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Protein

IgG receptor FcRn large subunit p51

Gene

Fcgrt

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to the Fc region of monomeric immunoglobulins gamma (PubMed:7504013). Mediates the selective uptake of IgG from milk and helps newborn animals to acquire passive immunity. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids (By similarity). Possible role in transfer of immunoglobulin G from mother to fetus (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • immune response Source: GO_Central

Keywordsi

Molecular functionIgG-binding protein, Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
IgG receptor FcRn large subunit p51
Short name:
FcRn
Alternative name(s):
IgG Fc fragment receptor transporter alpha chain
Neonatal Fc receptor
Gene namesi
Name:Fcgrt
Synonyms:Fcrn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:103017 Fcgrt

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 297ExtracellularSequence analysisAdd BLAST276
Transmembranei298 – 321HelicalSequence analysisAdd BLAST24
Topological domaini322 – 365CytoplasmicSequence analysisAdd BLAST44

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000001515922 – 365IgG receptor FcRn large subunit p51By similarityAdd BLAST344

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi108N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi119 ↔ 182PROSITE-ProRule annotation
Glycosylationi125N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi149N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi221 ↔ 275PROSITE-ProRule annotation
Glycosylationi246N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei334PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ61559
PaxDbiQ61559
PeptideAtlasiQ61559
PRIDEiQ61559

PTM databases

PhosphoSitePlusiQ61559

Expressioni

Tissue specificityi

Intestinal epithelium of suckling rodents. Expressed in neonatal intestine and fetal yolk sac.1 Publication

Gene expression databases

BgeeiENSMUSG00000003420 Expressed in 263 organ(s), highest expression level in small intestine
CleanExiMM_FCGRT
ExpressionAtlasiQ61559 baseline and differential
GenevisibleiQ61559 MM

Interactioni

Subunit structurei

FcRn complex consist of two subunits: p51, and p14 which is equivalent to beta-2-microglobulin. It forms an MHC class I-like heterodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ61559, 2 interactors
MINTiQ61559
STRINGi10090.ENSMUSP00000003512

Structurei

3D structure databases

ProteinModelPortaliQ61559
SMRiQ61559
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini202 – 289Ig-like C1-typePROSITE-ProRule annotationAdd BLAST88

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni22 – 110Alpha-1By similarityAdd BLAST89
Regioni111 – 200Alpha-2By similarityAdd BLAST90
Regioni201 – 290Alpha-3By similarityAdd BLAST90
Regioni291 – 297Connecting peptide7

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPRY Eukaryota
ENOG4111C4R LUCA
GeneTreeiENSGT00740000114936
HOVERGENiHBG100415
InParanoidiQ61559
OrthoDBiEOG091G0KJB
PhylomeDBiQ61559
TreeFamiTF336617

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q61559-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGMPLPWALS LLLVLLPQTW GSETRPPLMY HLTAVSNPST GLPSFWATGW
60 70 80 90 100
LGPQQYLTYN SLRQEADPCG AWMWENQVSW YWEKETTDLK SKEQLFLEAL
110 120 130 140 150
KTLEKILNGT YTLQGLLGCE LASDNSSVPT AVFALNGEEF MKFNPRIGNW
160 170 180 190 200
TGEWPETEIV ANLWMKQPDA ARKESEFLLN SCPERLLGHL ERGRRNLEWK
210 220 230 240 250
EPPSMRLKAR PGNSGSSVLT CAAFSFYPPE LKFRFLRNGL ASGSGNCSTG
260 270 280 290 300
PNGDGSFHAW SLLEVKRGDE HHYQCQVEHE GLAQPLTVDL DSSARSSVPV
310 320 330 340 350
VGIVLGLLLV VVAIAGGVLL WGRMRSGLPA PWLSLSGDDS GDLLPGGNLP
360
PEAEPQGANA FPATS
Length:365
Mass (Da):40,093
Last modified:November 1, 1997 - v1
Checksum:i0A2290A54507E0C4
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6PKB0Q6PKB0_MOUSE
Fcgrt protein
Fcgrt
369Annotation score:
A0A1B0GSK0A0A1B0GSK0_MOUSE
IgG receptor FcRn large subunit p51
Fcgrt
154Annotation score:
A0A1B0GS17A0A1B0GS17_MOUSE
IgG receptor FcRn large subunit p51
Fcgrt
36Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti73M → V in strain: FVB/N. 1
Natural varianti111Y → F in strain: P/J. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D37874 mRNA Translation: BAA07111.1
D37873 Genomic DNA Translation: BAA07110.1
L17022 mRNA Translation: AAA16904.1
D37903 Genomic DNA Translation: BAA07134.1
D37905 Genomic DNA Translation: BAA07135.1
D37907 Genomic DNA Translation: BAA07136.1
D37909 Genomic DNA Translation: BAA07137.1
D37911 Genomic DNA Translation: BAA07138.1
D37913 Genomic DNA Translation: BAA07139.1
CCDSiCCDS52243.1
PIRiI56197
RefSeqiNP_034319.2, NM_010189.3
UniGeneiMm.3303

Genome annotation databases

EnsembliENSMUST00000003512; ENSMUSP00000003512; ENSMUSG00000003420
GeneIDi14132
KEGGimmu:14132
UCSCiuc009gtf.2 mouse

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D37874 mRNA Translation: BAA07111.1
D37873 Genomic DNA Translation: BAA07110.1
L17022 mRNA Translation: AAA16904.1
D37903 Genomic DNA Translation: BAA07134.1
D37905 Genomic DNA Translation: BAA07135.1
D37907 Genomic DNA Translation: BAA07136.1
D37909 Genomic DNA Translation: BAA07137.1
D37911 Genomic DNA Translation: BAA07138.1
D37913 Genomic DNA Translation: BAA07139.1
CCDSiCCDS52243.1
PIRiI56197
RefSeqiNP_034319.2, NM_010189.3
UniGeneiMm.3303

3D structure databases

ProteinModelPortaliQ61559
SMRiQ61559
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ61559, 2 interactors
MINTiQ61559
STRINGi10090.ENSMUSP00000003512

PTM databases

PhosphoSitePlusiQ61559

Proteomic databases

MaxQBiQ61559
PaxDbiQ61559
PeptideAtlasiQ61559
PRIDEiQ61559

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000003512; ENSMUSP00000003512; ENSMUSG00000003420
GeneIDi14132
KEGGimmu:14132
UCSCiuc009gtf.2 mouse

Organism-specific databases

CTDi2217
MGIiMGI:103017 Fcgrt

Phylogenomic databases

eggNOGiENOG410IPRY Eukaryota
ENOG4111C4R LUCA
GeneTreeiENSGT00740000114936
HOVERGENiHBG100415
InParanoidiQ61559
OrthoDBiEOG091G0KJB
PhylomeDBiQ61559
TreeFamiTF336617

Miscellaneous databases

PROiPR:Q61559
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000003420 Expressed in 263 organ(s), highest expression level in small intestine
CleanExiMM_FCGRT
ExpressionAtlasiQ61559 baseline and differential
GenevisibleiQ61559 MM

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFCGRN_MOUSE
AccessioniPrimary (citable) accession number: Q61559
Secondary accession number(s): Q9QUR0, Q9R2A5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 7, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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