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Protein

Gamma-crystallin C

Gene

Crygc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Crystallins are the dominant structural components of the vertebrate eye lens.

Miscellaneous

There are six different gamma crystallins identified in mouse lens.

GO - Molecular functioni

  • structural constituent of eye lens Source: MGI

GO - Biological processi

  • camera-type eye development Source: MGI
  • eye development Source: MGI
  • visual perception Source: MGI

Keywordsi

Molecular functionEye lens protein

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-crystallin C
Alternative name(s):
Gamma-C-crystallin
Gene namesi
Name:Crygc
Synonyms:Gammab-cry
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:88523 Crygc

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000575971 – 174Gamma-crystallin CAdd BLAST174

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23S-methylcysteineBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiQ61597
PRIDEiQ61597

PTM databases

PhosphoSitePlusiQ61597

Expressioni

Gene expression databases

BgeeiENSMUSG00000025952 Expressed in 9 organ(s), highest expression level in lens of camera-type eye
CleanExiMM_CRYGC
ExpressionAtlasiQ61597 baseline and differential
GenevisibleiQ61597 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109698

Structurei

Secondary structure

1174
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ61597
SMRiQ61597
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ61597

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 40Beta/gamma crystallin 'Greek key' 1PROSITE-ProRule annotationAdd BLAST39
Domaini41 – 83Beta/gamma crystallin 'Greek key' 2PROSITE-ProRule annotationAdd BLAST43
Domaini88 – 128Beta/gamma crystallin 'Greek key' 3PROSITE-ProRule annotationAdd BLAST41
Domaini129 – 171Beta/gamma crystallin 'Greek key' 4PROSITE-ProRule annotationAdd BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni84 – 87Connecting peptide4

Domaini

Has a two-domain beta-structure, folded into four very similar Greek key motifs.

Sequence similaritiesi

Belongs to the beta/gamma-crystallin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IWCR Eukaryota
ENOG411298R LUCA
GeneTreeiENSGT00760000118812
HOGENOMiHOG000234389
HOVERGENiHBG003364
InParanoidiQ61597

Family and domain databases

InterProiView protein in InterPro
IPR001064 Beta/gamma_crystallin
IPR033483 CRYGC
IPR011024 G_crystallin-like
PANTHERiPTHR11818:SF32 PTHR11818:SF32, 1 hit
PfamiView protein in Pfam
PF00030 Crystall, 2 hits
PRINTSiPR01367 BGCRYSTALLIN
SMARTiView protein in SMART
SM00247 XTALbg, 2 hits
SUPFAMiSSF49695 SSF49695, 1 hit
PROSITEiView protein in PROSITE
PS50915 CRYSTALLIN_BETA_GAMMA, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q61597-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKITFFEDR SFQGRCYECS SDCPNLQTYF SRCNSVRVDS GCWMLYERPN
60 70 80 90 100
YQGHQYFLRR GEYPDYQQWM GFSDSIRSCR LIPHAGSHRM RLYEKEDHKG
110 120 130 140 150
VMMELSEDCS CIQDRFHLSE VRSLQVLEGC WVLYEMPNYR GRQYLLRPQE
160 170
YRRFQDWGSV DAKAGSLRRV VDLY
Length:174
Mass (Da):20,917
Last modified:January 23, 2007 - v3
Checksum:iECEF819F051D431D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A3RLD5A3RLD5_MOUSE
Gamma-crystallin C
Crygc
175Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti11S → G in strain: CD-1. 1
Natural varianti14G → A in strain: CD-1. 1
Natural varianti154 – 155FQ → YH in strain: CD-1. 2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22574 Genomic DNA Translation: CAA80297.1
BC056454 mRNA Translation: AAH56454.1
M64544 mRNA Translation: AAA53524.1
CCDSiCCDS15012.1
PIRiI48360 S33526
I49614
RefSeqiNP_031801.1, NM_007775.2
UniGeneiMm.491115

Genome annotation databases

EnsembliENSMUST00000027089; ENSMUSP00000027089; ENSMUSG00000025952
GeneIDi12966
KEGGimmu:12966
UCSCiuc007bhi.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22574 Genomic DNA Translation: CAA80297.1
BC056454 mRNA Translation: AAH56454.1
M64544 mRNA Translation: AAA53524.1
CCDSiCCDS15012.1
PIRiI48360 S33526
I49614
RefSeqiNP_031801.1, NM_007775.2
UniGeneiMm.491115

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2V2UX-ray1.90A/B2-174[»]
ProteinModelPortaliQ61597
SMRiQ61597
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109698

PTM databases

PhosphoSitePlusiQ61597

Proteomic databases

PaxDbiQ61597
PRIDEiQ61597

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027089; ENSMUSP00000027089; ENSMUSG00000025952
GeneIDi12966
KEGGimmu:12966
UCSCiuc007bhi.2 mouse

Organism-specific databases

CTDi1420
MGIiMGI:88523 Crygc

Phylogenomic databases

eggNOGiENOG410IWCR Eukaryota
ENOG411298R LUCA
GeneTreeiENSGT00760000118812
HOGENOMiHOG000234389
HOVERGENiHBG003364
InParanoidiQ61597

Miscellaneous databases

EvolutionaryTraceiQ61597
PROiPR:Q61597
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025952 Expressed in 9 organ(s), highest expression level in lens of camera-type eye
CleanExiMM_CRYGC
ExpressionAtlasiQ61597 baseline and differential
GenevisibleiQ61597 MM

Family and domain databases

InterProiView protein in InterPro
IPR001064 Beta/gamma_crystallin
IPR033483 CRYGC
IPR011024 G_crystallin-like
PANTHERiPTHR11818:SF32 PTHR11818:SF32, 1 hit
PfamiView protein in Pfam
PF00030 Crystall, 2 hits
PRINTSiPR01367 BGCRYSTALLIN
SMARTiView protein in SMART
SM00247 XTALbg, 2 hits
SUPFAMiSSF49695 SSF49695, 1 hit
PROSITEiView protein in PROSITE
PS50915 CRYSTALLIN_BETA_GAMMA, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCRGC_MOUSE
AccessioniPrimary (citable) accession number: Q61597
Secondary accession number(s): Q03739
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 133 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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