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Protein

Fragile X mental retardation syndrome-related protein 1

Gene

Fxr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, RNA-binding
Biological processDifferentiation, Myogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Fragile X mental retardation syndrome-related protein 1
Short name:
mFxr1p
Gene namesi
Name:Fxr1
Synonyms:Fxr1h
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:104860 Fxr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Death shortly after birth. Mice expressing low levels of Fxr1 show postnatal growth retardation with reduced increase in muscle mass and strength. They die within 3 weeks of birth.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000501072 – 677Fragile X mental retardation syndrome-related protein 1Add BLAST676

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Cross-linki56Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei68PhosphotyrosineCombined sources1
Modified residuei398PhosphothreonineBy similarity1
Modified residuei430PhosphothreonineBy similarity1
Modified residuei432PhosphoserineBy similarity1
Modified residuei435PhosphoserineCombined sources1
Modified residuei438PhosphoserineCombined sources1
Modified residuei449PhosphoserineCombined sources1
Modified residuei452PhosphoserineBy similarity1
Modified residuei474Omega-N-methylated arginineBy similarity1
Modified residuei512PhosphothreonineCombined sources1
Modified residuei514PhosphoserineBy similarity1
Modified residuei553PhosphoserineBy similarity1
Modified residuei643PhosphoserineCombined sources1
Modified residuei667PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ61584
PeptideAtlasiQ61584
PRIDEiQ61584

PTM databases

iPTMnetiQ61584
PhosphoSitePlusiQ61584

Expressioni

Tissue specificityi

In early embryogenesis, highest expression in somites and central nervous system. Also expressed in spinal cord, surrounding mesenchymal tissue and undifferentiated gonad. In mid-embryogenesis, most prominent in gonad and muscle tissue. Also expressed in liver, retina, telencephalon and mesencephalon. In late embryogenesis, restricted to skeletal muscle and proliferative active layers of brain. After birth, highly expressed in postmeiotic spermatids. Intermediate levels are found in heart, liver and kidney with lower levels in brain and skeletal muscle. Isoform(s) containing the 27 amino acid pocket (residues 564-590) are present in adult heart and muscle.2 Publications

Gene expression databases

BgeeiENSMUSG00000027680 Expressed in 293 organ(s), highest expression level in seminiferous tubule of testis
ExpressionAtlasiQ61584 baseline and differential
GenevisibleiQ61584 MM

Interactioni

Subunit structurei

Interacts with FMR1 (By similarity). Interacts with FRX2 (By similarity). Interacts with TDRD3 (By similarity). Interacts with HABP4 (By similarity). Interacts with CYFIP2 but not with CYFIP1 (PubMed:11438699).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199772, 158 interactors
IntActiQ61584, 154 interactors
MINTiQ61584
STRINGi10090.ENSMUSP00000001620

Structurei

3D structure databases

ProteinModelPortaliQ61584
SMRiQ61584
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 50Agenet-like 1PROSITE-ProRule annotationAdd BLAST47
Domaini63 – 115Agenet-like 2PROSITE-ProRule annotationAdd BLAST53
Domaini222 – 251KH 1PROSITE-ProRule annotationAdd BLAST30
Domaini285 – 314KH 2PROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni471 – 486RNA-binding RGG-boxAdd BLAST16

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi50 – 53Poly-Pro4
Compositional biasi531 – 539Poly-Arg9

Domaini

The tandem Agenet-like domains preferentially recognize trimethylated histone peptides.By similarity

Sequence similaritiesi

Belongs to the FMR1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IF9J Eukaryota
ENOG410ZDJG LUCA
GeneTreeiENSGT00390000017033
HOVERGENiHBG005739
InParanoidiQ61584
KOiK15516
OrthoDBiEOG091G08EZ
PhylomeDBiQ61584
TreeFamiTF105427

Family and domain databases

Gene3Di3.30.1370.10, 2 hits
InterProiView protein in InterPro
IPR008395 Agenet-like_dom
IPR022034 FXMRP1_C_core
IPR032172 FXR_C1
IPR032177 FXR_C3
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
PfamiView protein in Pfam
PF05641 Agenet, 2 hits
PF12235 FXMRP1_C_core, 1 hit
PF16096 FXR_C1, 1 hit
PF16097 FXR_C3, 1 hit
PF00013 KH_1, 2 hits
SMARTiView protein in SMART
SM00322 KH, 2 hits
SUPFAMiSSF54791 SSF54791, 2 hits
PROSITEiView protein in PROSITE
PS51641 AGENET_LIKE, 2 hits
PS50084 KH_TYPE_1, 2 hits

Sequences (7+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform E (identifier: Q61584-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAELTVEVRG SNGAFYKGFI KDVHEDSLTV VFENNWQPER QVPFNEVRLP
60 70 80 90 100
PPPDIKKEIS EGDEVEVYSR ANDQEPCGWW LAKVRMMKGE FYVIEYAACD
110 120 130 140 150
ATYNEIVTFE RLRPVNQNKT VKKNTFFKCT VDVPEDLREA CANENAHKDF
160 170 180 190 200
KKAVGACRIF YHPETTQLMI LSASEATVKR VNILSDMHLR SIRTKLMLMS
210 220 230 240 250
RNEEATKHLE CTKQLAAAFH EEFVVREDLM GLAIGTHGSN IQQARKVPGV
260 270 280 290 300
TAIELDEDTG TFRIYGESAE AVKKARGFLE FVEDFIQVPR NLVGKVIGKN
310 320 330 340 350
GKVIQEIVDK SGVVRVRIEG DNENKLPRED GMVPFVFVGT KESIGNVQVL
360 370 380 390 400
LEYHIAYLKE VEQLRMERLQ IDEQLRQIGM GFRPSSTRGP EREKGYATDE
410 420 430 440 450
STVSSVQGSR SYSGRGRGRR GPNYTSGYGT NSELSNPSET ESERKDELSD
460 470 480 490 500
WSLAGEDDRE TRHQRDSRRR PGGRGRSVSG GRGRGGPRGG KSSISSVLKD
510 520 530 540 550
PDSNPYSLLD NTESDQTADT DASESHHSTN RRRRSRRRRT DEDAVLMDGL
560 570 580 590 600
TESDTASVNE NGLDDSEKKP QRRNRSRRRR FRGQAEDRQP VTVADYISRA
610 620 630 640 650
ESQSRQRNLP RETLAKNKKE MAKDVIEEHG PSEKAINGPT SASGDEIPKL
660 670
PRTLGEEKTK TLKEDSTQEA AVLNGVS
Length:677
Mass (Da):76,222
Last modified:March 1, 2001 - v2
Checksum:i908104FC95431A11
GO
Isoform A (identifier: Q61584-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     380-408: Missing.
     564-568: DDSEK → GKRCD
     569-677: Missing.

Show »
Length:539
Mass (Da):60,816
Checksum:i46FC7A21E1C1697C
GO
Isoform B (identifier: Q61584-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     564-568: DDSEK → GKRCD

Show »
Length:677
Mass (Da):76,207
Checksum:i189DF067FC611A20
GO
Isoform C (identifier: Q61584-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     564-590: Missing.

Show »
Length:650
Mass (Da):72,814
Checksum:i4E1E7192CF7A0E85
GO
Isoform D (identifier: Q61584-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     380-408: Missing.
     564-590: Missing.

Show »
Length:621
Mass (Da):69,715
Checksum:i92C675950981B238
GO
Isoform F (identifier: Q61584-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     380-408: Missing.

Show »
Length:648
Mass (Da):73,123
Checksum:iEF2F32D4150CF24E
GO
Isoform G (identifier: Q61584-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     430-455: Missing.

Show »
Length:651
Mass (Da):73,358
Checksum:i9E24A06DDB03FA63
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JEP0A0A0G2JEP0_MOUSE
Fragile X mental retardation syndro...
Fxr1
568Annotation score:
A0A0H2UH27A0A0H2UH27_MOUSE
Fragile X mental retardation syndro...
Fxr1
454Annotation score:
A0A0G2JGL6A0A0G2JGL6_MOUSE
Fragile X mental retardation syndro...
Fxr1
133Annotation score:
A0A0G2JGH0A0A0G2JGH0_MOUSE
Fragile X mental retardation syndro...
Fxr1
54Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti136D → H in AAH19139 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002836380 – 408Missing in isoform A, isoform D and isoform F. 3 PublicationsAdd BLAST29
Alternative sequenceiVSP_002837430 – 455Missing in isoform G. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_002839564 – 590Missing in isoform C and isoform D. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_002838564 – 568DDSEK → GKRCD in isoform A and isoform B. 3 Publications5
Alternative sequenceiVSP_002840569 – 677Missing in isoform A. 3 PublicationsAdd BLAST109

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90875 mRNA Translation: CAA62383.1
AF124385 mRNA Translation: AAD30211.1
AF124394
, AF124386, AF124387, AF124388, AF124389, AF124390, AF124391, AF124392, AF124393 Genomic DNA Translation: AAD30212.1
AF124394
, AF124386, AF124387, AF124388, AF124389, AF124390, AF124391, AF124392, AF124393 Genomic DNA Translation: AAD30213.1
AF124394
, AF124386, AF124387, AF124388, AF124389, AF124390, AF124391, AF124392, AF124393 Genomic DNA Translation: AAD30214.1
AF124394
, AF124386, AF124387, AF124388, AF124389, AF124390, AF124391, AF124392, AF124393 Genomic DNA Translation: AAD30215.1
AF124394
, AF124386, AF124387, AF124388, AF124389, AF124390, AF124391, AF124392, AF124393 Genomic DNA Translation: AAD30216.1
AF124394
, AF124386, AF124387, AF124388, AF124389, AF124390, AF124391, AF124392, AF124393 Genomic DNA Translation: AAD30217.1
AF124394
, AF124386, AF124387, AF124388, AF124389, AF124390, AF124391, AF124392, AF124393 Genomic DNA Translation: AAD30218.1
BC019139 mRNA Translation: AAH19139.1
CCDSiCCDS50890.1 [Q61584-2]
CCDS50891.1 [Q61584-1]
CCDS79896.1 [Q61584-5]
RefSeqiNP_001106659.1, NM_001113188.1 [Q61584-1]
NP_001106660.1, NM_001113189.1 [Q61584-5]
NP_032079.1, NM_008053.2 [Q61584-2]
XP_006535463.1, XM_006535400.1 [Q61584-4]
XP_006535464.1, XM_006535401.1 [Q61584-6]
XP_006535465.1, XM_006535402.1
UniGeneiMm.259021

Genome annotation databases

EnsembliENSMUST00000001620; ENSMUSP00000001620; ENSMUSG00000027680 [Q61584-1]
ENSMUST00000197694; ENSMUSP00000142441; ENSMUSG00000027680 [Q61584-5]
ENSMUST00000200392; ENSMUSP00000143392; ENSMUSG00000027680 [Q61584-2]
GeneIDi14359
KEGGimmu:14359
UCSCiuc008oxk.2 mouse [Q61584-2]
uc008oxl.2 mouse [Q61584-5]
uc008oxn.2 mouse [Q61584-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90875 mRNA Translation: CAA62383.1
AF124385 mRNA Translation: AAD30211.1
AF124394
, AF124386, AF124387, AF124388, AF124389, AF124390, AF124391, AF124392, AF124393 Genomic DNA Translation: AAD30212.1
AF124394
, AF124386, AF124387, AF124388, AF124389, AF124390, AF124391, AF124392, AF124393 Genomic DNA Translation: AAD30213.1
AF124394
, AF124386, AF124387, AF124388, AF124389, AF124390, AF124391, AF124392, AF124393 Genomic DNA Translation: AAD30214.1
AF124394
, AF124386, AF124387, AF124388, AF124389, AF124390, AF124391, AF124392, AF124393 Genomic DNA Translation: AAD30215.1
AF124394
, AF124386, AF124387, AF124388, AF124389, AF124390, AF124391, AF124392, AF124393 Genomic DNA Translation: AAD30216.1
AF124394
, AF124386, AF124387, AF124388, AF124389, AF124390, AF124391, AF124392, AF124393 Genomic DNA Translation: AAD30217.1
AF124394
, AF124386, AF124387, AF124388, AF124389, AF124390, AF124391, AF124392, AF124393 Genomic DNA Translation: AAD30218.1
BC019139 mRNA Translation: AAH19139.1
CCDSiCCDS50890.1 [Q61584-2]
CCDS50891.1 [Q61584-1]
CCDS79896.1 [Q61584-5]
RefSeqiNP_001106659.1, NM_001113188.1 [Q61584-1]
NP_001106660.1, NM_001113189.1 [Q61584-5]
NP_032079.1, NM_008053.2 [Q61584-2]
XP_006535463.1, XM_006535400.1 [Q61584-4]
XP_006535464.1, XM_006535401.1 [Q61584-6]
XP_006535465.1, XM_006535402.1
UniGeneiMm.259021

3D structure databases

ProteinModelPortaliQ61584
SMRiQ61584
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199772, 158 interactors
IntActiQ61584, 154 interactors
MINTiQ61584
STRINGi10090.ENSMUSP00000001620

PTM databases

iPTMnetiQ61584
PhosphoSitePlusiQ61584

Proteomic databases

PaxDbiQ61584
PeptideAtlasiQ61584
PRIDEiQ61584

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001620; ENSMUSP00000001620; ENSMUSG00000027680 [Q61584-1]
ENSMUST00000197694; ENSMUSP00000142441; ENSMUSG00000027680 [Q61584-5]
ENSMUST00000200392; ENSMUSP00000143392; ENSMUSG00000027680 [Q61584-2]
GeneIDi14359
KEGGimmu:14359
UCSCiuc008oxk.2 mouse [Q61584-2]
uc008oxl.2 mouse [Q61584-5]
uc008oxn.2 mouse [Q61584-1]

Organism-specific databases

CTDi8087
MGIiMGI:104860 Fxr1

Phylogenomic databases

eggNOGiENOG410IF9J Eukaryota
ENOG410ZDJG LUCA
GeneTreeiENSGT00390000017033
HOVERGENiHBG005739
InParanoidiQ61584
KOiK15516
OrthoDBiEOG091G08EZ
PhylomeDBiQ61584
TreeFamiTF105427

Miscellaneous databases

PROiPR:Q61584
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027680 Expressed in 293 organ(s), highest expression level in seminiferous tubule of testis
ExpressionAtlasiQ61584 baseline and differential
GenevisibleiQ61584 MM

Family and domain databases

Gene3Di3.30.1370.10, 2 hits
InterProiView protein in InterPro
IPR008395 Agenet-like_dom
IPR022034 FXMRP1_C_core
IPR032172 FXR_C1
IPR032177 FXR_C3
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
PfamiView protein in Pfam
PF05641 Agenet, 2 hits
PF12235 FXMRP1_C_core, 1 hit
PF16096 FXR_C1, 1 hit
PF16097 FXR_C3, 1 hit
PF00013 KH_1, 2 hits
SMARTiView protein in SMART
SM00322 KH, 2 hits
SUPFAMiSSF54791 SSF54791, 2 hits
PROSITEiView protein in PROSITE
PS51641 AGENET_LIKE, 2 hits
PS50084 KH_TYPE_1, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFXR1_MOUSE
AccessioniPrimary (citable) accession number: Q61584
Secondary accession number(s): Q8VCU4
, Q9R1E2, Q9R1E3, Q9R1E4, Q9R1E5, Q9WUA7, Q9WUA8, Q9WUA9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 170 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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