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Protein

Zinc finger protein 148

Gene

Znf148

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri171 – 193C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri199 – 221C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri227 – 249C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri255 – 278C2H2-type 4PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 148
Alternative name(s):
Beta enolase repressor factor 1
G-rich box-binding protein
Transcription factor BFCOL1
Transcription factor ZBP-89
Zinc finger DNA-binding protein 89
Gene namesi
Name:Znf148
Synonyms:Zbp89, Zfp148
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1332234 Zfp148

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474281 – 794Zinc finger protein 148Add BLAST794

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki6Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei51PhosphoserineCombined sources1
Cross-linki88Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki115Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki132Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei194PhosphothreonineBy similarity1
Modified residuei250PhosphoserineBy similarity1
Cross-linki291Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei301PhosphoserineCombined sources1
Modified residuei306PhosphoserineCombined sources1
Cross-linki308Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki356Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki356Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki402Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei412PhosphoserineBy similarity1
Cross-linki421Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki424Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei607N6-acetyllysineBy similarity1
Modified residuei665PhosphoserineBy similarity1
Modified residuei784PhosphoserineBy similarity1

Post-translational modificationi

Sumoylated with SUMO2. Desumoylated by SENP3, resulting in the stimulation of transcription of its target genes.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ61624
MaxQBiQ61624
PaxDbiQ61624
PRIDEiQ61624

PTM databases

iPTMnetiQ61624
PhosphoSitePlusiQ61624

Expressioni

Tissue specificityi

Strong expression detected in brain, lung, liver and kidney, with lower levels detected in spleen, skeletal muscle, testis and heart.1 Publication

Developmental stagei

Detected in embryos from E7 to E17. Expression decreases in developing skeletal muscles.2 Publications

Gene expression databases

BgeeiENSMUSG00000022811 Expressed in 287 organ(s), highest expression level in rostral migratory stream
CleanExiMM_ZFP148
ExpressionAtlasiQ61624 baseline and differential
GenevisibleiQ61624 MM

Interactioni

Subunit structurei

Interacts with HNRNPDL (By similarity). Interacts with the 5FMC complex; the interaction requires association with CHTOP (PubMed:22872859). Interacts with CAVIN1 (PubMed:10727401).By similarity2 Publications

Protein-protein interaction databases

BioGridi204640, 1 interactor
IntActiQ61624, 1 interactor
MINTiQ61624
STRINGi10090.ENSMUSP00000087106

Structurei

3D structure databases

ProteinModelPortaliQ61624
SMRiQ61624
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri171 – 193C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri199 – 221C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri227 – 249C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri255 – 278C2H2-type 4PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063238
HOGENOMiHOG000293204
HOVERGENiHBG054247
InParanoidiQ61624
OMAiEMISHDE
OrthoDBiEOG091G02EU
PhylomeDBiQ61624
TreeFamiTF331779

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q61624-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNIDDKLEGL FLKCGGIDEM QSSRAMVVMG GVSGQSAVSG ELQESVLQDR
60 70 80 90 100
SLPHQEILAA DEVLQESEMR QQDMISHDEL MVHEETVKND EEQMDTHERL
110 120 130 140 150
PQGLQYALNV PISVKQEITF TDVSEQLMRD KKQVREPVDL QKKKKRKQRS
160 170 180 190 200
PAKILTINED GSLGLKTPKS HVCEHCNAAF RTNYHLQRHV FIHTGEKPFQ
210 220 230 240 250
CSQCDMRFIQ KYLLQRHEKI HTGEKPFRCD ECGMRFIQKY HMERHKRTHS
260 270 280 290 300
GEKPYQCEYC LQYFSRTDRV LKHKRMCHEN HDKKLNRCAI KGGLLTSEED
310 320 330 340 350
SGFSTSPKDN SLPKKKRQKT EKKSSGMDKE SVLDKSDLKK DKNDYLPLYS
360 370 380 390 400
SSTKVKDEYM VAEYAVEMPH SSVGGSHLED ASGEIHPPKL VLKKINSKRS
410 420 430 440 450
LKQPLEQSQT ISPLSSYEDS KVSKYAFELV DKQALLDSEG SADIDQVDNL
460 470 480 490 500
QEGPSKPVHS STNYDDAMQF LKKKRYLQAA SNNSREYALN VGTIASQPSV
510 520 530 540 550
TQAAVASVID ESTTASILDS QALNVEIKSN HDKNVIPDEV LQTLLDHYSH
560 570 580 590 600
KPNGQHEISF SVADTEVTSS ISINSSDVPE VTQSENVGSS SQASSSDKAN
610 620 630 640 650
MLQEYSKFLQ QALDRTSQND AYLNSPSLNF VTDNQTLPNP PAFSSIDKQV
660 670 680 690 700
YAAMPINSFR SGMNSPLRTT PDKSHFGLIV GDSQHPFPFS GDETNHASAT
710 720 730 740 750
STADFLDQVT SQKKAEAQPV HQAYQMSSFE QPFRAPYHGS RAGIATQFST
760 770 780 790
ANGQVNLRGP GTSAEFSEFP LVNVNDNRAG MTSSPDATTG QTFG
Length:794
Mass (Da):88,751
Last modified:June 1, 1998 - v2
Checksum:i4CB1C2A1822703FD
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A338P6K3A0A338P6K3_MOUSE
Zinc finger protein 148
Zfp148
752Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti283K → N in AAB38507 (PubMed:9030551).Curated1
Sequence conflicti314K → P in AAB38507 (PubMed:9030551).Curated1
Sequence conflicti319K → Q in AAB38507 (PubMed:9030551).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98096 mRNA Translation: CAA66725.1
BC026144 mRNA Translation: AAH26144.1
U80078 mRNA Translation: AAB38507.1
CCDSiCCDS28130.1
RefSeqiNP_035879.1, NM_011749.4
XP_006522165.1, XM_006522102.3
XP_017172469.1, XM_017316980.1
UniGeneiMm.392667

Genome annotation databases

EnsembliENSMUST00000089677; ENSMUSP00000087106; ENSMUSG00000022811
ENSMUST00000165418; ENSMUSP00000126338; ENSMUSG00000022811
GeneIDi22661
KEGGimmu:22661
UCSCiuc007zab.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98096 mRNA Translation: CAA66725.1
BC026144 mRNA Translation: AAH26144.1
U80078 mRNA Translation: AAB38507.1
CCDSiCCDS28130.1
RefSeqiNP_035879.1, NM_011749.4
XP_006522165.1, XM_006522102.3
XP_017172469.1, XM_017316980.1
UniGeneiMm.392667

3D structure databases

ProteinModelPortaliQ61624
SMRiQ61624
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204640, 1 interactor
IntActiQ61624, 1 interactor
MINTiQ61624
STRINGi10090.ENSMUSP00000087106

PTM databases

iPTMnetiQ61624
PhosphoSitePlusiQ61624

Proteomic databases

EPDiQ61624
MaxQBiQ61624
PaxDbiQ61624
PRIDEiQ61624

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000089677; ENSMUSP00000087106; ENSMUSG00000022811
ENSMUST00000165418; ENSMUSP00000126338; ENSMUSG00000022811
GeneIDi22661
KEGGimmu:22661
UCSCiuc007zab.1 mouse

Organism-specific databases

CTDi22661
MGIiMGI:1332234 Zfp148

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063238
HOGENOMiHOG000293204
HOVERGENiHBG054247
InParanoidiQ61624
OMAiEMISHDE
OrthoDBiEOG091G02EU
PhylomeDBiQ61624
TreeFamiTF331779

Miscellaneous databases

ChiTaRSiZfp148 mouse
PROiPR:Q61624
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022811 Expressed in 287 organ(s), highest expression level in rostral migratory stream
CleanExiMM_ZFP148
ExpressionAtlasiQ61624 baseline and differential
GenevisibleiQ61624 MM

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN148_MOUSE
AccessioniPrimary (citable) accession number: Q61624
Secondary accession number(s): P97475
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: June 1, 1998
Last modified: November 7, 2018
This is version 164 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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