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Protein

Forkhead box protein N1

Gene

Foxn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) both in the prenatal and postnatal thymus. Acts as a master regulator of the TECs lineage development and is required from the onset of differentiation in progenitor TECs in the developing fetus to the final differentiation steps through which TECs mature to acquire their full functionality. Regulates, either directly or indirectly the expression of a variety of genes that mediate diverse aspects of thymus development and function, including MHC Class II, DLL4, CCL25, CTSL, CD40 and PAX1. Regulates the differentiation of the immature TECs into functional cortical TECs (cTECs) and medullary TECs (mTECs) (PubMed:22072979). Essential for maintenance of mTECs population in the postnatal thymus (PubMed:19955175). Involved in the morphogenesis and maintenance of the three-dimensional thymic microstructure which is necessary for a fully functional thymus (PubMed:21109991). Plays an important role in the maintenance of hematopoiesis and particularly T lineage progenitors within the bone marrow niche with age (PubMed:24184560). Essential for the vascularization of the thymus anlage (PubMed:19853842). Promotes the terminal differentiation of epithelial cells in the epidermis and hair follicles, partly by negatively regulating the activity of protein kinase C (PubMed:17459087).6 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi271 – 367Fork-headPROSITE-ProRule annotationAdd BLAST97

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein N1
Alternative name(s):
Hepatocyte nuclear factor 3 forkhead homolog 11
Short name:
HFH-11
Short name:
HNF-3/forkhead homolog 11
Winged-helix transcription factor nude
Gene namesi
Name:Foxn1
Synonyms:Fkh19, Hfh11, Whn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:102949 Foxn1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Defects in FOXN1 are the cause of the nude/severe combined immunodeficiency (SCID) phenotype which is characterized by athymia and hairlessness. Mice develop largely normal hair follicles and produce hair shafts. However, presumably because of a lack of certain hair keratins, the hair shafts that are generated twist and coil in the hair follicle infundibulum, which becomes dilated. Since hair shafts fail to penetrate the epidermis, macroscopic nudity results and generates the grossly misleading impression that nude mice are hairless.2 Publications

Disruption phenotypei

Mice exhibit nude skin phenotype and acute thymic atrophy with a severe early block in thymic epithelial cells (TECs) differentiation. A more severe deterioration seen in medullary thymic epithelial cells (mTECs) than in cortical thymic epithelial cells (cTECs).3 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000918671 – 648Forkhead box protein N1Add BLAST648

Proteomic databases

MaxQBiQ61575
PaxDbiQ61575
PRIDEiQ61575

PTM databases

PhosphoSitePlusiQ61575

Expressioni

Tissue specificityi

Bone marrow (at protein level). Expressed in thymus and skin.1 Publication

Gene expression databases

BgeeiENSMUSG00000002057 Expressed in 49 organ(s), highest expression level in thymus primordium
CleanExiMM_FOXN1
ExpressionAtlasiQ61575 baseline and differential
GenevisibleiQ61575 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000103929

Structurei

3D structure databases

ProteinModelPortaliQ61575
SMRiQ61575
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi573 – 576Poly-Pro4

Phylogenomic databases

eggNOGiKOG2294 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00930000150842
HOGENOMiHOG000059593
HOVERGENiHBG051653
InParanoidiQ61575
KOiK09407
OMAiGHSFKTP
OrthoDBiEOG091G02YE
PhylomeDBiQ61575
TreeFamiTF329867

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q61575-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSLLPPQSD VTLPGSTRLE GEPQGDLMQA PGLPDSPAPQ NKHANFSCSS
60 70 80 90 100
FVPDGPPERT PSLPPHSPSI ASPDPEQIQG HCTAGPGPGS FRLSPSEKYP
110 120 130 140 150
GFGFEEGPAG SPGRFLKGNH MPFHPYKRHF HEDIFSEAQT AMALDGHSFK
160 170 180 190 200
TQGALEAFEE IPVDMGDAEA FLPSFPAEAW CNKLPYPSQE HNQILQGSEV
210 220 230 240 250
KVKPQALDSG PGMYCYQPPL QHMYCSSQPA FHQYSPGGGS YPVPYLGSPH
260 270 280 290 300
YPYQRIAPQA NAEGHQPLFP KPIYSYSILI FMALKNSKTG SLPVSEIYNF
310 320 330 340 350
MTEHFPYFKT APDGWKNSVR HNLSLNKCFE KVENKSGSSS RKGCLWALNP
360 370 380 390 400
SKIDKMQEEL QKWKRKDPIA VRKSMAKPEE LDSLIGDKRE KLGSPLLGCP
410 420 430 440 450
PPGLAGPGPI RPMAPSAGLS QPLHPMHPAP GPMPGKNPLQ DLLGGHAPSC
460 470 480 490 500
YGQTYPHLSP SLAPSGHQQP LFPQPDGHLE LQAQPGTPQD SPLPAHTPPS
510 520 530 540 550
HGAKLMAEPS SARTMHDTLL PDGDLGTDLD AINPSLTDFD FQGNLWEQLK
560 570 580 590 600
DDSLALDPLV LVTSSPTSSS MLPPPPAAHC FPPGPCLAET GNEAGELAPP
610 620 630 640
GSGGSGALGD MHLSTLYSAF VELESTPSSA AAGPAVYLSP GSKPLALA
Length:648
Mass (Da):69,245
Last modified:November 1, 1996 - v1
Checksum:i7A75411BDE2B23E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81593 mRNA Translation: CAA57279.1
CCDSiCCDS25102.1
RefSeqiNP_032264.1, NM_008238.2
XP_006532327.2, XM_006532264.2
XP_006532329.1, XM_006532266.3
XP_017169774.1, XM_017314285.1
XP_017169775.1, XM_017314286.1
XP_017169776.1, XM_017314287.1
XP_017169777.1, XM_017314288.1
XP_017169778.1, XM_017314289.1
XP_017169779.1, XM_017314290.1
XP_017169780.1, XM_017314291.1
XP_017169781.1, XM_017314292.1
UniGeneiMm.392151
Mm.4496

Genome annotation databases

EnsembliENSMUST00000108294; ENSMUSP00000103929; ENSMUSG00000002057
GeneIDi15218
KEGGimmu:15218
UCSCiuc007kjd.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81593 mRNA Translation: CAA57279.1
CCDSiCCDS25102.1
RefSeqiNP_032264.1, NM_008238.2
XP_006532327.2, XM_006532264.2
XP_006532329.1, XM_006532266.3
XP_017169774.1, XM_017314285.1
XP_017169775.1, XM_017314286.1
XP_017169776.1, XM_017314287.1
XP_017169777.1, XM_017314288.1
XP_017169778.1, XM_017314289.1
XP_017169779.1, XM_017314290.1
XP_017169780.1, XM_017314291.1
XP_017169781.1, XM_017314292.1
UniGeneiMm.392151
Mm.4496

3D structure databases

ProteinModelPortaliQ61575
SMRiQ61575
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000103929

PTM databases

PhosphoSitePlusiQ61575

Proteomic databases

MaxQBiQ61575
PaxDbiQ61575
PRIDEiQ61575

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000108294; ENSMUSP00000103929; ENSMUSG00000002057
GeneIDi15218
KEGGimmu:15218
UCSCiuc007kjd.2 mouse

Organism-specific databases

CTDi8456
MGIiMGI:102949 Foxn1

Phylogenomic databases

eggNOGiKOG2294 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00930000150842
HOGENOMiHOG000059593
HOVERGENiHBG051653
InParanoidiQ61575
KOiK09407
OMAiGHSFKTP
OrthoDBiEOG091G02YE
PhylomeDBiQ61575
TreeFamiTF329867

Miscellaneous databases

ChiTaRSiFoxn2 mouse
PROiPR:Q61575
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000002057 Expressed in 49 organ(s), highest expression level in thymus primordium
CleanExiMM_FOXN1
ExpressionAtlasiQ61575 baseline and differential
GenevisibleiQ61575 MM

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFOXN1_MOUSE
AccessioniPrimary (citable) accession number: Q61575
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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