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Protein

Rab GDP dissociation inhibitor beta

Gene

Gdi2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

ReactomeiR-MMU-194840 Rho GTPase cycle
R-MMU-6798695 Neutrophil degranulation
R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Rab GDP dissociation inhibitor beta
Short name:
Rab GDI beta
Alternative name(s):
GDI-3
Guanosine diphosphate dissociation inhibitor 2
Short name:
GDI-2
Gene namesi
Name:Gdi2
Synonyms:Gdi3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:99845 Gdi2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000566801 – 445Rab GDP dissociation inhibitor betaAdd BLAST445

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei57N6-succinyllysineCombined sources1
Modified residuei112N6-acetyllysineBy similarity1
Modified residuei130PhosphoserineBy similarity1
Modified residuei269N6-acetyllysineBy similarity1
Modified residuei382PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ61598
PaxDbiQ61598
PeptideAtlasiQ61598
PRIDEiQ61598

2D gel databases

REPRODUCTION-2DPAGEiQ61598

PTM databases

iPTMnetiQ61598
PhosphoSitePlusiQ61598
SwissPalmiQ61598

Expressioni

Gene expression databases

BgeeiENSMUSG00000021218 Expressed in 310 organ(s), highest expression level in cochlea
ExpressionAtlasiQ61598 baseline and differential
GenevisibleiQ61598 MM

Interactioni

Subunit structurei

Interacts with RHOH.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Dzip1Q8BMD22EBI-6665490,EBI-7089968

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199892, 12 interactors
DIPiDIP-348N
IntActiQ61598, 8 interactors
MINTiQ61598
STRINGi10090.ENSMUSP00000062996

Structurei

3D structure databases

ProteinModelPortaliQ61598
SMRiQ61598
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Rab GDI family.Curated

Phylogenomic databases

eggNOGiKOG1439 Eukaryota
COG5044 LUCA
GeneTreeiENSGT00530000063044
HOGENOMiHOG000163825
HOVERGENiHBG000839
InParanoidiQ61598
KOiK17255
OMAiRMMGSEF
OrthoDBiEOG091G06PV
PhylomeDBiQ61598
TreeFamiTF300449

Family and domain databases

Gene3Di3.50.50.60, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR018203 GDP_dissociation_inhibitor
IPR000806 RabGDI
PANTHERiPTHR11787 PTHR11787, 1 hit
PfamiView protein in Pfam
PF00996 GDI, 1 hit
PRINTSiPR00892 RABGDI
PR00891 RABGDIREP
SUPFAMiSSF51905 SSF51905, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q61598-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNEEYDVIVL GTGLTECILS GIMSVNGKKV LHMDQNPYYG GESASITPLE
60 70 80 90 100
DLYKRFKLPG QPPASMGRGR DWNVDLIPKF LMANGQLVKM LLFTEVTRYM
110 120 130 140 150
DFKVIEGSFV YKGGKIYKVP STEAEALASS LMGLFEKRRF RKFLVYVANF
160 170 180 190 200
DEKDPRTFEG VDPKKTSMRD VYKKFDLGQD VIDFTGHSLA LYRTDDYLDQ
210 220 230 240 250
PCCETINRIK LYSESLARYG KSPYLYPLYG LGELPQGFAR LSAIYGGTYM
260 270 280 290 300
LNKPIEEIIV QNGKVVGVKS EGEIARCKQL ICDPSYVKDR VEKVGQVIRV
310 320 330 340 350
ICILSHPIKN TNDANSCQII IPQNQVNRKS DIYVCMISFA HNVAAQGKYI
360 370 380 390 400
AIVSTTVETK EPEKEIRPAL ELLEPIEQKF VSISDLFVPK DLGTDSQIFI
410 420 430 440
SRAYDATTHF ETTCDDIKDI YKRMTGSEFD FEEMKRKKND IYGED
Length:445
Mass (Da):50,537
Last modified:November 1, 1996 - v1
Checksum:i483B7C7456B30525
GO
Isoform 2 (identifier: Q61598-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-51: Missing.

Note: No experimental confirmation available.
Show »
Length:409
Mass (Da):46,658
Checksum:iB4E0C7F07AA73D0D
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1Y7VL99A0A1Y7VL99_MOUSE
Rab GDP dissociation inhibitor
Gdi2
318Annotation score:
A0A1Y7VLG4A0A1Y7VLG4_MOUSE
Rab GDP dissociation inhibitor
Gdi2
104Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti156R → K in BAC37725 (PubMed:16141072).Curated1
Sequence conflicti298I → N in BAB25321 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01057916 – 51Missing in isoform 2. 1 PublicationAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36314 mRNA Translation: AAA78786.1
AK007871 mRNA Translation: BAB25321.1
AK078144 mRNA Translation: BAC37145.1
AK079690 mRNA Translation: BAC37725.1
AK090083 mRNA Translation: BAC41085.1
AK143633 mRNA Translation: BAE25473.1
AK149958 mRNA Translation: BAE29194.1
AK152250 mRNA Translation: BAE31072.1
AK153381 mRNA Translation: BAE31947.1
AK159734 mRNA Translation: BAE35328.1
AK166317 mRNA Translation: BAE38700.1
AK169299 mRNA Translation: BAE41055.1
BC055341 mRNA Translation: AAH55341.1
CCDSiCCDS36581.1 [Q61598-1]
PIRiA56024
C56956
RefSeqiNP_032138.3, NM_008112.4 [Q61598-1]
UniGeneiMm.153226
Mm.221609

Genome annotation databases

EnsembliENSMUST00000059515; ENSMUSP00000062996; ENSMUSG00000021218 [Q61598-2]
ENSMUST00000223396; ENSMUSP00000152454; ENSMUSG00000021218 [Q61598-1]
GeneIDi14569
KEGGimmu:14569
UCSCiuc007piu.1 mouse [Q61598-1]
uc011yvx.1 mouse [Q61598-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36314 mRNA Translation: AAA78786.1
AK007871 mRNA Translation: BAB25321.1
AK078144 mRNA Translation: BAC37145.1
AK079690 mRNA Translation: BAC37725.1
AK090083 mRNA Translation: BAC41085.1
AK143633 mRNA Translation: BAE25473.1
AK149958 mRNA Translation: BAE29194.1
AK152250 mRNA Translation: BAE31072.1
AK153381 mRNA Translation: BAE31947.1
AK159734 mRNA Translation: BAE35328.1
AK166317 mRNA Translation: BAE38700.1
AK169299 mRNA Translation: BAE41055.1
BC055341 mRNA Translation: AAH55341.1
CCDSiCCDS36581.1 [Q61598-1]
PIRiA56024
C56956
RefSeqiNP_032138.3, NM_008112.4 [Q61598-1]
UniGeneiMm.153226
Mm.221609

3D structure databases

ProteinModelPortaliQ61598
SMRiQ61598
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199892, 12 interactors
DIPiDIP-348N
IntActiQ61598, 8 interactors
MINTiQ61598
STRINGi10090.ENSMUSP00000062996

PTM databases

iPTMnetiQ61598
PhosphoSitePlusiQ61598
SwissPalmiQ61598

2D gel databases

REPRODUCTION-2DPAGEiQ61598

Proteomic databases

EPDiQ61598
PaxDbiQ61598
PeptideAtlasiQ61598
PRIDEiQ61598

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000059515; ENSMUSP00000062996; ENSMUSG00000021218 [Q61598-2]
ENSMUST00000223396; ENSMUSP00000152454; ENSMUSG00000021218 [Q61598-1]
GeneIDi14569
KEGGimmu:14569
UCSCiuc007piu.1 mouse [Q61598-1]
uc011yvx.1 mouse [Q61598-2]

Organism-specific databases

CTDi2665
MGIiMGI:99845 Gdi2

Phylogenomic databases

eggNOGiKOG1439 Eukaryota
COG5044 LUCA
GeneTreeiENSGT00530000063044
HOGENOMiHOG000163825
HOVERGENiHBG000839
InParanoidiQ61598
KOiK17255
OMAiRMMGSEF
OrthoDBiEOG091G06PV
PhylomeDBiQ61598
TreeFamiTF300449

Enzyme and pathway databases

ReactomeiR-MMU-194840 Rho GTPase cycle
R-MMU-6798695 Neutrophil degranulation
R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRSiGdi2 mouse
PROiPR:Q61598
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021218 Expressed in 310 organ(s), highest expression level in cochlea
ExpressionAtlasiQ61598 baseline and differential
GenevisibleiQ61598 MM

Family and domain databases

Gene3Di3.50.50.60, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR018203 GDP_dissociation_inhibitor
IPR000806 RabGDI
PANTHERiPTHR11787 PTHR11787, 1 hit
PfamiView protein in Pfam
PF00996 GDI, 1 hit
PRINTSiPR00892 RABGDI
PR00891 RABGDIREP
SUPFAMiSSF51905 SSF51905, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiGDIB_MOUSE
AccessioniPrimary (citable) accession number: Q61598
Secondary accession number(s): Q541Z9, Q8C530, Q9D8M9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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