Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Forkhead box protein S1

Gene

Foxs1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional repressor that suppresses transcription from the FASLG, FOXO3 and FOXO4 promoters. May have a role in the organization of the testicular vasculature.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi17 – 108Fork-headPROSITE-ProRule annotationAdd BLAST92

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein S1
Alternative name(s):
Forkhead-like 18 protein
Forkhead-related transcription factor 10
Short name:
FREAC-10
Transcription factor FKH-3
Gene namesi
Name:Foxs1
Synonyms:Fkh3, Fkhl18, Freac10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:95546 Foxs1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Accumulation of blood in the central part of the fetal testis. Increased ectopic apoptosis in periendothelial cells of the testis.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000918941 – 329Forkhead box protein S1Add BLAST329

Proteomic databases

PaxDbiQ61574
PRIDEiQ61574

PTM databases

iPTMnetiQ61574
PhosphoSitePlusiQ61574

Expressioni

Developmental stagei

Expressed in the testis in Sertoli and periendothelial cells at 14 dpc.1 Publication

Gene expression databases

BgeeiENSMUSG00000074676 Expressed in 51 organ(s), highest expression level in kidney interstitium
ExpressionAtlasiQ61574 baseline and differential
GenevisibleiQ61574 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096806

Structurei

3D structure databases

ProteinModelPortaliQ61574
SMRiQ61574
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG2294 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00760000118904
HOGENOMiHOG000112635
HOVERGENiHBG051661
InParanoidiQ61574
KOiK09412
OMAiPKEPWVA
OrthoDBiEOG091G0HW9
PhylomeDBiQ61574
TreeFamiTF316127

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR033067 FoxS1
IPR018122 TF_fork_head_CS_1
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR11829:SF68 PTHR11829:SF68, 1 hit
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00657 FORK_HEAD_1, 1 hit
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q61574-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQKQPSPESL APSAEPTKPP YSYIALIAMA IQSSPGQRAT LSGIYRYIMG
60 70 80 90 100
RFAFYRHNRP GWQNSIRHNL SLNECFVKVP RDDRKPGKGS YWTLDPDCHD
110 120 130 140 150
MFQHGSFLRR RRRFTKRTGA QGTKGPVKID HRPHRATSPD PGAPKTTTGR
160 170 180 190 200
LCPFPQEVPN PKGLSFEGLM GSLPANMSST TSDVRPQLPT GPKEMCSAKS
210 220 230 240 250
GGPRELSEAT SPSPCPAFGF SSAFSDAESL GKAPTPGVAP ESVGSSYQCR
260 270 280 290 300
MQTLNFCMGT DPGLEHLLVS SVPTPGSSTP SASHRAPLPL PADSKEPWVA
310 320
GSFPVQGGSG YPLGLPPCLY RTPGMFFFE
Length:329
Mass (Da):35,567
Last modified:January 4, 2005 - v2
Checksum:iE0196C8408AEA6AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077935 mRNA Translation: BAC37074.1
X71941 Genomic DNA Translation: CAA50743.1
CCDSiCCDS16901.1
PIRiC47746
RefSeqiNP_034356.1, NM_010226.2
UniGeneiMm.205798

Genome annotation databases

EnsembliENSMUST00000099200; ENSMUSP00000096806; ENSMUSG00000074676
GeneIDi14239
KEGGimmu:14239
UCSCiuc008ngt.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077935 mRNA Translation: BAC37074.1
X71941 Genomic DNA Translation: CAA50743.1
CCDSiCCDS16901.1
PIRiC47746
RefSeqiNP_034356.1, NM_010226.2
UniGeneiMm.205798

3D structure databases

ProteinModelPortaliQ61574
SMRiQ61574
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096806

PTM databases

iPTMnetiQ61574
PhosphoSitePlusiQ61574

Proteomic databases

PaxDbiQ61574
PRIDEiQ61574

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000099200; ENSMUSP00000096806; ENSMUSG00000074676
GeneIDi14239
KEGGimmu:14239
UCSCiuc008ngt.1 mouse

Organism-specific databases

CTDi2307
MGIiMGI:95546 Foxs1

Phylogenomic databases

eggNOGiKOG2294 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00760000118904
HOGENOMiHOG000112635
HOVERGENiHBG051661
InParanoidiQ61574
KOiK09412
OMAiPKEPWVA
OrthoDBiEOG091G0HW9
PhylomeDBiQ61574
TreeFamiTF316127

Miscellaneous databases

PROiPR:Q61574
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000074676 Expressed in 51 organ(s), highest expression level in kidney interstitium
ExpressionAtlasiQ61574 baseline and differential
GenevisibleiQ61574 MM

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR033067 FoxS1
IPR018122 TF_fork_head_CS_1
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR11829:SF68 PTHR11829:SF68, 1 hit
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00657 FORK_HEAD_1, 1 hit
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFOXS1_MOUSE
AccessioniPrimary (citable) accession number: Q61574
Secondary accession number(s): Q8C5N7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 4, 2005
Last modified: November 7, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again