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Protein

Peptidyl-prolyl cis-trans isomerase FKBP10

Gene

Fkbp10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins during protein synthesis.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Activity regulationi

Inhibited by both FK506 and rapamycin, but not by cyclosporin A.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi509 – 5201PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi554 – 5652PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Rotamase
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP10 (EC:5.2.1.8)
Short name:
PPIase FKBP10
Alternative name(s):
65 kDa FK506-binding protein
Short name:
65 kDa FKBP
Short name:
FKBP-65
FK506-binding protein 10
Short name:
FKBP-10
Immunophilin FKBP65
Rotamase
Gene namesi
Name:Fkbp10
Synonyms:Fkbp-rs, Fkbp1-rs, Fkbp6, Fkbp65, Fkbprp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:104769 Fkbp10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000002551834 – 581Peptidyl-prolyl cis-trans isomerase FKBP10Add BLAST548

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi69N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi181N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi293N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi309N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi351N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi392N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi406N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Glycosylated and phosphorylated.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ61576
PaxDbiQ61576
PeptideAtlasiQ61576
PRIDEiQ61576

PTM databases

PhosphoSitePlusiQ61576

Expressioni

Tissue specificityi

Expressed in aorta, brain, kidney, and lung.1 Publication

Developmental stagei

Expressed in 12-day-old mouse; no or barely detectable expression is found in adult tissues.1 Publication

Gene expression databases

BgeeiENSMUSG00000001555 Expressed in 216 organ(s), highest expression level in vault of skull
CleanExiMM_FKBP10
MM_FKBP6
ExpressionAtlasiQ61576 baseline and differential
GenevisibleiQ61576 MM

Interactioni

Protein-protein interaction databases

BioGridi199687, 1 interactor
DIPiDIP-448N
IntActiQ61576, 1 interactor
MINTiQ61576
STRINGi10090.ENSMUSP00000001595

Structurei

3D structure databases

ProteinModelPortaliQ61576
SMRiQ61576
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 149PPIase FKBP-type 1PROSITE-ProRule annotationAdd BLAST89
Domaini173 – 261PPIase FKBP-type 2PROSITE-ProRule annotationAdd BLAST89
Domaini285 – 373PPIase FKBP-type 3PROSITE-ProRule annotationAdd BLAST89
Domaini398 – 485PPIase FKBP-type 4PROSITE-ProRule annotationAdd BLAST88
Domaini496 – 531EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini541 – 576EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi578 – 581Prevents secretion from ERPROSITE-ProRule annotation4

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG0549 Eukaryota
COG0545 LUCA
GeneTreeiENSGT00530000062784
HOGENOMiHOG000230960
HOVERGENiHBG051620
InParanoidiQ61576
KOiK09575
OrthoDBiEOG091G02W1
TreeFamiTF105296

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR023566 PPIase_FKBP
IPR001179 PPIase_FKBP_dom
PANTHERiPTHR10516 PTHR10516, 5 hits
PfamiView protein in Pfam
PF13202 EF-hand_5, 2 hits
PF00254 FKBP_C, 4 hits
PIRSFiPIRSF001473 FK506-bp_FPR3, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 2 hits
PS00014 ER_TARGET, 1 hit
PS50059 FKBP_PPIASE, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q61576-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFLVGSSSHT LHRLRILPLL LLLQTLERGL GRASPAGAPL EDVVIERYHI
60 70 80 90 100
PRACPREVQM GDFVRYHYNG TFEDGKKFDS SYDRSTLVAI VVGVGRLITG
110 120 130 140 150
MDRGLMGMCV NERRRLIVPP HLGYGSIGVA GLIPPDATLY FDVVLLDVWN
160 170 180 190 200
KADTVQSTIL LRPPYCPRMV QNSDFVRYHY NGTLLDGTAF DNSYSRGGTY
210 220 230 240 250
DTYIGSGWLI KGMDQGLLGM CPGEKRKIII PPFLAYGEKG YGTVIPPQAS
260 270 280 290 300
LVFYVLLLDV HNPKDTVQLE TLELPQGCVR RAVAGDFMRY HYNGSLMDGT
310 320 330 340 350
LFDSSYSRNH TYNTYVGQGY IIPGMDQGLQ GACIGERRRI TVPPHLAYGE
360 370 380 390 400
NGTGDKIPGS AVLIFDVHVI DFHNPSDPVE IKTLSRPPEN CNETSKIGDF
410 420 430 440 450
IRYHYNCSLL DGTRLFSSHD YEAPQEITLG ANKVIEGLDR GLQGMCVGER
460 470 480 490 500
RQLIVPPHLA HGENGARGVP GSAVLLFEVE LVSREDGLPT GYLFVWYQDP
510 520 530 540 550
STSLFEDMDL NKDGEVPPEE FSSFIKAQVN EGKGRLMPGQ DPDKTISDMF
560 570 580
QNQDRNQDGK ITAEELKLKS DEDQERVHEE L
Length:581
Mass (Da):64,697
Last modified:July 27, 2011 - v2
Checksum:iFD6F777940AD91E9
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A4H9A2A4H9_MOUSE
Peptidylprolyl isomerase
Fkbp10
469Annotation score:
F6W360F6W360_MOUSE
Peptidylprolyl isomerase
Fkbp10
66Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14L → V in AAC37678 (PubMed:7493967).Curated1
Sequence conflicti189A → G in AAC37678 (PubMed:7493967).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07063 mRNA Translation: AAC37678.1
AF456413, AF456412 Genomic DNA Translation: AAL57621.1
AL590968 Genomic DNA Translation: CAM23033.1
CH466662 Genomic DNA Translation: EDL02562.1
BC029546 mRNA Translation: AAH29546.1
CCDSiCCDS25422.1
PIRiI49669
RefSeqiNP_034351.2, NM_010221.2
UniGeneiMm.3894

Genome annotation databases

EnsembliENSMUST00000001595; ENSMUSP00000001595; ENSMUSG00000001555
GeneIDi14230
KEGGimmu:14230
UCSCiuc007llb.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07063 mRNA Translation: AAC37678.1
AF456413, AF456412 Genomic DNA Translation: AAL57621.1
AL590968 Genomic DNA Translation: CAM23033.1
CH466662 Genomic DNA Translation: EDL02562.1
BC029546 mRNA Translation: AAH29546.1
CCDSiCCDS25422.1
PIRiI49669
RefSeqiNP_034351.2, NM_010221.2
UniGeneiMm.3894

3D structure databases

ProteinModelPortaliQ61576
SMRiQ61576
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199687, 1 interactor
DIPiDIP-448N
IntActiQ61576, 1 interactor
MINTiQ61576
STRINGi10090.ENSMUSP00000001595

PTM databases

PhosphoSitePlusiQ61576

Proteomic databases

MaxQBiQ61576
PaxDbiQ61576
PeptideAtlasiQ61576
PRIDEiQ61576

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001595; ENSMUSP00000001595; ENSMUSG00000001555
GeneIDi14230
KEGGimmu:14230
UCSCiuc007llb.2 mouse

Organism-specific databases

CTDi60681
MGIiMGI:104769 Fkbp10

Phylogenomic databases

eggNOGiKOG0549 Eukaryota
COG0545 LUCA
GeneTreeiENSGT00530000062784
HOGENOMiHOG000230960
HOVERGENiHBG051620
InParanoidiQ61576
KOiK09575
OrthoDBiEOG091G02W1
TreeFamiTF105296

Miscellaneous databases

ChiTaRSiFkbp10 mouse
PROiPR:Q61576
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001555 Expressed in 216 organ(s), highest expression level in vault of skull
CleanExiMM_FKBP10
MM_FKBP6
ExpressionAtlasiQ61576 baseline and differential
GenevisibleiQ61576 MM

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR023566 PPIase_FKBP
IPR001179 PPIase_FKBP_dom
PANTHERiPTHR10516 PTHR10516, 5 hits
PfamiView protein in Pfam
PF13202 EF-hand_5, 2 hits
PF00254 FKBP_C, 4 hits
PIRSFiPIRSF001473 FK506-bp_FPR3, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 2 hits
PS00014 ER_TARGET, 1 hit
PS50059 FKBP_PPIASE, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFKB10_MOUSE
AccessioniPrimary (citable) accession number: Q61576
Secondary accession number(s): A2A4I0, Q8VHI1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 164 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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