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Protein

NADPH:adrenodoxin oxidoreductase, mitochondrial

Gene

Fdxr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.By similarity

Catalytic activityi

2 reduced adrenodoxin + NADP+ = 2 oxidized adrenodoxin + NADPH.By similarity

Cofactori

FADBy similarity

Pathwayi: cholesterol metabolism

This protein is involved in the pathway cholesterol metabolism, which is part of Steroid metabolism.
View all proteins of this organism that are known to be involved in the pathway cholesterol metabolism and in Steroid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei51FAD; via amide nitrogenBy similarity1
Binding sitei72FADBy similarity1
Binding sitei80FAD; via amide nitrogenBy similarity1
Binding sitei116FAD; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei243NADPBy similarity1
Binding sitei401FAD; via amide nitrogenBy similarity1
Binding sitei408NADP; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi187 – 190NADPBy similarity4
Nucleotide bindingi231 – 232NADPBy similarity2
Nucleotide bindingi408 – 410FADBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCholesterol metabolism, Electron transport, Lipid metabolism, Steroid metabolism, Sterol metabolism, Transport
LigandFAD, Flavoprotein, NADP

Enzyme and pathway databases

ReactomeiR-MMU-196108 Pregnenolone biosynthesis
R-MMU-211976 Endogenous sterols
R-MMU-2395516 Electron transport from NADPH to Ferredoxin
UniPathwayiUPA00296

Names & Taxonomyi

Protein namesi
Recommended name:
NADPH:adrenodoxin oxidoreductase, mitochondrial (EC:1.18.1.6By similarity)
Short name:
AR
Short name:
Adrenodoxin reductase
Alternative name(s):
Ferredoxin--NADP(+) reductase
Short name:
Ferredoxin reductase
Gene namesi
Name:Fdxr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:104724 Fdxr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 34MitochondrionBy similarityAdd BLAST34
ChainiPRO_000001942135 – 494NADPH:adrenodoxin oxidoreductase, mitochondrialAdd BLAST460

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei313PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ61578
MaxQBiQ61578
PaxDbiQ61578
PRIDEiQ61578

2D gel databases

REPRODUCTION-2DPAGEiQ61578

PTM databases

iPTMnetiQ61578
PhosphoSitePlusiQ61578

Expressioni

Tissue specificityi

Expressed in the adrenal, testis and ovary and to a lesser extent in the liver and kidney.1 Publication

Gene expression databases

BgeeiENSMUSG00000018861
CleanExiMM_FDXR
GenevisibleiQ61578 MM

Interactioni

Subunit structurei

Monomer. Interacts directly with FDX1.By similarity

Protein-protein interaction databases

IntActiQ61578, 1 interactor
MINTiQ61578
STRINGi10090.ENSMUSP00000021078

Structurei

3D structure databases

ProteinModelPortaliQ61578
SMRiQ61578
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1800 Eukaryota
COG0493 LUCA
GeneTreeiENSGT00390000013574
HOVERGENiHBG002132
InParanoidiQ61578
KOiK18914
OMAiWGLRFFR
OrthoDBiEOG091G0EIW
TreeFamiTF314193

Family and domain databases

Gene3Di3.50.50.60, 2 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR021163 Ferredox_Rdtase_adrenod
PfamiView protein in Pfam
PF07992 Pyr_redox_2, 1 hit
PIRSFiPIRSF000362 FNR, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61578-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPRCWHWWR WSAWSGLRPS PSRSTPTPGF CQKFSTQEKT PQICVVGSGP
60 70 80 90 100
AGFYTAQHLL KHHTHAHVDI YEKQLVPFGL VRFGVAPDHP EVKNVINTFT
110 120 130 140 150
QTARSDRCAF QGNVVVGRDV SVPELREAYH AVVLSYGAED HQPLGIPGEE
160 170 180 190 200
LPGVVSARAF VGWYNGLPEN QELAPDLSCD TAVILGQGNV ALDVARILLT
210 220 230 240 250
PPEHLEKTDI TEAALGALRQ SRVKTVWIVG RRGPLQVAFT IKELREMIQL
260 270 280 290 300
PGTRPILDPS DFLGLQDRIK DVPRPRRRLT ELLLRTATEK PGVEEAARQA
310 320 330 340 350
LASRAWGLRF FRSPQQVLPT PDGQRVAGIR LAVTSLEGVG ESTRAVPTGD
360 370 380 390 400
VEDLPCGLLL SSVGYKSRPI DPSVPFDPKL GVIPNTEGRV VNVPGLYCSG
410 420 430 440 450
WVKRGPTGVI TTTMTDSFLT SQALLEDLKA GLLPSGPRPG YVAIQALLSN
460 470 480 490
RGVRPVSFSD WEKLDAEEVS RGQGTGKPRE KLVDRREMLR LLGH
Length:494
Mass (Da):54,202
Last modified:November 1, 1996 - v1
Checksum:i4BD279DFC606A5C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49920 mRNA Translation: BAA08659.1
CCDSiCCDS25625.1
PIRiS60028
RefSeqiNP_032023.1, NM_007997.1
UniGeneiMm.4719

Genome annotation databases

EnsembliENSMUST00000021078; ENSMUSP00000021078; ENSMUSG00000018861
GeneIDi14149
KEGGimmu:14149
UCSCiuc007mgy.1 mouse

Similar proteinsi

Entry informationi

Entry nameiADRO_MOUSE
AccessioniPrimary (citable) accession number: Q61578
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: June 20, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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