Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Growth arrest-specific protein 6

Gene

Gas6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.1 Publication

Miscellaneous

GAS6 deficient mice show protection against thrombosis, but no spontaneous bleeding.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi326CalciumBy similarity1
Metal bindingi328Calcium; via carbonyl oxygenBy similarity1
Metal bindingi437Calcium; via carbonyl oxygenBy similarity1
Metal bindingi652CalciumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processGrowth regulation
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation
R-MMU-159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
R-MMU-159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins
R-MMU-202733 Cell surface interactions at the vascular wall
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Growth arrest-specific protein 6
Short name:
GAS-6
Alternative name(s):
AXL receptor tyrosine kinase ligand
Gene namesi
Name:Gas6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:95660 Gas6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000000759028 – 674Growth arrest-specific protein 6Add BLAST647

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi62 ↔ 67By similarity
Modified residuei68PhosphoserineBy similarity1
Disulfide bondi117 ↔ 130By similarity
Disulfide bondi122 ↔ 139By similarity
Disulfide bondi141 ↔ 150By similarity
Disulfide bondi157 ↔ 168By similarity
Disulfide bondi164 ↔ 177By similarity
Disulfide bondi179 ↔ 192By similarity
Disulfide bondi198 ↔ 209By similarity
Disulfide bondi204 ↔ 218By similarity
Disulfide bondi220 ↔ 233By similarity
Disulfide bondi239 ↔ 248By similarity
Disulfide bondi244 ↔ 257By similarity
Disulfide bondi259 ↔ 274By similarity
Disulfide bondi280 ↔ 566By similarity
Glycosylationi417N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi441 ↔ 467By similarity
Glycosylationi488N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei609PhosphothreonineBy similarity1
Modified residuei614PhosphoserineBy similarity1
Modified residuei617PhosphothreonineBy similarity1
Modified residuei633PhosphothreonineBy similarity1
Modified residuei636PhosphotyrosineBy similarity1
Disulfide bondi639 ↔ 666By similarity

Post-translational modificationi

Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Gamma-carboxyglutamic acid, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ61592
PaxDbiQ61592
PRIDEiQ61592

Expressioni

Gene expression databases

BgeeiENSMUSG00000031451
CleanExiMM_GAS6
GenevisibleiQ61592 MM

Interactioni

Subunit structurei

Heterodimer and heterotetramer with AXL.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033828

Structurei

3D structure databases

ProteinModelPortaliQ61592
SMRiQ61592
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 91GlaPROSITE-ProRule annotationAdd BLAST42
Domaini113 – 151EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini153 – 193EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini194 – 234EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini235 – 275EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini295 – 467Laminin G-like 1PROSITE-ProRule annotationAdd BLAST173
Domaini474 – 666Laminin G-like 2PROSITE-ProRule annotationAdd BLAST193

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IGK1 Eukaryota
ENOG410ZPM2 LUCA
GeneTreeiENSGT00530000063339
HOGENOMiHOG000065758
HOVERGENiHBG051702
InParanoidiQ61592
KOiK05464
OMAiVIRLRFK
OrthoDBiEOG091G034Z
PhylomeDBiQ61592
TreeFamiTF352157

Family and domain databases

Gene3Di4.10.740.10, 1 hit
InterProiView protein in InterPro
IPR017857 Coagulation_fac-like_Gla_dom
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR035972 GLA-like_dom_SF
IPR000294 GLA_domain
IPR009030 Growth_fac_rcpt_cys_sf
IPR001791 Laminin_G
PfamiView protein in Pfam
PF07645 EGF_CA, 2 hits
PF00594 Gla, 1 hit
PF00054 Laminin_G_1, 1 hit
PF02210 Laminin_G_2, 1 hit
PRINTSiPR00001 GLABLOOD
SMARTiView protein in SMART
SM00181 EGF, 4 hits
SM00179 EGF_CA, 4 hits
SM00069 GLA, 1 hit
SM00282 LamG, 2 hits
SUPFAMiSSF49899 SSF49899, 2 hits
SSF57184 SSF57184, 1 hit
SSF57630 SSF57630, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 4 hits
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 3 hits
PS50026 EGF_3, 4 hits
PS01187 EGF_CA, 3 hits
PS00011 GLA_1, 1 hit
PS50998 GLA_2, 1 hit
PS50025 LAM_G_DOMAIN, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61592-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPPPGPAAA LGTALLLLLL ASESSHTVLL RAREAAQFLR PRQRRAYQVF
60 70 80 90 100
EEAKQGHLER ECVEEVCSKE EAREVFENDP ETEYFYPRYQ ECMRKYGRPE
110 120 130 140 150
EKNPDFAKCV QNLPDQCTPN PCDKKGTHIC QDLMGNFFCV CTDGWGGRLC
160 170 180 190 200
DKDVNECVQK NGGCSQVCHN KPGSFQCACH SGFSLASDGQ TCQDIDECTD
210 220 230 240 250
SDTCGDARCK NLPGSYSCLC DEGYTYSSKE KTCQDVDECQ QDRCEQTCVN
260 270 280 290 300
SPGSYTCHCD GRGGLKLSPD MDTCEDILPC VPFSMAKSVK SLYLGRMFSG
310 320 330 340 350
TPVIRLRFKR LQPTRLLAEF DFRTFDPEGV LFFAGGRSDS TWIVLGLRAG
360 370 380 390 400
RLELQLRYNG VGRITSSGPT INHGMWQTIS VEELERNLVI KVNKDAVMKI
410 420 430 440 450
AVAGELFQLE RGLYHLNLTV GGIPFKESEL VQPINPRLDG CMRSWNWLNG
460 470 480 490 500
EDSAIQETVK ANTKMQCFSV TERGSFFPGN GFATYRLNYT RTSLDVGTET
510 520 530 540 550
TWEVKVVARI RPATDTGVLL ALVGDDDVVP ISVALVDYHS TKKLKKQLVV
560 570 580 590 600
LAVEDVALAL MEIKVCDSQE HTVTVSLREG EATLEVDGTK GQSEVSTAQL
610 620 630 640 650
QERLDTLKTH LQGSVHTYVG GLPEVSVISA PVTAFYRGCM TLEVNGKILD
660 670
LDTASYKHSD ITSHSCPPVE HATP
Length:674
Mass (Da):74,610
Last modified:June 7, 2004 - v2
Checksum:i7C41F7693903F401
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti530Missing in CAA42507 (PubMed:8336730).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59846 mRNA Translation: CAA42507.1
BC005444 mRNA Translation: AAH05444.1
CCDSiCCDS40232.1
PIRiA48089
RefSeqiNP_062394.2, NM_019521.2
UniGeneiMm.3982

Genome annotation databases

EnsembliENSMUST00000033828; ENSMUSP00000033828; ENSMUSG00000031451
GeneIDi14456
KEGGimmu:14456
UCSCiuc009kya.1 mouse

Similar proteinsi

Entry informationi

Entry nameiGAS6_MOUSE
AccessioniPrimary (citable) accession number: Q61592
Secondary accession number(s): Q99K57
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: June 20, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health