UniProtKB - Q61595 (KTN1_MOUSE)
Kinectin
Ktn1
Functioni
GO - Molecular functioni
- kinesin binding Source: MGI
GO - Biological processi
- microtubule-based movement Source: MGI
- protein transport Source: InterPro
Enzyme and pathway databases
Reactomei | R-MMU-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-MMU-5625970, RHO GTPases activate KTN1 R-MMU-8957275, Post-translational protein phosphorylation |
Names & Taxonomyi
Protein namesi | Recommended name: Kinectin |
Gene namesi | Name:Ktn1Imported |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:109153, Ktn1 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Single-pass type II membrane protein 1 Publication
Note: Vesicle membrane protein anchored to the endoplasmic reticulum (By similarity). Some isoforms containing the inserts at residues 1007-1035 and 1154-1177 are detected in neurite processes.By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: MGI
- integral component of endoplasmic reticulum membrane Source: InterPro
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 8 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 9 – 29 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 30 – 1327 | LumenalSequence analysisAdd BLAST | 1298 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000238620 | 1 – 1327 | KinectinAdd BLAST | 1327 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 69 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 75 | PhosphoserineBy similarity | 1 | |
Modified residuei | 77 | PhosphoserineBy similarity | 1 | |
Glycosylationi | 1031 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 1060 | PhosphoserineBy similarity | 1 | |
Glycosylationi | 1066 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 1290 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
jPOSTi | Q61595 |
PaxDbi | Q61595 |
PeptideAtlasi | Q61595 |
PRIDEi | Q61595 |
PTM databases
GlyGeni | Q61595, 3 sites |
iPTMneti | Q61595 |
PhosphoSitePlusi | Q61595 |
SwissPalmi | Q61595 |
Expressioni
Tissue specificityi
Developmental stagei
Interactioni
GO - Molecular functioni
- kinesin binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 201049, 84 interactors |
IntActi | Q61595, 8 interactors |
MINTi | Q61595 |
STRINGi | 10090.ENSMUSP00000140324 |
Miscellaneous databases
RNActi | Q61595, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 329 – 1327 | Sequence analysisAdd BLAST | 999 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 40 – 219 | Lys-richSequence analysisAdd BLAST | 180 |
Sequence similaritiesi
Keywords - Domaini
Coiled coil, Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QSIW, Eukaryota |
InParanoidi | Q61595 |
OrthoDBi | 327650at2759 |
PhylomeDBi | Q61595 |
Family and domain databases
InterProi | View protein in InterPro IPR024854, Kinectin IPR007794, Rib_rcpt_KP |
PANTHERi | PTHR18864, PTHR18864, 1 hit |
Pfami | View protein in Pfam PF05104, Rib_recp_KP_reg, 1 hit |
s (16+)i Sequence
Sequence statusi: Complete.
This entry describes 16 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 16 described isoforms and 19 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MELYESTYFI VLIPSVVITV IFLFFWLFMK ETLYDEVLAK QKREQKLIST
60 70 80 90 100
KTDKKKAEKK KNKKKEIQNG TLRESDSEHV PRDFKLSDAS PAEDEQFVPA
110 120 130 140 150
PLNVAETSSS VRERQKKEKK QKPSLEEQVI KESDASKIPG KKVEPVLVTK
160 170 180 190 200
QPAPPPPLEA AALKKKAGQK KSKNGSEEQD KKVEMLMAPS KEQDVLLSHQ
210 220 230 240 250
DTKQEGGLGK KKGLSKKQKS ENVAVLVDEP LIHATTYMPL DNANSNLMMD
260 270 280 290 300
KREIIDMIKP DHVEGIQKSG TKKLKIETDK ENAEVKFKDF LLSLKTMMFS
310 320 330 340 350
EDEALCVVDL LKEKSGVIKE ALKKSNKGEL SGLLHQLQEK ERLLSAMKED
360 370 380 390 400
AAASKERCKR LTQEMMTEKE RSSVVIARMK DRIGTLEKEH NIFQNKMHAS
410 420 430 440 450
YQETQQMQMK FQQVQEQMEA EIAHLKQENG ILRDAVSNTT NQLESKQSAE
460 470 480 490 500
LNKLRQDCGR LVSELNEKTG KLQQEGVQKK NAEQAATQLK VQLQEAERRW
510 520 530 540 550
EEVQSYIRKR TAEHEAAQQD LQSKFVAKEN EVQSLHSKLT DTLVSKQQLE
560 570 580 590 600
QRLMQLMESE QKRASKEESL QIQVQDILEQ NEALKAQIQQ FHSQIAAQTS
610 620 630 640 650
ASVLAEELHK VIAEKDKQLK QTEDSLANEQ DHLASKEEEL KDVQNMNFLL
660 670 680 690 700
KAEVQKWQAL ANEQAATAHE VEKMQKSIHV KEDEIRLLEE QLQHEVASKM
710 720 730 740 750
EELKILSEQN KALQSEVRKL QTAVSQQPNK DVVEQMEKCI QEKDEKLRTV
760 770 780 790 800
EELLETGLIQ VATREEELSA IRTENSTLTR EVQELKAKQS DQVSFVSLIE
810 820 830 840 850
DLKRVIHEKD GQIKSVEELL EVELLKVANK EKTVQALKQE IEVLKEEIGN
860 870 880 890 900
AQLEKAHQLS VTSQVQELQN LLRGKEEQVN SMKAALEDRD RGLTGRGTCA
910 920 930 940 950
QVCSTPQFEE LESVLKEKDN EIKRIEVKLK DTESDVSKMS ELLKEVQEEN
960 970 980 990 1000
KFLKCQLSHQ KHQQASFPSQ EELQTVISEK EKEITDLCNE LESLKNAVEH
1010 1020 1030 1040 1050
QRKKNNDLRE KNWEAMEALA STEKMLQDRV NKTSKERRQH VEAIELESKD
1060 1070 1080 1090 1100
LLKRLFPTVS VPSNLNYSEW LRGFEKKAKA CVAGTSDAEA VKVLEHRLKE
1110 1120 1130 1140 1150
ASEMHTLLQL ECEKYKSVLA ETEGILQKLQ RSVEQEESKW KIKADESQRM
1160 1170 1180 1190 1200
IKQMQSSFTA SERELERLRQ ENKDMENLRR EREHLEMELE KAEMERSTYV
1210 1220 1230 1240 1250
MEVRELKDLL TELQKKLDDS YSEAVRQNEE LNLLKTQLNE THSKLQNEQT
1260 1270 1280 1290 1300
ERKKVADDLH KAQQSLNSIH SKISLKAAGD TVVIENSDIS PEMESPEKET
1310 1320
MSVSLNQTVT QLQQLLQEVN QQLTKET
The sequence of this isoform differs from the canonical sequence as follows:
836-858: Missing.
1007-1035: Missing.
1154-1177: Missing.
1208-1235: Missing.
1294-1327: ESPEKETMSVSLNQTVTQLQQLLQEVNQQLTKET → SEVIGKLLVRS
The sequence of this isoform differs from the canonical sequence as follows:
836-858: Missing.
1007-1035: Missing.
1154-1177: Missing.
1294-1327: ESPEKETMSVSLNQTVTQLQQLLQEVNQQLTKET → SEVIGKLLVRS
The sequence of this isoform differs from the canonical sequence as follows:
836-858: Missing.
1007-1035: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
836-858: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
836-858: Missing.
1007-1035: Missing.
1154-1177: Missing.
1208-1235: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
836-858: Missing.
1208-1235: Missing.
1294-1327: ESPEKETMSVSLNQTVTQLQQLLQEVNQQLTKET → SEVIGKLLVRS
The sequence of this isoform differs from the canonical sequence as follows:
836-858: Missing.
1154-1177: Missing.
1208-1235: Missing.
1294-1327: ESPEKETMSVSLNQTVTQLQQLLQEVNQQLTKET → SEVIGKLLVRS
The sequence of this isoform differs from the canonical sequence as follows:
1154-1177: Missing.
1208-1235: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
836-858: Missing.
1007-1035: Missing.
1208-1235: Missing.
1294-1327: ESPEKETMSVSLNQTVTQLQQLLQEVNQQLTKET → SEVIGKLLVRS
Computationally mapped potential isoform sequencesi
There are 19 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8VQC7 | F8VQC7_MOUSE | Kinectin | Ktn1 | 1,327 | Annotation score: | ||
A0A087WNW3 | A0A087WNW3_MOUSE | Kinectin | Ktn1 | 1,247 | Annotation score: | ||
A0A087WP14 | A0A087WP14_MOUSE | Kinectin | Ktn1 | 1,280 | Annotation score: | ||
A0A087WP85 | A0A087WP85_MOUSE | Kinectin | Ktn1 | 1,275 | Annotation score: | ||
A0A087WPX0 | A0A087WPX0_MOUSE | Kinectin | Ktn1 | 1,304 | Annotation score: | ||
A0A087WQ25 | A0A087WQ25_MOUSE | Kinectin | Ktn1 | 1,270 | Annotation score: | ||
A0A087WQQ5 | A0A087WQQ5_MOUSE | Kinectin | Ktn1 | 1,275 | Annotation score: | ||
A0A087WPW5 | A0A087WPW5_MOUSE | Kinectin | Ktn1 | 1,252 | Annotation score: | ||
A0A087WQD0 | A0A087WQD0_MOUSE | Kinectin | Ktn1 | 1,247 | Annotation score: | ||
A0A087WQF8 | A0A087WQF8_MOUSE | Kinectin | Ktn1 | 1,200 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 10 | I → V in BAC30538 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 115 | Q → K in BAC30538 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 178 | Missing (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 238 | M → I (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 360 | R → Q (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 1118 | V → VS in CAD56927 (PubMed:15316074).Curated | 1 | |
Sequence conflicti | 1183 | E → G in CAD56935 (PubMed:15316074).Curated | 1 | |
Sequence conflicti | 1238 | L → F in CAD56936 (PubMed:15316074).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_052042 | 836 – 858 | Missing in isoform 2, isoform 3, isoform 4, isoform 7, isoform 8, isoform 10, isoform 11, isoform 12, isoform 13, isoform 14 and isoform 16. 1 PublicationAdd BLAST | 23 | |
Alternative sequenceiVSP_052043 | 1007 – 1035 | Missing in isoform 2, isoform 3, isoform 4, isoform 5, isoform 6, isoform 10, isoform 12 and isoform 16. 1 PublicationAdd BLAST | 29 | |
Alternative sequenceiVSP_052044 | 1154 – 1177 | Missing in isoform 2, isoform 3, isoform 7, isoform 8, isoform 9, isoform 12, isoform 14 and isoform 15. 1 PublicationAdd BLAST | 24 | |
Alternative sequenceiVSP_052045 | 1208 – 1235 | Missing in isoform 2, isoform 4, isoform 6, isoform 8, isoform 9, isoform 12, isoform 13, isoform 14, isoform 15 and isoform 16. 1 PublicationAdd BLAST | 28 | |
Alternative sequenceiVSP_052046 | 1294 – 1327 | ESPEK…LTKET → SEVIGKLLVRS in isoform 2, isoform 3, isoform 5, isoform 6, isoform 9, isoform 13, isoform 14 and isoform 16. 1 PublicationAdd BLAST | 34 |
Sequence databases
Genome annotation databases
GeneIDi | 16709 |
KEGGi | mmu:16709 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
SMRi | Q61595 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 201049, 84 interactors |
IntActi | Q61595, 8 interactors |
MINTi | Q61595 |
STRINGi | 10090.ENSMUSP00000140324 |
PTM databases
GlyGeni | Q61595, 3 sites |
iPTMneti | Q61595 |
PhosphoSitePlusi | Q61595 |
SwissPalmi | Q61595 |
Proteomic databases
jPOSTi | Q61595 |
PaxDbi | Q61595 |
PeptideAtlasi | Q61595 |
PRIDEi | Q61595 |
Genome annotation databases
GeneIDi | 16709 |
KEGGi | mmu:16709 |
Organism-specific databases
CTDi | 3895 |
MGIi | MGI:109153, Ktn1 |
Phylogenomic databases
eggNOGi | ENOG502QSIW, Eukaryota |
InParanoidi | Q61595 |
OrthoDBi | 327650at2759 |
PhylomeDBi | Q61595 |
Enzyme and pathway databases
Reactomei | R-MMU-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-MMU-5625970, RHO GTPases activate KTN1 R-MMU-8957275, Post-translational protein phosphorylation |
Miscellaneous databases
BioGRID-ORCSi | 16709, 1 hit in 17 CRISPR screens |
ChiTaRSi | Ktn1, mouse |
PROi | PR:Q61595 |
RNActi | Q61595, protein |
SOURCEi | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR024854, Kinectin IPR007794, Rib_rcpt_KP |
PANTHERi | PTHR18864, PTHR18864, 1 hit |
Pfami | View protein in Pfam PF05104, Rib_recp_KP_reg, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KTN1_MOUSE | |
Accessioni | Q61595Primary (citable) accession number: Q61595 Secondary accession number(s): Q8BG49 Q8CG63 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2006 |
Last sequence update: | November 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 124 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families