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Protein

D(1A) dopamine receptor

Gene

Drd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

GO - Biological processi

  • activation of adenylate cyclase activity Source: MGI
  • adenylate cyclase-activating dopamine receptor signaling pathway Source: MGI
  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI
  • adult walking behavior Source: MGI
  • associative learning Source: MGI
  • astrocyte development Source: MGI
  • behavioral fear response Source: MGI
  • behavioral response to cocaine Source: MGI
  • calcium-mediated signaling Source: MGI
  • cellular response to catecholamine stimulus Source: MGI
  • cellular response to dopamine Source: MGI
  • cerebral cortex GABAergic interneuron migration Source: MGI
  • conditioned taste aversion Source: MGI
  • dentate gyrus development Source: MGI
  • dopamine receptor signaling pathway Source: MGI
  • dopamine transport Source: MGI
  • eating behavior Source: MGI
  • feeding behavior Source: MGI
  • glucose import Source: MGI
  • G-protein coupled receptor signaling pathway Source: MGI
  • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: MGI
  • grooming behavior Source: MGI
  • habituation Source: MGI
  • hippocampus development Source: MGI
  • histone H3-S10 phosphorylation Source: MGI
  • intracellular protein transport Source: MGI
  • learning Source: MGI
  • locomotory behavior Source: MGI
  • long term synaptic depression Source: MGI
  • long-term synaptic potentiation Source: MGI
  • maternal behavior Source: MGI
  • mating behavior Source: MGI
  • memory Source: MGI
  • muscle contraction Source: MGI
  • negative regulation of cell death Source: MGI
  • negative regulation of cell migration Source: MGI
  • negative regulation of circadian sleep/wake cycle, sleep Source: MGI
  • negative regulation of protein kinase activity Source: MGI
  • neuronal action potential Source: MGI
  • operant conditioning Source: MGI
  • peristalsis Source: MGI
  • phospholipase C-activating dopamine receptor signaling pathway Source: MGI
  • positive regulation of adenylate cyclase activity Source: MGI
  • positive regulation of cell migration Source: MGI
  • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: MGI
  • positive regulation of feeding behavior Source: MGI
  • positive regulation of gene expression Source: MGI
  • positive regulation of long-term synaptic potentiation Source: MGI
  • positive regulation of membrane potential Source: MGI
  • positive regulation of protein phosphorylation Source: MGI
  • positive regulation of release of sequestered calcium ion into cytosol Source: MGI
  • positive regulation of synaptic transmission, glutamatergic Source: MGI
  • protein import into nucleus Source: MGI
  • regulation of dopamine metabolic process Source: MGI
  • regulation of ion transport Source: MGI
  • regulation of long-term neuronal synaptic plasticity Source: MGI
  • regulation of protein phosphorylation Source: MGI
  • regulation of vasoconstriction Source: MGI
  • response to amphetamine Source: MGI
  • response to cocaine Source: MGI
  • response to drug Source: MGI
  • sensitization Source: MGI
  • social behavior Source: MGI
  • striatum development Source: MGI
  • synaptic transmission, dopaminergic Source: MGI
  • temperature homeostasis Source: MGI
  • transmission of nerve impulse Source: MGI
  • vasodilation Source: InterPro
  • visual learning Source: MGI

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-390651 Dopamine receptors
R-MMU-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
D(1A) dopamine receptor
Alternative name(s):
Dopamine D1 receptor
Gene namesi
Name:Drd1
Synonyms:Drd1a, Gpcr15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:99578 Drd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22ExtracellularSequence analysisAdd BLAST22
Transmembranei23 – 48Helical; Name=1Sequence analysisAdd BLAST26
Topological domaini49 – 59CytoplasmicSequence analysisAdd BLAST11
Transmembranei60 – 86Helical; Name=2Sequence analysisAdd BLAST27
Topological domaini87 – 95ExtracellularSequence analysis9
Transmembranei96 – 118Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini119 – 137CytoplasmicSequence analysisAdd BLAST19
Transmembranei138 – 162Helical; Name=4Sequence analysisAdd BLAST25
Topological domaini163 – 192ExtracellularSequence analysisAdd BLAST30
Transmembranei193 – 218Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini219 – 272CytoplasmicSequence analysisAdd BLAST54
Transmembranei273 – 299Helical; Name=6Sequence analysisAdd BLAST27
Topological domaini300 – 312ExtracellularSequence analysisAdd BLAST13
Transmembranei313 – 337Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini338 – 446CytoplasmicSequence analysisAdd BLAST109

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3071

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000693751 – 446D(1A) dopamine receptorAdd BLAST446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi95 ↔ 186PROSITE-ProRule annotation
Lipidationi347S-palmitoyl cysteineBy similarity1
Lipidationi351S-palmitoyl cysteineBy similarity1
Modified residuei441PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ61616
PRIDEiQ61616

PTM databases

iPTMnetiQ61616
PhosphoSitePlusiQ61616
SwissPalmiQ61616

Expressioni

Gene expression databases

BgeeiENSMUSG00000021478
CleanExiMM_DRD1A
ExpressionAtlasiQ61616 baseline and differential
GenevisibleiQ61616 MM

Interactioni

Subunit structurei

Interacts with DNAJC14 via its C-terminus. Interacts with DRD1IP.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199305, 1 interactor
STRINGi10090.ENSMUSP00000021932

Chemistry databases

BindingDBiQ61616

Structurei

3D structure databases

ProteinModelPortaliQ61616
SMRiQ61616
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00890000139331
HOGENOMiHOG000239242
HOVERGENiHBG106962
InParanoidiQ61616
KOiK04144
OMAiSLNRMYA
OrthoDBiEOG091G06VI
PhylomeDBiQ61616
TreeFamiTF325181

Family and domain databases

InterProiView protein in InterPro
IPR001413 Dopamine_D1_rcpt
IPR000929 Dopamine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR43893:SF10 PTHR43893:SF10, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00565 DOPAMINED1AR
PR00242 DOPAMINER
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q61616-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPNTSTMDE TGLPVERDFS FRILTACFLS LLILSTLLGN TLVCAAVIRF
60 70 80 90 100
RHLRSKVTNF FVISLAVSDL LVAVLVMPWK AVAEIAGFWP FGSFCNIWVA
110 120 130 140 150
FDIMCSTASI LNLCVISVDR YWAISSPFQY ERKMTPKAAF ILISVAWTLS
160 170 180 190 200
VLISFIPVQL SWHKAKPTWP LDGNFTSLED AEDDNCDTRL SRTYAISSSL
210 220 230 240 250
ISFYIPVAIM IVTYTSIYRI AQKQIRRISA LERAAVHAKN CQTTTGNGNP
260 270 280 290 300
VECSQSESSF KMSFKRETKV LKTLSVIMGV FVCCWLPFFI SNCMVPFCGS
310 320 330 340 350
EETQPFCIDS ITFDVFVWFG WANSSLNPII YAFNADFQKA FSTLLGCYRL
360 370 380 390 400
CPTTNNAIET VSINNNGAVM FSSHHEPRGS ISKDCNLVYL IPHAVGSSED
410 420 430 440
LKREEAGGIP KPLEKLSPAL SVILDYDTDV SLEKIQPVTH SGQHST
Length:446
Mass (Da):49,612
Last modified:May 30, 2003 - v2
Checksum:i509BA66F9DF82A74
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti193 – 196TYAI → DIRH (PubMed:8288218).Curated4
Sequence conflicti240N → S in AAA16848 (PubMed:8288218).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044723 mRNA Translation: BAC32050.1
BC137641 mRNA Translation: AAI37642.1
BC137655 mRNA Translation: AAI37656.1
L20336 mRNA Translation: AAA16848.1
CCDSiCCDS26524.1
RefSeqiNP_001278730.1, NM_001291801.1
NP_034206.1, NM_010076.3
UniGeneiMm.54161

Genome annotation databases

EnsembliENSMUST00000021932; ENSMUSP00000021932; ENSMUSG00000021478
GeneIDi13488
KEGGimmu:13488
UCSCiuc011yzm.3 mouse

Similar proteinsi

Entry informationi

Entry nameiDRD1_MOUSE
AccessioniPrimary (citable) accession number: Q61616
Secondary accession number(s): B2RPW8, Q8C8P8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2003
Last modified: July 18, 2018
This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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