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Entry version 170 (16 Oct 2019)
Sequence version 2 (27 Jul 2011)
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Protein

Fibrillin-2

Gene

Fbn2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Fibrillin-2: Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2-containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively (PubMed:20855508).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-1474228 Degradation of the extracellular matrix
R-MMU-1566948 Elastic fibre formation
R-MMU-2129379 Molecules associated with elastic fibres

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fibrillin-2
Cleaved into the following chain:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Fbn2
Synonyms:Fbn-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:95490 Fbn2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Limb-patterning defects characterized by bilateral syndactyly due to disorganized matrix (PubMed:11470817). Digit fusion involves both soft and hard tissues and is associated with reduced apoptosis at affected sites (PubMed:11470817). Mice show a well developed and morphologically normal aortic wall (PubMed:16407178). Mice display a low bone mass phenotype that is associated with reduced bone formation (PubMed:20855508).3 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Sequence analysisAdd BLAST28
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000043688929 – 77CuratedAdd BLAST49
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000758578 – 2773Fibrillin-2Add BLAST2696
ChainiPRO_00004368902774 – 2907Fibrillin-2 C-terminal peptideBy similarityAdd BLAST134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi115 ↔ 124PROSITE-ProRule annotation
Disulfide bondi119 ↔ 130PROSITE-ProRule annotation
Disulfide bondi132 ↔ 141PROSITE-ProRule annotation
Disulfide bondi149 ↔ 159PROSITE-ProRule annotation
Disulfide bondi153 ↔ 164PROSITE-ProRule annotation
Disulfide bondi166 ↔ 175PROSITE-ProRule annotation
Disulfide bondi180 ↔ 190PROSITE-ProRule annotation
Disulfide bondi184 ↔ 196PROSITE-ProRule annotation
Disulfide bondi198 ↔ 207PROSITE-ProRule annotation
Disulfide bondi280 ↔ 292PROSITE-ProRule annotation
Disulfide bondi287 ↔ 301PROSITE-ProRule annotation
Disulfide bondi303 ↔ 316PROSITE-ProRule annotation
Disulfide bondi322 ↔ 334PROSITE-ProRule annotation
Disulfide bondi329 ↔ 343PROSITE-ProRule annotation
Disulfide bondi345 ↔ 358PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi485N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi491 ↔ 503PROSITE-ProRule annotation
Disulfide bondi498 ↔ 512PROSITE-ProRule annotation
Disulfide bondi514 ↔ 526PROSITE-ProRule annotation
Disulfide bondi532 ↔ 542PROSITE-ProRule annotation
Disulfide bondi537 ↔ 551PROSITE-ProRule annotation
Disulfide bondi553 ↔ 566PROSITE-ProRule annotation
Disulfide bondi572 ↔ 584PROSITE-ProRule annotation
Disulfide bondi579 ↔ 593PROSITE-ProRule annotation
Disulfide bondi595 ↔ 608PROSITE-ProRule annotation
Disulfide bondi614 ↔ 625PROSITE-ProRule annotation
Disulfide bondi620 ↔ 634PROSITE-ProRule annotation
Disulfide bondi636 ↔ 649PROSITE-ProRule annotation
Disulfide bondi655 ↔ 666PROSITE-ProRule annotation
Disulfide bondi661 ↔ 675PROSITE-ProRule annotation
Disulfide bondi677 ↔ 690PROSITE-ProRule annotation
Disulfide bondi765 ↔ 777PROSITE-ProRule annotation
Disulfide bondi772 ↔ 786PROSITE-ProRule annotation
Disulfide bondi788 ↔ 801PROSITE-ProRule annotation
Disulfide bondi807 ↔ 819PROSITE-ProRule annotation
Disulfide bondi814 ↔ 828PROSITE-ProRule annotation
Disulfide bondi830 ↔ 843PROSITE-ProRule annotation
Disulfide bondi849 ↔ 859PROSITE-ProRule annotation
Disulfide bondi854 ↔ 868PROSITE-ProRule annotation
Disulfide bondi870 ↔ 883PROSITE-ProRule annotation
Disulfide bondi952 ↔ 964PROSITE-ProRule annotation
Disulfide bondi959 ↔ 973PROSITE-ProRule annotation
Disulfide bondi975 ↔ 988PROSITE-ProRule annotation
Disulfide bondi1070 ↔ 1082PROSITE-ProRule annotation
Disulfide bondi1077 ↔ 1091PROSITE-ProRule annotation
Disulfide bondi1093 ↔ 1106PROSITE-ProRule annotation
Glycosylationi1105N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1112 ↔ 1124PROSITE-ProRule annotation
Disulfide bondi1119 ↔ 1133PROSITE-ProRule annotation
Disulfide bondi1135 ↔ 1149PROSITE-ProRule annotation
Disulfide bondi1155 ↔ 1167PROSITE-ProRule annotation
Disulfide bondi1162 ↔ 1176PROSITE-ProRule annotation
Disulfide bondi1178 ↔ 1191PROSITE-ProRule annotation
Disulfide bondi1197 ↔ 1209PROSITE-ProRule annotation
Disulfide bondi1204 ↔ 1218PROSITE-ProRule annotation
Disulfide bondi1220 ↔ 1233PROSITE-ProRule annotation
Disulfide bondi1239 ↔ 1250PROSITE-ProRule annotation
Disulfide bondi1246 ↔ 1259PROSITE-ProRule annotation
Disulfide bondi1261 ↔ 1274PROSITE-ProRule annotation
Disulfide bondi1280 ↔ 1292PROSITE-ProRule annotation
Disulfide bondi1287 ↔ 1301PROSITE-ProRule annotation
Disulfide bondi1303 ↔ 1316PROSITE-ProRule annotation
Disulfide bondi1322 ↔ 1334PROSITE-ProRule annotation
Disulfide bondi1329 ↔ 1343PROSITE-ProRule annotation
Disulfide bondi1345 ↔ 1358PROSITE-ProRule annotation
Disulfide bondi1364 ↔ 1377PROSITE-ProRule annotation
Disulfide bondi1371 ↔ 1386PROSITE-ProRule annotation
Disulfide bondi1388 ↔ 1399PROSITE-ProRule annotation
Disulfide bondi1405 ↔ 1418PROSITE-ProRule annotation
Glycosylationi1407N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1412 ↔ 1427PROSITE-ProRule annotation
Disulfide bondi1429 ↔ 1440PROSITE-ProRule annotation
Disulfide bondi1446 ↔ 1458PROSITE-ProRule annotation
Disulfide bondi1453 ↔ 1467PROSITE-ProRule annotation
Disulfide bondi1469 ↔ 1482PROSITE-ProRule annotation
Disulfide bondi1488 ↔ 1499PROSITE-ProRule annotation
Disulfide bondi1494 ↔ 1508PROSITE-ProRule annotation
Disulfide bondi1510 ↔ 1523PROSITE-ProRule annotation
Glycosylationi1522N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1529 ↔ 1540PROSITE-ProRule annotation
Disulfide bondi1535 ↔ 1549PROSITE-ProRule annotation
Disulfide bondi1551 ↔ 1564PROSITE-ProRule annotation
Glycosylationi1618N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1647 ↔ 1659PROSITE-ProRule annotation
Disulfide bondi1654 ↔ 1668PROSITE-ProRule annotation
Disulfide bondi1670 ↔ 1683PROSITE-ProRule annotation
Disulfide bondi1689 ↔ 1701PROSITE-ProRule annotation
Disulfide bondi1696 ↔ 1710PROSITE-ProRule annotation
Glycosylationi1707N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1712 ↔ 1725PROSITE-ProRule annotation
Glycosylationi1738N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1749N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1805 ↔ 1817PROSITE-ProRule annotation
Disulfide bondi1812 ↔ 1826PROSITE-ProRule annotation
Disulfide bondi1828 ↔ 1841PROSITE-ProRule annotation
Disulfide bondi1847 ↔ 1860PROSITE-ProRule annotation
Disulfide bondi1854 ↔ 1869PROSITE-ProRule annotation
Disulfide bondi1871 ↔ 1883PROSITE-ProRule annotation
Disulfide bondi1889 ↔ 1901PROSITE-ProRule annotation
Disulfide bondi1896 ↔ 1910PROSITE-ProRule annotation
Disulfide bondi1912 ↔ 1925PROSITE-ProRule annotation
Disulfide bondi1931 ↔ 1941PROSITE-ProRule annotation
Disulfide bondi1936 ↔ 1950PROSITE-ProRule annotation
Glycosylationi1938N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1952 ↔ 1964PROSITE-ProRule annotation
Disulfide bondi1970 ↔ 1983PROSITE-ProRule annotation
Disulfide bondi1978 ↔ 1992PROSITE-ProRule annotation
Disulfide bondi1994 ↔ 2007PROSITE-ProRule annotation
Disulfide bondi2013 ↔ 2025PROSITE-ProRule annotation
Disulfide bondi2020 ↔ 2034PROSITE-ProRule annotation
Disulfide bondi2036 ↔ 2047PROSITE-ProRule annotation
Disulfide bondi2053 ↔ 2065PROSITE-ProRule annotation
Disulfide bondi2060 ↔ 2074PROSITE-ProRule annotation
Disulfide bondi2076 ↔ 2089PROSITE-ProRule annotation
Glycosylationi2113N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2168 ↔ 2180PROSITE-ProRule annotation
Disulfide bondi2175 ↔ 2189PROSITE-ProRule annotation
Disulfide bondi2191 ↔ 2204PROSITE-ProRule annotation
Disulfide bondi2210 ↔ 2221PROSITE-ProRule annotation
Disulfide bondi2216 ↔ 2230PROSITE-ProRule annotation
Glycosylationi2218N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2232 ↔ 2244PROSITE-ProRule annotation
Disulfide bondi2250 ↔ 2261PROSITE-ProRule annotation
Disulfide bondi2257 ↔ 2270PROSITE-ProRule annotation
Disulfide bondi2272 ↔ 2285PROSITE-ProRule annotation
Disulfide bondi2291 ↔ 2305PROSITE-ProRule annotation
Disulfide bondi2298 ↔ 2314PROSITE-ProRule annotation
Disulfide bondi2316 ↔ 2329PROSITE-ProRule annotation
Disulfide bondi2335 ↔ 2347PROSITE-ProRule annotation
Disulfide bondi2342 ↔ 2356PROSITE-ProRule annotation
Disulfide bondi2358 ↔ 2371PROSITE-ProRule annotation
Disulfide bondi2446 ↔ 2458PROSITE-ProRule annotation
Disulfide bondi2453 ↔ 2467PROSITE-ProRule annotation
Disulfide bondi2469 ↔ 2482PROSITE-ProRule annotation
Disulfide bondi2488 ↔ 2499PROSITE-ProRule annotation
Disulfide bondi2495 ↔ 2508PROSITE-ProRule annotation
Disulfide bondi2510 ↔ 2523PROSITE-ProRule annotation
Disulfide bondi2529 ↔ 2540PROSITE-ProRule annotation
Disulfide bondi2536 ↔ 2549PROSITE-ProRule annotation
Disulfide bondi2551 ↔ 2562PROSITE-ProRule annotation
Disulfide bondi2568 ↔ 2581PROSITE-ProRule annotation
Disulfide bondi2575 ↔ 2590PROSITE-ProRule annotation
Disulfide bondi2592 ↔ 2605PROSITE-ProRule annotation
Disulfide bondi2611 ↔ 2621PROSITE-ProRule annotation
Disulfide bondi2617 ↔ 2630PROSITE-ProRule annotation
Disulfide bondi2632 ↔ 2645PROSITE-ProRule annotation
Disulfide bondi2651 ↔ 2662PROSITE-ProRule annotation
Disulfide bondi2657 ↔ 2671PROSITE-ProRule annotation
Disulfide bondi2673 ↔ 2686PROSITE-ProRule annotation
Disulfide bondi2692 ↔ 2703PROSITE-ProRule annotation
Disulfide bondi2699 ↔ 2712PROSITE-ProRule annotation
Disulfide bondi2714 ↔ 2726PROSITE-ProRule annotation
Glycosylationi2803N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q61555

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q61555

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q61555

PeptideAtlas

More...
PeptideAtlasi
Q61555

PRoteomics IDEntifications database

More...
PRIDEi
Q61555

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q61555

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q61555

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Strongly expressed during the first week of osteoblast differentiation.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000024598 Expressed in 224 organ(s), highest expression level in ureter smooth muscle

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q61555 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with BMP2, BMP4, BMP7, BMP10 and GDF5.

Interacts with MFAP2 and MFAP5.

Interacts with ADAMTSL5.

Interacts with MFAP4.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000025497

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q61555

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini111 – 142EGF-like 1PROSITE-ProRule annotationAdd BLAST32
Domaini145 – 176EGF-like 2PROSITE-ProRule annotationAdd BLAST32
Domaini176 – 208EGF-like 3PROSITE-ProRule annotationAdd BLAST33
Domaini214 – 266TB 1Add BLAST53
Domaini276 – 317EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini318 – 359EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini364 – 417TB 2Add BLAST54
Domaini487 – 527EGF-like 6PROSITE-ProRule annotationAdd BLAST41
Domaini528 – 567EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini568 – 609EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini610 – 650EGF-like 9; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini651 – 691EGF-like 10; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini697 – 749TB 3Add BLAST53
Domaini761 – 802EGF-like 11; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini803 – 844EGF-like 12; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini845 – 883EGF-like 13; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini889 – 940TB 4Add BLAST52
Domaini948 – 989EGF-like 14; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini994 – 1045TB 5Add BLAST52
Domaini1066 – 1107EGF-like 15; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini1108 – 1150EGF-like 16; calcium-bindingPROSITE-ProRule annotationAdd BLAST43
Domaini1151 – 1192EGF-like 17; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini1193 – 1234EGF-like 18; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini1235 – 1275EGF-like 19; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini1276 – 1317EGF-like 20; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini1318 – 1359EGF-like 21; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini1360 – 1400EGF-like 22; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini1401 – 1441EGF-like 23; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini1442 – 1483EGF-like 24; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini1484 – 1524EGF-like 25; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini1525 – 1565EGF-like 26; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini1570 – 1626TB 6Add BLAST57
Domaini1643 – 1684EGF-like 27; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini1685 – 1726EGF-like 28; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini1731 – 1784TB 7Add BLAST54
Domaini1801 – 1842EGF-like 29; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini1843 – 1884EGF-like 30; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini1885 – 1926EGF-like 31; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini1927 – 1965EGF-like 32; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini1966 – 2008EGF-like 33; calcium-bindingPROSITE-ProRule annotationAdd BLAST43
Domaini2009 – 2048EGF-like 34; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini2049 – 2090EGF-like 35; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini2095 – 2148TB 8Add BLAST54
Domaini2164 – 2205EGF-like 36; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini2206 – 2245EGF-like 37; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini2246 – 2286EGF-like 38; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini2287 – 2330EGF-like 39; calcium-bindingPROSITE-ProRule annotationAdd BLAST44
Domaini2331 – 2372EGF-like 40; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini2377 – 2430TB 9Add BLAST54
Domaini2442 – 2483EGF-like 41; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini2484 – 2524EGF-like 42; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini2525 – 2563EGF-like 43; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini2564 – 2606EGF-like 44; calcium-bindingPROSITE-ProRule annotationAdd BLAST43
Domaini2607 – 2646EGF-like 45; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini2647 – 2687EGF-like 46; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini2688 – 2727EGF-like 47; calcium-bindingPROSITE-ProRule annotationAdd BLAST40

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni149 – 359Interaction with MFAP4By similarityAdd BLAST211
Regioni1728 – 2164Interaction with MFAP4By similarityAdd BLAST437

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the fibrillin family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IR7H Eukaryota
ENOG410XSTY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183158

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231768

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q61555

KEGG Orthology (KO)

More...
KOi
K23342

Identification of Orthologs from Complete Genome Data

More...
OMAi
HQCVACP

Database of Orthologous Groups

More...
OrthoDBi
1174178at2759

TreeFam database of animal gene trees

More...
TreeFami
TF316849

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.290.10, 9 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026823 cEGF
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR040872 Fibrillin_U_N
IPR009030 Growth_fac_rcpt_cys_sf
IPR017878 TB_dom
IPR036773 TB_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12662 cEGF, 2 hits
PF07645 EGF_CA, 39 hits
PF18193 Fibrillin_U_N, 1 hit
PF12661 hEGF, 1 hit
PF00683 TB, 9 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 46 hits
SM00179 EGF_CA, 44 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184 SSF57184, 13 hits
SSF57581 SSF57581, 9 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 43 hits
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 37 hits
PS50026 EGF_3, 45 hits
PS01187 EGF_CA, 43 hits
PS51364 TB, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q61555-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRRRRLCLQ PYFVWLGCVA LWAQGTDGQP QPPPPKTLRP QPPPQQVRPA
60 70 80 90 100
VAGSEGGFMG PEYRDEGAVA ASRVRRRGQQ EILRGPNVCG SRFHSYCCPG
110 120 130 140 150
WKTLPGGNQC IVPICRNSCG DGFCSRPNMC TCSSGQISPT CGAKSIQQCS
160 170 180 190 200
VRCMNGGTCA DDHCQCQKGY IGTYCGQPVC ENGCQNGGRC IGPNRCACVY
210 220 230 240 250
GFTGPQCERD YRTGPCFTQV NNQMCQGQLT GIVCTKTLCC ATIGRAWGHP
260 270 280 290 300
CEMCPAQPQP CRRGFIPNIR TGACQDVDEC QAIPGLCQGG NCINTVGSFE
310 320 330 340 350
CRCPAGHKQS ETTQKCEDID ECSVIPGVCE TGDCSNTVGS YFCLCPRGFV
360 370 380 390 400
TSTDGSRCID QRAGTCFSGL VNGRCAQELP GRMAKAQCCC EPGRCWSIGT
410 420 430 440 450
IPEACPVRGS EEYRRLCLDG LPMGGIPGSS VSRPGGTGST GNGYGPGGTG
460 470 480 490 500
FLPIPGDNGF SPGVGGAGVG AGGQGPIITG LTILNQTIDI CKHHANLCLN
510 520 530 540 550
GRCIPTVSSY RCECNMGYKQ DANGDCIDVD ECTSNPCSNG DCVNTPGSYY
560 570 580 590 600
CKCHAGFQRT PTKQACIDID ECIQNGVLCK NGRCVNTDGS FQCICNAGFE
610 620 630 640 650
LTTDGKNCVD HDECTTTNMC LNGMCINEDG SFKCVCKPGF ILAPNGRYCT
660 670 680 690 700
DVDECQTPGI CMNGHCINNE GSFRCDCPPG LAVGVDGRVC VDTHMRSTCY
710 720 730 740 750
GEIKKGVCVR PFPGAVTKSE CCCANPDYGF GEPCQPCPAK NSAEFHGLCS
760 770 780 790 800
SGIGITVDGR DINECALDPD ICANGICENL RGSYRCNCNS GYEPDASGRN
810 820 830 840 850
CIDIDECLVN RLLCDNGLCR NTPGSYSCTC PPGYVFRTET ETCEDVNECE
860 870 880 890 900
SNPCVNGACR NNLGSFHCEC SPGSKLSSTG LICIDSLKGT CWLNIQDNRC
910 920 930 940 950
EVNINGATLK SECCATLGAA WGSPCERCEL DAACPRGFAR IKGVTCEDVN
960 970 980 990 1000
ECEVFPGVCP NGRCVNSKGS FHCECPEGLT LDGTGRVCLD IRMEHCFLKW
1010 1020 1030 1040 1050
DEDECIHPVP GKFRMDACCC AVGAAWGTEC EECPKPGTKE YETLCPRGPG
1060 1070 1080 1090 1100
FANRGDILTG RPFYKDINEC KAFPGMCTYG KCRNTIGSFK CRCNNGFALD
1110 1120 1130 1140 1150
MEERNCTDID ECRISPDLCG SGICVNTPGS FECECFEGYE SGFMMMKNCM
1160 1170 1180 1190 1200
DIDECERNPL LCRGGTCVNT EGSFQCDCPL GHELSPSRED CVDINECSLS
1210 1220 1230 1240 1250
DNLCRNGKCV NMIGTYQCSC NPGYQATPDR QGCTDIDECM IMNGGCDTQC
1260 1270 1280 1290 1300
TNSEGSYECS CSEGYALMPD GRSCADIDEC ENNPDICDGG QCTNIPGEYR
1310 1320 1330 1340 1350
CLCYDGFMAS MDMKTCIDVN ECDLNPNICM FGECENTKGS FICHCQLGYS
1360 1370 1380 1390 1400
VKKGTTGCTD VDECEIGAHN CDMHASCLNV PGSFKCSCRE GWVGNGIKCI
1410 1420 1430 1440 1450
DLDECANGTH QCSINAQCVN TPGSYRCACS EGFTGDGFTC SDVDECAENT
1460 1470 1480 1490 1500
NLCENGQCLN VPGAYRCECE MGFTPASDSR SCQDIDECSF QNICVFGTCN
1510 1520 1530 1540 1550
NLPGMFHCIC DDGYELDRTG GNCTDIDECA DPINCVNGLC VNTPGRYECN
1560 1570 1580 1590 1600
CPPDFQLNPT GVGCVDNRVG NCYLKFGPRG DGSLSCNTEV GVGVSRSSCC
1610 1620 1630 1640 1650
CSLGKAWGNP CETCPPVNST EYYTLCPGGE GFRPNPITII LEDIDECQEL
1660 1670 1680 1690 1700
PGLCQGGNCI NTFGSFQCEC PQGYYLSEET RICEDIDECF AHPGVCGPGT
1710 1720 1730 1740 1750
CYNTLGNYTC ICPPEYMQVN GGHNCMDMRK SFCYRSYNGT TCENELPFNV
1760 1770 1780 1790 1800
TKRMCCCTYN VGKAWNKPCE PCPTPGTADF KTICGNIPGF TFDIHTGKAV
1810 1820 1830 1840 1850
DIDECKEIPG ICANGVCINQ IGSFRCECPT GFSYNDLLLV CEDIDECSNG
1860 1870 1880 1890 1900
DNLCQRNADC INSPGSYRCE CAAGFKLSPN GACVDRNECL EIPNVCSHGL
1910 1920 1930 1940 1950
CVDLQGSYQC ICNNGFKASQ DQTMCMDVDE CERHPCGNGT CKNTVGSYNC
1960 1970 1980 1990 2000
LCYPGFELTH NNDCLDIDEC SSFFGQVCRN GRCFNEIGSF KCLCNEGYEL
2010 2020 2030 2040 2050
TPDGKNCIDT NECVALPGSC SPGTCQNLEG SFRCICPPGY EVRSENCIDI
2060 2070 2080 2090 2100
NECDEDPNIC LFGSCTNTPG GFQCICPPGF VLSDNGRRCF DTRQSFCFTN
2110 2120 2130 2140 2150
FENGKCSVPK AFNTTKAKCC CSKMPGEGWG DPCELCPKDD EVAFQDLCPY
2160 2170 2180 2190 2200
GHGTVPSLHD TREDVNECLE SPGICSNGQC INTDGSFRCE CPMGYNLDYT
2210 2220 2230 2240 2250
GVRCVDTDEC SIGNPCGNGT CTNVIGSFEC TCNEGFEPGP MMNCEDINEC
2260 2270 2280 2290 2300
AQNPLLCAFR CMNTFGSYEC TCPVGYALRE DQKMCKDLDE CAEGLHDCES
2310 2320 2330 2340 2350
RGMMCKNLIG TFMCICPPGM ARRPDGEGCV DENECRTKPG ICENGRCVNI
2360 2370 2380 2390 2400
IGSYRCECNE GFQSSSSGTE CLDNRQGLCF AEVLQTMCQM ASSSRNLVTK
2410 2420 2430 2440 2450
SECCCDGGRG WGHQCELCPL PGTAQYKKIC PHGPGYATDG RDIDECKVMP
2460 2470 2480 2490 2500
SLCTNGQCVN TMGSFRCFCK VGYTTDISGT ACVDLDECSQ SPKPCNFICK
2510 2520 2530 2540 2550
NTKGSYQCSC PRGYVLQEDG KTCKDLDECQ TKQHNCQFLC VNTLGGFTCK
2560 2570 2580 2590 2600
CPPGFTQHHT ACIDNNECGS QPSLCGAKGI CQNTPGSFSC ECQRGFSLDA
2610 2620 2630 2640 2650
SGLNCEDVDE CDGNHRCQHG CQNILGGYRC GCPQGYVQHY QWNQCVDENE
2660 2670 2680 2690 2700
CSNPGACGSA SCYNTLGSYK CACPSGFSFD QFSSACHDVN ECSSSKNPCS
2710 2720 2730 2740 2750
YGCSNTEGGY LCGCPPGYFR VGQGHCVSGM GFNKGQYLSV DAEAEDDENA
2760 2770 2780 2790 2800
LSPEACYECK INGYTKKDGR RKRSAQEPEP ASAEEQISLE SVAMDSPVNM
2810 2820 2830 2840 2850
KFNLSGLGSK EHILELVPAI EPLNNHIRYV ISQGNEDGVF RIHQRNGLSY
2860 2870 2880 2890 2900
LHTAKKKLAP GTYTLEITSI PLYGKKELRK LEEHNEDDYL LGVLGEALRM

RLQIQLY
Length:2,907
Mass (Da):313,818
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i57FCD5188B1D63FF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti39R → W in AAA74908 (PubMed:7744963).Curated1
Sequence conflicti70A → R in AAA74908 (PubMed:7744963).Curated1
Sequence conflicti143A → R in AAA74908 (PubMed:7744963).Curated1
Sequence conflicti263R → P in AAA74908 (PubMed:7744963).Curated1
Sequence conflicti263R → P in AAC60685 (PubMed:8307578).Curated1
Sequence conflicti440T → N in AAA74908 (PubMed:7744963).Curated1
Sequence conflicti513E → R in AAA74908 (PubMed:7744963).Curated1
Sequence conflicti587T → S in AAA74908 (PubMed:7744963).Curated1
Sequence conflicti783S → T in AAA74908 (PubMed:7744963).Curated1
Sequence conflicti836 – 837FR → LP in AAA74908 (PubMed:7744963).Curated2
Sequence conflicti919A → G in AAA74908 (PubMed:7744963).Curated1
Sequence conflicti1064Y → C in AAA74908 (PubMed:7744963).Curated1
Sequence conflicti1559P → A in AAA74908 (PubMed:7744963).Curated1
Sequence conflicti1590V → A in AAA74908 (PubMed:7744963).Curated1
Sequence conflicti1622Y → H in AAA74908 (PubMed:7744963).Curated1
Sequence conflicti1765W → G in AAA74908 (PubMed:7744963).Curated1
Sequence conflicti1937G → A in AAA74908 (PubMed:7744963).Curated1
Sequence conflicti2227S → C in AAA74908 (PubMed:7744963).Curated1
Sequence conflicti2277A → G in AAA74908 (PubMed:7744963).Curated1
Sequence conflicti2475T → M in AAA74908 (PubMed:7744963).Curated1
Sequence conflicti2634 – 2636QGY → HGD in AAA74908 (PubMed:7744963).Curated3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L39790 Genomic DNA Translation: AAA74908.1
AC102317 Genomic DNA No translation available.
AC127358 Genomic DNA No translation available.
S69359 Unassigned DNA Translation: AAC60685.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS37827.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A57278

NCBI Reference Sequences

More...
RefSeqi
NP_034311.2, NM_010181.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000025497; ENSMUSP00000025497; ENSMUSG00000024598

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
14119

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:14119

UCSC genome browser

More...
UCSCi
uc008ezn.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39790 Genomic DNA Translation: AAA74908.1
AC102317 Genomic DNA No translation available.
AC127358 Genomic DNA No translation available.
S69359 Unassigned DNA Translation: AAC60685.1
CCDSiCCDS37827.1
PIRiA57278
RefSeqiNP_034311.2, NM_010181.2

3D structure databases

SMRiQ61555
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025497

PTM databases

iPTMnetiQ61555
PhosphoSitePlusiQ61555

Proteomic databases

jPOSTiQ61555
MaxQBiQ61555
PaxDbiQ61555
PeptideAtlasiQ61555
PRIDEiQ61555

Genome annotation databases

EnsembliENSMUST00000025497; ENSMUSP00000025497; ENSMUSG00000024598
GeneIDi14119
KEGGimmu:14119
UCSCiuc008ezn.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2201
MGIiMGI:95490 Fbn2

Phylogenomic databases

eggNOGiENOG410IR7H Eukaryota
ENOG410XSTY LUCA
GeneTreeiENSGT00950000183158
HOGENOMiHOG000231768
InParanoidiQ61555
KOiK23342
OMAiHQCVACP
OrthoDBi1174178at2759
TreeFamiTF316849

Enzyme and pathway databases

ReactomeiR-MMU-1474228 Degradation of the extracellular matrix
R-MMU-1566948 Elastic fibre formation
R-MMU-2129379 Molecules associated with elastic fibres

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Fbn2 mouse

Protein Ontology

More...
PROi
PR:Q61555

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000024598 Expressed in 224 organ(s), highest expression level in ureter smooth muscle
GenevisibleiQ61555 MM

Family and domain databases

Gene3Di3.90.290.10, 9 hits
InterProiView protein in InterPro
IPR026823 cEGF
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR040872 Fibrillin_U_N
IPR009030 Growth_fac_rcpt_cys_sf
IPR017878 TB_dom
IPR036773 TB_dom_sf
PfamiView protein in Pfam
PF12662 cEGF, 2 hits
PF07645 EGF_CA, 39 hits
PF18193 Fibrillin_U_N, 1 hit
PF12661 hEGF, 1 hit
PF00683 TB, 9 hits
SMARTiView protein in SMART
SM00181 EGF, 46 hits
SM00179 EGF_CA, 44 hits
SUPFAMiSSF57184 SSF57184, 13 hits
SSF57581 SSF57581, 9 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 43 hits
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 37 hits
PS50026 EGF_3, 45 hits
PS01187 EGF_CA, 43 hits
PS51364 TB, 9 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFBN2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q61555
Secondary accession number(s): E9QJZ4, Q63957
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 27, 2011
Last modified: October 16, 2019
This is version 170 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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