Expressioni

Tissue specificityi

Expressed predominantly in brain, hair follicles and interfollicular epidermis. No expression in dermis.

Gene expression databases

BgeeiENSMUSG00000022096 Expressed in 130 organ(s), highest expression level in skin of back
CleanExiMM_HR
ExpressionAtlasiQ61645 baseline and differential
GenevisibleiQ61645 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200415, 3 interactors
STRINGi10090.ENSMUSP00000022691

Structurei

3D structure databases

ProteinModelPortaliQ61645
SMRiQ61645
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini939 – 1150JmjCPROSITE-ProRule annotationAdd BLAST212

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi561 – 565LXXLL motif 15
Motifi753 – 757LXXLL motif 25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi535 – 540Poly-Gly6

Domaini

Contains two Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. The LXXLL motifs are essential for the association with nuclear receptors (By similarity).By similarity
The JmjC domain and the C6-type zinc-finger are required for the demethylation activity.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri595 – 620C6-typeAdd BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1356 Eukaryota
ENOG410XTAA LUCA
GeneTreeiENSGT00530000063039
HOGENOMiHOG000293150
HOVERGENiHBG000171
InParanoidiQ61645
KOiK00478
PhylomeDBiQ61645
TreeFamiTF324723

Family and domain databases

InterProiView protein in InterPro
IPR003347 JmjC_dom
PfamiView protein in Pfam
PF02373 JmjC, 1 hit
SMARTiView protein in SMART
SM00558 JmjC, 1 hit
PROSITEiView protein in PROSITE
PS51184 JMJC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q61645-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESMPSFLKD TPAWEKTAPV NGIVGQEPGT SPQDGLRHGA LCLGEPAPFW
60 70 80 90 100
RGVLSTPDSW LPPGFLQGPK DTLSLVEGEG PRNGERKGSW LGGKEGLRWK
110 120 130 140 150
EAMLAHPLAF CGPACPPRYG PLIPEHSGGH PKSDPVAFRP LHCPFLLETK
160 170 180 190 200
ILERAPFWVP TCLPPYLMSS LPPERPYDWP LAPNPWVYSG SQPKVPSAFG
210 220 230 240 250
LGSKGFYHKD PNILRPAKEP LAESGMLGLA PGGHLQQACE SEGPSLHQRD
260 270 280 290 300
GETGAGRQQN LCPVFLGYPD TVPRAPWPSC PPGLVHSLGN IWAGPGSNSL
310 320 330 340 350
GYQLGPPATP RCPSPGPPTP PGGCCSSHLP AREGDLGPCR KCQDSPEGGS
360 370 380 390 400
SGPGESSEER NKADSRACPP SHHTKLKKTW LTRHSEQFEC PGGCSGKEES
410 420 430 440 450
PATGLRALKR AGSPEVQGAS RGPAPKRPSH PFPGTGRQGA RAWQETPETI
460 470 480 490 500
IGSKAEAEQQ EEQRGPRDGR IRLQESRLVD TSCQHHLAGV TQCQSCVQAA
510 520 530 540 550
GEVGVLTGHS QKSRRSPLEE KQLEEEDSSA TSEEGGGGPG PEASLNKGLA
560 570 580 590 600
KHLLSGLGDR LCRLLRKERE ALAWAQREGQ GPAMTEDSPG IPHCCSRCHH
610 620 630 640 650
GLFNTHWRCS HCSHRLCVAC GRIAGAGKNR EKTGSQEQHT DDCAQEAGHA
660 670 680 690 700
ACSLILTQFV SSQALAELST VMHQVWAKFD IRGHCFCQVD ARVWAPGDGG
710 720 730 740 750
QQKEPTEKTP PTPQPSCNGD SNRTKDIKEE TPDSTESPAE DGAGRSPLPC
760 770 780 790 800
PSLCELLAST AVKLCLGHDR IHMAFAPVTP ALPSDDRITN ILDSIIAQVV
810 820 830 840 850
ERKIQEKALG PGLRAGSGLR KGLSLPLSPV RTRLSPPGAL LWLQEPRPKH
860 870 880 890 900
GFHLFQEHWR QGQPVLVSGI QKTLRLSLWG MEALGTLGGQ VQTLTALGPP
910 920 930 940 950
QPTNLDSTAF WEGFSHPETR PKLDEGSVLL LHRTLGDKDA SRVQNLASSL
960 970 980 990 1000
PLPEYCAHQG KLNLASYLPL GLTLHPLEPQ LWAAYGVNSH RGHLGTKNLC
1010 1020 1030 1040 1050
VEVSDLISIL VHAEAQLPPW YRAQKDFLSG LDGEGLWSPG SQTSTVWHVF
1060 1070 1080 1090 1100
RAQDAQRIRR FLQMVCPAGA GTLEPGAPGS CYLDAGLRRR LREEWGVSCW
1110 1120 1130 1140 1150
TLLQAPGEAV LVPAGAPHQV QGLVSTISVT QHFLSPETSA LSAQLYHQGA
1160 1170 1180
SLPPDHRMLY AQMDRAVFQA VKAAVGALQE AK
Length:1,182
Mass (Da):127,193
Last modified:August 15, 2003 - v2
Checksum:i3AFABE96C6EB3241
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PZ81E9PZ81_MOUSE
Lysine-specific demethylase hairles...
Hr
1,211Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti401P → S in CAA83587 (PubMed:8052649).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z32675 mRNA Translation: CAA83587.1
BC049182 mRNA Translation: AAH49182.1
CCDSiCCDS27257.1
PIRiI48378
RefSeqiNP_068677.2, NM_021877.3
XP_011243268.1, XM_011244966.1
UniGeneiMm.7598

Genome annotation databases

EnsembliENSMUST00000022691; ENSMUSP00000022691; ENSMUSG00000022096
ENSMUST00000161069; ENSMUSP00000124816; ENSMUSG00000022096
GeneIDi15460
KEGGimmu:15460
UCSCiuc007uoj.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z32675 mRNA Translation: CAA83587.1
BC049182 mRNA Translation: AAH49182.1
CCDSiCCDS27257.1
PIRiI48378
RefSeqiNP_068677.2, NM_021877.3
XP_011243268.1, XM_011244966.1
UniGeneiMm.7598

3D structure databases

ProteinModelPortaliQ61645
SMRiQ61645
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200415, 3 interactors
STRINGi10090.ENSMUSP00000022691

PTM databases

iPTMnetiQ61645
PhosphoSitePlusiQ61645

Proteomic databases

PaxDbiQ61645
PRIDEiQ61645

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022691; ENSMUSP00000022691; ENSMUSG00000022096
ENSMUST00000161069; ENSMUSP00000124816; ENSMUSG00000022096
GeneIDi15460
KEGGimmu:15460
UCSCiuc007uoj.2 mouse

Organism-specific databases

CTDi55806
MGIiMGI:96223 Hr

Phylogenomic databases

eggNOGiKOG1356 Eukaryota
ENOG410XTAA LUCA
GeneTreeiENSGT00530000063039
HOGENOMiHOG000293150
HOVERGENiHBG000171
InParanoidiQ61645
KOiK00478
PhylomeDBiQ61645
TreeFamiTF324723

Miscellaneous databases

ChiTaRSiHr mouse
PROiPR:Q61645
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022096 Expressed in 130 organ(s), highest expression level in skin of back
CleanExiMM_HR
ExpressionAtlasiQ61645 baseline and differential
GenevisibleiQ61645 MM

Family and domain databases

InterProiView protein in InterPro
IPR003347 JmjC_dom
PfamiView protein in Pfam
PF02373 JmjC, 1 hit
SMARTiView protein in SMART
SM00558 JmjC, 1 hit
PROSITEiView protein in PROSITE
PS51184 JMJC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHAIR_MOUSE
AccessioniPrimary (citable) accession number: Q61645
Secondary accession number(s): Q80Y47
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 15, 2003
Last modified: September 12, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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