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Protein

Glutamate receptor ionotropic, delta-1

Gene

Grid1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei73Essential for dimerization1 Publication1

GO - Molecular functioni

  • glutamate receptor activity Source: GO_Central
  • ionotropic glutamate receptor activity Source: InterPro

GO - Biological processi

  • modulation of chemical synaptic transmission Source: GO_Central
  • social behavior Source: UniProtKB
  • synaptic transmission, glutamatergic Source: GO_Central

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate receptor ionotropic, delta-1
Short name:
GluD1
Short name:
GluR delta-1 subunit
Gene namesi
Name:Grid1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:95812 Grid1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 562ExtracellularSequence analysisAdd BLAST542
Transmembranei563 – 583HelicalSequence analysisAdd BLAST21
Topological domaini584 – 637CytoplasmicSequence analysisAdd BLAST54
Transmembranei638 – 658HelicalSequence analysisAdd BLAST21
Topological domaini659 – 830ExtracellularSequence analysisAdd BLAST172
Transmembranei831 – 851HelicalSequence analysisAdd BLAST21
Topological domaini852 – 1009CytoplasmicSequence analysisAdd BLAST158

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi73F → D: Abolishes dimerization. Weakly interacts with C1q domain of CBLN1. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001156221 – 1009Glutamate receptor ionotropic, delta-1Add BLAST989

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi80 ↔ 351Combined sources1 Publication
Disulfide bondi96 ↔ 128Combined sources1 Publication
Glycosylationi200N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi294 ↔ 306Combined sources1 Publication
Glycosylationi422N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi498N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ61627
PaxDbiQ61627
PeptideAtlasiQ61627
PRIDEiQ61627

PTM databases

iPTMnetiQ61627
PhosphoSitePlusiQ61627

Expressioni

Tissue specificityi

Equally in forebrain and cerebellum.1 Publication

Gene expression databases

BgeeiENSMUSG00000041078 Expressed in 105 organ(s), highest expression level in lumbar subsegment of spinal cord
CleanExiMM_GRID1
GenevisibleiQ61627 MM

Interactioni

Subunit structurei

Dimer (PubMed:27418511). Interacts (via extracellular N-terminal domain) with CBLN1 (via C1q domain), and more weakly with CBLN2 (PubMed:22220752, PubMed:27418511).2 Publications

Protein-protein interaction databases

IntActiQ61627, 1 interactor
MINTiQ61627
STRINGi10090.ENSMUSP00000044009

Structurei

Secondary structure

11009
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ61627
SMRiQ61627
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 436Interaction with CBLN11 PublicationAdd BLAST416

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1052 Eukaryota
ENOG410XQQV LUCA
GeneTreeiENSGT00910000143978
HOGENOMiHOG000264260
HOVERGENiHBG051840
InParanoidiQ61627
KOiK05206
OMAiMGRCDLT
OrthoDBiEOG091G010L
TreeFamiTF352434

Family and domain databases

InterProiView protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR019594 Glu/Gly-bd
IPR001508 Iono_rcpt_met
IPR001320 Iontro_rcpt
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF01094 ANF_receptor, 1 hit
PF00060 Lig_chan, 1 hit
PF10613 Lig_chan-Glu_bd, 1 hit
PRINTSiPR00177 NMDARECEPTOR
SMARTiView protein in SMART
SM00918 Lig_chan-Glu_bd, 1 hit
SM00079 PBPe, 1 hit
SUPFAMiSSF53822 SSF53822, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61627-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEALTLWLLP WICQCVTVRA DSIIHIGAIF EENAAKDDRV FQLAVSDLSL
60 70 80 90 100
NDDILQSEKI TYSIKVIEAN NPFQAVQEAC DLMTQGILAL VTSTGCASAN
110 120 130 140 150
ALQSLTDAMH IPHLFVQRNP GGSPRTACHL NPSPDGEAYT LASRPPVRLN
160 170 180 190 200
DVMLRLVTEL RWQKFVMFYD SEYDIRGLQS FLDQASRLGL DVSLQKVDKN
210 220 230 240 250
ISHVFTSLFT TMKTEELNRY RDTLRRAILL LSPQGAHSFI NEAVETNLAS
260 270 280 290 300
KDSHWVFVNE EISDPEILDL VHSALGRMTV VRQIFPSAKD NQKCMRNNHR
310 320 330 340 350
ISSLLCDPQE GYLQMLQISN LYLYDSVLML ANAFHRKLED RKWHSMASLN
360 370 380 390 400
CIRKSTKPWN GGRSMLDTIK KGHITGLTGV MEFREDSSNP YVQFEILGTT
410 420 430 440 450
YSETFGKDMR KLATWDSEKG LNGSLQERPM GSRLQGLTLK VVTVLEEPFV
460 470 480 490 500
MVAENILGQP KRYKGFSIDV LDALAKALGF KYEIYQAPDG RYGHQLHNTS
510 520 530 540 550
WNGMIGELIS KRADLAISAI TITPERESVV DFSKRYMDYS VGILIKKPEE
560 570 580 590 600
KISIFSLFAP FDFAVWACIA AAIPVVGVLI FVLNRIQAVR SQSATQPRPS
610 620 630 640 650
ASATLHSAIW IVYGAFVQQG GESSVNSVAM RIVMGSWWLF TLIVCSSYTA
660 670 680 690 700
NLAAFLTVSR MDNPIRTFQD LSKQLEMSYG TVRDSAVYEY FRAKGTNPLE
710 720 730 740 750
QDSTFAELWR TISKNGGADN CVSNPSEGIR KAKKGNYAFL WDVAVVEYAA
760 770 780 790 800
LTDDDCSVTV IGNSISSKGY GIALQHGSPY RDLFSQRILE LQDTGDLDVL
810 820 830 840 850
KQKWWPHTGR CDLTSHSSTQ TEGKSLKLHS FAGVFCILAI GLLLACLVAA
860 870 880 890 900
LELWWNSNRC HQETPKEDKE VNLEQVHRRI NSLMDEDIAH KQISPASIEL
910 920 930 940 950
SALEMGGLAP SQALEPTREY QNTQLSVSTF LPEQSSHGTS RTLSSGPSSN
960 970 980 990 1000
LPLPLSSSAT MPSIQCKHRS PNGGLFRQSP VKTPIPMSFQ PVPGGVLPEA

LDTSHGTSI
Length:1,009
Mass (Da):112,210
Last modified:July 27, 2011 - v2
Checksum:i143243A1E3EBD660
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti178L → F in BAA01041 (PubMed:1372507).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10171 mRNA Translation: BAA01041.1
AK138279 mRNA Translation: BAE23610.1
CT009532
, AC114572, AC154388, AC154730, AC163280, AC169510, CT030647 Genomic DNA Translation: CAX15538.1
CT030647
, AC114572, AC154388, AC154730, AC163280, AC169510, CT009532 Genomic DNA Translation: CAX15982.1
CH466573 Genomic DNA Translation: EDL24889.1
CCDSiCCDS26944.1
PIRiJH0266
RefSeqiNP_032192.2, NM_008166.2
UniGeneiMm.121569
Mm.413604
Mm.483550

Genome annotation databases

EnsembliENSMUST00000043349; ENSMUSP00000044009; ENSMUSG00000041078
GeneIDi14803
KEGGimmu:14803
UCSCiuc007tbj.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10171 mRNA Translation: BAA01041.1
AK138279 mRNA Translation: BAE23610.1
CT009532
, AC114572, AC154388, AC154730, AC163280, AC169510, CT030647 Genomic DNA Translation: CAX15538.1
CT030647
, AC114572, AC154388, AC154730, AC163280, AC169510, CT009532 Genomic DNA Translation: CAX15982.1
CH466573 Genomic DNA Translation: EDL24889.1
CCDSiCCDS26944.1
PIRiJH0266
RefSeqiNP_032192.2, NM_008166.2
UniGeneiMm.121569
Mm.413604
Mm.483550

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5KC9X-ray2.30A/B/C21-436[»]
ProteinModelPortaliQ61627
SMRiQ61627
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ61627, 1 interactor
MINTiQ61627
STRINGi10090.ENSMUSP00000044009

PTM databases

iPTMnetiQ61627
PhosphoSitePlusiQ61627

Proteomic databases

MaxQBiQ61627
PaxDbiQ61627
PeptideAtlasiQ61627
PRIDEiQ61627

Protocols and materials databases

DNASUi14803
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043349; ENSMUSP00000044009; ENSMUSG00000041078
GeneIDi14803
KEGGimmu:14803
UCSCiuc007tbj.1 mouse

Organism-specific databases

CTDi2894
MGIiMGI:95812 Grid1

Phylogenomic databases

eggNOGiKOG1052 Eukaryota
ENOG410XQQV LUCA
GeneTreeiENSGT00910000143978
HOGENOMiHOG000264260
HOVERGENiHBG051840
InParanoidiQ61627
KOiK05206
OMAiMGRCDLT
OrthoDBiEOG091G010L
TreeFamiTF352434

Miscellaneous databases

ChiTaRSiGrid1 mouse
PROiPR:Q61627
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041078 Expressed in 105 organ(s), highest expression level in lumbar subsegment of spinal cord
CleanExiMM_GRID1
GenevisibleiQ61627 MM

Family and domain databases

InterProiView protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR019594 Glu/Gly-bd
IPR001508 Iono_rcpt_met
IPR001320 Iontro_rcpt
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF01094 ANF_receptor, 1 hit
PF00060 Lig_chan, 1 hit
PF10613 Lig_chan-Glu_bd, 1 hit
PRINTSiPR00177 NMDARECEPTOR
SMARTiView protein in SMART
SM00918 Lig_chan-Glu_bd, 1 hit
SM00079 PBPe, 1 hit
SUPFAMiSSF53822 SSF53822, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGRID1_MOUSE
AccessioniPrimary (citable) accession number: Q61627
Secondary accession number(s): Q3UUL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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